PL3280257T3 - Odpowiedzi odpornościowe za pośrednictwem humanizowanych komórek t u zwierząt innych niż człowiek - Google Patents
Odpowiedzi odpornościowe za pośrednictwem humanizowanych komórek t u zwierząt innych niż człowiekInfo
- Publication number
- PL3280257T3 PL3280257T3 PL16766106.5T PL16766106T PL3280257T3 PL 3280257 T3 PL3280257 T3 PL 3280257T3 PL 16766106 T PL16766106 T PL 16766106T PL 3280257 T3 PL3280257 T3 PL 3280257T3
- Authority
- PL
- Poland
- Prior art keywords
- humanized
- immune responses
- human animals
- cell mediated
- mediated immune
- Prior art date
Links
- 230000021633 leukocyte mediated immunity Effects 0.000 title 1
Classifications
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
- A01K67/027—New or modified breeds of vertebrates
- A01K67/0275—Genetically modified vertebrates, e.g. transgenic
- A01K67/0278—Knock-in vertebrates, e.g. humanised vertebrates
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70503—Immunoglobulin superfamily
- C07K14/7051—T-cell receptor (TcR)-CD3 complex
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70503—Immunoglobulin superfamily
- C07K14/70517—CD8
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70503—Immunoglobulin superfamily
- C07K14/70539—MHC-molecules, e.g. HLA-molecules
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
- C12N15/8509—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells for producing genetically modified animals, e.g. transgenic
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2207/00—Modified animals
- A01K2207/15—Humanized animals
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2217/00—Genetically modified animals
- A01K2217/07—Animals genetically altered by homologous recombination
- A01K2217/072—Animals genetically altered by homologous recombination maintaining or altering function, i.e. knock in
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2217/00—Genetically modified animals
- A01K2217/15—Animals comprising multiple alterations of the genome, by transgenesis or homologous recombination, e.g. obtained by cross-breeding
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2267/00—Animals characterised by purpose
- A01K2267/01—Animal expressing industrially exogenous proteins
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
- C07K2319/03—Fusion polypeptide containing a localisation/targetting motif containing a transmembrane segment
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2800/00—Nucleic acids vectors
- C12N2800/10—Plasmid DNA
- C12N2800/106—Plasmid DNA for vertebrates
- C12N2800/107—Plasmid DNA for vertebrates for mammalian
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Zoology (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Medicinal Chemistry (AREA)
- Environmental Sciences (AREA)
- Cell Biology (AREA)
- Gastroenterology & Hepatology (AREA)
- Toxicology (AREA)
- Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Biodiversity & Conservation Biology (AREA)
- Animal Husbandry (AREA)
- Biomedical Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- Wood Science & Technology (AREA)
- Plant Pathology (AREA)
- Physics & Mathematics (AREA)
- Microbiology (AREA)
- Peptides Or Proteins (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201562143687P | 2015-04-06 | 2015-04-06 | |
US201562158804P | 2015-05-08 | 2015-05-08 | |
US201562186935P | 2015-06-30 | 2015-06-30 | |
PCT/US2016/026260 WO2016164492A2 (en) | 2015-04-06 | 2016-04-06 | Humanized t cell mediated immune responses in non-human animals |
Publications (1)
Publication Number | Publication Date |
---|---|
PL3280257T3 true PL3280257T3 (pl) | 2023-10-23 |
Family
ID=56926255
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PL16766106.5T PL3280257T3 (pl) | 2015-04-06 | 2016-04-06 | Odpowiedzi odpornościowe za pośrednictwem humanizowanych komórek t u zwierząt innych niż człowiek |
Country Status (25)
Country | Link |
---|---|
US (2) | US11259510B2 (pl) |
EP (2) | EP3280257B1 (pl) |
JP (4) | JP6796597B2 (pl) |
KR (1) | KR20170133498A (pl) |
CN (2) | CN113349159B (pl) |
AU (2) | AU2016246698B2 (pl) |
BR (1) | BR112017021250A2 (pl) |
CA (2) | CA2980771C (pl) |
DK (1) | DK3280257T3 (pl) |
ES (1) | ES2954865T3 (pl) |
FI (1) | FI3280257T3 (pl) |
HK (1) | HK1250884A1 (pl) |
HR (1) | HRP20231039T1 (pl) |
HU (1) | HUE064168T2 (pl) |
IL (3) | IL284809B2 (pl) |
LT (1) | LT3280257T (pl) |
MX (2) | MX2017012829A (pl) |
NZ (1) | NZ736031A (pl) |
PL (1) | PL3280257T3 (pl) |
PT (1) | PT3280257T (pl) |
RS (1) | RS64540B1 (pl) |
RU (1) | RU2732628C2 (pl) |
SG (2) | SG10201909320UA (pl) |
SI (1) | SI3280257T1 (pl) |
WO (1) | WO2016164492A2 (pl) |
Families Citing this family (27)
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US9591835B2 (en) | 2011-10-28 | 2017-03-14 | Regeneron Pharmaceuticals, Inc. | Genetically modified major histocompatibility complex animals |
EP4052572A1 (en) | 2011-10-28 | 2022-09-07 | Regeneron Pharmaceuticals, Inc. | Genetically modified mice expressing chimeric major histocompatibility complex (mhc) ii molecules |
RS57893B1 (sr) | 2011-10-28 | 2019-01-31 | Regeneron Pharma | Miševi sa genetski modifikovanim receptorom t ćelija |
ES2651517T3 (es) | 2011-10-28 | 2018-01-26 | Regeneron Pharmaceuticals, Inc. | Ratones con complejo mayor de histocompatibilidad modificado genéticamente |
EP2958938B1 (en) | 2013-02-20 | 2019-04-17 | Regeneron Pharmaceuticals, Inc. | Mice expressing humanized t-cell co-receptors |
US20150342163A1 (en) | 2013-02-22 | 2015-12-03 | Regeneron Pharmaceuticals, Inc. | Genetically modified major histocompatibility complex mice |
CA2900824A1 (en) | 2013-02-22 | 2014-08-28 | Regeneron Pharmaceuticals, Inc. | Mice expressing humanized major histocompatibility complex |
RU2745403C2 (ru) | 2015-11-20 | 2021-03-24 | Регенерон Фармасьютикалз, Инк. | Животные, отличные от человека, имеющие гуманизированный ген активации лимфоцитов-3 |
CN109068621B (zh) | 2016-02-29 | 2021-07-20 | 再生元制药公司 | 具有人源化的tmprss基因的啮齿类动物 |
CN109640644B (zh) | 2016-06-03 | 2021-10-26 | 瑞泽恩制药公司 | 表达外源末端脱氧核苷酸转移酶的非人动物 |
CA3084476A1 (en) * | 2017-10-19 | 2019-04-25 | Cellectis | Targeted gene integration of nk inhibitors genes for improved immune cells therapy |
EP3585164B1 (en) | 2017-11-30 | 2023-12-27 | Regeneron Pharmaceuticals, Inc. | Rats comprising a humanized trkb locus |
US11747340B2 (en) | 2018-03-24 | 2023-09-05 | Regeneron Pharmaceuticals, Inc. | Systems and methods for identifying HLA-associated tumor peptides |
MA52177A (fr) | 2018-03-26 | 2021-02-17 | Regeneron Pharma | Rongeurs humanisés pour tester des agents thérapeutiques |
AU2019308205A1 (en) | 2018-07-16 | 2020-11-19 | Regeneron Pharmaceuticals, Inc. | Non-human animal models of DITRA disease and uses thereof |
EA202191107A1 (ru) | 2018-10-23 | 2021-09-17 | Ридженерон Фармасьютикалз, Инк. | T-клеточные рецепторы ny-eso-1 и способы их применения |
US20210355190A1 (en) * | 2018-10-31 | 2021-11-18 | Mayo Foundation For Medical Education And Research | Methods and materials for treating cancer |
AU2020253532A1 (en) | 2019-04-04 | 2021-09-02 | Regeneron Pharmaceuticals, Inc. | Non-human animals comprising a humanized coagulation factor 12 locus |
KR20220016869A (ko) | 2019-06-04 | 2022-02-10 | 리제너론 파마슈티칼스 인코포레이티드 | 베타-슬립 돌연변이를 갖는 인간화 ttr 좌위를 포함하는 비-인간 동물 및 사용 방법 |
JP2022534560A (ja) | 2019-06-07 | 2022-08-02 | リジェネロン・ファーマシューティカルズ・インコーポレイテッド | ヒト化アルブミン遺伝子座を含む非ヒト動物 |
JP2023511417A (ja) | 2020-01-24 | 2023-03-17 | リジェネロン・ファーマシューティカルズ・インコーポレイテッド | 黒色腫において優先的に発現する抗原(prame)t細胞受容体およびそれらの使用方法 |
CA3213460A1 (en) * | 2021-03-31 | 2022-10-06 | Regeneron Pharmaceuticals, Inc. | Genetically modified mice comprising humanized cellular immune system components with improved diversity of tcrb repertoire |
WO2023092119A2 (en) | 2021-11-22 | 2023-05-25 | Ludwig Institute For Cancer Research Ltd | Methods for predicting responsiveness to a cancer therapy |
CN113999873B (zh) * | 2021-12-31 | 2022-05-20 | 北京市疾病预防控制中心 | 一种基因修饰的非人动物的构建方法及其应用 |
CN115074368B (zh) * | 2022-06-09 | 2023-08-08 | 澳门科技大学 | 一种耐药型类风湿性关节炎动物模型的构建及其应用 |
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US20240148867A1 (en) | 2022-10-31 | 2024-05-09 | Regeneron Pharmaceuticals, Inc. | Methods of treating cancer with a combination of adoptive cell therapy and a targeted immunocytokine |
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