EA202191107A1 - T-клеточные рецепторы ny-eso-1 и способы их применения - Google Patents
T-клеточные рецепторы ny-eso-1 и способы их примененияInfo
- Publication number
- EA202191107A1 EA202191107A1 EA202191107A EA202191107A EA202191107A1 EA 202191107 A1 EA202191107 A1 EA 202191107A1 EA 202191107 A EA202191107 A EA 202191107A EA 202191107 A EA202191107 A EA 202191107A EA 202191107 A1 EA202191107 A1 EA 202191107A1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- eso
- cell receptors
- methods
- application
- tcrs
- Prior art date
Links
- 108091008874 T cell receptors Proteins 0.000 title abstract 4
- 102000016266 T-Cell Antigen Receptors Human genes 0.000 title abstract 4
- 102100025570 Cancer/testis antigen 1 Human genes 0.000 title abstract 2
- 101000856237 Homo sapiens Cancer/testis antigen 1 Proteins 0.000 title abstract 2
- 102000004196 processed proteins & peptides Human genes 0.000 abstract 1
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 1
- 206010041823 squamous cell carcinoma Diseases 0.000 abstract 1
- 230000001225 therapeutic effect Effects 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70503—Immunoglobulin superfamily
- C07K14/7051—T-cell receptor (TcR)-CD3 complex
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/14—Blood; Artificial blood
- A61K35/17—Lymphocytes; B-cells; T-cells; Natural killer cells; Interferon-activated or cytokine-activated lymphocytes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/46—Cellular immunotherapy
- A61K39/461—Cellular immunotherapy characterised by the cell type used
- A61K39/4611—T-cells, e.g. tumor infiltrating lymphocytes [TIL], lymphokine-activated killer cells [LAK] or regulatory T cells [Treg]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/46—Cellular immunotherapy
- A61K39/463—Cellular immunotherapy characterised by recombinant expression
- A61K39/4632—T-cell receptors [TCR]; antibody T-cell receptor constructs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/46—Cellular immunotherapy
- A61K39/464—Cellular immunotherapy characterised by the antigen targeted or presented
- A61K39/4643—Vertebrate antigens
- A61K39/4644—Cancer antigens
- A61K39/464484—Cancer testis antigens, e.g. SSX, BAGE, GAGE or SAGE
- A61K39/464488—NY-ESO
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0634—Cells from the blood or the immune system
- C12N5/0636—T lymphocytes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2239/00—Indexing codes associated with cellular immunotherapy of group A61K39/46
- A61K2239/46—Indexing codes associated with cellular immunotherapy of group A61K39/46 characterised by the cancer treated
- A61K2239/48—Blood cells, e.g. leukemia or lymphoma
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/50—Fusion polypeptide containing protease site
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2510/00—Genetically modified cells
Abstract
Данное изобретение относится к выделенным Т-клеточным рецепторам (TCR), которые специфически связываются с пептидами плоскоклеточной карциномы пищевода 1 типа Нью-Йорк (NY-ESO-1), экспонируемыми HLA, а также к терапевтическим и диагностическим способам применения этих выделенных TCR.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201862749194P | 2018-10-23 | 2018-10-23 | |
PCT/US2019/057543 WO2020086647A1 (en) | 2018-10-23 | 2019-10-23 | Ny-eso-1 t cell receptors and methods of use thereof |
Publications (1)
Publication Number | Publication Date |
---|---|
EA202191107A1 true EA202191107A1 (ru) | 2021-09-17 |
Family
ID=68582342
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EA202191107A EA202191107A1 (ru) | 2018-10-23 | 2019-10-23 | T-клеточные рецепторы ny-eso-1 и способы их применения |
Country Status (10)
Country | Link |
---|---|
US (1) | US20210403527A1 (ru) |
EP (1) | EP3870602A1 (ru) |
JP (1) | JP2022505679A (ru) |
KR (1) | KR20210093908A (ru) |
CN (1) | CN113454110A (ru) |
AU (1) | AU2019364367A1 (ru) |
CA (1) | CA3117539A1 (ru) |
EA (1) | EA202191107A1 (ru) |
MA (1) | MA53981A (ru) |
WO (1) | WO2020086647A1 (ru) |
Families Citing this family (17)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA3142513A1 (en) | 2019-06-25 | 2020-12-30 | Gilead Sciences, Inc. | Flt3l-fc fusion proteins and methods of use |
CN117964757A (zh) | 2020-02-14 | 2024-05-03 | 吉利德科学公司 | 与ccr8结合的抗体和融合蛋白及其用途 |
US20230250149A1 (en) * | 2020-06-25 | 2023-08-10 | The Methodist Hospital | Antigen-specific t cell receptors and chimeric antigen receptors, and methods of use in immune signaling modulation for cancer immunotherapy |
TWI815194B (zh) | 2020-10-22 | 2023-09-11 | 美商基利科學股份有限公司 | 介白素2-Fc融合蛋白及使用方法 |
WO2022183076A1 (en) * | 2021-02-25 | 2022-09-01 | Lyell Immunopharma, Inc. | Enhanced immune cell therapy targeting ny-eso-1 |
TW202313094A (zh) | 2021-05-18 | 2023-04-01 | 美商基利科學股份有限公司 | 使用FLT3L—Fc融合蛋白之方法 |
CN113912701A (zh) * | 2021-10-14 | 2022-01-11 | 深圳大学总医院 | Tcr及其在诊断/治疗中的应用 |
TW202330504A (zh) | 2021-10-28 | 2023-08-01 | 美商基利科學股份有限公司 | 嗒𠯤—3(2h)—酮衍生物 |
US11919869B2 (en) | 2021-10-29 | 2024-03-05 | Gilead Sciences, Inc. | CD73 compounds |
WO2023114433A1 (en) * | 2021-12-15 | 2023-06-22 | 3T Biosciences, Inc. | Methods and systems for assessing immune cell receptors and antigens |
US20230242508A1 (en) | 2021-12-22 | 2023-08-03 | Gilead Sciences, Inc. | Ikaros zinc finger family degraders and uses thereof |
WO2023122581A2 (en) | 2021-12-22 | 2023-06-29 | Gilead Sciences, Inc. | Ikaros zinc finger family degraders and uses thereof |
WO2023141587A2 (en) * | 2022-01-20 | 2023-07-27 | 3T Biosciences, Inc. | T cell receptor (tcr) compositions and methods for optimizing antigen reactive t-cells |
TW202340168A (zh) | 2022-01-28 | 2023-10-16 | 美商基利科學股份有限公司 | Parp7抑制劑 |
TW202346277A (zh) | 2022-03-17 | 2023-12-01 | 美商基利科學股份有限公司 | Ikaros鋅指家族降解劑及其用途 |
TW202400138A (zh) | 2022-04-21 | 2024-01-01 | 美商基利科學股份有限公司 | Kras g12d調節化合物 |
WO2024006929A1 (en) | 2022-07-01 | 2024-01-04 | Gilead Sciences, Inc. | Cd73 compounds |
Family Cites Families (27)
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ATE68013T1 (de) | 1985-07-05 | 1991-10-15 | Whitehead Biomedical Inst | Expression von fremdem genetischem material in epithelzellen. |
US4980286A (en) | 1985-07-05 | 1990-12-25 | Whitehead Institute For Biomedical Research | In vivo introduction and expression of foreign genetic material in epithelial cells |
US4690915A (en) | 1985-08-08 | 1987-09-01 | The United States Of America As Represented By The Department Of Health And Human Services | Adoptive immunotherapy as a treatment modality in humans |
EP0378576B1 (en) | 1987-09-11 | 1995-01-18 | Whitehead Institute For Biomedical Research | Transduced fibroblasts and uses therefor |
JP2914692B2 (ja) | 1987-12-11 | 1999-07-05 | ホワイトヘツド・インスチチユート・フオー・バイオメデイカル・リサーチ | 内皮細胞の遺伝子修飾 |
DE68927996T2 (de) | 1988-02-05 | 1997-12-04 | Whitehead Biomedical Inst | Modifizierte hepatozyten und deren anwendung |
CA2095256A1 (en) | 1990-10-31 | 1992-05-01 | Brad Guild | Retroviral vectors useful for gene therapy |
EA200001216A1 (ru) | 1998-05-19 | 2001-06-25 | Авидекс Лимитед | Растворимый т-лимфоцитный рецептор |
US7087411B2 (en) | 1999-06-08 | 2006-08-08 | Regeneron Pharmaceuticals, Inc. | Fusion protein capable of binding VEGF |
US6867041B2 (en) | 2000-02-24 | 2005-03-15 | Xcyte Therapies, Inc. | Simultaneous stimulation and concentration of cells |
ATE373078T1 (de) | 2000-02-24 | 2007-09-15 | Xcyte Therapies Inc | Gleichzeitige stimulation und konzentration von zellen |
US6797514B2 (en) | 2000-02-24 | 2004-09-28 | Xcyte Therapies, Inc. | Simultaneous stimulation and concentration of cells |
US20030170238A1 (en) | 2002-03-07 | 2003-09-11 | Gruenberg Micheal L. | Re-activated T-cells for adoptive immunotherapy |
WO2005113595A2 (en) | 2004-05-19 | 2005-12-01 | Avidex Ltd | High affinity ny-eso t cell receptor |
US9281917B2 (en) | 2007-01-03 | 2016-03-08 | Nokia Technologies Oy | Shared control channel structure |
JP5947311B2 (ja) | 2010-12-09 | 2016-07-06 | ザ トラスティーズ オブ ザ ユニバーシティ オブ ペンシルバニア | 癌を治療するためのキメラ抗原受容体改変t細胞の使用 |
WO2014160030A2 (en) * | 2013-03-13 | 2014-10-02 | Health Research, Inc. | Compositions and methods for use of recombinant t cell receptors for direct recognition of tumor antigen |
EP3015477B1 (en) * | 2013-06-26 | 2021-08-18 | XLifeSc, Ltd. | High-stability t-cell receptor and preparation method and application thereof |
PL228457B1 (pl) | 2013-08-30 | 2018-03-30 | Univ Jagiellonski | Tomograf hybrydowy TOF-PET/CT |
CN117143814A (zh) | 2014-11-17 | 2023-12-01 | 阿迪塞特治疗公司 | 工程化的γδ T细胞 |
CN105985427A (zh) * | 2015-02-06 | 2016-10-05 | 广州市香雪制药股份有限公司 | 高亲和力ny-eso t细胞受体 |
PT3280257T (pt) | 2015-04-06 | 2023-09-12 | Regeneron Pharma | Respostas imunes mediadas por células t humanizadas em animais não humanos |
CN106188275A (zh) * | 2015-05-06 | 2016-12-07 | 广州市香雪制药股份有限公司 | 识别ny-eso-1抗原短肽的t细胞受体 |
CN106432475B (zh) * | 2015-10-19 | 2018-06-01 | 广东香雪精准医疗技术有限公司 | 高亲和力ny-eso t细胞受体 |
GB201522592D0 (en) * | 2015-12-22 | 2016-02-03 | Immunocore Ltd | T cell receptors |
GB201616238D0 (en) * | 2016-09-23 | 2016-11-09 | Adaptimmune Ltd | Modified T cells |
CN108456247A (zh) * | 2017-02-20 | 2018-08-28 | 上海恒润达生生物科技有限公司 | 靶向ny-eso-1的t细胞受体及其用途 |
-
2019
- 2019-10-23 WO PCT/US2019/057543 patent/WO2020086647A1/en unknown
- 2019-10-23 EP EP19804919.9A patent/EP3870602A1/en active Pending
- 2019-10-23 EA EA202191107A patent/EA202191107A1/ru unknown
- 2019-10-23 JP JP2021522096A patent/JP2022505679A/ja active Pending
- 2019-10-23 CA CA3117539A patent/CA3117539A1/en active Pending
- 2019-10-23 CN CN201980085431.3A patent/CN113454110A/zh active Pending
- 2019-10-23 MA MA053981A patent/MA53981A/fr unknown
- 2019-10-23 US US17/287,643 patent/US20210403527A1/en active Pending
- 2019-10-23 AU AU2019364367A patent/AU2019364367A1/en active Pending
- 2019-10-23 KR KR1020217015373A patent/KR20210093908A/ko active Search and Examination
Also Published As
Publication number | Publication date |
---|---|
CA3117539A1 (en) | 2020-04-30 |
AU2019364367A1 (en) | 2021-05-27 |
KR20210093908A (ko) | 2021-07-28 |
US20210403527A1 (en) | 2021-12-30 |
WO2020086647A8 (en) | 2020-05-28 |
JP2022505679A (ja) | 2022-01-14 |
MA53981A (fr) | 2021-09-01 |
EP3870602A1 (en) | 2021-09-01 |
CN113454110A (zh) | 2021-09-28 |
WO2020086647A1 (en) | 2020-04-30 |
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