JP2008501357A5 - - Google Patents
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- Publication number
- JP2008501357A5 JP2008501357A5 JP2007526577A JP2007526577A JP2008501357A5 JP 2008501357 A5 JP2008501357 A5 JP 2008501357A5 JP 2007526577 A JP2007526577 A JP 2007526577A JP 2007526577 A JP2007526577 A JP 2007526577A JP 2008501357 A5 JP2008501357 A5 JP 2008501357A5
- Authority
- JP
- Japan
- Prior art keywords
- human
- genetically modified
- human mammal
- gene
- cells
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 210000005260 human cell Anatomy 0.000 claims 25
- 238000000034 method Methods 0.000 claims 22
- 108090000623 proteins and genes Proteins 0.000 claims 22
- 101710117460 Mannan-binding lectin serine protease 2 Proteins 0.000 claims 12
- 229920001184 polypeptide Polymers 0.000 claims 7
- 102000004196 processed proteins & peptides Human genes 0.000 claims 7
- 108090000765 processed proteins & peptides Proteins 0.000 claims 7
- 241000124008 Mammalia Species 0.000 claims 6
- 210000004027 cell Anatomy 0.000 claims 6
- 210000001671 embryonic stem cell Anatomy 0.000 claims 6
- 238000004519 manufacturing process Methods 0.000 claims 5
- 102100026046 Mannan-binding lectin serine protease 2 Human genes 0.000 claims 4
- 241000699666 Mus <mouse, genus> Species 0.000 claims 4
- 108091028043 Nucleic acid sequence Proteins 0.000 claims 4
- 150000007523 nucleic acids Chemical group 0.000 claims 4
- 210000004962 mammalian cell Anatomy 0.000 claims 3
- 241000699670 Mus sp. Species 0.000 claims 2
- 239000003550 marker Substances 0.000 claims 2
- 238000011144 upstream manufacturing Methods 0.000 claims 2
- 108020004414 DNA Proteins 0.000 claims 1
- 102000004856 Lectins Human genes 0.000 claims 1
- 108090001090 Lectins Proteins 0.000 claims 1
- 241001465754 Metazoa Species 0.000 claims 1
- 210000002459 blastocyst Anatomy 0.000 claims 1
- 230000024203 complement activation Effects 0.000 claims 1
- 238000012217 deletion Methods 0.000 claims 1
- 230000037430 deletion Effects 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 230000016784 immunoglobulin production Effects 0.000 claims 1
- 238000009399 inbreeding Methods 0.000 claims 1
- 238000010348 incorporation Methods 0.000 claims 1
- 230000010354 integration Effects 0.000 claims 1
- 239000002523 lectin Substances 0.000 claims 1
- 238000000520 microinjection Methods 0.000 claims 1
- 210000000287 oocyte Anatomy 0.000 claims 1
- 102000004169 proteins and genes Human genes 0.000 claims 1
- 238000005215 recombination Methods 0.000 claims 1
- 230000006798 recombination Effects 0.000 claims 1
- 230000004044 response Effects 0.000 claims 1
- 238000012216 screening Methods 0.000 claims 1
- 230000008685 targeting Effects 0.000 claims 1
- 238000001890 transfection Methods 0.000 claims 1
- 108700026220 vif Genes Proteins 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB0412966.4A GB0412966D0 (en) | 2004-06-10 | 2004-06-10 | Genetically modified non-human mammals and cells |
| PCT/GB2005/050086 WO2005120222A2 (en) | 2004-06-10 | 2005-06-08 | Genetically modified non-human mammals and cells |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2008501357A JP2008501357A (ja) | 2008-01-24 |
| JP2008501357A5 true JP2008501357A5 (https=) | 2008-07-24 |
Family
ID=32732258
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007526577A Pending JP2008501357A (ja) | 2004-06-10 | 2005-06-08 | 遺伝子改変された非ヒト哺乳動物および非ヒト細胞 |
Country Status (6)
| Country | Link |
|---|---|
| US (3) | US8785717B2 (https=) |
| EP (1) | EP1766033B1 (https=) |
| JP (1) | JP2008501357A (https=) |
| ES (1) | ES2535639T3 (https=) |
| GB (1) | GB0412966D0 (https=) |
| WO (1) | WO2005120222A2 (https=) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7083786B2 (en) | 1997-04-03 | 2006-08-01 | Jensenius Jens Chr | MASP-2, a complement-fixing enzyme, and uses for it |
| EP1625166B1 (en) | 2003-05-12 | 2015-04-08 | Helion Biotech ApS | Antibodies to masp-2 |
| US7919094B2 (en) * | 2004-06-10 | 2011-04-05 | Omeros Corporation | Methods for treating conditions associated with MASP-2 dependent complement activation |
| US8840893B2 (en) | 2004-06-10 | 2014-09-23 | Omeros Corporation | Methods for treating conditions associated with MASP-2 dependent complement activation |
| EP2386316B1 (en) * | 2004-06-10 | 2018-02-28 | Omeros Corporation | Methods for treating conditions associated with MASP-2 dependent complement activation |
| CN102781471B (zh) | 2009-10-16 | 2016-10-12 | 奥默罗斯公司 | 通过抑制masp-2依赖性补体活化治疗弥散性血管内凝血的方法 |
| US9644035B2 (en) | 2011-04-08 | 2017-05-09 | Omeros Corporation | Methods for treating conditions associated with MASP-2 dependent complement activation |
| KR101870915B1 (ko) | 2011-04-08 | 2018-06-25 | 유니버시티 오브 레스터 | Ｍａｓｐ-2 의존적 보체 활성화와 관련된 질병을 치료하는 방법 |
| EP2704743B1 (en) | 2011-05-04 | 2020-03-11 | Omeros Corporation | Compositions for inhibiting masp-2 dependent complement acitivation |
| CN112481302B (zh) * | 2021-02-05 | 2021-05-14 | 百奥赛图(北京)医药科技股份有限公司 | Masp2基因人源化的非人动物的构建方法及应用 |
Family Cites Families (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4331647A (en) | 1980-03-03 | 1982-05-25 | Goldenberg Milton David | Tumor localization and therapy with labeled antibody fragments specific to tumor-associated markers |
| US4816567A (en) | 1983-04-08 | 1989-03-28 | Genentech, Inc. | Recombinant immunoglobin preparations |
| US4946778A (en) | 1987-09-21 | 1990-08-07 | Genex Corporation | Single polypeptide chain binding molecules |
| US5530101A (en) | 1988-12-28 | 1996-06-25 | Protein Design Labs, Inc. | Humanized immunoglobulins |
| US5464764A (en) * | 1989-08-22 | 1995-11-07 | University Of Utah Research Foundation | Positive-negative selection methods and vectors |
| SG46445A1 (en) | 1990-01-26 | 1998-02-20 | Immunomedics Inc | Vaccines against cancer and infectious diseases |
| US7083786B2 (en) * | 1997-04-03 | 2006-08-01 | Jensenius Jens Chr | MASP-2, a complement-fixing enzyme, and uses for it |
| US7273925B1 (en) * | 1998-12-15 | 2007-09-25 | Brigham And Women's Hospital, Inc. | Methods and products for regulating lectin complement pathway associated complement activation |
| JP2002532079A (ja) | 1998-12-15 | 2002-10-02 | ザ ブライハム アンド ウイミンズ ホスピタル， インコーポレイテッド | 補体活性化に関連するレクチン補体経路を調節するための方法および産物 |
| JP2003507338A (ja) | 1999-08-13 | 2003-02-25 | ザ ブリグハム アンド ウイメンズ ホスピタル インコーポレイテッド | レクチン補体経路（ｌｃｐ）のインヒビターおよびその使用 |
| AU2001261103B2 (en) * | 2000-04-29 | 2007-08-23 | University Of Iowa Research Foundation | Diagnostics and therapeutics for macular degeneration-related disorders |
| NZ523900A (en) * | 2000-07-13 | 2004-02-27 | Jens Christian Jensenius | Isolation and characterisation of a mannan-binding lectin (MBL) associated serine protease (MASP-2) and uses thereof to treat infections |
| US20020094332A1 (en) * | 2001-01-18 | 2002-07-18 | Alexion Pharmaceuticals | Method of prophylaxis against large myocardial infractions |
| CA2454562A1 (en) | 2001-07-26 | 2003-02-06 | Alexion Pharmaceuticals, Inc. | Method of improving cognitive function |
| CA2473786A1 (en) | 2002-01-22 | 2003-07-31 | Alexion Pharmaceuticals, Inc. | Method of prophylaxis against large myocardial infarctions |
| EP1570075A2 (en) * | 2002-12-03 | 2005-09-07 | Aarhus Universitet | Method for determing predisposition to manifestation of immune system related diseases |
| US7361339B2 (en) * | 2003-01-09 | 2008-04-22 | Alexion Pharmaceuticals, Inc. | Methods for reducing morality associated with acute myocardial infarction |
| AU2004216176B2 (en) * | 2003-02-21 | 2008-04-03 | Genentech, Inc. | Methods for preventing and treating tissue damage associated with ischemia-reperfusion injury |
| EP1625166B1 (en) | 2003-05-12 | 2015-04-08 | Helion Biotech ApS | Antibodies to masp-2 |
| WO2005014849A2 (en) * | 2003-07-03 | 2005-02-17 | Euro-Celtique, S.A. | Genes associated with responses to neuropathic pain |
| US7482376B2 (en) * | 2003-07-03 | 2009-01-27 | 3-Dimensional Pharmaceuticals, Inc. | Conjugated complement cascade inhibitors |
| WO2005024013A1 (en) | 2003-09-05 | 2005-03-17 | Natimmune A/S | Masp-2 crystal structure and uses thereof |
| WO2005123776A1 (en) | 2004-06-10 | 2005-12-29 | Omeros Corporation | Methods for treating conditions associated with lectin-dependent complement activation |
| EP2386316B1 (en) | 2004-06-10 | 2018-02-28 | Omeros Corporation | Methods for treating conditions associated with MASP-2 dependent complement activation |
-
2004
- 2004-06-10 GB GBGB0412966.4A patent/GB0412966D0/en not_active Ceased
-
2005
- 2005-06-08 EP EP05748982.5A patent/EP1766033B1/en not_active Expired - Lifetime
- 2005-06-08 WO PCT/GB2005/050086 patent/WO2005120222A2/en not_active Ceased
- 2005-06-08 JP JP2007526577A patent/JP2008501357A/ja active Pending
- 2005-06-08 US US11/570,087 patent/US8785717B2/en active Active
- 2005-06-08 ES ES05748982.5T patent/ES2535639T3/es not_active Expired - Lifetime
-
2014
- 2014-06-26 US US14/316,235 patent/US20150067897A1/en not_active Abandoned
-
2016
- 2016-11-10 US US15/348,162 patent/US10660317B2/en not_active Expired - Lifetime
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