JP2019022518A5 - - Google Patents
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- Publication number
- JP2019022518A5 JP2019022518A5 JP2018194898A JP2018194898A JP2019022518A5 JP 2019022518 A5 JP2019022518 A5 JP 2019022518A5 JP 2018194898 A JP2018194898 A JP 2018194898A JP 2018194898 A JP2018194898 A JP 2018194898A JP 2019022518 A5 JP2019022518 A5 JP 2019022518A5
- Authority
- JP
- Japan
- Prior art keywords
- rodent
- exon
- human
- humanized
- gene
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 241000283984 Rodentia Species 0.000 claims 57
- 108090000172 Interleukin-15 Proteins 0.000 claims 45
- 102000003812 Interleukin-15 Human genes 0.000 claims 27
- 101001055157 Homo sapiens Interleukin-15 Proteins 0.000 claims 16
- 102000056003 human IL15 Human genes 0.000 claims 16
- 239000012634 fragment Substances 0.000 claims 12
- 241000700159 Rattus Species 0.000 claims 6
- 230000001105 regulatory effect Effects 0.000 claims 6
- 210000001519 tissue Anatomy 0.000 claims 6
- 238000011144 upstream manufacturing Methods 0.000 claims 6
- 238000000034 method Methods 0.000 claims 5
- 108700024394 Exon Proteins 0.000 claims 4
- 108090000623 proteins and genes Proteins 0.000 claims 2
- 102000004169 proteins and genes Human genes 0.000 claims 2
- 210000000981 epithelium Anatomy 0.000 claims 1
- 210000001161 mammalian embryo Anatomy 0.000 claims 1
- 210000003205 muscle Anatomy 0.000 claims 1
- 238000006467 substitution reaction Methods 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361891013P | 2013-10-15 | 2013-10-15 | |
| US61/891,013 | 2013-10-15 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016549191A Division JP6492095B2 (ja) | 2013-10-15 | 2014-10-15 | ヒト化ｉｌ−１５動物 |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019182817A Division JP2019216750A (ja) | 2013-10-15 | 2019-10-03 | ヒト化ｉｌ−１５動物 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2019022518A JP2019022518A (ja) | 2019-02-14 |
| JP2019022518A5 true JP2019022518A5 (https=) | 2019-04-18 |
| JP6600061B2 JP6600061B2 (ja) | 2019-10-30 |
Family
ID=51830649
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016549191A Active JP6492095B2 (ja) | 2013-10-15 | 2014-10-15 | ヒト化ｉｌ−１５動物 |
| JP2018194898A Active JP6600061B2 (ja) | 2013-10-15 | 2018-10-16 | ヒト化ｉｌ−１５動物 |
| JP2019182817A Pending JP2019216750A (ja) | 2013-10-15 | 2019-10-03 | ヒト化ｉｌ−１５動物 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016549191A Active JP6492095B2 (ja) | 2013-10-15 | 2014-10-15 | ヒト化ｉｌ−１５動物 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019182817A Pending JP2019216750A (ja) | 2013-10-15 | 2019-10-03 | ヒト化ｉｌ−１５動物 |
Country Status (27)
| Country | Link |
|---|---|
| US (5) | US9155290B2 (https=) |
| EP (3) | EP3461331A1 (https=) |
| JP (3) | JP6492095B2 (https=) |
| KR (1) | KR102376041B1 (https=) |
| CN (2) | CN109090037B (https=) |
| AU (2) | AU2014337526B2 (https=) |
| BR (1) | BR112016008175A2 (https=) |
| CA (1) | CA2926090C (https=) |
| CY (2) | CY1118675T1 (https=) |
| DK (2) | DK2908626T3 (https=) |
| ES (2) | ES2613379T3 (https=) |
| HR (2) | HRP20170380T1 (https=) |
| HU (2) | HUE033272T2 (https=) |
| IL (2) | IL244525B (https=) |
| LT (2) | LT2908626T (https=) |
| MX (1) | MX2016004781A (https=) |
| NZ (1) | NZ718655A (https=) |
| PL (2) | PL3138397T3 (https=) |
| PT (2) | PT3138397T (https=) |
| RS (2) | RS58465B1 (https=) |
| RU (1) | RU2674910C2 (https=) |
| SG (2) | SG11201601828XA (https=) |
| SI (2) | SI3138397T1 (https=) |
| SM (3) | SMT201700024T1 (https=) |
| TR (1) | TR201904342T4 (https=) |
| WO (1) | WO2015057758A1 (https=) |
| ZA (1) | ZA201601676B (https=) |
Families Citing this family (49)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP4502152A3 (en) | 2009-10-06 | 2025-04-30 | Regeneron Pharmaceuticals, Inc. | Genetically modified mice and engraftment |
| SG10202008003VA (en) | 2011-02-15 | 2020-10-29 | Regeneron Pharma | Humanized m-csf mice |
| FI2892330T3 (fi) | 2012-09-07 | 2023-03-25 | Univ Yale | Geneettisesti muokattuja hiiriä ja menetelmiä niiden käyttämiseksi |
| MX377561B (es) | 2012-11-05 | 2025-03-10 | Regeneron Pharma | Animales no humanos genéticamente modificados y métodos de uso de los mismos. |
| ES2613379T3 (es) | 2013-10-15 | 2017-05-24 | Regeneron Pharmaceuticals, Inc. | Animales con IL-15 humanizada |
| RU2671101C1 (ru) | 2013-11-19 | 2018-10-29 | Регенерон Фармасьютикалс, Инк. | Отличные от человека животные, содержащие гуманизированный ген индуцирующего пролиферацию лиганда |
| EP3636073B1 (en) | 2014-05-05 | 2023-11-15 | Regeneron Pharmaceuticals, Inc. | Humanized c5 and c3 animals |
| NO2785538T3 (https=) | 2014-05-07 | 2018-08-04 | ||
| MX2016014995A (es) | 2014-05-19 | 2017-03-31 | Regeneron Pharma | Animales no humanos geneticamente modificados que expresan eritropoyetina de humano. |
| HUE064960T2 (hu) | 2014-12-05 | 2024-04-28 | Regeneron Pharma | Differenciációs 47 gén humanizált klasztert tartalmazó nem-humán állatok |
| ES2950399T3 (es) | 2015-04-13 | 2023-10-09 | Regeneron Pharma | Ratones humanizados Sirpa-IL15 insertados y métodos de uso de los mismos |
| SG11201806176PA (en) | 2016-02-04 | 2018-08-30 | Regeneron Pharma | Non-human animals having an engineered angptl8 gene |
| DK3422845T3 (da) | 2016-02-29 | 2021-08-30 | Regeneron Pharma | Gnavere med et humaniseret tmprss-gen |
| WO2018001241A1 (zh) | 2016-06-28 | 2018-01-04 | 北京百奥赛图基因生物技术有限公司 | 一种pd-1基因修饰人源化动物模型的构建方法及其应用 |
| WO2018041118A1 (en) | 2016-08-31 | 2018-03-08 | Beijing Biocytogen Co., Ltd | Genetically modified non-human animal with human or chimeric pd-l1 |
| WO2018041121A1 (en) | 2016-08-31 | 2018-03-08 | Beijing Biocytogen Co., Ltd | Genetically modified non-human animal with human or chimeric ctla-4 |
| CN107815467B (zh) | 2016-08-31 | 2021-03-16 | 百奥赛图(北京)医药科技股份有限公司 | 人源化基因改造动物模型的制备方法及应用 |
| US11279948B2 (en) | 2016-08-31 | 2022-03-22 | Biocytogen Pharmaceuticals (Beijing) Co., Ltd. | Genetically modified non-human animal with human or chimeric OX40 |
| WO2018041120A1 (en) | 2016-08-31 | 2018-03-08 | Beijing Biocytogen Co., Ltd | Genetically modified non-human animal with human or chimeric tigit |
| CN107815468B (zh) | 2016-08-31 | 2021-03-16 | 百奥赛图(北京)医药科技股份有限公司 | 人源化基因改造动物模型的制备方法及应用 |
| WO2018086594A1 (en) | 2016-11-11 | 2018-05-17 | Beijing Biocytogen Co., Ltd | Genetically modified non-human animal with human or chimeric tim-3 |
| CN108070613B (zh) | 2016-11-11 | 2020-03-13 | 百奥赛图江苏基因生物技术有限公司 | 人源化基因改造动物模型的制备方法及应用 |
| CN110740641A (zh) | 2016-11-30 | 2020-01-31 | 杰克逊实验室 | 具有改善的人先天免疫细胞发育的人源化小鼠模型 |
| CN108239659B (zh) | 2016-12-23 | 2020-03-03 | 百奥赛图江苏基因生物技术有限公司 | 人源化基因改造动物模型的制备方法及应用 |
| CN108424928B (zh) | 2016-12-30 | 2021-03-16 | 百奥赛图(北京)医药科技股份有限公司 | 人源化基因改造动物模型的制备方法及应用 |
| US11629340B2 (en) | 2017-03-03 | 2023-04-18 | Obsidian Therapeutics, Inc. | DHFR tunable protein regulation |
| CN108467873B (zh) | 2017-03-17 | 2020-03-13 | 百奥赛图江苏基因生物技术有限公司 | 一种cd132基因缺失的免疫缺陷动物模型的制备方法及应用 |
| WO2018177441A1 (en) | 2017-03-31 | 2018-10-04 | Beijing Biocytogen Co., Ltd | GENETICALLY MODIFIED NON-HUMAN ANIMAL WITH HUMAN OR CHIMERIC SIRPα |
| CN108588126B (zh) | 2017-03-31 | 2020-04-10 | 北京百奥赛图基因生物技术有限公司 | Cd47基因人源化改造动物模型的制备方法及应用 |
| CN109136275B (zh) | 2017-06-19 | 2021-03-16 | 百奥赛图(北京)医药科技股份有限公司 | 人源化gitr基因改造动物模型的制备方法及应用 |
| CN109136274B (zh) | 2017-06-19 | 2021-04-23 | 百奥赛图江苏基因生物技术有限公司 | 人源化cd40基因改造动物模型的制备方法及应用 |
| CN109136261B (zh) | 2017-06-19 | 2021-03-16 | 百奥赛图(北京)医药科技股份有限公司 | 人源化cd28基因改造动物模型的制备方法及应用 |
| EP3664603B1 (en) * | 2017-08-09 | 2024-01-03 | The Jackson Laboratory | Immunodeficient mice expressing human interleukin 15 |
| US20190098879A1 (en) | 2017-09-29 | 2019-04-04 | Regeneron Pharmaceuticals, Inc. | Non-Human Animals Comprising A Humanized TTR Locus And Methods Of Use |
| WO2019072241A1 (en) | 2017-10-13 | 2019-04-18 | Beijing Biocytogen Co., Ltd | NON-HUMAN ANIMAL GENETICALLY MODIFIED WITH PD-1 HUMAN OR CHIMERIC |
| WO2019114768A1 (en) | 2017-12-12 | 2019-06-20 | Biocytogen Jiangsu Co., Ltd. | GENETICALLY MODIFIED NON-HUMAN ANIMAL WITH HUMAN OR CHIMERIC CD3e |
| HRP20240999T1 (hr) | 2018-07-16 | 2024-10-25 | Regeneron Pharmaceuticals, Inc. | Glodavački modeli bolesti ditra i njihova upotreba |
| CN111057721B (zh) | 2018-10-12 | 2021-03-16 | 百奥赛图(北京)医药科技股份有限公司 | 人源化IL-4和/或IL-4Rα改造动物模型的制备方法及应用 |
| WO2020125763A1 (en) | 2018-12-20 | 2020-06-25 | Biocytogen Jiangsu Co., Ltd. | Genetically modified non-human animal with human or chimeric lag3 |
| CN111304248B (zh) | 2018-12-25 | 2021-08-24 | 百奥赛图江苏基因生物技术有限公司 | 人源化细胞因子il15基因改造非人动物的构建方法及应用 |
| CN114107385A (zh) * | 2019-01-17 | 2022-03-01 | 百奥赛图(北京)医药科技股份有限公司 | 人源化转基因动物 |
| KR102661779B1 (ko) | 2019-04-04 | 2024-04-30 | 리제너론 파마슈티칼스 인코포레이티드 | 인간화 응고 인자 12 좌위를 포함하는 비-인간 동물 |
| US11891618B2 (en) | 2019-06-04 | 2024-02-06 | Regeneron Pharmaceuticals, Inc. | Mouse comprising a humanized TTR locus with a beta-slip mutation and methods of use |
| MX2021015122A (es) | 2019-06-07 | 2022-04-06 | Regeneron Pharma | Animales no humanos que comprenden un locus de albumina humanizado. |
| CN114786479B (zh) * | 2019-12-25 | 2023-12-15 | 江苏集萃药康生物科技股份有限公司 | 一种il-15人源化小鼠模型及其用途 |
| WO2021154791A1 (en) * | 2020-01-28 | 2021-08-05 | Regeneron Pharmaceuticals, Inc. | Non-human animals comprising a humanized pnpla3 locus and methods of use |
| CN111485001A (zh) * | 2020-04-14 | 2020-08-04 | 澎立生物医药技术（上海）有限公司 | 具有nk细胞及adcc能力的人源化免疫系统小鼠的构建方法 |
| CN112481303B (zh) * | 2021-02-09 | 2021-05-25 | 百奥赛图(北京)医药科技股份有限公司 | Il15ra基因人源化非人动物及其构建方法和应用 |
| WO2025212991A1 (en) | 2024-04-05 | 2025-10-09 | Regeneron Pharmaceuticals, Inc. | Rodent models of disease |
Family Cites Families (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2001058914A2 (en) * | 2000-02-08 | 2001-08-16 | Genaissance Pharmaceuticals, Inc. | Haplotypes of the interleukin 15 gene |
| US7759541B2 (en) * | 2004-12-13 | 2010-07-20 | Iti Life Sciences | Transgenic animals for assessing drug metabolism and toxicity |
| EP3263581B2 (en) * | 2005-05-17 | 2025-07-09 | University of Connecticut | Compositions and methods for immunomodulation in an organism |
| EP2147594B1 (en) * | 2008-06-27 | 2013-11-13 | Merus B.V. | Antibody producing non-human mammals |
| RU2425880C2 (ru) * | 2009-07-30 | 2011-08-10 | Учреждение Российской академии наук Институт общей генетики им. Н.И. Вавилова РАН | Способ получения трансгенных мышей |
| EP4502152A3 (en) | 2009-10-06 | 2025-04-30 | Regeneron Pharmaceuticals, Inc. | Genetically modified mice and engraftment |
| CA2784953C (en) * | 2009-12-21 | 2018-05-22 | Regeneron Pharmaceuticals, Inc. | Humanized fc.gamma.r mice |
| SG10202008003VA (en) * | 2011-02-15 | 2020-10-29 | Regeneron Pharma | Humanized m-csf mice |
| US9043996B2 (en) * | 2011-10-28 | 2015-06-02 | Regeneron Pharmaceuticals, Inc. | Genetically modified major histocompatibility complex animals |
| CN108866101A (zh) * | 2011-10-28 | 2018-11-23 | 瑞泽恩制药公司 | 人源化il-6和il-6受体 |
| SMT202200205T1 (it) * | 2011-10-28 | 2022-07-21 | Regeneron Pharma | Topi geneticamente modificati che esprimono molecole chimeriche del complesso maggiore di istocompatibilità (mhc) ii |
| SMT201900478T1 (it) | 2011-10-28 | 2019-09-09 | Regeneron Pharma | Topi con complesso maggiore di istocompatibilita' geneticamente modificati |
| US8962913B2 (en) | 2012-06-18 | 2015-02-24 | Regeneron Pharmaceuticals, Inc. | Humanized IL-7 rodents |
| FI2892330T3 (fi) | 2012-09-07 | 2023-03-25 | Univ Yale | Geneettisesti muokattuja hiiriä ja menetelmiä niiden käyttämiseksi |
| MX377561B (es) | 2012-11-05 | 2025-03-10 | Regeneron Pharma | Animales no humanos genéticamente modificados y métodos de uso de los mismos. |
| EP3699190B9 (en) | 2013-02-22 | 2023-10-04 | Regeneron Pharmaceuticals, Inc. | Murine cell expressing humanized major histocompatibility complex |
| TR201901782T4 (tr) | 2013-09-23 | 2019-03-21 | Regeneron Pharma | İnsanlaştirilmiş bi̇r si̇nyal düzenleyi̇ci̇ protei̇n geni̇ne sahi̇p olan i̇nsan dişi hayvanlar. |
| ES2613379T3 (es) | 2013-10-15 | 2017-05-24 | Regeneron Pharmaceuticals, Inc. | Animales con IL-15 humanizada |
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2014
- 2014-10-15 ES ES14790452.8T patent/ES2613379T3/es active Active
- 2014-10-15 PL PL16192440T patent/PL3138397T3/pl unknown
- 2014-10-15 SG SG11201601828XA patent/SG11201601828XA/en unknown
- 2014-10-15 HU HUE14790452A patent/HUE033272T2/en unknown
- 2014-10-15 SI SI201431130T patent/SI3138397T1/sl unknown
- 2014-10-15 DK DK14790452.8T patent/DK2908626T3/en active
- 2014-10-15 CN CN201810808707.3A patent/CN109090037B/zh active Active
- 2014-10-15 ES ES16192440T patent/ES2715949T3/es active Active
- 2014-10-15 EP EP18206034.3A patent/EP3461331A1/en not_active Withdrawn
- 2014-10-15 PT PT16192440T patent/PT3138397T/pt unknown
- 2014-10-15 HU HUE16192440A patent/HUE043969T2/hu unknown
- 2014-10-15 SG SG10201607768YA patent/SG10201607768YA/en unknown
- 2014-10-15 LT LTEP14790452.8T patent/LT2908626T/lt unknown
- 2014-10-15 JP JP2016549191A patent/JP6492095B2/ja active Active
- 2014-10-15 PL PL14790452T patent/PL2908626T3/pl unknown
- 2014-10-15 AU AU2014337526A patent/AU2014337526B2/en active Active
- 2014-10-15 EP EP14790452.8A patent/EP2908626B1/en active Active
- 2014-10-15 RS RS20190349A patent/RS58465B1/sr unknown
- 2014-10-15 DK DK16192440.2T patent/DK3138397T3/en active
- 2014-10-15 WO PCT/US2014/060568 patent/WO2015057758A1/en not_active Ceased
- 2014-10-15 KR KR1020167009228A patent/KR102376041B1/ko active Active
- 2014-10-15 SM SM20170024T patent/SMT201700024T1/it unknown
- 2014-10-15 HR HRP20170380TT patent/HRP20170380T1/hr unknown
- 2014-10-15 MX MX2016004781A patent/MX2016004781A/es unknown
- 2014-10-15 SI SI201430109T patent/SI2908626T1/sl unknown
- 2014-10-15 RS RS20161140A patent/RS55472B1/sr unknown
- 2014-10-15 PT PT147904528T patent/PT2908626T/pt unknown
- 2014-10-15 TR TR2019/04342T patent/TR201904342T4/tr unknown
- 2014-10-15 BR BR112016008175A patent/BR112016008175A2/pt not_active Application Discontinuation
- 2014-10-15 CN CN201480056455.3A patent/CN105744829B/zh active Active
- 2014-10-15 SM SM20190177T patent/SMT201900177T1/it unknown
- 2014-10-15 EP EP16192440.2A patent/EP3138397B1/en active Active
- 2014-10-15 NZ NZ718655A patent/NZ718655A/en unknown
- 2014-10-15 LT LTEP16192440.2T patent/LT3138397T/lt unknown
- 2014-10-15 CA CA2926090A patent/CA2926090C/en active Active
- 2014-10-15 RU RU2016116847A patent/RU2674910C2/ru active
- 2014-10-15 US US14/514,454 patent/US9155290B2/en active Active
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2015
- 2015-09-01 US US14/842,342 patent/US20150366175A1/en not_active Abandoned
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2016
- 2016-03-10 IL IL24452516A patent/IL244525B/en active IP Right Grant
- 2016-03-10 ZA ZA2016/01676A patent/ZA201601676B/en unknown
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2017
- 2017-01-04 CY CY20171100008T patent/CY1118675T1/el unknown
- 2017-01-16 SM SM201700024T patent/SMT201700024B/it unknown
- 2017-12-06 US US15/832,976 patent/US10561125B2/en active Active
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2018
- 2018-10-16 JP JP2018194898A patent/JP6600061B2/ja active Active
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2019
- 2019-03-18 CY CY20191100323T patent/CY1121405T1/el unknown
- 2019-03-20 HR HRP20190542TT patent/HRP20190542T1/hr unknown
- 2019-10-03 JP JP2019182817A patent/JP2019216750A/ja active Pending
- 2019-10-10 IL IL269907A patent/IL269907B/en active IP Right Grant
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2020
- 2020-01-02 US US16/732,400 patent/US11503813B2/en active Active
- 2020-12-08 AU AU2020286186A patent/AU2020286186B2/en active Active
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2022
- 2022-10-17 US US18/047,014 patent/US12369570B2/en active Active
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