JP2018531982A5 - - Google Patents
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- JP2018531982A5 JP2018531982A5 JP2018522556A JP2018522556A JP2018531982A5 JP 2018531982 A5 JP2018531982 A5 JP 2018531982A5 JP 2018522556 A JP2018522556 A JP 2018522556A JP 2018522556 A JP2018522556 A JP 2018522556A JP 2018531982 A5 JP2018531982 A5 JP 2018531982A5
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- compound
- formula
- hydrogen
- optionally substituted
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 125000000217 alkyl group Chemical group 0.000 claims description 154
- 150000001875 compounds Chemical class 0.000 claims description 86
- 229910052739 hydrogen Inorganic materials 0.000 claims description 54
- 239000001257 hydrogen Substances 0.000 claims description 54
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims description 42
- 125000002947 alkylene group Chemical group 0.000 claims description 41
- 150000003839 salts Chemical class 0.000 claims description 35
- 125000005843 halogen group Chemical group 0.000 claims description 32
- 125000004093 cyano group Chemical group *C#N 0.000 claims description 26
- 125000001424 substituent group Chemical group 0.000 claims description 26
- 208000023504 respiratory system disease Diseases 0.000 claims description 24
- 125000006645 (C3-C4) cycloalkyl group Chemical group 0.000 claims description 23
- 125000005913 (C3-C6) cycloalkyl group Chemical group 0.000 claims description 22
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims description 20
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 18
- 125000004432 carbon atom Chemical group C* 0.000 claims description 14
- 238000000034 method Methods 0.000 claims description 14
- 208000006545 Chronic Obstructive Pulmonary Disease Diseases 0.000 claims description 12
- 208000006673 asthma Diseases 0.000 claims description 12
- 150000002431 hydrogen Chemical class 0.000 claims description 12
- 125000003566 oxetanyl group Chemical group 0.000 claims description 10
- 239000008194 pharmaceutical composition Substances 0.000 claims description 10
- 125000001412 tetrahydropyranyl group Chemical group 0.000 claims description 10
- 125000003507 tetrahydrothiofenyl group Chemical group 0.000 claims description 10
- 206010006448 Bronchiolitis Diseases 0.000 claims description 9
- 230000000414 obstructive effect Effects 0.000 claims description 9
- YEGFDJOAFMPJSE-UHFFFAOYSA-N C(C)C=1C(=CC(=C(C=1)O)F)C1=CC=C2C(=NNC2=C1)C=1NC2=C(CN(CC2)C2CCN(CC2)C)N=1 Chemical compound C(C)C=1C(=CC(=C(C=1)O)F)C1=CC=C2C(=NNC2=C1)C=1NC2=C(CN(CC2)C2CCN(CC2)C)N=1 YEGFDJOAFMPJSE-UHFFFAOYSA-N 0.000 claims description 8
- 229910052799 carbon Inorganic materials 0.000 claims description 8
- 125000001559 cyclopropyl group Chemical group [H]C1([H])C([H])([H])C1([H])* 0.000 claims description 8
- 125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 claims description 8
- 241000124008 Mammalia Species 0.000 claims description 7
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 claims description 6
- WEVYAHXRMPXWCK-UHFFFAOYSA-N Acetonitrile Chemical compound CC#N WEVYAHXRMPXWCK-UHFFFAOYSA-N 0.000 claims description 6
- 206010001052 Acute respiratory distress syndrome Diseases 0.000 claims description 6
- 201000003883 Cystic fibrosis Diseases 0.000 claims description 6
- 206010014561 Emphysema Diseases 0.000 claims description 6
- 201000009794 Idiopathic Pulmonary Fibrosis Diseases 0.000 claims description 6
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 claims description 6
- 206010035664 Pneumonia Diseases 0.000 claims description 6
- 206010035742 Pneumonitis Diseases 0.000 claims description 6
- 208000013616 Respiratory Distress Syndrome Diseases 0.000 claims description 6
- DKGAVHZHDRPRBM-UHFFFAOYSA-N Tert-Butanol Chemical compound CC(C)(C)O DKGAVHZHDRPRBM-UHFFFAOYSA-N 0.000 claims description 6
- 206010069351 acute lung injury Diseases 0.000 claims description 6
- 201000000028 adult respiratory distress syndrome Diseases 0.000 claims description 6
- 206010006451 bronchitis Diseases 0.000 claims description 6
- 238000000113 differential scanning calorimetry Methods 0.000 claims description 6
- 208000036971 interstitial lung disease 2 Diseases 0.000 claims description 6
- 238000000634 powder X-ray diffraction Methods 0.000 claims description 6
- 239000002002 slurry Substances 0.000 claims description 6
- 125000004105 2-pyridyl group Chemical group N1=C([*])C([H])=C([H])C([H])=C1[H] 0.000 claims description 5
- ISWSIDIOOBJBQZ-UHFFFAOYSA-N Phenol Chemical compound OC1=CC=CC=C1 ISWSIDIOOBJBQZ-UHFFFAOYSA-N 0.000 claims description 5
- 238000004519 manufacturing process Methods 0.000 claims description 5
- WYURNTSHIVDZCO-UHFFFAOYSA-N Tetrahydrofuran Chemical compound C1CCOC1 WYURNTSHIVDZCO-UHFFFAOYSA-N 0.000 claims description 4
- 238000010438 heat treatment Methods 0.000 claims description 4
- 125000006239 protecting group Chemical group 0.000 claims description 4
- 125000004484 1-methylpiperidin-4-yl group Chemical group CN1CCC(CC1)* 0.000 claims description 3
- HROWLWGDTOBEDM-UHFFFAOYSA-N C(C)C=1C(=CC(=C(C=1)O)F)C1=CC=C2C(=NNC2=C1)C=1NC2=C(CN(CC2)C2CN(C2)C)N=1 Chemical compound C(C)C=1C(=CC(=C(C=1)O)F)C1=CC=C2C(=NNC2=C1)C=1NC2=C(CN(CC2)C2CN(C2)C)N=1 HROWLWGDTOBEDM-UHFFFAOYSA-N 0.000 claims description 3
- 239000003937 drug carrier Substances 0.000 claims description 3
- PRNDBSRPZSZAPK-UHFFFAOYSA-N C(C)(CC)N(CCN1CC2=C(CC1)NC(=N2)C1=NNC2=CC(=CC=C12)C1=CC(=C(C=C1CC)O)F)C Chemical compound C(C)(CC)N(CCN1CC2=C(CC1)NC(=N2)C1=NNC2=CC(=CC=C12)C1=CC(=C(C=C1CC)O)F)C PRNDBSRPZSZAPK-UHFFFAOYSA-N 0.000 claims description 2
- VKFCLOVOQMXKJM-UHFFFAOYSA-N C(C)(CC)N1CC(C1)N1CC2=C(CC1)NC(=N2)C1=NNC2=CC(=CC=C12)C1=CC(=C(C=C1CC)O)F Chemical compound C(C)(CC)N1CC(C1)N1CC2=C(CC1)NC(=N2)C1=NNC2=CC(=CC=C12)C1=CC(=C(C=C1CC)O)F VKFCLOVOQMXKJM-UHFFFAOYSA-N 0.000 claims description 2
- YKKSLFAFHDNXRX-UHFFFAOYSA-N C(C)C=1C(=CC(=C(C=1)O)F)C1=CC=C2C(=NNC2=C1)C=1NC2=C(CN(CC2)C2CN(C2)C(C)C)N=1 Chemical compound C(C)C=1C(=CC(=C(C=1)O)F)C1=CC=C2C(=NNC2=C1)C=1NC2=C(CN(CC2)C2CN(C2)C(C)C)N=1 YKKSLFAFHDNXRX-UHFFFAOYSA-N 0.000 claims description 2
- AOGXHIHTHRCTPK-UHFFFAOYSA-N C(C)C=1C(=CC(=C(C=1)O)F)C1=CC=C2C(=NNC2=C1)C=1NC2=C(CN(CC2)CCN(C)CC)N=1 Chemical compound C(C)C=1C(=CC(=C(C=1)O)F)C1=CC=C2C(=NNC2=C1)C=1NC2=C(CN(CC2)CCN(C)CC)N=1 AOGXHIHTHRCTPK-UHFFFAOYSA-N 0.000 claims description 2
- ZFFSYYHNBNAIRW-KRWDZBQOSA-N C(C)C=1C(=CC(=C(C=1)O)F)C1=CC=C2C(=NNC2=C1)C=1NC2=C(CN(CC2)CCN2[C@H](CCC2)C)N=1 Chemical compound C(C)C=1C(=CC(=C(C=1)O)F)C1=CC=C2C(=NNC2=C1)C=1NC2=C(CN(CC2)CCN2[C@H](CCC2)C)N=1 ZFFSYYHNBNAIRW-KRWDZBQOSA-N 0.000 claims description 2
- SNPLAOHHBAWLMU-UHFFFAOYSA-N C(C)C=1C(=CC(=C(C=1)O)F)C1=CC=C2C(=NNC2=C1)C=1NC2=C(CN(CC2)CCNC2CC(C2)OC)N=1 Chemical compound C(C)C=1C(=CC(=C(C=1)O)F)C1=CC=C2C(=NNC2=C1)C=1NC2=C(CN(CC2)CCNC2CC(C2)OC)N=1 SNPLAOHHBAWLMU-UHFFFAOYSA-N 0.000 claims description 2
- JBYYBYKZQWGOJL-KRWDZBQOSA-N C(C)C=1C(=CC(=C(C=1)O)F)C1=CC=C2C(=NNC2=C1)C=1NC2=C(CN(CC2)C[C@@H]2NCCOC2)N=1 Chemical compound C(C)C=1C(=CC(=C(C=1)O)F)C1=CC=C2C(=NNC2=C1)C=1NC2=C(CN(CC2)C[C@@H]2NCCOC2)N=1 JBYYBYKZQWGOJL-KRWDZBQOSA-N 0.000 claims description 2
- JBYYBYKZQWGOJL-QGZVFWFLSA-N C(C)C=1C(=CC(=C(C=1)O)F)C1=CC=C2C(=NNC2=C1)C=1NC2=C(CN(CC2)C[C@H]2NCCOC2)N=1 Chemical compound C(C)C=1C(=CC(=C(C=1)O)F)C1=CC=C2C(=NNC2=C1)C=1NC2=C(CN(CC2)C[C@H]2NCCOC2)N=1 JBYYBYKZQWGOJL-QGZVFWFLSA-N 0.000 claims description 2
- CUIBPLIFKMBESI-UHFFFAOYSA-N C1(CC1)N1CC(C1)N1CC2=C(CC1)NC(=N2)C1=NNC2=CC(=CC=C12)C1=CC(=C(C=C1CC)O)F Chemical compound C1(CC1)N1CC(C1)N1CC2=C(CC1)NC(=N2)C1=NNC2=CC(=CC=C12)C1=CC(=C(C=C1CC)O)F CUIBPLIFKMBESI-UHFFFAOYSA-N 0.000 claims description 2
- FLPXNQWEAODYRF-UHFFFAOYSA-N CN(CC(CN1CC2=C(CC1)NC(=N2)C1=NNC2=CC(=CC=C12)C1=CC(=C(C=C1CC)O)F)F)C Chemical compound CN(CC(CN1CC2=C(CC1)NC(=N2)C1=NNC2=CC(=CC=C12)C1=CC(=C(C=C1CC)O)F)F)C FLPXNQWEAODYRF-UHFFFAOYSA-N 0.000 claims description 2
- YXKUPJSJNAKRLQ-UHFFFAOYSA-N CN(CCN1CC2=C(CC1)NC(=N2)C1=NNC2=CC(=CC=C12)C1=CC(=C(C=C1CC)O)F)C Chemical compound CN(CCN1CC2=C(CC1)NC(=N2)C1=NNC2=CC(=CC=C12)C1=CC(=C(C=C1CC)O)F)C YXKUPJSJNAKRLQ-UHFFFAOYSA-N 0.000 claims description 2
- HGQQGQFLBDQYCO-UHFFFAOYSA-N N1CC(C1)N1CC2=C(CC1)NC(=N2)C1=NNC2=CC(=CC=C12)C1=CC(=C(C=C1CC)O)F Chemical compound N1CC(C1)N1CC2=C(CC1)NC(=N2)C1=NNC2=CC(=CC=C12)C1=CC(=C(C=C1CC)O)F HGQQGQFLBDQYCO-UHFFFAOYSA-N 0.000 claims description 2
- RWRDLPDLKQPQOW-UHFFFAOYSA-N Pyrrolidine Chemical group C1CCNC1 RWRDLPDLKQPQOW-UHFFFAOYSA-N 0.000 claims description 2
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 claims description 2
- 125000001995 cyclobutyl group Chemical group [H]C1([H])C([H])([H])C([H])(*)C1([H])[H] 0.000 claims description 2
- 239000003085 diluting agent Substances 0.000 claims description 2
- 239000003814 drug Substances 0.000 claims description 2
- 125000001153 fluoro group Chemical group F* 0.000 claims description 2
- JMMWKPVZQRWMSS-UHFFFAOYSA-N isopropanol acetate Natural products CC(C)OC(C)=O JMMWKPVZQRWMSS-UHFFFAOYSA-N 0.000 claims description 2
- 229940011051 isopropyl acetate Drugs 0.000 claims description 2
- GWYFCOCPABKNJV-UHFFFAOYSA-N isovaleric acid Chemical compound CC(C)CC(O)=O GWYFCOCPABKNJV-UHFFFAOYSA-N 0.000 claims description 2
- 229910052757 nitrogen Inorganic materials 0.000 claims description 2
- 125000004433 nitrogen atom Chemical group N* 0.000 claims description 2
- 239000003960 organic solvent Substances 0.000 claims description 2
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims description 2
- 239000012453 solvate Substances 0.000 claims description 2
- YLQBMQCUIZJEEH-UHFFFAOYSA-N tetrahydrofuran Natural products C=1C=COC=1 YLQBMQCUIZJEEH-UHFFFAOYSA-N 0.000 claims description 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 2
- 239000000203 mixture Substances 0.000 claims 6
- QCQCHGYLTSGIGX-GHXANHINSA-N 4-[[(3ar,5ar,5br,7ar,9s,11ar,11br,13as)-5a,5b,8,8,11a-pentamethyl-3a-[(5-methylpyridine-3-carbonyl)amino]-2-oxo-1-propan-2-yl-4,5,6,7,7a,9,10,11,11b,12,13,13a-dodecahydro-3h-cyclopenta[a]chrysen-9-yl]oxy]-2,2-dimethyl-4-oxobutanoic acid Chemical compound N([C@@]12CC[C@@]3(C)[C@]4(C)CC[C@H]5C(C)(C)[C@@H](OC(=O)CC(C)(C)C(O)=O)CC[C@]5(C)[C@H]4CC[C@@H]3C1=C(C(C2)=O)C(C)C)C(=O)C1=CN=CC(C)=C1 QCQCHGYLTSGIGX-GHXANHINSA-N 0.000 claims 1
- 125000000753 cycloalkyl group Chemical group 0.000 claims 1
- 0 CCc(cc(c(F)c1)O)c1-c(cc1)cc2c1c(-c1nc(CN(*)CC3)c3[n]1)n[n]2 Chemical compound CCc(cc(c(F)c1)O)c1-c(cc1)cc2c1c(-c1nc(CN(*)CC3)c3[n]1)n[n]2 0.000 description 14
- UPJNSCOYLNAEKD-UHFFFAOYSA-N Brc(cc1)cc2c1c(-c1nc(CN(Cc3ccccc3)CC3)c3[nH]1)n[nH]2 Chemical compound Brc(cc1)cc2c1c(-c1nc(CN(Cc3ccccc3)CC3)c3[nH]1)n[nH]2 UPJNSCOYLNAEKD-UHFFFAOYSA-N 0.000 description 2
- ZTQVHAJNEIOLPB-UHFFFAOYSA-N CCc(cc(c(F)c1)O)c1-c(cc1)cc2c1c(-c1nc(CNCC3)c3[nH]1)n[nH]2 Chemical compound CCc(cc(c(F)c1)O)c1-c(cc1)cc2c1c(-c1nc(CNCC3)c3[nH]1)n[nH]2 ZTQVHAJNEIOLPB-UHFFFAOYSA-N 0.000 description 2
- 239000013078 crystal Substances 0.000 description 2
- -1 tetrahydropyran-4-yl Chemical group 0.000 description 2
- 125000000339 4-pyridyl group Chemical group N1=C([H])C([H])=C([*])C([H])=C1[H] 0.000 description 1
- DLABLFPCTXRQMY-UHFFFAOYSA-N CC1CSCC1 Chemical compound CC1CSCC1 DLABLFPCTXRQMY-UHFFFAOYSA-N 0.000 description 1
- XBSDJXNXYCRWDX-UHFFFAOYSA-N CNC(C1)CC1OC Chemical compound CNC(C1)CC1OC XBSDJXNXYCRWDX-UHFFFAOYSA-N 0.000 description 1
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562250113P | 2015-11-03 | 2015-11-03 | |
| US62/250,113 | 2015-11-03 | ||
| PCT/US2016/059999 WO2017079205A1 (en) | 2015-11-03 | 2016-11-02 | Jak kinase inhibitor compounds for treatment of respiratory disease |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2018531982A JP2018531982A (ja) | 2018-11-01 |
| JP2018531982A5 true JP2018531982A5 (https=) | 2019-09-26 |
| JP6800969B2 JP6800969B2 (ja) | 2020-12-16 |
Family
ID=57442794
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018522556A Expired - Fee Related JP6800969B2 (ja) | 2015-11-03 | 2016-11-02 | 呼吸器疾患の処置のためのｊａｋキナーゼ阻害剤化合物 |
Country Status (22)
| Country | Link |
|---|---|
| US (6) | US10100049B2 (https=) |
| EP (1) | EP3371186A1 (https=) |
| JP (1) | JP6800969B2 (https=) |
| KR (1) | KR20180073687A (https=) |
| CN (1) | CN108349972B (https=) |
| AU (1) | AU2016350816B2 (https=) |
| BR (1) | BR112018008966B1 (https=) |
| CA (1) | CA3001542C (https=) |
| CL (1) | CL2018001145A1 (https=) |
| CO (1) | CO2018005640A2 (https=) |
| EA (1) | EA034914B1 (https=) |
| HK (1) | HK1252685A1 (https=) |
| IL (1) | IL258772B (https=) |
| MX (1) | MX374605B (https=) |
| MY (1) | MY195427A (https=) |
| NZ (1) | NZ741737A (https=) |
| PH (1) | PH12018500828B1 (https=) |
| SA (1) | SA518391470B1 (https=) |
| TW (1) | TWI710560B (https=) |
| UA (1) | UA123633C2 (https=) |
| WO (1) | WO2017079205A1 (https=) |
| ZA (1) | ZA201802496B (https=) |
Families Citing this family (27)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3712152B1 (en) | 2015-11-03 | 2021-01-13 | Topivert Pharma Limited | 4,5,6,7-tetrahydro-1h-imidazo[4,5-c]pyridine and 1,4,5,6,7,8-hexahydroimidazo[4,5-d]azepine derivatives as janus kinase inhibitors |
| US10556901B2 (en) | 2015-11-03 | 2020-02-11 | Topivert Pharma Limited | 4,5,6,7-tetrahydro-1H-imidazo[4,5-c]pyridine and 1,4,5,6,7,8-hexahydroimidazo[4,5-d]azepine derivatives as Janus kinase inhibitors |
| HK1252685A1 (zh) | 2015-11-03 | 2019-05-31 | Theravance Biopharma R&D Ip, Llc | 用於治疗呼吸疾病的jak激酶抑制剂化合物 |
| BR112019018648A2 (pt) | 2017-03-09 | 2020-06-16 | Theravance Biopharma R&D Ip, Llc | Inibidores de jak contendo uma amida heterocíclica com 4 membros |
| US10406148B2 (en) | 2017-05-01 | 2019-09-10 | Theravance Biopharma R&D Ip, Llc | Methods of treatment using a JAK inhibitor compound |
| CN110603255B (zh) * | 2017-05-01 | 2023-02-10 | 施万生物制药研发Ip有限责任公司 | Jak抑制剂化合物的结晶型式 |
| AR111495A1 (es) | 2017-05-01 | 2019-07-17 | Theravance Biopharma R&D Ip Llc | Compuestos de imidazo-piperidina fusionada como inhibidores de jak |
| WO2019104225A1 (en) | 2017-11-22 | 2019-05-31 | Dauntless 2, Inc. | Therapeutic compound formulations |
| WO2019246273A1 (en) | 2018-06-20 | 2019-12-26 | Progenity, Inc. | Treatment of a disease of the gastrointestinal tract with a jak or other kinase inhibitor |
| PT3837258T (pt) * | 2018-09-04 | 2024-06-20 | Theravance Biopharma R&D Ip Llc | Amidas de dimetil amino azetidina como inibidores de jak |
| CA3108848A1 (en) * | 2018-09-04 | 2020-03-12 | Theravance Biopharma R&D Ip, Llc | Process for preparing jak inhibitors and intermediates thereof |
| WO2020051139A1 (en) * | 2018-09-04 | 2020-03-12 | Theravance Biopharma R&D Ip, Llc | 5 to 7 membered heterocyclic amides as jak inhibitors |
| MX2021004582A (es) | 2018-10-29 | 2021-06-15 | Theravance Biopharma R&D Ip Llc | Compuesto 2-azabiciclo hexano inhibidor de jak. |
| CA3120614A1 (en) | 2018-11-19 | 2020-05-28 | New York University | Inhibitors of gli1 as therapeutic agents |
| CN114075200A (zh) * | 2020-08-14 | 2022-02-22 | 河南迈英诺医药科技有限公司 | 用于治疗重症肺炎的jak抑制剂化合物 |
| FI3932919T3 (fi) | 2019-02-25 | 2024-08-30 | Henan Medinno Pharmaceutical Tech Co Ltd | Jak-inhibiittoriyhdiste ja sen käyttö |
| MA55201A (fr) | 2019-03-05 | 2022-01-12 | Incyte Corp | Inhibiteurs de la voie jak1 pour le traitement d'un dysfonctionnement chronique de l'allogreffe pulmonaire |
| US20220143049A1 (en) | 2019-03-21 | 2022-05-12 | Onxeo | A dbait molecule in combination with kinase inhibitor for the treatment of cancer |
| EP4054579A1 (en) | 2019-11-08 | 2022-09-14 | Institut National de la Santé et de la Recherche Médicale (INSERM) | Methods for the treatment of cancers that have acquired resistance to kinase inhibitors |
| WO2021136345A1 (zh) * | 2019-12-30 | 2021-07-08 | 路良 | Jak抑制剂化合物及其用途 |
| WO2021148581A1 (en) | 2020-01-22 | 2021-07-29 | Onxeo | Novel dbait molecule and its use |
| TW202144343A (zh) | 2020-03-02 | 2021-12-01 | 美商施萬生物製藥研發 Ip有限責任公司 | Jak抑制劑化合物之結晶水合物 |
| WO2022178215A1 (en) * | 2021-02-19 | 2022-08-25 | Theravance Biopharma R&D Ip, Llc | Amino amide tetrahydro imidazo pyridines as jak inhibitors |
| TW202304902A (zh) | 2021-03-26 | 2023-02-01 | 美商施萬生物製藥研發 Ip有限責任公司 | Jak抑制劑化合物之二鹽酸鹽之結晶形式 |
| TW202317550A (zh) | 2021-06-25 | 2023-05-01 | 美商施萬生物製藥研發 Ip有限責任公司 | 作為jak抑制劑之咪唑吲唑化合物 |
| CN114181055A (zh) * | 2021-12-21 | 2022-03-15 | 苏州楚凯药业有限公司 | 1-苄氧基-4-溴-5-乙基-2-氟苯的制备方法 |
| US20250288561A1 (en) | 2022-05-05 | 2025-09-18 | Theravance Biopharma R&D Ip, Llc | Nezulcitinib for delivery by nebulized oral inhalation |
Family Cites Families (34)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TWI262914B (en) | 1999-07-02 | 2006-10-01 | Agouron Pharma | Compounds and pharmaceutical compositions for inhibiting protein kinases |
| JP4836788B2 (ja) | 2003-07-23 | 2011-12-14 | エグゼリクシス， インコーポレイテッド | 未分化リンパ腫キナーゼ変調因子及びその使用法 |
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| TW202304902A (zh) | 2021-03-26 | 2023-02-01 | 美商施萬生物製藥研發 Ip有限責任公司 | Jak抑制劑化合物之二鹽酸鹽之結晶形式 |
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