SA518391470B1 - مركبات تثبيط كيناز لعائلة جانيس من الكينازات لمعالجة مرض تنفسي - Google Patents

مركبات تثبيط كيناز لعائلة جانيس من الكينازات لمعالجة مرض تنفسي Download PDF

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Publication number
SA518391470B1
SA518391470B1 SA518391470A SA518391470A SA518391470B1 SA 518391470 B1 SA518391470 B1 SA 518391470B1 SA 518391470 A SA518391470 A SA 518391470A SA 518391470 A SA518391470 A SA 518391470A SA 518391470 B1 SA518391470 B1 SA 518391470B1
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SA
Saudi Arabia
Prior art keywords
imidazo
ethyl
tetrahydro
fluoro
compound
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SA518391470A
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Arabic (ar)
English (en)
Inventor
مارتا بابروس
جارى اى. ال براندت
نوا بينجامين
انى – مارى بيوسليل
فينكات ار ثالادى
جون ار جاكوبسين
لان جينج
ميروسلاف رابتا
كاميرون سميث
ستيفن دى. اى سوليفان
بول ار فاثير
جين تيموثى فاس
اوردين لورى جين فان
ميليسا فليورى
بير- جين كولسون
Original Assignee
ثيرافانس بيوفارما ار اند دى اى بى ، ال ال سى
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Application filed by ثيرافانس بيوفارما ار اند دى اى بى ، ال ال سى filed Critical ثيرافانس بيوفارما ار اند دى اى بى ، ال ال سى
Publication of SA518391470B1 publication Critical patent/SA518391470B1/ar

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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D471/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04Ortho-condensed systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4151,2-Diazoles
    • A61K31/4161,2-Diazoles condensed with carbocyclic ring systems, e.g. indazole
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • A61P11/06Antiasthmatics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pulmonology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
SA518391470A 2015-11-03 2018-04-30 مركبات تثبيط كيناز لعائلة جانيس من الكينازات لمعالجة مرض تنفسي SA518391470B1 (ar)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201562250113P 2015-11-03 2015-11-03
PCT/US2016/059999 WO2017079205A1 (en) 2015-11-03 2016-11-02 Jak kinase inhibitor compounds for treatment of respiratory disease

Publications (1)

Publication Number Publication Date
SA518391470B1 true SA518391470B1 (ar) 2021-03-31

Family

ID=57442794

Family Applications (1)

Application Number Title Priority Date Filing Date
SA518391470A SA518391470B1 (ar) 2015-11-03 2018-04-30 مركبات تثبيط كيناز لعائلة جانيس من الكينازات لمعالجة مرض تنفسي

Country Status (22)

Country Link
US (6) US10100049B2 (https=)
EP (1) EP3371186A1 (https=)
JP (1) JP6800969B2 (https=)
KR (1) KR20180073687A (https=)
CN (1) CN108349972B (https=)
AU (1) AU2016350816B2 (https=)
BR (1) BR112018008966B1 (https=)
CA (1) CA3001542C (https=)
CL (1) CL2018001145A1 (https=)
CO (1) CO2018005640A2 (https=)
EA (1) EA034914B1 (https=)
HK (1) HK1252685A1 (https=)
IL (1) IL258772B (https=)
MX (1) MX374605B (https=)
MY (1) MY195427A (https=)
NZ (1) NZ741737A (https=)
PH (1) PH12018500828B1 (https=)
SA (1) SA518391470B1 (https=)
TW (1) TWI710560B (https=)
UA (1) UA123633C2 (https=)
WO (1) WO2017079205A1 (https=)
ZA (1) ZA201802496B (https=)

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BR112019018648A2 (pt) 2017-03-09 2020-06-16 Theravance Biopharma R&D Ip, Llc Inibidores de jak contendo uma amida heterocíclica com 4 membros
AR111495A1 (es) 2017-05-01 2019-07-17 Theravance Biopharma R&D Ip Llc Compuestos de imidazo-piperidina fusionada como inhibidores de jak
CN110603255B (zh) 2017-05-01 2023-02-10 施万生物制药研发Ip有限责任公司 Jak抑制剂化合物的结晶型式
US10406148B2 (en) 2017-05-01 2019-09-10 Theravance Biopharma R&D Ip, Llc Methods of treatment using a JAK inhibitor compound
WO2020051139A1 (en) 2018-09-04 2020-03-12 Theravance Biopharma R&D Ip, Llc 5 to 7 membered heterocyclic amides as jak inhibitors
CA3108848A1 (en) 2018-09-04 2020-03-12 Theravance Biopharma R&D Ip, Llc Process for preparing jak inhibitors and intermediates thereof
PT3837258T (pt) 2018-09-04 2024-06-20 Theravance Biopharma R&D Ip Llc Amidas de dimetil amino azetidina como inibidores de jak
MX2021004582A (es) 2018-10-29 2021-06-15 Theravance Biopharma R&D Ip Llc Compuesto 2-azabiciclo hexano inhibidor de jak.
TW202304902A (zh) 2021-03-26 2023-02-01 美商施萬生物製藥研發 Ip有限責任公司 Jak抑制劑化合物之二鹽酸鹽之結晶形式

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Publication number Publication date
BR112018008966B1 (pt) 2023-05-02
AU2016350816A1 (en) 2018-05-17
PH12018500828A1 (en) 2018-10-29
CA3001542C (en) 2021-02-16
CO2018005640A2 (es) 2018-05-31
HK1252685A1 (zh) 2019-05-31
ZA201802496B (en) 2025-01-29
TWI710560B (zh) 2020-11-21
TW201726673A (zh) 2017-08-01
CN108349972B (zh) 2021-06-08
CL2018001145A1 (es) 2018-07-06
US20220306624A1 (en) 2022-09-29
KR20180073687A (ko) 2018-07-02
US20170121327A1 (en) 2017-05-04
AU2016350816B2 (en) 2020-06-25
US20210130351A1 (en) 2021-05-06
US20200087303A1 (en) 2020-03-19
JP6800969B2 (ja) 2020-12-16
US10526330B2 (en) 2020-01-07
CN108349972A (zh) 2018-07-31
US10913740B2 (en) 2021-02-09
PH12018500828B1 (en) 2023-06-30
IL258772B (en) 2021-01-31
MX374605B (es) 2025-03-06
US11718616B2 (en) 2023-08-08
US10183942B2 (en) 2019-01-22
MY195427A (en) 2023-01-20
EA034914B1 (ru) 2020-04-06
US10100049B2 (en) 2018-10-16
US11299492B2 (en) 2022-04-12
NZ741737A (en) 2023-11-24
EA201891091A1 (ru) 2018-12-28
IL258772A (en) 2018-06-28
US20190106420A1 (en) 2019-04-11
EP3371186A1 (en) 2018-09-12
MX2018005446A (es) 2018-08-01
UA123633C2 (uk) 2021-05-05
BR112018008966A2 (pt) 2018-11-27
WO2017079205A1 (en) 2017-05-11
JP2018531982A (ja) 2018-11-01
US20180319796A1 (en) 2018-11-08
CA3001542A1 (en) 2017-05-11

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