BR112018008966B1 - Compostos inibidores de jak quinase, hidrato cristalino, composição farmacêutica, processos, método de preparação do hidrato cristalino e uso dos referidos compostos e hidrato cristalino no tratamento de doença respiratória - Google Patents

Compostos inibidores de jak quinase, hidrato cristalino, composição farmacêutica, processos, método de preparação do hidrato cristalino e uso dos referidos compostos e hidrato cristalino no tratamento de doença respiratória Download PDF

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Publication number
BR112018008966B1
BR112018008966B1 BR112018008966-4A BR112018008966A BR112018008966B1 BR 112018008966 B1 BR112018008966 B1 BR 112018008966B1 BR 112018008966 A BR112018008966 A BR 112018008966A BR 112018008966 B1 BR112018008966 B1 BR 112018008966B1
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BR
Brazil
Prior art keywords
alkyl
compound
ethyl
formula
hydrogen
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BR112018008966-4A
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English (en)
Portuguese (pt)
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BR112018008966A2 (pt
Inventor
Paul R. Fatheree
John R. Jacobsen
Anne-Marie Beausoleil
Gary E. L. Brandt
Melissa Fleury
Lan Jiang
Cameron Smith
Steven D.E. Sullivan
Lori Jean Van Orden
Pierre-Jean Colson
Gene Timothy Fass
Miroslav Rapta
Noah Benjamin
Marta Dabros
Venkat R. Thalladi
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Theravance Biopharma R&D Ip, Llc
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Application filed by Theravance Biopharma R&D Ip, Llc filed Critical Theravance Biopharma R&D Ip, Llc
Publication of BR112018008966A2 publication Critical patent/BR112018008966A2/pt
Publication of BR112018008966B1 publication Critical patent/BR112018008966B1/pt

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A61K31/416—1,2-Diazoles condensed with carbocyclic ring systems, e.g. indazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pulmonology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
BR112018008966-4A 2015-11-03 2016-11-02 Compostos inibidores de jak quinase, hidrato cristalino, composição farmacêutica, processos, método de preparação do hidrato cristalino e uso dos referidos compostos e hidrato cristalino no tratamento de doença respiratória BR112018008966B1 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201562250113P 2015-11-03 2015-11-03
US62/250,113 2015-11-03
PCT/US2016/059999 WO2017079205A1 (en) 2015-11-03 2016-11-02 Jak kinase inhibitor compounds for treatment of respiratory disease

Publications (2)

Publication Number Publication Date
BR112018008966A2 BR112018008966A2 (pt) 2018-11-27
BR112018008966B1 true BR112018008966B1 (pt) 2023-05-02

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BR112018008966-4A BR112018008966B1 (pt) 2015-11-03 2016-11-02 Compostos inibidores de jak quinase, hidrato cristalino, composição farmacêutica, processos, método de preparação do hidrato cristalino e uso dos referidos compostos e hidrato cristalino no tratamento de doença respiratória

Country Status (22)

Country Link
US (6) US10100049B2 (https=)
EP (1) EP3371186A1 (https=)
JP (1) JP6800969B2 (https=)
KR (1) KR20180073687A (https=)
CN (1) CN108349972B (https=)
AU (1) AU2016350816B2 (https=)
BR (1) BR112018008966B1 (https=)
CA (1) CA3001542C (https=)
CL (1) CL2018001145A1 (https=)
CO (1) CO2018005640A2 (https=)
EA (1) EA034914B1 (https=)
HK (1) HK1252685A1 (https=)
IL (1) IL258772B (https=)
MX (1) MX374605B (https=)
MY (1) MY195427A (https=)
NZ (1) NZ741737A (https=)
PH (1) PH12018500828B1 (https=)
SA (1) SA518391470B1 (https=)
TW (1) TWI710560B (https=)
UA (1) UA123633C2 (https=)
WO (1) WO2017079205A1 (https=)
ZA (1) ZA201802496B (https=)

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AR111495A1 (es) 2017-05-01 2019-07-17 Theravance Biopharma R&D Ip Llc Compuestos de imidazo-piperidina fusionada como inhibidores de jak
CN110603255B (zh) 2017-05-01 2023-02-10 施万生物制药研发Ip有限责任公司 Jak抑制剂化合物的结晶型式
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WO2020051139A1 (en) 2018-09-04 2020-03-12 Theravance Biopharma R&D Ip, Llc 5 to 7 membered heterocyclic amides as jak inhibitors
CA3108848A1 (en) 2018-09-04 2020-03-12 Theravance Biopharma R&D Ip, Llc Process for preparing jak inhibitors and intermediates thereof
PT3837258T (pt) 2018-09-04 2024-06-20 Theravance Biopharma R&D Ip Llc Amidas de dimetil amino azetidina como inibidores de jak
MX2021004582A (es) 2018-10-29 2021-06-15 Theravance Biopharma R&D Ip Llc Compuesto 2-azabiciclo hexano inhibidor de jak.
TW202304902A (zh) 2021-03-26 2023-02-01 美商施萬生物製藥研發 Ip有限責任公司 Jak抑制劑化合物之二鹽酸鹽之結晶形式

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AU2016350816A1 (en) 2018-05-17
PH12018500828A1 (en) 2018-10-29
CA3001542C (en) 2021-02-16
CO2018005640A2 (es) 2018-05-31
HK1252685A1 (zh) 2019-05-31
ZA201802496B (en) 2025-01-29
TWI710560B (zh) 2020-11-21
TW201726673A (zh) 2017-08-01
CN108349972B (zh) 2021-06-08
CL2018001145A1 (es) 2018-07-06
US20220306624A1 (en) 2022-09-29
KR20180073687A (ko) 2018-07-02
US20170121327A1 (en) 2017-05-04
AU2016350816B2 (en) 2020-06-25
US20210130351A1 (en) 2021-05-06
US20200087303A1 (en) 2020-03-19
SA518391470B1 (ar) 2021-03-31
JP6800969B2 (ja) 2020-12-16
US10526330B2 (en) 2020-01-07
CN108349972A (zh) 2018-07-31
US10913740B2 (en) 2021-02-09
PH12018500828B1 (en) 2023-06-30
IL258772B (en) 2021-01-31
MX374605B (es) 2025-03-06
US11718616B2 (en) 2023-08-08
US10183942B2 (en) 2019-01-22
MY195427A (en) 2023-01-20
EA034914B1 (ru) 2020-04-06
US10100049B2 (en) 2018-10-16
US11299492B2 (en) 2022-04-12
NZ741737A (en) 2023-11-24
EA201891091A1 (ru) 2018-12-28
IL258772A (en) 2018-06-28
US20190106420A1 (en) 2019-04-11
EP3371186A1 (en) 2018-09-12
MX2018005446A (es) 2018-08-01
UA123633C2 (uk) 2021-05-05
BR112018008966A2 (pt) 2018-11-27
WO2017079205A1 (en) 2017-05-11
JP2018531982A (ja) 2018-11-01
US20180319796A1 (en) 2018-11-08
CA3001542A1 (en) 2017-05-11

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