TWI710560B - 用於治療呼吸疾病之jak激酶抑制劑化合物 - Google Patents

用於治療呼吸疾病之jak激酶抑制劑化合物 Download PDF

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TWI710560B
TWI710560B TW105135436A TW105135436A TWI710560B TW I710560 B TWI710560 B TW I710560B TW 105135436 A TW105135436 A TW 105135436A TW 105135436 A TW105135436 A TW 105135436A TW I710560 B TWI710560 B TW I710560B
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Taiwan
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alkyl
compound
ethyl
hydrogen
imidazo
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TW105135436A
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Chinese (zh)
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TW201726673A (zh
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保羅 R 費瑟里
約翰 R 傑柯森
安－瑪莉 柏索里爾
蓋瑞 E L 布蘭德
梅莉沙 佛羅瑞
姜嵐
卡梅朗 史密斯
史蒂芬 D E 蘇利文
羅利 珍 凡歐丹
彼瑞 珍 寇森
吉尼 提摩西 法斯
麥洛史夫 瑞帕達
諾瓦 班傑明
瑪塔 代布洛斯
凡凱特 R 泰拉狄
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美商施萬生物製藥研發Ｉｐ有限責任公司
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A61K31/416—1,2-Diazoles condensed with carbocyclic ring systems, e.g. indazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pulmonology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
TW105135436A 2015-11-03 2016-11-02 用於治療呼吸疾病之jak激酶抑制劑化合物 TWI710560B (zh)

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US201562250113P 2015-11-03 2015-11-03
US62/250,113 2015-11-03

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TW201726673A TW201726673A (zh) 2017-08-01
TWI710560B true TWI710560B (zh) 2020-11-21

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US (6) US10100049B2 (https=)
EP (1) EP3371186A1 (https=)
JP (1) JP6800969B2 (https=)
KR (1) KR20180073687A (https=)
CN (1) CN108349972B (https=)
AU (1) AU2016350816B2 (https=)
BR (1) BR112018008966B1 (https=)
CA (1) CA3001542C (https=)
CL (1) CL2018001145A1 (https=)
CO (1) CO2018005640A2 (https=)
EA (1) EA034914B1 (https=)
HK (1) HK1252685A1 (https=)
IL (1) IL258772B (https=)
MX (1) MX374605B (https=)
MY (1) MY195427A (https=)
NZ (1) NZ741737A (https=)
PH (1) PH12018500828B1 (https=)
SA (1) SA518391470B1 (https=)
TW (1) TWI710560B (https=)
UA (1) UA123633C2 (https=)
WO (1) WO2017079205A1 (https=)
ZA (1) ZA201802496B (https=)

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TW202317550A (zh) 2021-06-25 2023-05-01 美商施萬生物製藥研發 Ip有限責任公司 作為jak抑制劑之咪唑吲唑化合物
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BR112018008966B1 (pt) 2023-05-02
AU2016350816A1 (en) 2018-05-17
PH12018500828A1 (en) 2018-10-29
CA3001542C (en) 2021-02-16
CO2018005640A2 (es) 2018-05-31
HK1252685A1 (zh) 2019-05-31
ZA201802496B (en) 2025-01-29
TW201726673A (zh) 2017-08-01
CN108349972B (zh) 2021-06-08
CL2018001145A1 (es) 2018-07-06
US20220306624A1 (en) 2022-09-29
KR20180073687A (ko) 2018-07-02
US20170121327A1 (en) 2017-05-04
AU2016350816B2 (en) 2020-06-25
US20210130351A1 (en) 2021-05-06
US20200087303A1 (en) 2020-03-19
SA518391470B1 (ar) 2021-03-31
JP6800969B2 (ja) 2020-12-16
US10526330B2 (en) 2020-01-07
CN108349972A (zh) 2018-07-31
US10913740B2 (en) 2021-02-09
PH12018500828B1 (en) 2023-06-30
IL258772B (en) 2021-01-31
MX374605B (es) 2025-03-06
US11718616B2 (en) 2023-08-08
US10183942B2 (en) 2019-01-22
MY195427A (en) 2023-01-20
EA034914B1 (ru) 2020-04-06
US10100049B2 (en) 2018-10-16
US11299492B2 (en) 2022-04-12
NZ741737A (en) 2023-11-24
EA201891091A1 (ru) 2018-12-28
IL258772A (en) 2018-06-28
US20190106420A1 (en) 2019-04-11
EP3371186A1 (en) 2018-09-12
MX2018005446A (es) 2018-08-01
UA123633C2 (uk) 2021-05-05
BR112018008966A2 (pt) 2018-11-27
WO2017079205A1 (en) 2017-05-11
JP2018531982A (ja) 2018-11-01
US20180319796A1 (en) 2018-11-08
CA3001542A1 (en) 2017-05-11

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