CN108349972B - 用于治疗呼吸疾病的jak激酶抑制剂化合物 - Google Patents

用于治疗呼吸疾病的jak激酶抑制剂化合物 Download PDF

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Publication number
CN108349972B
CN108349972B CN201680063886.1A CN201680063886A CN108349972B CN 108349972 B CN108349972 B CN 108349972B CN 201680063886 A CN201680063886 A CN 201680063886A CN 108349972 B CN108349972 B CN 108349972B
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alkyl
compound
ethyl
formula
hydrogen
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Chinese (zh)
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CN108349972A (zh
Inventor
保罗·R·法特里
约翰·R·雅各布森
安妮-玛丽·博索莱伊
加里·E·L·勃兰特
梅丽莎·弗勒里
姜岚
卡梅伦·史密斯
史蒂文·D·E·沙利文
洛里·琼·范奥登
皮埃尔-让·科尔松
吉恩·蒂莫西·法斯
米罗斯拉夫·拉普塔
诺亚·本杰明
马尔塔·达布罗斯
文卡特·R·萨兰迪
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Theravance Biopharma R&D IP LLC
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Theravance Biopharma R&D IP LLC
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A61K31/416—1,2-Diazoles condensed with carbocyclic ring systems, e.g. indazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pulmonology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
CN201680063886.1A 2015-11-03 2016-11-02 用于治疗呼吸疾病的jak激酶抑制剂化合物 Expired - Fee Related CN108349972B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201562250113P 2015-11-03 2015-11-03
US62/250,113 2015-11-03
PCT/US2016/059999 WO2017079205A1 (en) 2015-11-03 2016-11-02 Jak kinase inhibitor compounds for treatment of respiratory disease

Publications (2)

Publication Number Publication Date
CN108349972A CN108349972A (zh) 2018-07-31
CN108349972B true CN108349972B (zh) 2021-06-08

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US (6) US10100049B2 (https=)
EP (1) EP3371186A1 (https=)
JP (1) JP6800969B2 (https=)
KR (1) KR20180073687A (https=)
CN (1) CN108349972B (https=)
AU (1) AU2016350816B2 (https=)
BR (1) BR112018008966B1 (https=)
CA (1) CA3001542C (https=)
CL (1) CL2018001145A1 (https=)
CO (1) CO2018005640A2 (https=)
EA (1) EA034914B1 (https=)
HK (1) HK1252685A1 (https=)
IL (1) IL258772B (https=)
MX (1) MX374605B (https=)
MY (1) MY195427A (https=)
NZ (1) NZ741737A (https=)
PH (1) PH12018500828B1 (https=)
SA (1) SA518391470B1 (https=)
TW (1) TWI710560B (https=)
UA (1) UA123633C2 (https=)
WO (1) WO2017079205A1 (https=)
ZA (1) ZA201802496B (https=)

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CN114075200A (zh) * 2020-08-14 2022-02-22 河南迈英诺医药科技有限公司 用于治疗重症肺炎的jak抑制剂化合物
WO2020181034A1 (en) 2019-03-05 2020-09-10 Incyte Corporation Jak1 pathway inhibitors for the treatment of chronic lung allograft dysfunction
EA202192575A1 (ru) 2019-03-21 2022-01-14 Онксео Соединения dbait в сочетании с ингибиторами киназ для лечения рака
CN114761006A (zh) 2019-11-08 2022-07-15 Inserm(法国国家健康医学研究院) 对激酶抑制剂产生耐药性的癌症的治疗方法
JP7580136B2 (ja) * 2019-12-30 2024-11-11 路良 Ｊａｋ阻害剤化合物及びその使用
WO2021148581A1 (en) 2020-01-22 2021-07-29 Onxeo Novel dbait molecule and its use
TW202144343A (zh) 2020-03-02 2021-12-01 美商施萬生物製藥研發 Ip有限責任公司 Jak抑制劑化合物之結晶水合物
WO2022178215A1 (en) 2021-02-19 2022-08-25 Theravance Biopharma R&D Ip, Llc Amino amide tetrahydro imidazo pyridines as jak inhibitors
WO2022204473A1 (en) 2021-03-26 2022-09-29 Theravance Biopharma R&D Ip, Llc Crystalline form of a dihydrochloride salt of a jak inhibitor compound
EP4359402B1 (en) * 2021-06-25 2026-03-11 Theravance Biopharma R&D IP, LLC Imidazolo indazole compounds as jak inhibitors
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UA123633C2 (uk) 2015-11-03 2021-05-05 Тереванс Байофарма Ар Енд Ді Айпі, Елелсі Сполуки інгібітору jak-кінази для лікування респіраторного захворювання
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KR20200003121A (ko) 2017-05-01 2020-01-08 세라밴스 바이오파마 알앤디 아이피, 엘엘씨 Jak 저해제 화합물의 결정형
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UA127328C2 (uk) 2018-09-04 2023-07-19 Тереванс Байофарма Ар Енд Ді Айпі, Елелсі 5-7-членні гетероциклічні аміди як інгібітори jak
JP2021535176A (ja) 2018-09-04 2021-12-16 セラヴァンス バイオファーマ アール＆ディー アイピー， エルエルシー Ｊａｋ阻害剤およびその中間体を調製するためのプロセス
FI3837258T3 (fi) 2018-09-04 2024-05-27 Theravance Biopharma R&D Ip Llc Dimetyyliaminoatsetidiiniamideja jak-estäjinä
KR20210084512A (ko) 2018-10-29 2021-07-07 세라밴스 바이오파마 알앤디 아이피, 엘엘씨 Jak 억제제로서 2-아자비시클로 헥산 화합물
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Patent Citations (3)

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WO2013014567A1 (en) * 2011-07-27 2013-01-31 Pfizer Limited Indazoles
WO2014111380A1 (en) * 2013-01-17 2014-07-24 Galapagos Nv Novel compound useful for the treatment of degenerative and inflammatory diseases

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US20210130351A1 (en) 2021-05-06
MX374605B (es) 2025-03-06
PH12018500828B1 (en) 2023-06-30
NZ741737A (en) 2023-11-24
US11718616B2 (en) 2023-08-08
JP6800969B2 (ja) 2020-12-16
US20190106420A1 (en) 2019-04-11
US10100049B2 (en) 2018-10-16
US10913740B2 (en) 2021-02-09
US20180319796A1 (en) 2018-11-08
ZA201802496B (en) 2025-01-29
JP2018531982A (ja) 2018-11-01
AU2016350816A1 (en) 2018-05-17
WO2017079205A1 (en) 2017-05-11
CA3001542C (en) 2021-02-16
MY195427A (en) 2023-01-20
US10526330B2 (en) 2020-01-07
AU2016350816B2 (en) 2020-06-25
CN108349972A (zh) 2018-07-31
TWI710560B (zh) 2020-11-21
UA123633C2 (uk) 2021-05-05
BR112018008966B1 (pt) 2023-05-02
SA518391470B1 (ar) 2021-03-31
US20200087303A1 (en) 2020-03-19
IL258772B (en) 2021-01-31
IL258772A (en) 2018-06-28
EA201891091A1 (ru) 2018-12-28
HK1252685A1 (zh) 2019-05-31
EP3371186A1 (en) 2018-09-12
CA3001542A1 (en) 2017-05-11
CL2018001145A1 (es) 2018-07-06
US20170121327A1 (en) 2017-05-04
KR20180073687A (ko) 2018-07-02
US10183942B2 (en) 2019-01-22
EA034914B1 (ru) 2020-04-06
US20220306624A1 (en) 2022-09-29
CO2018005640A2 (es) 2018-05-31
BR112018008966A2 (pt) 2018-11-27
PH12018500828A1 (en) 2018-10-29
TW201726673A (zh) 2017-08-01
US11299492B2 (en) 2022-04-12
MX2018005446A (es) 2018-08-01

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