JP2020529987A5 - - Google Patents
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- JP2020529987A5 JP2020529987A5 JP2020505224A JP2020505224A JP2020529987A5 JP 2020529987 A5 JP2020529987 A5 JP 2020529987A5 JP 2020505224 A JP2020505224 A JP 2020505224A JP 2020505224 A JP2020505224 A JP 2020505224A JP 2020529987 A5 JP2020529987 A5 JP 2020529987A5
- Authority
- JP
- Japan
- Prior art keywords
- group
- pharmaceutically acceptable
- acceptable salt
- alkyl
- compound according
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 0 *CC(CCCCCCN*I)IC(c1c(*)[n]nc1)=*C(c(cc1*)ccc1O)=I Chemical compound *CC(CCCCCCN*I)IC(c1c(*)[n]nc1)=*C(c(cc1*)ccc1O)=I 0.000 description 2
- OJTMTIGSEODYKN-ONEGZZNKSA-N CN(C)C/C=C/C(N1CC(COc2c(cn[nH]3)c3cc(-c(cc3)ccc3O)c2)C1)=O Chemical compound CN(C)C/C=C/C(N1CC(COc2c(cn[nH]3)c3cc(-c(cc3)ccc3O)c2)C1)=O OJTMTIGSEODYKN-ONEGZZNKSA-N 0.000 description 1
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2021043173A JP2021098751A (ja) | 2017-08-01 | 2021-03-17 | Jakキナーゼ阻害剤としてのピラゾロおよびトリアゾロ二環式化合物 |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201762539642P | 2017-08-01 | 2017-08-01 | |
| US62/539,642 | 2017-08-01 | ||
| PCT/US2018/044508 WO2019027960A1 (en) | 2017-08-01 | 2018-07-31 | BICYCLIC PYRAZOLO AND TRIAZOLO COMPOUNDS AS JAK KINASE INHIBITORS |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021043173A Division JP2021098751A (ja) | 2017-08-01 | 2021-03-17 | Jakキナーゼ阻害剤としてのピラゾロおよびトリアゾロ二環式化合物 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2020529987A JP2020529987A (ja) | 2020-10-15 |
| JP2020529987A5 true JP2020529987A5 (https=) | 2021-04-30 |
| JP7098716B2 JP7098716B2 (ja) | 2022-07-11 |
Family
ID=63209687
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020505224A Expired - Fee Related JP7098716B2 (ja) | 2017-08-01 | 2018-07-31 | Jakキナーゼ阻害剤としてのピラゾロおよびトリアゾロ二環式化合物 |
| JP2021043173A Withdrawn JP2021098751A (ja) | 2017-08-01 | 2021-03-17 | Jakキナーゼ阻害剤としてのピラゾロおよびトリアゾロ二環式化合物 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021043173A Withdrawn JP2021098751A (ja) | 2017-08-01 | 2021-03-17 | Jakキナーゼ阻害剤としてのピラゾロおよびトリアゾロ二環式化合物 |
Country Status (23)
| Country | Link |
|---|---|
| US (4) | US10392368B2 (https=) |
| EP (1) | EP3652169A1 (https=) |
| JP (2) | JP7098716B2 (https=) |
| KR (1) | KR20200036004A (https=) |
| CN (1) | CN111032646B (https=) |
| AR (1) | AR112348A1 (https=) |
| AU (1) | AU2018312349A1 (https=) |
| BR (1) | BR112020002265A2 (https=) |
| CA (1) | CA3069990A1 (https=) |
| CL (1) | CL2020000283A1 (https=) |
| CO (1) | CO2020001469A2 (https=) |
| EA (1) | EA038912B1 (https=) |
| IL (1) | IL272031A (https=) |
| MA (1) | MA49570A (https=) |
| MX (1) | MX2020001170A (https=) |
| MY (1) | MY200629A (https=) |
| PE (1) | PE20201028A1 (https=) |
| PH (1) | PH12020500201A1 (https=) |
| SG (1) | SG11202000602YA (https=) |
| TW (1) | TW201920150A (https=) |
| UA (1) | UA125318C2 (https=) |
| WO (1) | WO2019027960A1 (https=) |
| ZA (1) | ZA202000561B (https=) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2018312349A1 (en) | 2017-08-01 | 2020-02-06 | Theravance Biopharma R&D Ip, Llc | Pyrazolo and triazolo bicyclic compounds as JAK kinase inhibitors |
| CN113498352A (zh) | 2019-01-23 | 2021-10-12 | 施万生物制药研发Ip有限责任公司 | 作为jak抑制剂的咪唑并[1,5-a]吡啶、1,2,4-三唑并[4,3-a]吡啶和咪唑并[1,5-a]吡嗪 |
| EP3999055A1 (en) * | 2019-07-15 | 2022-05-25 | Novartis AG | Methods for treating meibomian gland dysfunction with liver x receptor agonists |
| CA3179566A1 (en) * | 2020-04-08 | 2021-10-14 | Pfizer Inc. | Crystalline forms of 3-cyano-1-[4-[6-(1-methyl-1h-pyrazol-4-yl)pyrazolo[1,5-a]pyrazin-4-yl]-1h-pyrazol-1-yl]cyclobutaneacetonitrile, and use thereof |
| CN115867272A (zh) * | 2020-05-14 | 2023-03-28 | 施万生物制药研发Ip有限责任公司 | 肠道选择性jak3抑制剂的给药 |
| CN114075220A (zh) * | 2020-08-13 | 2022-02-22 | 广东东阳光药业有限公司 | 取代的杂芳基化合物及其组合物和用途 |
| US20230339977A1 (en) * | 2020-08-13 | 2023-10-26 | Sunshine Lake Pharma Co., Ltd. | Substituted heteroaryl compound, and composition and application thereof |
| WO2022053000A1 (zh) * | 2020-09-10 | 2022-03-17 | 四川海思科制药有限公司 | 一种碳环酰胺衍生物及其在医药上的应用 |
| EP4271380A4 (en) * | 2020-12-29 | 2025-01-22 | Abbvie Inc. | UPADACITINIB EXTENDED RELEASE FORMULATIONS |
| WO2022199599A1 (zh) * | 2021-03-23 | 2022-09-29 | 凯复(苏州)生物医药有限公司 | 丙烯酰基取代的化合物、包含其的药物组合物及其用途 |
| CN117377667A (zh) * | 2021-03-29 | 2024-01-09 | 百时美施贵宝公司 | 6-(环丙烷甲酰胺基)-4-((2-甲氧基-3-(1-甲基-1H-1,2,4-三唑-3-基)苯基)氨基)-N-(甲基-d3)哒嗪-3-甲酰胺的晶型 |
| CN113061137B (zh) * | 2021-04-02 | 2022-08-02 | 广西医科大学 | 含氮杂环衍生物或其药学上可接受的盐和用途 |
| UA129643C2 (uk) * | 2021-05-03 | 2025-06-18 | Інсайт Корпорейшн | Інгібітори шляху jak1 для лікування вузлуватого свербця |
| US20250051360A1 (en) * | 2021-12-23 | 2025-02-13 | Sunshine Lake Pharma Co., Ltd. | Substituted heteroaryl compound, and composition and use thereof |
| WO2023165562A1 (zh) * | 2022-03-02 | 2023-09-07 | 南京明德新药研发有限公司 | 含氮杂环类化合物及其应用 |
| GB202213164D0 (en) | 2022-09-08 | 2022-10-26 | Cambridge Entpr Ltd | Novel compounds, compositions and therapeutic uses thereof |
| GB202213163D0 (en) | 2022-09-08 | 2022-10-26 | Cambridge Entpr Ltd | Novel compounds, compositions and therapeutic uses thereof |
| WO2025201397A1 (en) * | 2024-03-27 | 2025-10-02 | Insilico Medicine Ip Limited | Tead inhibitors and methods of uses thereof |
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| CN1293073C (zh) | 2001-04-20 | 2007-01-03 | 惠氏公司 | 作为5-羟色胺-6配体的杂环基烷氧基-、-烷硫基-和-烷基氨基吲哚衍生物 |
| FR2836915B1 (fr) | 2002-03-11 | 2008-01-11 | Aventis Pharma Sa | Derives d'aminoindazoles, procede de preparation et intermediaires de ce procede a titre de medicaments et compositions pharmaceutiques les renfermant |
| US20030139427A1 (en) * | 2002-08-23 | 2003-07-24 | Osi Pharmaceuticals Inc. | Bicyclic pyrimidinyl derivatives and methods of use thereof |
| DK1638941T3 (da) | 2003-05-22 | 2010-10-11 | Abbott Lab | Indazol-, benzisoxazol- og benzisothiazolkinaseinhibitorer |
| EP1647549A1 (en) | 2004-10-14 | 2006-04-19 | Laboratoire Theramex | Indazoles, benzisoxazoles and benzisothiazoles as estrogenic agents |
| EP1959926A1 (en) | 2005-10-25 | 2008-08-27 | Abbott Laboratories | Formulation comprising a drug of low water solubility and method of use thereof |
| JP2009532375A (ja) | 2006-03-30 | 2009-09-10 | タケダ サン ディエゴ インコーポレイテッド | キナーゼ阻害剤 |
| KR100834758B1 (ko) | 2006-07-05 | 2008-06-05 | 삼성전자주식회사 | 컴퓨터 시스템 보안 장치 및 방법 |
| JP2009007342A (ja) | 2007-06-01 | 2009-01-15 | Mitsubishi Tanabe Pharma Corp | 医薬組成物 |
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| FR2951172B1 (fr) | 2009-10-13 | 2014-09-26 | Pf Medicament | Derives pyrazolopyridines en tant qu'agent anticancereux |
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| WO2012061537A2 (en) | 2010-11-02 | 2012-05-10 | The Trustees Of Columbia University In The City Of New York | Methods for treating hair loss disorders |
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| WO2013037390A1 (en) | 2011-09-12 | 2013-03-21 | Sanofi | 6-(4-hydroxy-phenyl)-3-styryl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors |
| CN102993201A (zh) * | 2011-09-14 | 2013-03-27 | 赛诺菲 | 作为激酶抑制剂的6-(4-羟基-苯基)-3-苯乙烯基-1H-吡唑并[3,4-b]吡啶-4-羧酸酰胺衍生物 |
| WO2013045413A1 (en) | 2011-09-27 | 2013-04-04 | Sanofi | 6-(4-hydroxy-phenyl)-3-alkyl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors |
| US20130102601A1 (en) | 2011-10-21 | 2013-04-25 | F. Hoffmann-La Roche Ltd | Pyrimidin-4-one derivatives and their use in the treatment, amelioration or prevention of a viral disease |
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| KR20170002623A (ko) | 2014-05-14 | 2017-01-06 | 화이자 인코포레이티드 | 피라졸로피리딘 및 피라졸로피리미딘 |
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| CN105837574B (zh) | 2015-02-02 | 2018-03-02 | 四川大学 | N‑(3‑哌啶基)‑芳香胺衍生物及其制备方法和用途 |
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| CA2985185A1 (en) | 2015-05-07 | 2016-11-10 | The Trustees Of Columbia University In The City Of New York | Methods and compositions for promoting hair growth |
| WO2017077283A1 (en) | 2015-11-03 | 2017-05-11 | Topivert Pharma Limited | 4,5,6,7-tetrahydro-1h-imidazo[4,5-c]pyridine and 1,4,5,6,7,8-hexahydroimidazo[4,5-d]azepine derivatives as janus kinase inhibitors |
| US10973913B2 (en) | 2016-02-16 | 2021-04-13 | Washington University | JAK inhibitors and uses thereof |
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| EP3509572A4 (en) | 2016-09-08 | 2020-05-13 | Synergistic Therapeutics, LLC | TOPICAL FORMULATION FOR HAIR GROWTH |
| EP3528816A4 (en) | 2016-10-21 | 2020-04-08 | Nimbus Lakshmi, Inc. | TYK2 INHIBITORS AND USES THEREOF |
| US20180117148A1 (en) | 2016-10-28 | 2018-05-03 | Andrew J. Holman | Compounds, pharmaceutical compositions and methods of treatments of immune related diseases and disorders |
| KR102032418B1 (ko) * | 2017-06-15 | 2019-10-16 | 한국화학연구원 | 접합 피리미딘 유도체, 이의 제조방법 및 이를 유효성분으로 포함하는 브루톤티로신 키나제 활성 관련 질환의 예방 또는 치료용 약학적 조성물 |
| AU2018312349A1 (en) | 2017-08-01 | 2020-02-06 | Theravance Biopharma R&D Ip, Llc | Pyrazolo and triazolo bicyclic compounds as JAK kinase inhibitors |
| KR102821964B1 (ko) | 2017-11-03 | 2025-06-19 | 어클라리스 쎄라퓨틱스, 인코포레이티드 | 치환된 피롤로피리미딘 jak 억제제 및 이의 제조 및 사용 방법 |
| RU2758370C1 (ru) | 2017-12-28 | 2021-10-28 | Даевунг Фармасьютикал Ко., Лтд. | Производные оксифторпиперидина в качестве ингибитора киназы |
| KR102577241B1 (ko) | 2017-12-28 | 2023-09-11 | 주식회사 대웅제약 | 카이네이즈 저해제로서의 아미노-플루오로피페리딘 유도체 |
| KR102577242B1 (ko) | 2017-12-28 | 2023-09-11 | 주식회사 대웅제약 | 카이네이즈 저해제로서의 아미노-메틸피페리딘 유도체 |
| CN113498352A (zh) * | 2019-01-23 | 2021-10-12 | 施万生物制药研发Ip有限责任公司 | 作为jak抑制剂的咪唑并[1,5-a]吡啶、1,2,4-三唑并[4,3-a]吡啶和咪唑并[1,5-a]吡嗪 |
| CN115867272A (zh) * | 2020-05-14 | 2023-03-28 | 施万生物制药研发Ip有限责任公司 | 肠道选择性jak3抑制剂的给药 |
-
2018
- 2018-07-31 AU AU2018312349A patent/AU2018312349A1/en not_active Abandoned
- 2018-07-31 BR BR112020002265-9A patent/BR112020002265A2/pt not_active Application Discontinuation
- 2018-07-31 SG SG11202000602YA patent/SG11202000602YA/en unknown
- 2018-07-31 EA EA202090413A patent/EA038912B1/ru unknown
- 2018-07-31 PE PE2020000171A patent/PE20201028A1/es unknown
- 2018-07-31 JP JP2020505224A patent/JP7098716B2/ja not_active Expired - Fee Related
- 2018-07-31 KR KR1020207005956A patent/KR20200036004A/ko not_active Withdrawn
- 2018-07-31 TW TW107126579A patent/TW201920150A/zh unknown
- 2018-07-31 AR ARP180102151 patent/AR112348A1/es unknown
- 2018-07-31 CA CA3069990A patent/CA3069990A1/en not_active Abandoned
- 2018-07-31 MY MYPI2020000251A patent/MY200629A/en unknown
- 2018-07-31 UA UAA202001352A patent/UA125318C2/uk unknown
- 2018-07-31 MA MA049570A patent/MA49570A/fr unknown
- 2018-07-31 US US16/050,227 patent/US10392368B2/en active Active
- 2018-07-31 EP EP18755621.2A patent/EP3652169A1/en not_active Withdrawn
- 2018-07-31 MX MX2020001170A patent/MX2020001170A/es unknown
- 2018-07-31 WO PCT/US2018/044508 patent/WO2019027960A1/en not_active Ceased
- 2018-07-31 CN CN201880050675.3A patent/CN111032646B/zh not_active Expired - Fee Related
-
2019
- 2019-06-28 US US16/456,179 patent/US10538513B2/en active Active
- 2019-11-19 US US16/688,109 patent/US10968205B2/en not_active Expired - Fee Related
-
2020
- 2020-01-14 IL IL272031A patent/IL272031A/en unknown
- 2020-01-27 PH PH12020500201A patent/PH12020500201A1/en unknown
- 2020-01-28 ZA ZA2020/00561A patent/ZA202000561B/en unknown
- 2020-01-31 CL CL2020000283A patent/CL2020000283A1/es unknown
- 2020-02-11 CO CONC2020/0001469A patent/CO2020001469A2/es unknown
-
2021
- 2021-02-22 US US17/249,128 patent/US20220119369A1/en not_active Abandoned
- 2021-03-17 JP JP2021043173A patent/JP2021098751A/ja not_active Withdrawn
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