JP2018531035A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2018531035A5 JP2018531035A5 JP2018521024A JP2018521024A JP2018531035A5 JP 2018531035 A5 JP2018531035 A5 JP 2018531035A5 JP 2018521024 A JP2018521024 A JP 2018521024A JP 2018521024 A JP2018521024 A JP 2018521024A JP 2018531035 A5 JP2018531035 A5 JP 2018531035A5
- Authority
- JP
- Japan
- Prior art keywords
- binding
- receptor
- cells
- incubation
- molecule
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 230000027455 binding Effects 0.000 claims description 307
- 102000005962 receptors Human genes 0.000 claims description 286
- 108020003175 receptors Proteins 0.000 claims description 286
- 238000000034 method Methods 0.000 claims description 261
- 239000011230 binding agent Substances 0.000 claims description 190
- 210000001744 T-lymphocyte Anatomy 0.000 claims description 165
- 239000000126 substance Substances 0.000 claims description 122
- 238000011534 incubation Methods 0.000 claims description 113
- 239000003153 chemical reaction reagent Substances 0.000 claims description 108
- 239000000203 mixture Substances 0.000 claims description 85
- 210000004027 cell Anatomy 0.000 claims description 84
- 239000012634 fragment Substances 0.000 claims description 75
- 239000003795 chemical substances by application Substances 0.000 claims description 62
- 108010090804 Streptavidin Proteins 0.000 claims description 54
- 102000017420 CD3 protein, epsilon/gamma/delta subunit Human genes 0.000 claims description 53
- 108050005493 CD3 protein, epsilon/gamma/delta subunit Proteins 0.000 claims description 53
- 108091008874 T cell receptors Proteins 0.000 claims description 41
- 102000016266 T-Cell Antigen Receptors Human genes 0.000 claims description 41
- 102000003675 cytokine receptors Human genes 0.000 claims description 41
- 108010057085 cytokine receptors Proteins 0.000 claims description 41
- 101000914514 Homo sapiens T-cell-specific surface glycoprotein CD28 Proteins 0.000 claims description 34
- 102100027213 T-cell-specific surface glycoprotein CD28 Human genes 0.000 claims description 34
- YBJHBAHKTGYVGT-ZKWXMUAHSA-N (+)-Biotin Chemical compound N1C(=O)N[C@@H]2[C@H](CCCCC(=O)O)SC[C@@H]21 YBJHBAHKTGYVGT-ZKWXMUAHSA-N 0.000 claims description 32
- 102000003812 Interleukin-15 Human genes 0.000 claims description 32
- 108090000172 Interleukin-15 Proteins 0.000 claims description 32
- 230000002441 reversible effect Effects 0.000 claims description 28
- 102100032937 CD40 ligand Human genes 0.000 claims description 24
- 108010002350 Interleukin-2 Proteins 0.000 claims description 24
- 238000004519 manufacturing process Methods 0.000 claims description 24
- 108010002586 Interleukin-7 Proteins 0.000 claims description 21
- 108010018381 streptavidin-binding peptide Proteins 0.000 claims description 19
- 108090001008 Avidin Proteins 0.000 claims description 18
- 102000009410 Chemokine receptor Human genes 0.000 claims description 16
- 108050000299 Chemokine receptor Proteins 0.000 claims description 16
- 102100040247 Tumor necrosis factor Human genes 0.000 claims description 16
- 102100027207 CD27 antigen Human genes 0.000 claims description 15
- 101000914511 Homo sapiens CD27 antigen Proteins 0.000 claims description 15
- 101000611023 Homo sapiens Tumor necrosis factor receptor superfamily member 6 Proteins 0.000 claims description 15
- 108010021625 Immunoglobulin Fragments Proteins 0.000 claims description 15
- 102000008394 Immunoglobulin Fragments Human genes 0.000 claims description 15
- 102100040403 Tumor necrosis factor receptor superfamily member 6 Human genes 0.000 claims description 15
- 239000011616 biotin Substances 0.000 claims description 15
- 235000020958 biotin Nutrition 0.000 claims description 15
- 229960002685 biotin Drugs 0.000 claims description 15
- 108010029697 CD40 Ligand Proteins 0.000 claims description 12
- 102000004127 Cytokines Human genes 0.000 claims description 12
- 108090000695 Cytokines Proteins 0.000 claims description 12
- 101001047640 Homo sapiens Linker for activation of T-cells family member 1 Proteins 0.000 claims description 12
- 101000702132 Homo sapiens Protein spinster homolog 1 Proteins 0.000 claims description 12
- 101000800116 Homo sapiens Thy-1 membrane glycoprotein Proteins 0.000 claims description 12
- 102100024032 Linker for activation of T-cells family member 1 Human genes 0.000 claims description 12
- 108010061593 Member 14 Tumor Necrosis Factor Receptors Proteins 0.000 claims description 12
- 101150052863 THY1 gene Proteins 0.000 claims description 12
- 102100033523 Thy-1 membrane glycoprotein Human genes 0.000 claims description 12
- 102100028785 Tumor necrosis factor receptor superfamily member 14 Human genes 0.000 claims description 12
- 102100022153 Tumor necrosis factor receptor superfamily member 4 Human genes 0.000 claims description 12
- 101710165473 Tumor necrosis factor receptor superfamily member 4 Proteins 0.000 claims description 12
- 101001038499 Yarrowia lipolytica (strain CLIB 122 / E 150) Lysine acetyltransferase Proteins 0.000 claims description 12
- 150000001413 amino acids Chemical group 0.000 claims description 12
- 150000001615 biotins Chemical class 0.000 claims description 12
- 101000611183 Homo sapiens Tumor necrosis factor Proteins 0.000 claims description 11
- 230000001939 inductive effect Effects 0.000 claims description 11
- 238000012258 culturing Methods 0.000 claims description 9
- 229920000642 polymer Polymers 0.000 claims description 8
- 230000035755 proliferation Effects 0.000 claims description 8
- 230000011664 signaling Effects 0.000 claims description 8
- 102000000584 Calmodulin Human genes 0.000 claims description 7
- 108010041952 Calmodulin Proteins 0.000 claims description 7
- 101710175625 Maltose/maltodextrin-binding periplasmic protein Proteins 0.000 claims description 7
- 108090000765 processed proteins & peptides Proteins 0.000 claims description 7
- 230000000139 costimulatory effect Effects 0.000 claims description 6
- 230000006698 induction Effects 0.000 claims description 6
- 239000003550 marker Substances 0.000 claims description 6
- 210000003071 memory t lymphocyte Anatomy 0.000 claims description 6
- 239000007787 solid Substances 0.000 claims description 6
- 102000037982 Immune checkpoint proteins Human genes 0.000 claims description 5
- 108091008036 Immune checkpoint proteins Proteins 0.000 claims description 5
- 108060008683 Tumor Necrosis Factor Receptor Proteins 0.000 claims description 5
- 229940126546 immune checkpoint molecule Drugs 0.000 claims description 5
- 102000004169 proteins and genes Human genes 0.000 claims description 5
- 108090000623 proteins and genes Proteins 0.000 claims description 5
- 102000003298 tumor necrosis factor receptor Human genes 0.000 claims description 5
- 108091023037 Aptamer Proteins 0.000 claims description 4
- 102000014914 Carrier Proteins Human genes 0.000 claims description 4
- 108010078791 Carrier Proteins Proteins 0.000 claims description 4
- 108010019670 Chimeric Antigen Receptors Proteins 0.000 claims description 4
- 108010020195 FLAG peptide Proteins 0.000 claims description 4
- XZWYTXMRWQJBGX-VXBMVYAYSA-N FLAG peptide Chemical compound NCCCC[C@@H](C(O)=O)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@@H](NC(=O)[C@@H](N)CC(O)=O)CC1=CC=C(O)C=C1 XZWYTXMRWQJBGX-VXBMVYAYSA-N 0.000 claims description 4
- 230000005526 G1 to G0 transition Effects 0.000 claims description 4
- 108010070675 Glutathione transferase Proteins 0.000 claims description 4
- 102000005720 Glutathione transferase Human genes 0.000 claims description 4
- HVLSXIKZNLPZJJ-TXZCQADKSA-N HA peptide Chemical compound C([C@@H](C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](C(C)C)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC=1C=CC(O)=CC=1)C(=O)N[C@@H](C)C(O)=O)NC(=O)[C@H]1N(CCC1)C(=O)[C@@H](N)CC=1C=CC(O)=CC=1)C1=CC=C(O)C=C1 HVLSXIKZNLPZJJ-TXZCQADKSA-N 0.000 claims description 4
- 102000001706 Immunoglobulin Fab Fragments Human genes 0.000 claims description 4
- 108010054477 Immunoglobulin Fab Fragments Proteins 0.000 claims description 4
- 102000007056 Recombinant Fusion Proteins Human genes 0.000 claims description 4
- 108010008281 Recombinant Fusion Proteins Proteins 0.000 claims description 4
- 108020004707 nucleic acids Proteins 0.000 claims description 4
- 102000039446 nucleic acids Human genes 0.000 claims description 4
- 150000007523 nucleic acids Chemical class 0.000 claims description 4
- 229910001428 transition metal ion Inorganic materials 0.000 claims description 4
- 239000011324 bead Substances 0.000 claims description 3
- 230000009261 transgenic effect Effects 0.000 claims description 3
- 102000008102 Ankyrins Human genes 0.000 claims description 2
- 108010049777 Ankyrins Proteins 0.000 claims description 2
- 102000019034 Chemokines Human genes 0.000 claims description 2
- 108010012236 Chemokines Proteins 0.000 claims description 2
- 102000017727 Immunoglobulin Variable Region Human genes 0.000 claims description 2
- 108010067060 Immunoglobulin Variable Region Proteins 0.000 claims description 2
- 108050006654 Lipocalin Proteins 0.000 claims description 2
- 102000019298 Lipocalin Human genes 0.000 claims description 2
- 230000004913 activation Effects 0.000 claims description 2
- 239000013543 active substance Substances 0.000 claims description 2
- 230000001588 bifunctional effect Effects 0.000 claims description 2
- 150000004676 glycans Chemical class 0.000 claims description 2
- 210000005260 human cell Anatomy 0.000 claims description 2
- 239000006249 magnetic particle Substances 0.000 claims description 2
- 239000011159 matrix material Substances 0.000 claims description 2
- 230000002503 metabolic effect Effects 0.000 claims description 2
- 229910052751 metal Inorganic materials 0.000 claims description 2
- 239000002184 metal Substances 0.000 claims description 2
- 239000011859 microparticle Substances 0.000 claims description 2
- 229920001184 polypeptide Polymers 0.000 claims description 2
- 229920001282 polysaccharide Polymers 0.000 claims description 2
- 239000005017 polysaccharide Substances 0.000 claims description 2
- 102000004196 processed proteins & peptides Human genes 0.000 claims description 2
- 230000006378 damage Effects 0.000 claims 2
- 239000000463 material Substances 0.000 claims 1
- 239000003446 ligand Substances 0.000 description 43
- -1 TNF-αR Proteins 0.000 description 26
- 102000000588 Interleukin-2 Human genes 0.000 description 23
- 108090000978 Interleukin-4 Proteins 0.000 description 20
- 102000004388 Interleukin-4 Human genes 0.000 description 20
- 102000008616 interleukin-15 receptor activity proteins Human genes 0.000 description 20
- 108040002039 interleukin-15 receptor activity proteins Proteins 0.000 description 20
- 102100036301 C-C chemokine receptor type 7 Human genes 0.000 description 18
- 102100028990 C-X-C chemokine receptor type 3 Human genes 0.000 description 18
- 101000716065 Homo sapiens C-C chemokine receptor type 7 Proteins 0.000 description 18
- 101000916050 Homo sapiens C-X-C chemokine receptor type 3 Proteins 0.000 description 18
- 102100025390 Integrin beta-2 Human genes 0.000 description 18
- 102100036166 C-X-C chemokine receptor type 1 Human genes 0.000 description 15
- 102100031650 C-X-C chemokine receptor type 4 Human genes 0.000 description 15
- 101000947174 Homo sapiens C-X-C chemokine receptor type 1 Proteins 0.000 description 15
- 101000922348 Homo sapiens C-X-C chemokine receptor type 4 Proteins 0.000 description 15
- 108010066719 Interleukin Receptor Common gamma Subunit Proteins 0.000 description 15
- 102000018682 Interleukin Receptor Common gamma Subunit Human genes 0.000 description 15
- 102100023543 Vascular cell adhesion protein 1 Human genes 0.000 description 15
- 108010085650 interferon gamma receptor Proteins 0.000 description 15
- 108040003610 interleukin-12 receptor activity proteins Proteins 0.000 description 15
- 108040002099 interleukin-21 receptor activity proteins Proteins 0.000 description 15
- 102000008640 interleukin-21 receptor activity proteins Human genes 0.000 description 15
- 108040006852 interleukin-4 receptor activity proteins Proteins 0.000 description 15
- 108010064548 Lymphocyte Function-Associated Antigen-1 Proteins 0.000 description 13
- 125000003275 alpha amino acid group Chemical group 0.000 description 13
- 210000000662 T-lymphocyte subset Anatomy 0.000 description 12
- 102000013691 Interleukin-17 Human genes 0.000 description 11
- 108050003558 Interleukin-17 Proteins 0.000 description 11
- 102100022718 Atypical chemokine receptor 2 Human genes 0.000 description 10
- 102100031172 C-C chemokine receptor type 1 Human genes 0.000 description 10
- 101710149814 C-C chemokine receptor type 1 Proteins 0.000 description 10
- 102100031151 C-C chemokine receptor type 2 Human genes 0.000 description 10
- 101710149815 C-C chemokine receptor type 2 Proteins 0.000 description 10
- 102100024167 C-C chemokine receptor type 3 Human genes 0.000 description 10
- 101710149862 C-C chemokine receptor type 3 Proteins 0.000 description 10
- 102100037853 C-C chemokine receptor type 4 Human genes 0.000 description 10
- 101710149863 C-C chemokine receptor type 4 Proteins 0.000 description 10
- 102100035875 C-C chemokine receptor type 5 Human genes 0.000 description 10
- 101710149870 C-C chemokine receptor type 5 Proteins 0.000 description 10
- 102100036842 C-C motif chemokine 19 Human genes 0.000 description 10
- 102100036846 C-C motif chemokine 21 Human genes 0.000 description 10
- 102100021933 C-C motif chemokine 25 Human genes 0.000 description 10
- 102100025248 C-X-C motif chemokine 10 Human genes 0.000 description 10
- 102100036170 C-X-C motif chemokine 9 Human genes 0.000 description 10
- 101000678892 Homo sapiens Atypical chemokine receptor 2 Proteins 0.000 description 10
- 101000716070 Homo sapiens C-C chemokine receptor type 9 Proteins 0.000 description 10
- 101000713106 Homo sapiens C-C motif chemokine 19 Proteins 0.000 description 10
- 101000713085 Homo sapiens C-C motif chemokine 21 Proteins 0.000 description 10
- 101000897486 Homo sapiens C-C motif chemokine 25 Proteins 0.000 description 10
- 101000858088 Homo sapiens C-X-C motif chemokine 10 Proteins 0.000 description 10
- 101000947172 Homo sapiens C-X-C motif chemokine 9 Proteins 0.000 description 10
- 101000935043 Homo sapiens Integrin beta-1 Proteins 0.000 description 10
- 108010008212 Integrin alpha4beta1 Proteins 0.000 description 10
- 102100025304 Integrin beta-1 Human genes 0.000 description 10
- 102100037877 Intercellular adhesion molecule 1 Human genes 0.000 description 10
- 102000003814 Interleukin-10 Human genes 0.000 description 10
- 108090000174 Interleukin-10 Proteins 0.000 description 10
- 108010002335 Interleukin-9 Proteins 0.000 description 10
- 108010092694 L-Selectin Proteins 0.000 description 10
- 102000016551 L-selectin Human genes 0.000 description 10
- 102100033732 Tumor necrosis factor receptor superfamily member 1A Human genes 0.000 description 10
- 101710187743 Tumor necrosis factor receptor superfamily member 1A Proteins 0.000 description 10
- 102100033733 Tumor necrosis factor receptor superfamily member 1B Human genes 0.000 description 10
- 101710187830 Tumor necrosis factor receptor superfamily member 1B Proteins 0.000 description 10
- 108010000134 Vascular Cell Adhesion Molecule-1 Proteins 0.000 description 10
- 108040006732 interleukin-1 receptor activity proteins Proteins 0.000 description 10
- 102000014909 interleukin-1 receptor activity proteins Human genes 0.000 description 10
- 108040006870 interleukin-10 receptor activity proteins Proteins 0.000 description 10
- 108040006849 interleukin-2 receptor activity proteins Proteins 0.000 description 10
- 108010074108 interleukin-21 Proteins 0.000 description 10
- 108040001304 interleukin-17 receptor activity proteins Proteins 0.000 description 9
- 102000053460 interleukin-17 receptor activity proteins Human genes 0.000 description 9
- 102100037850 Interferon gamma Human genes 0.000 description 6
- 108010074328 Interferon-gamma Proteins 0.000 description 6
- 239000000427 antigen Substances 0.000 description 6
- 108091007433 antigens Proteins 0.000 description 6
- 102000036639 antigens Human genes 0.000 description 6
- MZOFCQQQCNRIBI-VMXHOPILSA-N (3s)-4-[[(2s)-1-[[(2s)-1-[[(1s)-1-carboxy-2-hydroxyethyl]amino]-4-methyl-1-oxopentan-2-yl]amino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-3-[[2-[[(2s)-2,6-diaminohexanoyl]amino]acetyl]amino]-4-oxobutanoic acid Chemical compound OC[C@@H](C(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(O)=O)NC(=O)CNC(=O)[C@@H](N)CCCCN MZOFCQQQCNRIBI-VMXHOPILSA-N 0.000 description 5
- 102100032912 CD44 antigen Human genes 0.000 description 5
- 101000868273 Homo sapiens CD44 antigen Proteins 0.000 description 5
- 101000994375 Homo sapiens Integrin alpha-4 Proteins 0.000 description 5
- 101000935040 Homo sapiens Integrin beta-2 Proteins 0.000 description 5
- 101000599852 Homo sapiens Intercellular adhesion molecule 1 Proteins 0.000 description 5
- 102100032818 Integrin alpha-4 Human genes 0.000 description 5
- 108010064593 Intercellular Adhesion Molecule-1 Proteins 0.000 description 5
- 108010002352 Interleukin-1 Proteins 0.000 description 5
- 102000000589 Interleukin-1 Human genes 0.000 description 5
- 102000013462 Interleukin-12 Human genes 0.000 description 5
- 108010065805 Interleukin-12 Proteins 0.000 description 5
- 102000016978 Orphan receptors Human genes 0.000 description 5
- 108070000031 Orphan receptors Proteins 0.000 description 5
- 102100024616 Platelet endothelial cell adhesion molecule Human genes 0.000 description 5
- 108091008731 RAR-related orphan receptors α Proteins 0.000 description 5
- 108091008773 RAR-related orphan receptors γ Proteins 0.000 description 5
- 108060008682 Tumor Necrosis Factor Proteins 0.000 description 5
- 230000014564 chemokine production Effects 0.000 description 5
- 230000016396 cytokine production Effects 0.000 description 5
- 201000010099 disease Diseases 0.000 description 5
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 5
- 230000008569 process Effects 0.000 description 5
- 102000003702 retinoic acid receptors Human genes 0.000 description 5
- 108090000064 retinoic acid receptors Proteins 0.000 description 5
- 230000009870 specific binding Effects 0.000 description 5
- 101150013553 CD40 gene Proteins 0.000 description 4
- 102100040245 Tumor necrosis factor receptor superfamily member 5 Human genes 0.000 description 4
- 238000006467 substitution reaction Methods 0.000 description 4
- 210000003719 b-lymphocyte Anatomy 0.000 description 3
- 230000006870 function Effects 0.000 description 3
- 230000001965 increasing effect Effects 0.000 description 3
- 239000003112 inhibitor Substances 0.000 description 3
- 208000023275 Autoimmune disease Diseases 0.000 description 2
- 208000035473 Communicable disease Diseases 0.000 description 2
- 206010028980 Neoplasm Diseases 0.000 description 2
- 201000011510 cancer Diseases 0.000 description 2
- 230000007423 decrease Effects 0.000 description 2
- 230000008030 elimination Effects 0.000 description 2
- 238000003379 elimination reaction Methods 0.000 description 2
- 230000002708 enhancing effect Effects 0.000 description 2
- 238000000338 in vitro Methods 0.000 description 2
- 208000015181 infectious disease Diseases 0.000 description 2
- 230000009467 reduction Effects 0.000 description 2
- 210000000130 stem cell Anatomy 0.000 description 2
- 230000000638 stimulation Effects 0.000 description 2
- 238000005406 washing Methods 0.000 description 2
- OWEGMIWEEQEYGQ-UHFFFAOYSA-N 100676-05-9 Natural products OC1C(O)C(O)C(CO)OC1OCC1C(O)C(O)C(O)C(OC2C(OC(O)C(O)C2O)CO)O1 OWEGMIWEEQEYGQ-UHFFFAOYSA-N 0.000 description 1
- 102000006306 Antigen Receptors Human genes 0.000 description 1
- 235000000638 D-biotin Nutrition 0.000 description 1
- 239000011665 D-biotin Substances 0.000 description 1
- GUBGYTABKSRVRQ-PICCSMPSSA-N Maltose Natural products O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@@H](CO)OC(O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-PICCSMPSSA-N 0.000 description 1
- 108010028230 Trp-Ser- His-Pro-Gln-Phe-Glu-Lys Proteins 0.000 description 1
- 230000002238 attenuated effect Effects 0.000 description 1
- 210000000601 blood cell Anatomy 0.000 description 1
- 230000020411 cell activation Effects 0.000 description 1
- 230000010261 cell growth Effects 0.000 description 1
- 210000004748 cultured cell Anatomy 0.000 description 1
- 210000001151 cytotoxic T lymphocyte Anatomy 0.000 description 1
- 238000010494 dissociation reaction Methods 0.000 description 1
- 230000005593 dissociations Effects 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 230000001747 exhibiting effect Effects 0.000 description 1
- 238000010353 genetic engineering Methods 0.000 description 1
- 210000002443 helper t lymphocyte Anatomy 0.000 description 1
- 230000003284 homeostatic effect Effects 0.000 description 1
- 210000002865 immune cell Anatomy 0.000 description 1
- 230000000977 initiatory effect Effects 0.000 description 1
- 230000003993 interaction Effects 0.000 description 1
- 210000000265 leukocyte Anatomy 0.000 description 1
- 210000004698 lymphocyte Anatomy 0.000 description 1
- 230000001404 mediated effect Effects 0.000 description 1
- 210000001806 memory b lymphocyte Anatomy 0.000 description 1
- 239000004005 microsphere Substances 0.000 description 1
- 239000002105 nanoparticle Substances 0.000 description 1
- 210000000822 natural killer cell Anatomy 0.000 description 1
- 239000002245 particle Substances 0.000 description 1
- 239000008194 pharmaceutical composition Substances 0.000 description 1
- 239000000546 pharmaceutical excipient Substances 0.000 description 1
- 210000004986 primary T-cell Anatomy 0.000 description 1
- 238000006722 reduction reaction Methods 0.000 description 1
- 210000003289 regulatory T cell Anatomy 0.000 description 1
- 210000002707 regulatory b cell Anatomy 0.000 description 1
- 238000002271 resection Methods 0.000 description 1
- 239000000021 stimulant Substances 0.000 description 1
- 238000010361 transduction Methods 0.000 description 1
- 230000026683 transduction Effects 0.000 description 1
Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2021095512A JP7390334B2 (ja) | 2015-10-22 | 2021-06-08 | 細胞を培養するための方法ならびにそのためのキットおよび装置 |
| JP2023129681A JP2023138707A (ja) | 2015-10-22 | 2023-08-09 | 細胞を培養するための方法ならびにそのためのキットおよび装置 |
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562245261P | 2015-10-22 | 2015-10-22 | |
| US201562245252P | 2015-10-22 | 2015-10-22 | |
| US62/245,252 | 2015-10-22 | ||
| US62/245,261 | 2015-10-22 | ||
| PCT/IB2016/001618 WO2017068421A1 (en) | 2015-10-22 | 2016-10-20 | Methods for culturing cells and kits and apparatus for same |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021095512A Division JP7390334B2 (ja) | 2015-10-22 | 2021-06-08 | 細胞を培養するための方法ならびにそのためのキットおよび装置 |
Publications (4)
| Publication Number | Publication Date |
|---|---|
| JP2018531035A JP2018531035A (ja) | 2018-10-25 |
| JP2018531035A6 JP2018531035A6 (ja) | 2018-12-13 |
| JP2018531035A5 true JP2018531035A5 (https=) | 2019-11-28 |
| JP6895959B2 JP6895959B2 (ja) | 2021-06-30 |
Family
ID=57394616
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018521024A Active JP6895959B2 (ja) | 2015-10-22 | 2016-10-20 | 細胞を培養するための方法ならびにそのためのキットおよび装置 |
| JP2021095512A Active JP7390334B2 (ja) | 2015-10-22 | 2021-06-08 | 細胞を培養するための方法ならびにそのためのキットおよび装置 |
| JP2023129681A Pending JP2023138707A (ja) | 2015-10-22 | 2023-08-09 | 細胞を培養するための方法ならびにそのためのキットおよび装置 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021095512A Active JP7390334B2 (ja) | 2015-10-22 | 2021-06-08 | 細胞を培養するための方法ならびにそのためのキットおよび装置 |
| JP2023129681A Pending JP2023138707A (ja) | 2015-10-22 | 2023-08-09 | 細胞を培養するための方法ならびにそのためのキットおよび装置 |
Country Status (15)
| Country | Link |
|---|---|
| US (2) | US11466253B2 (https=) |
| EP (1) | EP3365434A1 (https=) |
| JP (3) | JP6895959B2 (https=) |
| KR (1) | KR102908806B1 (https=) |
| CN (2) | CN117106716A (https=) |
| AU (1) | AU2016341529B2 (https=) |
| CA (1) | CA3002745A1 (https=) |
| HK (1) | HK1258931A1 (https=) |
| IL (2) | IL258844B2 (https=) |
| MA (1) | MA45488A (https=) |
| MX (3) | MX2018004874A (https=) |
| PH (1) | PH12018500860A1 (https=) |
| RU (1) | RU2761557C2 (https=) |
| SG (1) | SG11201803330WA (https=) |
| WO (1) | WO2017068421A1 (https=) |
Families Citing this family (73)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8263375B2 (en) | 2002-12-20 | 2012-09-11 | Acea Biosciences | Dynamic monitoring of activation of G-protein coupled receptor (GPCR) and receptor tyrosine kinase (RTK) in living cells using real-time microelectronic cell sensing technology |
| US7192752B2 (en) | 2002-12-20 | 2007-03-20 | Acea Biosciences | Real time electronic cell sensing systems and applications for cell-based assays |
| US11346797B2 (en) | 2002-12-20 | 2022-05-31 | Agilent Technologies, Inc. | System and method for monitoring cardiomyocyte beating, viability, morphology and electrophysiological properties |
| US10539523B2 (en) | 2002-12-20 | 2020-01-21 | Acea Biosciences, Inc. | System and method for monitoring cardiomyocyte beating, viability, morphology, and electrophysiological properties |
| US10551371B2 (en) | 2003-11-10 | 2020-02-04 | Acea Biosciences, Inc. | System and method for monitoring cardiomyocyte beating, viability and morphology and for screening for pharmacological agents which may induce cardiotoxicity or modulate cardiomyocyte function |
| US10215748B2 (en) | 2002-12-20 | 2019-02-26 | Acea Biosciences, Inc. | Using impedance-based cell response profiling to identify putative inhibitors for oncogene addicted targets or pathways |
| CA2723223C (en) | 2008-05-05 | 2017-06-06 | Acea Biosciences, Inc. | Label-free monitoring of excitation-contraction coupling and excitable cells using impedance based systems with millisecond time resolution |
| RU2746407C1 (ru) | 2012-02-23 | 2021-04-13 | Стейдж Селл Терапеутикс Гмбх | Хроматографическое выделение клеток и других сложных биологических материалов |
| BR112016024072B1 (pt) | 2014-04-16 | 2021-02-09 | Juno Therapeutics Gmbh | método in vitro de estimular uma população de células |
| RU2763795C2 (ru) | 2014-04-23 | 2022-01-11 | Джуно Терапьютикс, Инк. | Способы выделения, культивирования и генетической инженерии популяций клеток иммунной системы для адоптивной терапии |
| TWI750110B (zh) | 2014-07-21 | 2021-12-21 | 瑞士商諾華公司 | 使用人類化抗-bcma嵌合抗原受體治療癌症 |
| US11248238B2 (en) | 2015-10-22 | 2022-02-15 | Juno Therapeutics Gmbh | Methods, kits, agents and apparatuses for transduction |
| JP7194020B2 (ja) | 2015-10-22 | 2022-12-21 | ジュノ セラピューティクス ゲーエムベーハー | 細胞の培養方法ならびにそのためのキットおよび装置 |
| US20190119636A1 (en) | 2017-10-23 | 2019-04-25 | Poseida Therapeutics, Inc. | Modified stem cell memory t cells, methods of making and methods of using same |
| MX2019004707A (es) | 2016-10-26 | 2019-08-12 | Iovance Biotherapeutics Inc | Reestimulacion de linfocitos infiltrantes de tumor crioconservados. |
| TWI788307B (zh) | 2016-10-31 | 2023-01-01 | 美商艾歐凡斯生物治療公司 | 用於擴增腫瘤浸潤性淋巴細胞之工程化人造抗原呈現細胞 |
| US11401507B2 (en) | 2016-11-17 | 2022-08-02 | Iovance Biotherapeutics, Inc. | Remnant tumor infiltrating lymphocytes and methods of preparing and using the same |
| CA3049165A1 (en) | 2017-01-06 | 2018-07-12 | Iovance Biotherapeutics, Inc. | Expansion of tumor infiltrating lymphocytes with potassium channel agonists and therapeutic uses thereof |
| CN110582569B (zh) | 2017-03-03 | 2024-04-02 | 安捷伦科技有限公司 | 用于iPSC和ESC衍生的心肌细胞的功能成熟的方法和系统 |
| BR112019018915A2 (pt) | 2017-03-15 | 2020-04-14 | Pandion Therapeutics Inc | imunotolerância direcionada |
| US11254913B1 (en) | 2017-03-29 | 2022-02-22 | Iovance Biotherapeutics, Inc. | Processes for production of tumor infiltrating lymphocytes and uses of same in immunotherapy |
| JOP20190224A1 (ar) | 2017-03-29 | 2019-09-26 | Iovance Biotherapeutics Inc | عمليات من أجل إنتاج الخلايا اللمفاوية المرتشحة للأورام واستخداماتها في العلاج المناعي |
| JP7339160B2 (ja) | 2017-04-27 | 2023-09-05 | ジュノ セラピューティクス ゲーエムベーハー | オリゴマー粒子試薬およびその使用方法 |
| JP2020521452A (ja) | 2017-05-24 | 2020-07-27 | パンディオン・セラピューティクス・インコーポレイテッド | 標的化免疫寛容 |
| CA3065126A1 (en) * | 2017-06-01 | 2018-12-06 | Innovative Cellular Therapeutics CO., LTD. | Chimeric antigen receptor cell preparation and uses thereof |
| US11235004B2 (en) | 2017-06-30 | 2022-02-01 | Innovative Cellular Therapeutics Holdings, Ltd. | Lymphocyte cell lines and uses thereof |
| WO2019028122A1 (en) * | 2017-08-01 | 2019-02-07 | Acea Biosciences, Inc. | MONITORING IMPEDANCE OF CELLULAR SUBSTRATE OF CANCER CELLS OF DIFFERENT LINEAGE, ORIGIN OR STAGE |
| AU2018313950A1 (en) | 2017-08-09 | 2020-02-13 | Juno Therapeutics, Inc. | Methods for producing genetically engineered cell compositions and related compositions |
| EP3704230B1 (en) | 2017-11-01 | 2024-10-23 | Juno Therapeutics, Inc. | Process for generating therapeutic compositions of engineered cells |
| US10174091B1 (en) | 2017-12-06 | 2019-01-08 | Pandion Therapeutics, Inc. | IL-2 muteins |
| US10946068B2 (en) | 2017-12-06 | 2021-03-16 | Pandion Operations, Inc. | IL-2 muteins and uses thereof |
| USRE50550E1 (en) | 2017-12-06 | 2025-08-26 | Pandion Operations, Inc. | IL-2 muteins and uses thereof |
| WO2019113557A1 (en) | 2017-12-08 | 2019-06-13 | Juno Therapeutics, Inc. | Process for producing a composition of engineered t cells |
| JP7433230B2 (ja) | 2017-12-08 | 2024-02-19 | ジュノー セラピューティクス インコーポレイテッド | 細胞を培養するための無血清培地配合物およびその使用の方法 |
| SG11202006541UA (en) | 2018-01-08 | 2020-08-28 | Iovance Biotherapeutics Inc | Processes for generating til products enriched for tumor antigen-specific t-cells |
| WO2019217753A1 (en) | 2018-05-10 | 2019-11-14 | Iovance Biotherapeutics, Inc. | Processes for production of tumor infiltrating lymphocytes and uses of same in immunotherapy |
| KR20210008408A (ko) | 2018-05-23 | 2021-01-21 | 싱가포르국립대학교 | T-세포 악성 종양의 면역요법을 위한 cd2 표면 발현 및 키메라 항원 수용체의 발현에 대한 차단 |
| CA3100724A1 (en) | 2018-06-13 | 2019-12-19 | Novartis Ag | B-cell maturation antigen protein (bcma) chimeric antigen receptors and uses thereof |
| MX2021001493A (es) | 2018-08-06 | 2021-07-15 | Medikine Inc | Compuestos de fijación al receptor de il-2. |
| CN113474450A (zh) * | 2018-08-09 | 2021-10-01 | 朱诺治疗学股份有限公司 | 产生工程化细胞的方法以及所述工程化细胞的组合物 |
| BR112021003830A2 (pt) * | 2018-08-28 | 2021-07-20 | Fred Hutchinson Cancer Research Center | métodos e composições para terapia celular t adotiva incorporando sinalização notch induzida |
| CA3109959A1 (en) * | 2018-08-31 | 2020-03-05 | Novartis Ag | Methods of making chimeric antigen receptor-expressing cells |
| EP3874024A1 (en) | 2018-10-31 | 2021-09-08 | Juno Therapeutics GmbH | Methods for selection and stimulation of cells and apparatus for same |
| SG11202104524YA (en) | 2018-11-01 | 2021-05-28 | Gracell Biotechnologies Shanghai Co Ltd | Compositions and methods for t cell engineering |
| TW202039830A (zh) | 2018-11-05 | 2020-11-01 | 美商艾歐凡斯生物治療公司 | 用於製造腫瘤浸潤性淋巴細胞之方法及其在免疫療法中之用途 |
| AU2019375997A1 (en) | 2018-11-08 | 2021-06-03 | Neximmune, Inc. | T cell compositions with improved phenotypic properties |
| EP3908293A4 (en) * | 2019-01-07 | 2023-01-11 | Children's National Medical Center | EX VIVO ACTIVATED T LYMPHOCYTE COMPOSITIONS AND METHODS OF USE THEREOF |
| KR20200132147A (ko) * | 2019-05-15 | 2020-11-25 | 의료법인 성광의료재단 | 자연 살해 세포의 배양용 조성물 및 이를 이용한 방법 |
| WO2020236875A1 (en) | 2019-05-20 | 2020-11-26 | Pandion Therapeutics, Inc. | Madcam targeted immunotolerance |
| WO2021084050A1 (en) | 2019-10-30 | 2021-05-06 | Juno Therapeutics Gmbh | Cell selection and/or stimulation devices and methods of use |
| KR20220110207A (ko) | 2019-11-05 | 2022-08-05 | 메디카인 인코포레이티드 | IL-2RβγC 결합 화합물 |
| JP7543404B2 (ja) | 2019-11-20 | 2024-09-02 | ジーアイ・セル・インコーポレイテッド | T細胞培養用培地組成物及びこれを用いたt細胞の培養方法 |
| RS66373B1 (sr) * | 2019-11-20 | 2025-02-28 | Gi Cell Inc | Sastav za kultivaciju prirodnih ćelija ubica i postupak za pripremu prirodnih ćelija ubica njegovim korišćenjem |
| IL292924A (en) | 2019-11-26 | 2022-07-01 | Novartis Ag | Chimeric antigen receptors cd19 and cd22 and their uses |
| WO2021107689A1 (ko) | 2019-11-27 | 2021-06-03 | (주)지아이이노베이션 | Il-2 단백질 및 cd80 단백질을 포함하는 융합단백질 및 면역관문 억제제를 포함하는 암 치료용 약학 조성물 |
| US20240182920A1 (en) * | 2020-01-22 | 2024-06-06 | Carsgen Therapeutics Co., Ltd. | Method for transducing cells with viral vector |
| IL295304A (en) | 2020-02-03 | 2022-10-01 | Medikine Inc | Il-7 receptor alpha gamma c binding compounds, compositions comprising same and uses thereof |
| CA3169243A1 (en) * | 2020-02-11 | 2021-08-19 | HCW Biologics, Inc. | Methods of activating regulatory t cells |
| US11981715B2 (en) | 2020-02-21 | 2024-05-14 | Pandion Operations, Inc. | Tissue targeted immunotolerance with a CD39 effector |
| US20210301245A1 (en) | 2020-03-29 | 2021-09-30 | Agilent Technologies, Inc. | Systems and methods for electronically and optically monitoring biological samples |
| US20230372397A1 (en) | 2020-10-06 | 2023-11-23 | Iovance Biotherapeutics, Inc. | Treatment of nsclc patients with tumor infiltrating lymphocyte therapies |
| JP2023549780A (ja) | 2020-11-04 | 2023-11-29 | ジュノー セラピューティクス インコーポレイテッド | 改変されたインバリアントcd3免疫グロブリンスーパーファミリー鎖遺伝子座からキメラ受容体を発現する細胞ならびに関連するポリヌクレオチドおよび方法 |
| AU2022246174A1 (en) | 2021-03-25 | 2023-09-14 | Iovance Biotherapeutics, Inc. | Methods and compositions for t-cell coculture potency assays and use with cell therapy products |
| CN113125733A (zh) * | 2021-04-16 | 2021-07-16 | 浙江普罗亭健康科技有限公司 | 一种用于监测人体免疫状态的42抗体试剂盒及应用 |
| CN113125718A (zh) * | 2021-04-16 | 2021-07-16 | 浙江普罗亭健康科技有限公司 | 一种用于监测人体免疫状态的45抗体试剂盒及应用 |
| US20250283037A1 (en) | 2021-05-06 | 2025-09-11 | Juno Therapeutics Gmbh | Methods for stimulating and transducing t cells |
| TW202307210A (zh) | 2021-06-01 | 2023-02-16 | 瑞士商諾華公司 | Cd19和cd22嵌合抗原受體及其用途 |
| CN117264035B (zh) * | 2022-02-14 | 2024-05-14 | 西南大学 | 链霉亲和素第27位丝氨酸突变的突变蛋白s27k及其应用 |
| US11999771B2 (en) | 2022-04-07 | 2024-06-04 | Medikine, Inc. | IL-7Rαγc ligand immunoglobulin fusion proteins |
| CA3248034A1 (en) | 2022-04-15 | 2023-10-19 | Iovance Biotherapeutics, Inc. | METHODS FOR EXPANSION OF TIL CELLS BY MEANS OF SPECIFIC CYTOKINE COMBINATIONS AND/OR AKT INHIBITOR TREATMENT |
| WO2023213969A1 (en) * | 2022-05-05 | 2023-11-09 | Juno Therapeutics Gmbh | Viral-binding protein and related reagents, articles, and methods of use |
| CN121100267A (zh) | 2022-12-09 | 2025-12-09 | 朱诺治疗学股份有限公司 | 使用全息成像预测细胞表型的机器学习方法 |
| WO2025109111A1 (en) * | 2023-11-22 | 2025-05-30 | Immudex Aps | Immune cell activating multimers |
Family Cites Families (162)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4235871A (en) | 1978-02-24 | 1980-11-25 | Papahadjopoulos Demetrios P | Method of encapsulating biologically active materials in lipid vesicles |
| US4361549A (en) | 1979-04-26 | 1982-11-30 | Ortho Pharmaceutical Corporation | Complement-fixing monoclonal antibody to human T cells, and methods of preparing same |
| US4452773A (en) | 1982-04-05 | 1984-06-05 | Canadian Patents And Development Limited | Magnetic iron-dextran microspheres |
| US4501728A (en) | 1983-01-06 | 1985-02-26 | Technology Unlimited, Inc. | Masking of liposomes from RES recognition |
| WO1986002077A1 (en) | 1984-10-02 | 1986-04-10 | Meade Harry M | Production of streptavidin-like polypeptides |
| US5019369A (en) | 1984-10-22 | 1991-05-28 | Vestar, Inc. | Method of targeting tumors in humans |
| US4690915A (en) | 1985-08-08 | 1987-09-01 | The United States Of America As Represented By The Department Of Health And Human Services | Adoptive immunotherapy as a treatment modality in humans |
| US4795698A (en) | 1985-10-04 | 1989-01-03 | Immunicon Corporation | Magnetic-polymer particles |
| IN165717B (https=) | 1986-08-07 | 1989-12-23 | Battelle Memorial Institute | |
| US4851341A (en) | 1986-12-19 | 1989-07-25 | Immunex Corporation | Immunoaffinity purification system |
| US4837028A (en) | 1986-12-24 | 1989-06-06 | Liposome Technology, Inc. | Liposomes with enhanced circulation time |
| US5219740A (en) | 1987-02-13 | 1993-06-15 | Fred Hutchinson Cancer Research Center | Retroviral gene transfer into diploid fibroblasts for gene therapy |
| US6303121B1 (en) | 1992-07-30 | 2001-10-16 | Advanced Research And Technology | Method of using human receptor protein 4-1BB |
| US6352694B1 (en) | 1994-06-03 | 2002-03-05 | Genetics Institute, Inc. | Methods for inducing a population of T cells to proliferate using agents which recognize TCR/CD3 and ligands which stimulate an accessory molecule on the surface of the T cells |
| US6534055B1 (en) | 1988-11-23 | 2003-03-18 | Genetics Institute, Inc. | Methods for selectively stimulating proliferation of T cells |
| ES2067018T3 (es) | 1988-12-28 | 1995-03-16 | Stefan Miltenyi | Procedimiento y materiales para la separacion en alto gradiente magnetico de materiales biologicos. |
| US5200084A (en) | 1990-09-26 | 1993-04-06 | Immunicon Corporation | Apparatus and methods for magnetic separation |
| CA2096222C (en) | 1990-11-13 | 1998-12-29 | Stephen D. Lupton | Bifunctional selectable fusion genes |
| DE4237113B4 (de) | 1992-11-03 | 2006-10-12 | "Iba Gmbh" | Peptide und deren Fusionsproteine, Expressionsvektor und Verfahren zur Herstellung eines Fusionsproteins |
| WO1994028143A1 (en) | 1993-05-21 | 1994-12-08 | Targeted Genetics Corporation | Bifunctional selectable fusion genes based on the cytosine deaminase (cd) gene |
| EP0700430B1 (en) | 1993-06-04 | 2005-04-20 | The United States of America as Represented by the Secretary of the Navy | Methods for selectively stimulating proliferation of t cells |
| EP0638644A1 (en) | 1993-07-19 | 1995-02-15 | F. Hoffmann-La Roche Ag | Receptors of interleukin-12 and antibodies |
| US5827642A (en) | 1994-08-31 | 1998-10-27 | Fred Hutchinson Cancer Research Center | Rapid expansion method ("REM") for in vitro propagation of T lymphocytes |
| AU5132096A (en) | 1995-01-30 | 1996-08-21 | Terrapin Technologies, Inc. | Glubodies - multiplicities of proteins capable of binding a variety of small molecules |
| US5853721A (en) | 1995-01-31 | 1998-12-29 | Hoffmann-La Roche Inc. | Antibody to interleukin-12 receptor |
| CA2211951A1 (en) | 1995-02-09 | 1996-08-15 | University Of Washington | Modified-affinity streptavidin |
| US5795966A (en) | 1995-02-22 | 1998-08-18 | Immunex Corp | Antagonists of interleukin-15 |
| WO1997011183A1 (en) | 1995-04-11 | 1997-03-27 | Trustees Of Boston University | Streptavidin mutants |
| DE19608753C1 (de) | 1996-03-06 | 1997-06-26 | Medigene Gmbh | Transduktionssystem und seine Verwendung |
| WO1997034634A1 (en) | 1996-03-20 | 1997-09-25 | Sloan-Kettering Institute For Cancer Research | Single chain fv constructs of anti-ganglioside gd2 antibodies |
| US6140064A (en) | 1996-09-10 | 2000-10-31 | Theodor-Kocher Institute | Method of detecting or identifying ligands, inhibitors or promoters of CXC chemokine receptor 3 |
| DE19641876B4 (de) | 1996-10-10 | 2011-09-29 | Iba Gmbh | Streptavidinmuteine |
| AU6701498A (en) | 1997-03-14 | 1998-09-29 | Trustees Of Boston University | Multiflavor streptavidin |
| US5985658A (en) | 1997-11-14 | 1999-11-16 | Health Research Incorporated | Calmodulin-based cell separation technique |
| US6153441A (en) | 1998-02-17 | 2000-11-28 | Smithkline Beecham Corporation | Methods of screening for agonists and antagonists for human CCR7 receptor and CKβ-9 ligand and interaction thereof |
| US7198789B2 (en) | 1998-03-17 | 2007-04-03 | Genetics Institute, Llc | Methods and compositions for modulating interleukin-21 receptor activity |
| ES2330017T3 (es) | 1998-05-23 | 2009-12-03 | Leiden University Medical Center | Ligandos de cd40 y peptidos de ctl para tratar tumores. |
| JP2002524081A (ja) | 1998-09-04 | 2002-08-06 | スローン − ケッタリング インスティチュート フォー キャンサー リサーチ | 前立腺−特異的膜抗原に特異的な融合受容体およびその使用 |
| WO2000023573A2 (en) | 1998-10-20 | 2000-04-27 | City Of Hope | Cd20-specific redirected t cells and their use in cellular immunotherapy of cd20+ malignancies |
| BR0009403A (pt) | 1999-02-04 | 2001-11-27 | Technion Res & Dev Foundation | Método de expansão/conservação das células detronco hemopoiéticas indiferenciadas ou dascélulas progenitoras, método de preparação deum meio condicionado de célula estomacal útil naexpansão/conservação das células de troncohemopoiéticas indiferenciadas ou das célulasprogenitoras, método de transplante de célulasde tronco hemopoiéticas indiferenciadas ou decélulas progenitoras em um recipiente, tampão debiorreator e biorreator |
| DE19932688B4 (de) | 1999-07-13 | 2009-10-08 | Scil Proteins Gmbh | Design von Beta-Faltblatt-Proteinen des gamma-II-kristallins antikörperähnlichen |
| EP1975182A1 (en) | 2000-02-01 | 2008-10-01 | PanGenetics B.V. | CD40-binding APC-activating molecules |
| US20030235908A1 (en) | 2000-02-24 | 2003-12-25 | Xcyte Therapies, Inc. | Activation and expansion of cells |
| US7063845B2 (en) | 2000-04-28 | 2006-06-20 | Gemini Science, Inc. | Human anti-CD40 antibodies |
| AU2001259215A1 (en) | 2000-04-28 | 2001-11-12 | La Jolla Institute For Allergy And Immunology | Human anti-cd40 antibodies and methods of making and using same |
| US20020131960A1 (en) | 2000-06-02 | 2002-09-19 | Michel Sadelain | Artificial antigen presenting cells and methods of use thereof |
| ATE427318T1 (de) | 2000-09-14 | 2009-04-15 | Beth Israel Hospital | Modulierung von il-2 und il-15 vermittelten t zellantworten |
| AU2001297703B2 (en) | 2000-11-07 | 2006-10-19 | City Of Hope | CD19-specific redirected immune cells |
| EP1227321A1 (en) * | 2000-12-28 | 2002-07-31 | Institut für Bioanalytik GmbH | Reversible MHC multimer staining for functional purification of antigen-specific T cells |
| DE10113776B4 (de) | 2001-03-21 | 2012-08-09 | "Iba Gmbh" | Isoliertes streptavidinbindendes, kompetitiv eluierbares Peptid, dieses umfassendes Fusionspeptid, dafür codierende Nukleinsäure, Expressionsvektor, Verfahren zur Herstellung eines rekombinanten Fusionsproteins und Verfahren zum Nachweis und/oder zur Gewinnung des Fusionsproteins |
| US7070995B2 (en) | 2001-04-11 | 2006-07-04 | City Of Hope | CE7-specific redirected immune cells |
| PT1391464E (pt) | 2001-04-27 | 2007-11-15 | Kirin Pharma Kk | Anticorpo monoclonal anti-cd40 |
| US20090257994A1 (en) | 2001-04-30 | 2009-10-15 | City Of Hope | Chimeric immunoreceptor useful in treating human cancers |
| US20030077247A1 (en) | 2001-09-20 | 2003-04-24 | Schering Corporation | Chemokines as adjuvants of immune response |
| WO2003029462A1 (en) | 2001-09-27 | 2003-04-10 | Pieris Proteolab Ag | Muteins of human neutrophil gelatinase-associated lipocalin and related proteins |
| ATE370159T1 (de) | 2002-03-01 | 2007-09-15 | Volker A Erdmann | Streptavidin-bindungspeptid |
| US20030170238A1 (en) | 2002-03-07 | 2003-09-11 | Gruenberg Micheal L. | Re-activated T-cells for adoptive immunotherapy |
| US7754155B2 (en) | 2002-03-15 | 2010-07-13 | Ross Amelia A | Devices and methods for isolating target cells |
| WO2003090781A1 (en) | 2002-04-23 | 2003-11-06 | Meir Strahilevitz | Methods and devices for targeting a site in a mammal and for removing species from a mammal |
| US7446190B2 (en) | 2002-05-28 | 2008-11-04 | Sloan-Kettering Institute For Cancer Research | Nucleic acids encoding chimeric T cell receptors |
| FR2841905B1 (fr) | 2002-07-05 | 2004-09-03 | Centre Nat Rech Scient | Fragments fab mutants de l'anticorps anti-cd4 chimere 13b8.2 et leurs applications |
| EP2351770A1 (en) | 2002-07-17 | 2011-08-03 | Cytos Biotechnology AG | Molecular antigen arrays using a virus like particle derived from the ap205 coat protein |
| EP1447093A1 (en) | 2003-02-14 | 2004-08-18 | Deutsches Krebsforschungszentrum Stiftung des öffentlichen Rechts | Inhibition of the CD95 ligand/receptor system for the treatment of neurological disorders and injuries |
| US20050129671A1 (en) | 2003-03-11 | 2005-06-16 | City Of Hope | Mammalian antigen-presenting T cells and bi-specific T cells |
| KR20060015482A (ko) | 2003-03-21 | 2006-02-17 | 와이어쓰 | 인터루킨-21/인터루킨-21 수용체의 작용제를 이용한면역장애의 치료 |
| EP1623017B1 (en) | 2003-05-08 | 2010-09-15 | Life Technologies Corporation | Generation and isolation of antigen-specific t cells |
| US7943393B2 (en) | 2003-07-14 | 2011-05-17 | Phynexus, Inc. | Method and device for extracting an analyte |
| MXPA06004853A (es) | 2003-11-07 | 2006-07-06 | Immunex Corp | Anticuerpos que se aglutinan al receptor 4 de interleucina. |
| US20080050795A1 (en) | 2003-11-20 | 2008-02-28 | Biosensor Applications Sweden Ab | Mixture Of At Least Two Different Antibodies Specific For Predetermined Antigens And Use Of The Mixture |
| NZ547157A (en) | 2003-12-10 | 2009-07-31 | Medarex Inc | Interferon Alpha Antibodies and their uses |
| SE0400181D0 (sv) | 2004-01-29 | 2004-01-29 | Gyros Ab | Segmented porous and preloaded microscale devices |
| US7592431B2 (en) | 2004-02-26 | 2009-09-22 | Immunovative Therapies, Ltd. | Biodegradable T-cell Activation device |
| EP2573166B1 (en) | 2004-02-26 | 2016-05-11 | Immunovative Therapies, Ltd. | Methods for preparing T-cells for cell therapy |
| US7776583B2 (en) | 2004-06-03 | 2010-08-17 | Meso Scale Technologies, Llc | Methods and apparatuses for conducting assays |
| HUE035082T2 (en) | 2004-06-21 | 2018-05-02 | Squibb & Sons Llc | Interferon alpha receptor 1 antibodies and their use |
| EP1771204A4 (en) | 2004-07-01 | 2008-08-13 | Univ New York | COMPOSITIONS AND METHOD FOR MODULATING ROR-GAMMA-T |
| CA2574848A1 (en) | 2004-08-05 | 2006-12-21 | Wyeth | Antagonizing interleukin-21 receptor activity |
| US20110098184A1 (en) | 2004-10-15 | 2011-04-28 | Day Anthony G | Competitve differntial screeing |
| CA2586615C (en) | 2004-11-12 | 2017-06-27 | Genentech, Inc. | Pro87299 (btla), and variants thereof, for treating immune related disorders |
| US8188232B1 (en) | 2004-11-15 | 2012-05-29 | Washington University In St. Louis | Compositions and methods for modulating lymphocyte activity |
| WO2006058226A2 (en) | 2004-11-24 | 2006-06-01 | The Trustees Of Boston University | Modified dimeric streptavidins and uses thereof |
| US20060252087A1 (en) | 2005-01-18 | 2006-11-09 | Biocept, Inc. | Recovery of rare cells using a microchannel apparatus with patterned posts |
| US7553932B1 (en) | 2005-04-25 | 2009-06-30 | La Jolla Institute For Allergy And Immunology | Methods of treating viral infection with IL-10 receptor antagonists |
| CN101267834B (zh) | 2005-09-28 | 2013-06-05 | 赛托斯生物技术公司 | 白介素-1偶联物及其用途 |
| AU2006298188B2 (en) * | 2005-09-30 | 2012-03-15 | Takara Bio Inc. | Method for production of T cell population |
| TWI461436B (zh) | 2005-11-25 | 2014-11-21 | Kyowa Hakko Kirin Co Ltd | 人類cd134(ox40)之人類單株抗體及其製造及使用方法 |
| US7704708B2 (en) | 2006-02-13 | 2010-04-27 | Uti Limited Partnership | Monomeric streptavidin muteins |
| US7855057B2 (en) | 2006-03-23 | 2010-12-21 | Millipore Corporation | Protein splice variant/isoform discrimination and quantitative measurements thereof |
| US7833527B2 (en) | 2006-10-02 | 2010-11-16 | Amgen Inc. | Methods of treating psoriasis using IL-17 Receptor A antibodies |
| DK2091965T3 (da) | 2006-10-17 | 2013-08-05 | Oncotherapy Science Inc | Peptidvacciner mod cancere, der udtrykker MPHOSPH1- eller DEPDC1-polypeptider |
| GB0620894D0 (en) | 2006-10-20 | 2006-11-29 | Univ Southampton | Human immune therapies using a CD27 agonist alone or in combination with other immune modulators |
| JP5557450B2 (ja) | 2006-11-02 | 2014-07-23 | 協和メデックス株式会社 | 測定対象成分の免疫測定法 |
| AU2007353319A1 (en) | 2006-11-15 | 2008-11-20 | Invitrogen Dynal As | Methods for reversibly binding a biotin compound to a support |
| US20080131415A1 (en) | 2006-11-30 | 2008-06-05 | Riddell Stanley R | Adoptive transfer of cd8 + t cell clones derived from central memory cells |
| ES2523992T3 (es) | 2006-12-28 | 2014-12-03 | Deutsches Krebsforschungszentrum Stiftung des öffentlichen Rechts | La neutralización de la actividad de CD95 bloquea la invasión de células de glioblastoma in vivo |
| CN101226118B (zh) | 2007-01-19 | 2010-06-16 | 中国医学科学院肿瘤研究所 | 一种兼容免疫荧光分析的细胞化学染色方法及其用途 |
| KR20080076622A (ko) | 2007-02-16 | 2008-08-20 | 포항공과대학교 산학협력단 | 올리고머화된 단백질 전달체와 이를 이용한 세포내바이러스 벡터 전달 방법 |
| WO2008118476A2 (en) | 2007-03-26 | 2008-10-02 | Codon Devices, Inc. | Cell surface display, screening and production of proteins of interest |
| CA2682527C (en) | 2007-03-30 | 2017-07-11 | Memorial Sloan-Kettering Cancer Center | Constitutive expression of costimulatory ligands on adoptively transferred t lymphocytes |
| EP2068925A4 (en) | 2007-05-07 | 2011-08-31 | Medimmune Llc | ANTI-ICOS ANTIBODIES AND THEIR USE FOR THE TREATMENT OF CANCER, TRANSPLANTATIONS AND AUTOIMMUNE DISEASES |
| DK2193199T3 (da) | 2007-08-20 | 2014-01-13 | Nextera As | Pvii fag-display |
| WO2009072003A2 (en) | 2007-12-07 | 2009-06-11 | Miltenyi Biotec Gmbh | Sample processing system and methods |
| US8479118B2 (en) | 2007-12-10 | 2013-07-02 | Microsoft Corporation | Switching search providers within a browser search box |
| DK2240781T3 (en) | 2008-01-18 | 2018-03-26 | Harvard College | METHODS FOR DETECTING DISEASE OR STATE SIGNATURES IN BODY FLUIDS |
| CA2713462C (en) | 2008-01-29 | 2020-04-14 | Fred Hutchinson Cancer Research Center | Identification of cd8+ t cells that are cd161hi and/or il18r(alpha)hi and have rapid drug efflux capacity |
| CN106986926A (zh) | 2008-01-30 | 2017-07-28 | 皮里斯股份公司 | 具有对人c‑met受体酪氨酸激酶的亲和性的泪脂质运载蛋白的突变蛋白及其获得方法 |
| WO2009145831A1 (en) | 2008-04-02 | 2009-12-03 | Geisinger Clinic | Treatment of the idiopathic nephrotic syndrome spectrum diseases using basiliximab |
| US20120164718A1 (en) | 2008-05-06 | 2012-06-28 | Innovative Micro Technology | Removable/disposable apparatus for MEMS particle sorting device |
| JP5173594B2 (ja) | 2008-05-27 | 2013-04-03 | キヤノン株式会社 | 管理装置、画像形成装置及びそれらの処理方法 |
| KR20110039220A (ko) | 2008-06-30 | 2011-04-15 | 교와 핫꼬 기린 가부시키가이샤 | 항cd27 항체 |
| US8775327B2 (en) | 2008-07-03 | 2014-07-08 | Oracle International Corporation | Combined directory of personal and enterprise application system data |
| BRPI0918842A2 (pt) | 2008-08-28 | 2015-12-08 | Abbott Biotherapeutics Corp | método para tratar pacientes com esclerose múltipla com anticorpos anti-il2r |
| CN101446576B (zh) | 2008-12-29 | 2011-06-22 | 江苏省苏微微生物研究有限公司 | 一种微囊藻毒素-lr单抗免疫亲和柱的制备和使用方法 |
| WO2010080032A2 (en) | 2009-01-09 | 2010-07-15 | Stichting Het Nederlands Kanker Instituut | Bead-assisted viral transduction |
| AU2010237046B2 (en) | 2009-04-17 | 2015-06-04 | New York University | Peptides targeting TNF family receptors and antagonizing TNF action, compositions, methods and uses thereof |
| ES2456504T3 (es) | 2009-04-27 | 2014-04-22 | Abbvie Biotherapeutics Inc. | Procedimientos de supervisión de la eficacia de anticuerpos anti-IL-2R en pacientes con esclerosis múltiple |
| WO2011026117A1 (en) | 2009-08-31 | 2011-03-03 | Facet Biotech Corporation | Use of an immunoregulatory nk cell population for monitoring the efficacy of anti-il-2r antibodies in multiple sclerosis patients |
| US20120214187A1 (en) | 2009-11-02 | 2012-08-23 | Ffina Biolutions, Llc | Method for Enhancing the Sensitivity of Antibody Based Assays |
| US20120321665A1 (en) | 2009-12-14 | 2012-12-20 | Benaroya Research Institute At Virginia Mason | Compositions and methods for treating airway inflammatory diseases |
| EP2363501A1 (en) | 2010-03-02 | 2011-09-07 | Universitätsklinikum Hamburg-Eppendorf | Method for isolating target cells |
| EP3165540A1 (en) | 2010-04-13 | 2017-05-10 | Celldex Therapeutics, Inc. | Antibodies that bind human cd27 and uses thereof |
| EP2601521B1 (en) | 2010-08-06 | 2018-05-02 | Ludwig-Maximilians-Universität München | Identification of t cell target antigens |
| WO2012058627A2 (en) | 2010-10-29 | 2012-05-03 | Miqin Zhang | Pre-targeted nanoparticle system and method for labeling biological particles |
| PH12013501201A1 (en) | 2010-12-09 | 2013-07-29 | Univ Pennsylvania | Use of chimeric antigen receptor-modified t cells to treat cancer |
| CA2824278C (en) | 2010-12-20 | 2022-09-20 | The Rockefeller University | Modulating agonistic tnfr antibodies |
| CN110200997A (zh) | 2011-03-23 | 2019-09-06 | 弗雷德哈钦森癌症研究中心 | 用于细胞免疫治疗的方法和组合物 |
| US8398282B2 (en) | 2011-05-12 | 2013-03-19 | Delphi Technologies, Inc. | Vehicle front lighting assembly and systems having a variable tint electrowetting element |
| TR201811128T4 (tr) * | 2011-07-18 | 2018-08-27 | Iba Gmbh | Bir hedef hücrenin tersinir şekilde boyama yöntemi. |
| GB201116092D0 (en) | 2011-09-16 | 2011-11-02 | Bioceros B V | Antibodies and uses thereof |
| KR102134932B1 (ko) | 2011-11-11 | 2020-07-17 | 프레드 헛친슨 켄서 리서치 센터 | 암을 위한 사이클린 a1―표적화된 t―세포 면역요법 |
| JP6850528B2 (ja) | 2012-02-13 | 2021-03-31 | シアトル チルドレンズ ホスピタル ドゥーイング ビジネス アズ シアトル チルドレンズ リサーチ インスティテュート | 二重特異性キメラ抗原受容体およびその治療的使用 |
| WO2013126726A1 (en) | 2012-02-22 | 2013-08-29 | The Trustees Of The University Of Pennsylvania | Double transgenic t cells comprising a car and a tcr and their methods of use |
| RU2746407C1 (ru) | 2012-02-23 | 2021-04-13 | Стейдж Селл Терапеутикс Гмбх | Хроматографическое выделение клеток и других сложных биологических материалов |
| WO2013138586A1 (en) | 2012-03-15 | 2013-09-19 | Janssen Biotech, Inc. | Human anti-cd27 antibodies, methods and uses |
| SG10201609210SA (en) | 2012-05-03 | 2016-12-29 | Hutchinson Fred Cancer Res | Enhanced affinity t cell receptors and methods for making the same |
| UA114108C2 (uk) | 2012-07-10 | 2017-04-25 | Борд Оф Ріджентс, Дзе Юніверсіті Оф Техас Сістем | Моноклональне антитіло для застосування в діагностиці і терапії злоякісних пухлин і аутоімунного захворювання |
| CA2881981A1 (en) | 2012-08-20 | 2014-02-27 | Fred Hutchinson Cancer Research Center | Method and compositions for cellular immunotherapy |
| US10316289B2 (en) | 2012-09-06 | 2019-06-11 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Methods of producing T memory stem cell populations |
| EP2711418B1 (en) | 2012-09-25 | 2017-08-23 | Miltenyi Biotec GmbH | Method for polyclonal stimulation of T cells by flexible nanomatrices |
| AU2013327136A1 (en) | 2012-10-02 | 2015-04-16 | Memorial Sloan-Kettering Cancer Center | Compositions and methods for immunotherapy |
| WO2014076277A1 (en) | 2012-11-16 | 2014-05-22 | Iba Gmbh | Streptavidin muteins and methods of using them |
| DE112012007250B4 (de) | 2012-12-20 | 2024-10-24 | Mitsubishi Electric Corp. | Fahrzeuginterne Vorrichtung und Programm |
| CA2917858A1 (en) | 2013-08-02 | 2015-02-05 | Aduro Biotech Holdings, Europe B.V. | Combining cd27 agonists and immune checkpoint inhibition for immune stimulation |
| US9108442B2 (en) | 2013-08-20 | 2015-08-18 | Ricoh Company, Ltd. | Image forming apparatus |
| CN113354744A (zh) | 2013-12-20 | 2021-09-07 | 弗雷德哈钦森癌症研究中心 | 带标签的嵌合效应分子及其受体 |
| EP3126394B1 (en) | 2014-03-31 | 2019-10-30 | F.Hoffmann-La Roche Ag | Anti-ox40 antibodies and methods of use |
| RU2016142476A (ru) | 2014-03-31 | 2018-05-07 | Дженентек, Инк. | Комбинированная терапия, включающая антиангиогенезные агенты и агонисты, связывающие ох40 |
| BR112016024072B1 (pt) | 2014-04-16 | 2021-02-09 | Juno Therapeutics Gmbh | método in vitro de estimular uma população de células |
| RU2763795C2 (ru) | 2014-04-23 | 2022-01-11 | Джуно Терапьютикс, Инк. | Способы выделения, культивирования и генетической инженерии популяций клеток иммунной системы для адоптивной терапии |
| JP6661544B2 (ja) | 2014-04-24 | 2020-03-11 | ミルテニイ バイオテック ゲゼルシャフト ミット ベシュレンクテル ハフツング | 遺伝子改変したt細胞の自動生成法 |
| CA2945414C (en) | 2014-04-30 | 2023-05-09 | Iba Gmbh | Method of isolating a target cell |
| EP2955196A1 (en) | 2014-06-10 | 2015-12-16 | Effimune | Antibodies directed against CD127 |
| WO2015197874A2 (en) | 2014-06-27 | 2015-12-30 | Apogenix Gmbh | Combination of cd95/cd95l inhibition and cancer immunotherapy |
| KR20170065662A (ko) | 2014-10-18 | 2017-06-13 | 화이자 인코포레이티드 | 항-il-7r 항체 조성물 |
| WO2016166568A1 (en) | 2015-04-16 | 2016-10-20 | Juno Therapeutics Gmbh | Methods, kits and apparatus for expanding a population of cells |
| US11248238B2 (en) | 2015-10-22 | 2022-02-15 | Juno Therapeutics Gmbh | Methods, kits, agents and apparatuses for transduction |
| JP7194020B2 (ja) | 2015-10-22 | 2022-12-21 | ジュノ セラピューティクス ゲーエムベーハー | 細胞の培養方法ならびにそのためのキットおよび装置 |
| CN108884140B (zh) | 2015-12-03 | 2022-10-25 | 朱诺治疗学股份有限公司 | 修饰的嵌合受体及相关组合物和方法 |
| MX2019008538A (es) | 2017-01-20 | 2019-11-05 | Juno Therapeutics Gmbh | Conjugados de superficie celular y composiciones y métodos celulares relacionados. |
| JP7339160B2 (ja) | 2017-04-27 | 2023-09-05 | ジュノ セラピューティクス ゲーエムベーハー | オリゴマー粒子試薬およびその使用方法 |
| CN113474450A (zh) | 2018-08-09 | 2021-10-01 | 朱诺治疗学股份有限公司 | 产生工程化细胞的方法以及所述工程化细胞的组合物 |
| EP3874024A1 (en) | 2018-10-31 | 2021-09-08 | Juno Therapeutics GmbH | Methods for selection and stimulation of cells and apparatus for same |
-
2016
- 2016-10-20 SG SG11201803330WA patent/SG11201803330WA/en unknown
- 2016-10-20 US US15/770,179 patent/US11466253B2/en active Active
- 2016-10-20 JP JP2018521024A patent/JP6895959B2/ja active Active
- 2016-10-20 CN CN202310604691.5A patent/CN117106716A/zh active Pending
- 2016-10-20 CN CN201680075211.9A patent/CN108431210B/zh active Active
- 2016-10-20 IL IL258844A patent/IL258844B2/en unknown
- 2016-10-20 EP EP16801293.8A patent/EP3365434A1/en active Pending
- 2016-10-20 MA MA045488A patent/MA45488A/fr unknown
- 2016-10-20 MX MX2018004874A patent/MX2018004874A/es unknown
- 2016-10-20 IL IL307934A patent/IL307934A/en unknown
- 2016-10-20 AU AU2016341529A patent/AU2016341529B2/en active Active
- 2016-10-20 CA CA3002745A patent/CA3002745A1/en active Pending
- 2016-10-20 KR KR1020187014396A patent/KR102908806B1/ko active Active
- 2016-10-20 HK HK19101410.9A patent/HK1258931A1/zh unknown
- 2016-10-20 RU RU2018118575A patent/RU2761557C2/ru active
- 2016-10-20 WO PCT/IB2016/001618 patent/WO2017068421A1/en not_active Ceased
-
2018
- 2018-04-19 MX MX2022012148A patent/MX2022012148A/es unknown
- 2018-04-19 MX MX2022012147A patent/MX2022012147A/es unknown
- 2018-04-20 PH PH12018500860A patent/PH12018500860A1/en unknown
-
2021
- 2021-06-08 JP JP2021095512A patent/JP7390334B2/ja active Active
-
2022
- 2022-10-07 US US18/045,137 patent/US20230295567A1/en not_active Abandoned
-
2023
- 2023-08-09 JP JP2023129681A patent/JP2023138707A/ja active Pending
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2018531035A5 (https=) | ||
| RU2018118575A (ru) | Способы культивирования клеток и наборы и устройство для них | |
| ES3038614T3 (en) | Oligomeric particle reagents and methods of use thereof | |
| JP2020198875A5 (https=) | ||
| JP2018531035A6 (ja) | 細胞を培養するための方法ならびにそのためのキットおよび装置 | |
| CN108473958A (zh) | 非造血组织驻留γδT细胞的扩增及这些细胞的用途 | |
| CA2555714C (en) | Methods for preparing t-cells for cell therapy | |
| JP2024020231A5 (https=) | ||
| AU2018277294A1 (en) | Oncolytic virus and method | |
| JP2020191873A5 (https=) | ||
| RU2021134611A (ru) | Способы культивирования клеток и наборы и устройство для них | |
| US20240424114A1 (en) | Immunomodulatory nanofilaments | |
| RU2777989C2 (ru) | Олигомерные реагенты в виде частиц и способы их применения | |
| NZ741878B2 (en) | Methods for culturing cells and kits and apparatus for same | |
| WO2025011609A1 (zh) | 细胞治疗产品制备工艺及其应用 | |
| NZ763583A (en) | Methods, kits and apparatus for expanding a population of cells |