JP2024020231A5 - - Google Patents
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- JP2024020231A5 JP2024020231A5 JP2023181879A JP2023181879A JP2024020231A5 JP 2024020231 A5 JP2024020231 A5 JP 2024020231A5 JP 2023181879 A JP2023181879 A JP 2023181879A JP 2023181879 A JP2023181879 A JP 2023181879A JP 2024020231 A5 JP2024020231 A5 JP 2024020231A5
- Authority
- JP
- Japan
- Prior art keywords
- antigen
- presenting
- molecule
- cells
- tcr
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
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- 239000003446 ligand Substances 0.000 claims 18
- 108091008874 T cell receptors Proteins 0.000 claims 15
- 102000016266 T-Cell Antigen Receptors Human genes 0.000 claims 15
- 210000001744 T-lymphocyte Anatomy 0.000 claims 14
- 238000000034 method Methods 0.000 claims 10
- 230000004913 activation Effects 0.000 claims 7
- 230000003081 coactivator Effects 0.000 claims 7
- 239000000427 antigen Substances 0.000 claims 6
- 102000036639 antigens Human genes 0.000 claims 6
- 108091007433 antigens Proteins 0.000 claims 6
- 239000011324 bead Substances 0.000 claims 6
- 239000012634 fragment Substances 0.000 claims 5
- 239000012190 activator Substances 0.000 claims 4
- 230000027455 binding Effects 0.000 claims 4
- 101000914514 Homo sapiens T-cell-specific surface glycoprotein CD28 Proteins 0.000 claims 3
- 108700018351 Major Histocompatibility Complex Proteins 0.000 claims 3
- 102100027213 T-cell-specific surface glycoprotein CD28 Human genes 0.000 claims 3
- 230000003213 activating effect Effects 0.000 claims 3
- 230000000890 antigenic effect Effects 0.000 claims 3
- 230000006690 co-activation Effects 0.000 claims 3
- 238000012258 culturing Methods 0.000 claims 3
- 108090000765 processed proteins & peptides Proteins 0.000 claims 3
- 230000020382 suppression by virus of host antigen processing and presentation of peptide antigen via MHC class I Effects 0.000 claims 3
- 102000009465 Growth Factor Receptors Human genes 0.000 claims 2
- 108010009202 Growth Factor Receptors Proteins 0.000 claims 2
- 206010028980 Neoplasm Diseases 0.000 claims 2
- 239000002202 Polyethylene glycol Substances 0.000 claims 2
- 230000000903 blocking effect Effects 0.000 claims 2
- 210000004027 cell Anatomy 0.000 claims 2
- 229920001223 polyethylene glycol Polymers 0.000 claims 2
- 230000004936 stimulating effect Effects 0.000 claims 2
- 229940121697 CD27 agonist Drugs 0.000 claims 1
- 210000001266 CD8-positive T-lymphocyte Anatomy 0.000 claims 1
- 101000578784 Homo sapiens Melanoma antigen recognized by T-cells 1 Proteins 0.000 claims 1
- 101001094545 Homo sapiens Retrotransposon-like protein 1 Proteins 0.000 claims 1
- 101000837401 Homo sapiens T-cell leukemia/lymphoma protein 1A Proteins 0.000 claims 1
- 101000807990 Homo sapiens Variable charge X-linked protein 3 Proteins 0.000 claims 1
- 102100028389 Melanoma antigen recognized by T-cells 1 Human genes 0.000 claims 1
- 102100037258 Membrane-associated transporter protein Human genes 0.000 claims 1
- 108091007563 SLC45A2 Proteins 0.000 claims 1
- 102100028676 T-cell leukemia/lymphoma protein 1A Human genes 0.000 claims 1
- 102100038978 Variable charge X-linked protein 3 Human genes 0.000 claims 1
- 239000000556 agonist Substances 0.000 claims 1
- 150000001732 carboxylic acid derivatives Chemical group 0.000 claims 1
- 239000000919 ceramic Substances 0.000 claims 1
- 239000011521 glass Substances 0.000 claims 1
- 239000002184 metal Substances 0.000 claims 1
- 229910044991 metal oxide Inorganic materials 0.000 claims 1
- 150000004706 metal oxides Chemical class 0.000 claims 1
Applications Claiming Priority (8)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201762535742P | 2017-07-21 | 2017-07-21 | |
| US62/535,742 | 2017-07-21 | ||
| US201862660779P | 2018-04-20 | 2018-04-20 | |
| US62/660,779 | 2018-04-20 | ||
| US201862664279P | 2018-04-30 | 2018-04-30 | |
| US62/664,279 | 2018-04-30 | ||
| PCT/US2018/043146 WO2019018801A1 (en) | 2017-07-21 | 2018-07-20 | SYNTHETIC SURFACES FOR PRESENTING ANTIGENS, COVALENTLY FUNCTIONALIZED SURFACES, ACTIVATED T CELLS AND USES THEREOF |
| JP2020502582A JP2020528747A (ja) | 2017-07-21 | 2018-07-20 | 抗原提示合成表面、共有結合官能化表面、活性化ｔ細胞及びそれらの使用 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020502582A Division JP2020528747A (ja) | 2017-07-21 | 2018-07-20 | 抗原提示合成表面、共有結合官能化表面、活性化ｔ細胞及びそれらの使用 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2024020231A JP2024020231A (ja) | 2024-02-14 |
| JP2024020231A5 true JP2024020231A5 (https=) | 2024-06-27 |
Family
ID=65015614
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020502582A Pending JP2020528747A (ja) | 2017-07-21 | 2018-07-20 | 抗原提示合成表面、共有結合官能化表面、活性化ｔ細胞及びそれらの使用 |
| JP2023181879A Withdrawn JP2024020231A (ja) | 2017-07-21 | 2023-10-23 | 抗原提示合成表面、共有結合官能化表面、活性化ｔ細胞及びそれらの使用 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020502582A Pending JP2020528747A (ja) | 2017-07-21 | 2018-07-20 | 抗原提示合成表面、共有結合官能化表面、活性化ｔ細胞及びそれらの使用 |
Country Status (11)
| Country | Link |
|---|---|
| US (2) | US20200299351A1 (https=) |
| EP (2) | EP3655027B1 (https=) |
| JP (2) | JP2020528747A (https=) |
| KR (1) | KR20200030593A (https=) |
| CN (2) | CN111107871A (https=) |
| AU (1) | AU2018304543A1 (https=) |
| CA (1) | CA3070289A1 (https=) |
| IL (1) | IL272151A (https=) |
| SG (1) | SG11202000425QA (https=) |
| TW (1) | TWI832820B (https=) |
| WO (1) | WO2019018801A1 (https=) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US10799865B2 (en) | 2015-10-27 | 2020-10-13 | Berkeley Lights, Inc. | Microfluidic apparatus having an optimized electrowetting surface and related systems and methods |
| IL263274B2 (en) | 2016-05-26 | 2023-10-01 | Berkeley Lights Inc | Covalently adapted surfaces, kits and methods for their production and uses |
| CA3112813A1 (en) * | 2018-09-21 | 2020-03-26 | Berkeley Lights, Inc. | Functionalized well plate, methods of preparation and use thereof |
| CN113366312A (zh) | 2018-11-01 | 2021-09-07 | 伯克利之光生命科技公司 | 在微流体环境中测定生物细胞的方法 |
| WO2020168258A1 (en) | 2019-02-15 | 2020-08-20 | Berkeley Lights, Inc. | Laser-assisted repositioning of a micro-object and culturing of an attachment-dependent cell in a microfluidic environment |
| WO2020223555A1 (en) | 2019-04-30 | 2020-11-05 | Berkeley Lights, Inc. | Methods for encapsulating and assaying cells |
| US20220204943A1 (en) * | 2020-12-31 | 2022-06-30 | Academia Sinica | Cell culture systems, methods and uses thereof |
| US12275932B2 (en) * | 2021-04-28 | 2025-04-15 | A.U. Vista, Inc. | TFT-based cell isolation device and cell manipulation panel thereof |
| WO2023161961A1 (en) * | 2022-02-24 | 2023-08-31 | Lymphon Biologics Pvt. Ltd. | A system and method for t cell activation and immunomodulation |
| WO2025111584A1 (en) * | 2023-11-22 | 2025-05-30 | Georgia Tech Research Corporation | An electronic microfluidic platform for on-chip apoptosis quantification using annexin v-based ps externalization detection |
Family Cites Families (44)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4690915A (en) | 1985-08-08 | 1987-09-01 | The United States Of America As Represented By The Department Of Health And Human Services | Adoptive immunotherapy as a treatment modality in humans |
| US5827642A (en) | 1994-08-31 | 1998-10-27 | Fred Hutchinson Cancer Research Center | Rapid expansion method ("REM") for in vitro propagation of T lymphocytes |
| JP3926842B2 (ja) * | 1995-03-08 | 2007-06-06 | ザ・スクリプス・リサーチ・インステイチユート | 抗原提示系およびｔ−細胞の活性化方法 |
| JP2000184880A (ja) * | 1998-10-14 | 2000-07-04 | Kanegafuchi Chem Ind Co Ltd | ガン細胞特異的傷害性ｔ細胞の増殖・活性化誘導方法及びそれに用いるデバイス |
| US6294063B1 (en) | 1999-02-12 | 2001-09-25 | Board Of Regents, The University Of Texas System | Method and apparatus for programmable fluidic processing |
| US6942776B2 (en) | 1999-05-18 | 2005-09-13 | Silicon Biosystems S.R.L. | Method and apparatus for the manipulation of particles by means of dielectrophoresis |
| IL147302A0 (en) | 1999-06-28 | 2002-08-14 | California Inst Of Techn | Microfabricated elastomeric valve and pump systems |
| CA2406864A1 (en) * | 2000-02-24 | 2001-08-30 | Life Technologies Corporation | Simultaneous stimulation and concentration of cells |
| US20020044948A1 (en) * | 2000-03-15 | 2002-04-18 | Samir Khleif | Methods and compositions for co-stimulation of immunological responses to peptide antigens |
| US20150329617A1 (en) * | 2001-03-14 | 2015-11-19 | Dynal Biotech Asa | Novel MHC molecule constructs, and methods of employing these constructs for diagnosis and therapy, and uses of MHC molecules |
| US20030170238A1 (en) | 2002-03-07 | 2003-09-11 | Gruenberg Micheal L. | Re-activated T-cells for adoptive immunotherapy |
| US7312085B2 (en) * | 2002-04-01 | 2007-12-25 | Fluidigm Corporation | Microfluidic particle-analysis systems |
| US6958132B2 (en) | 2002-05-31 | 2005-10-25 | The Regents Of The University Of California | Systems and methods for optical actuation of microfluidics based on opto-electrowetting |
| EP1623017B1 (en) * | 2003-05-08 | 2010-09-15 | Life Technologies Corporation | Generation and isolation of antigen-specific t cells |
| US7612355B2 (en) | 2004-04-12 | 2009-11-03 | The Regents Of The University Of California | Optoelectronic tweezers for microparticle and cell manipulation |
| WO2006065495A2 (en) | 2004-11-24 | 2006-06-22 | Fred Hutchinson Cancer Research Center | Methods of using il-21 for adoptive immunotherapy and identification of tumor antigens |
| ES2368152T3 (es) * | 2005-07-01 | 2011-11-14 | Txcell S.A. | Obtención de células tr1 específicas de antígenos de los alimentos o de autoantígenos a partir de una población de leucocitos o pbmc. |
| CA2665568C (en) * | 2006-10-04 | 2018-01-09 | Janssen Pharmaceutica, N.V. | Preparation of inactivated artificial antigen presenting cells and their use in cell therapies |
| US8685344B2 (en) | 2007-01-22 | 2014-04-01 | Advanced Liquid Logic, Inc. | Surface assisted fluid loading and droplet dispensing |
| WO2008119066A1 (en) | 2007-03-28 | 2008-10-02 | The Regents Of The University Of California | Single-sided lateral-field and phototransistor-based optoelectronic tweezers |
| US20080241892A1 (en) * | 2007-03-29 | 2008-10-02 | Pacific Biosciences Of California, Inc. | Modified surfaces for immobilization of active molecules |
| US9809797B2 (en) | 2007-10-03 | 2017-11-07 | National Institutes Of Health (Nih) U.S. Dept. Of Health And Human Services (Dhhs) Division Of Extramural Inventions And Technology | Enhanced generation of cytotoxic T-lymphocytes by IL-21 mediated FOXP3 suppression |
| BR112012029066A2 (pt) | 2010-05-14 | 2020-09-01 | The General Hospital Corporation | composições e processos de identificação de neoantígenos específicos de tumor. |
| US9533306B2 (en) | 2010-08-02 | 2017-01-03 | The Regents Of The University Of California | Single sided continuous optoelectrowetting (SCEOW) device for droplet manipulation with light patterns |
| US9511151B2 (en) * | 2010-11-12 | 2016-12-06 | Uti Limited Partnership | Compositions and methods for the prevention and treatment of cancer |
| US9227200B2 (en) | 2011-06-03 | 2016-01-05 | The Regents Of The University Of California | Microfluidic devices with flexible optically transparent electrodes |
| CA2858115A1 (en) * | 2011-12-09 | 2013-06-13 | The Johns Hopkins University | Artificial antigen presenting cells having a defined and dynamic shape |
| US9857333B2 (en) | 2012-10-31 | 2018-01-02 | Berkeley Lights, Inc. | Pens for biological micro-objects |
| US9403172B2 (en) | 2012-11-08 | 2016-08-02 | Berkeley Lights, Inc. | Circuit based optoelectronic tweezers |
| AU2014245806B2 (en) | 2013-03-28 | 2019-10-31 | The University Of British Columbia | Microfluidic devices and methods for use thereof in multicellular assays of secretion |
| WO2015051247A1 (en) * | 2013-10-03 | 2015-04-09 | University Of Maryland, Baltimore | Nanoparticle based artificial antigen presenting cell mediated activation of nkt cells |
| US9889445B2 (en) | 2013-10-22 | 2018-02-13 | Berkeley Lights, Inc. | Micro-fluidic devices for assaying biological activity |
| EP3060645B1 (en) | 2013-10-22 | 2019-01-02 | Berkeley Lights, Inc. | Microfluidic devices having isolation pens and methods of testing biological micro-objects with same |
| RU2763795C2 (ru) * | 2014-04-23 | 2022-01-11 | Джуно Терапьютикс, Инк. | Способы выделения, культивирования и генетической инженерии популяций клеток иммунной системы для адоптивной терапии |
| CA2945177C (en) | 2014-04-25 | 2021-12-21 | Berkeley Lights, Inc. | Providing dep manipulation devices and controllable electrowetting devices in the same microfluidic apparatus |
| US20150306599A1 (en) | 2014-04-25 | 2015-10-29 | Berkeley Lights, Inc. | Providing DEP Manipulation Devices And Controllable Electrowetting Devices In The Same Microfluidic Apparatus |
| US20150306598A1 (en) | 2014-04-25 | 2015-10-29 | Berkeley Lights, Inc. | DEP Force Control And Electrowetting Control In Different Sections Of The Same Microfluidic Apparatus |
| SG11201705064XA (en) * | 2014-12-24 | 2017-07-28 | Neximmune Inc | Nanoparticle compositions and methods for immunotherapy |
| US10520251B2 (en) | 2015-01-15 | 2019-12-31 | Heraeus Noblelight America Llc | UV light curing systems, and methods of designing and operating the same |
| WO2016166568A1 (en) * | 2015-04-16 | 2016-10-20 | Juno Therapeutics Gmbh | Methods, kits and apparatus for expanding a population of cells |
| WO2017117521A1 (en) * | 2015-12-31 | 2017-07-06 | Berkeley Lights, Inc. | Tumor infilitrating cells engineered to express a pro-inflammatory polypeptide |
| WO2017124101A2 (en) | 2016-01-15 | 2017-07-20 | The Broad Institute Inc. | Semi-permeable arrays for analyzing biological systems and methods of using same |
| DK3430131T3 (da) * | 2016-03-17 | 2022-08-22 | Berkeley Lights Inc | Selektion og kloning af t-lymfocytter i en mikrofluidanordning |
| IL263274B2 (en) | 2016-05-26 | 2023-10-01 | Berkeley Lights Inc | Covalently adapted surfaces, kits and methods for their production and uses |
-
2018
- 2018-07-20 TW TW107125207A patent/TWI832820B/zh not_active IP Right Cessation
- 2018-07-20 SG SG11202000425QA patent/SG11202000425QA/en unknown
- 2018-07-20 EP EP18836214.9A patent/EP3655027B1/en active Active
- 2018-07-20 KR KR1020207005086A patent/KR20200030593A/ko not_active Ceased
- 2018-07-20 WO PCT/US2018/043146 patent/WO2019018801A1/en not_active Ceased
- 2018-07-20 AU AU2018304543A patent/AU2018304543A1/en not_active Abandoned
- 2018-07-20 CA CA3070289A patent/CA3070289A1/en active Pending
- 2018-07-20 CN CN201880058921.XA patent/CN111107871A/zh active Pending
- 2018-07-20 CN CN202410633579.9A patent/CN118846017A/zh active Pending
- 2018-07-20 EP EP25194457.5A patent/EP4620977A3/en active Pending
- 2018-07-20 JP JP2020502582A patent/JP2020528747A/ja active Pending
-
2020
- 2020-01-15 US US16/743,849 patent/US20200299351A1/en not_active Abandoned
- 2020-01-20 IL IL272151A patent/IL272151A/en unknown
-
2023
- 2023-10-23 JP JP2023181879A patent/JP2024020231A/ja not_active Withdrawn
-
2024
- 2024-07-26 US US18/785,725 patent/US20250051417A1/en active Pending