JP2020528747A5 - - Google Patents
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- Publication number
- JP2020528747A5 JP2020528747A5 JP2020502582A JP2020502582A JP2020528747A5 JP 2020528747 A5 JP2020528747 A5 JP 2020528747A5 JP 2020502582 A JP2020502582 A JP 2020502582A JP 2020502582 A JP2020502582 A JP 2020502582A JP 2020528747 A5 JP2020528747 A5 JP 2020528747A5
- Authority
- JP
- Japan
- Prior art keywords
- antigen
- activating
- presenting
- cells
- molecule
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 210000001744 T-lymphocyte Anatomy 0.000 claims 29
- 238000000034 method Methods 0.000 claims 24
- 239000003446 ligand Substances 0.000 claims 23
- 230000003213 activating effect Effects 0.000 claims 21
- 108091008874 T cell receptors Proteins 0.000 claims 19
- 102000016266 T-Cell Antigen Receptors Human genes 0.000 claims 19
- 230000027455 binding Effects 0.000 claims 15
- 239000000427 antigen Substances 0.000 claims 8
- 102000036639 antigens Human genes 0.000 claims 8
- 108091007433 antigens Proteins 0.000 claims 8
- 239000012634 fragment Substances 0.000 claims 8
- 239000011324 bead Substances 0.000 claims 7
- 108700018351 Major Histocompatibility Complex Proteins 0.000 claims 6
- 206010028980 Neoplasm Diseases 0.000 claims 5
- 230000020382 suppression by virus of host antigen processing and presentation of peptide antigen via MHC class I Effects 0.000 claims 5
- YBJHBAHKTGYVGT-ZKWXMUAHSA-N (+)-Biotin Chemical compound N1C(=O)N[C@@H]2[C@H](CCCCC(=O)O)SC[C@@H]21 YBJHBAHKTGYVGT-ZKWXMUAHSA-N 0.000 claims 4
- 102100028976 HLA class I histocompatibility antigen, B alpha chain Human genes 0.000 claims 4
- 108010088652 Histocompatibility Antigens Class I Proteins 0.000 claims 4
- 101000914514 Homo sapiens T-cell-specific surface glycoprotein CD28 Proteins 0.000 claims 4
- 102100027213 T-cell-specific surface glycoprotein CD28 Human genes 0.000 claims 4
- 230000004913 activation Effects 0.000 claims 4
- 230000000903 blocking effect Effects 0.000 claims 4
- 102100025237 T-cell surface antigen CD2 Human genes 0.000 claims 3
- 230000030741 antigen processing and presentation Effects 0.000 claims 3
- 238000012258 culturing Methods 0.000 claims 3
- 102000009465 Growth Factor Receptors Human genes 0.000 claims 2
- 108010009202 Growth Factor Receptors Proteins 0.000 claims 2
- 101000578784 Homo sapiens Melanoma antigen recognized by T-cells 1 Proteins 0.000 claims 2
- 101001094545 Homo sapiens Retrotransposon-like protein 1 Proteins 0.000 claims 2
- 101000837401 Homo sapiens T-cell leukemia/lymphoma protein 1A Proteins 0.000 claims 2
- 101000807990 Homo sapiens Variable charge X-linked protein 3 Proteins 0.000 claims 2
- 102100028389 Melanoma antigen recognized by T-cells 1 Human genes 0.000 claims 2
- 102100037258 Membrane-associated transporter protein Human genes 0.000 claims 2
- 239000002202 Polyethylene glycol Substances 0.000 claims 2
- 108091007563 SLC45A2 Proteins 0.000 claims 2
- 108010090804 Streptavidin Proteins 0.000 claims 2
- 102100028676 T-cell leukemia/lymphoma protein 1A Human genes 0.000 claims 2
- 102100038978 Variable charge X-linked protein 3 Human genes 0.000 claims 2
- 229960002685 biotin Drugs 0.000 claims 2
- 235000020958 biotin Nutrition 0.000 claims 2
- 239000011616 biotin Substances 0.000 claims 2
- 230000008878 coupling Effects 0.000 claims 2
- 238000010168 coupling process Methods 0.000 claims 2
- 238000005859 coupling reaction Methods 0.000 claims 2
- 229920001223 polyethylene glycol Polymers 0.000 claims 2
- 201000011510 cancer Diseases 0.000 claims 1
- 150000001735 carboxylic acids Chemical group 0.000 claims 1
- 210000004027 cell Anatomy 0.000 claims 1
- 239000000919 ceramic Substances 0.000 claims 1
- 239000003153 chemical reaction reagent Substances 0.000 claims 1
- 230000006690 co-activation Effects 0.000 claims 1
- 229940079593 drug Drugs 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 239000011521 glass Substances 0.000 claims 1
- 239000002184 metal Substances 0.000 claims 1
- 229910044991 metal oxide Inorganic materials 0.000 claims 1
- 150000004706 metal oxides Chemical class 0.000 claims 1
- 229920000642 polymer Polymers 0.000 claims 1
- 102000004169 proteins and genes Human genes 0.000 claims 1
- 108090000623 proteins and genes Proteins 0.000 claims 1
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2023181879A JP2024020231A (ja) | 2017-07-21 | 2023-10-23 | 抗原提示合成表面、共有結合官能化表面、活性化ｔ細胞及びそれらの使用 |
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201762535742P | 2017-07-21 | 2017-07-21 | |
| US62/535,742 | 2017-07-21 | ||
| US201862660779P | 2018-04-20 | 2018-04-20 | |
| US62/660,779 | 2018-04-20 | ||
| US201862664279P | 2018-04-30 | 2018-04-30 | |
| US62/664,279 | 2018-04-30 | ||
| PCT/US2018/043146 WO2019018801A1 (en) | 2017-07-21 | 2018-07-20 | SYNTHETIC SURFACES FOR PRESENTING ANTIGENS, COVALENTLY FUNCTIONALIZED SURFACES, ACTIVATED T CELLS AND USES THEREOF |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2023181879A Division JP2024020231A (ja) | 2017-07-21 | 2023-10-23 | 抗原提示合成表面、共有結合官能化表面、活性化ｔ細胞及びそれらの使用 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2020528747A JP2020528747A (ja) | 2020-10-01 |
| JP2020528747A5 true JP2020528747A5 (https=) | 2021-08-26 |
Family
ID=65015614
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020502582A Pending JP2020528747A (ja) | 2017-07-21 | 2018-07-20 | 抗原提示合成表面、共有結合官能化表面、活性化ｔ細胞及びそれらの使用 |
| JP2023181879A Withdrawn JP2024020231A (ja) | 2017-07-21 | 2023-10-23 | 抗原提示合成表面、共有結合官能化表面、活性化ｔ細胞及びそれらの使用 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2023181879A Withdrawn JP2024020231A (ja) | 2017-07-21 | 2023-10-23 | 抗原提示合成表面、共有結合官能化表面、活性化ｔ細胞及びそれらの使用 |
Country Status (11)
| Country | Link |
|---|---|
| US (2) | US20200299351A1 (https=) |
| EP (2) | EP3655027B1 (https=) |
| JP (2) | JP2020528747A (https=) |
| KR (1) | KR20200030593A (https=) |
| CN (2) | CN111107871A (https=) |
| AU (1) | AU2018304543A1 (https=) |
| CA (1) | CA3070289A1 (https=) |
| IL (1) | IL272151A (https=) |
| SG (1) | SG11202000425QA (https=) |
| TW (1) | TWI832820B (https=) |
| WO (1) | WO2019018801A1 (https=) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US10799865B2 (en) | 2015-10-27 | 2020-10-13 | Berkeley Lights, Inc. | Microfluidic apparatus having an optimized electrowetting surface and related systems and methods |
| CN115678773A (zh) | 2016-05-26 | 2023-02-03 | 伯克利之光生命科技公司 | 共价修饰的表面、试剂盒及制备方法和用途 |
| US11993766B2 (en) | 2018-09-21 | 2024-05-28 | Bruker Cellular Analysis, Inc. | Functionalized well plate, methods of preparation and use thereof |
| CN113366312A (zh) * | 2018-11-01 | 2021-09-07 | 伯克利之光生命科技公司 | 在微流体环境中测定生物细胞的方法 |
| WO2020168258A1 (en) | 2019-02-15 | 2020-08-20 | Berkeley Lights, Inc. | Laser-assisted repositioning of a micro-object and culturing of an attachment-dependent cell in a microfluidic environment |
| WO2020223555A1 (en) | 2019-04-30 | 2020-11-05 | Berkeley Lights, Inc. | Methods for encapsulating and assaying cells |
| CA3170695C (en) * | 2020-12-31 | 2023-10-17 | Ying-Chih Chang | Multilayered membrane for spheroid culture |
| US12275932B2 (en) * | 2021-04-28 | 2025-04-15 | A.U. Vista, Inc. | TFT-based cell isolation device and cell manipulation panel thereof |
| WO2023161961A1 (en) * | 2022-02-24 | 2023-08-31 | Lymphon Biologics Pvt. Ltd. | A system and method for t cell activation and immunomodulation |
| WO2025111584A1 (en) * | 2023-11-22 | 2025-05-30 | Georgia Tech Research Corporation | An electronic microfluidic platform for on-chip apoptosis quantification using annexin v-based ps externalization detection |
Family Cites Families (44)
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|---|---|---|---|---|
| US4690915A (en) | 1985-08-08 | 1987-09-01 | The United States Of America As Represented By The Department Of Health And Human Services | Adoptive immunotherapy as a treatment modality in humans |
| US5827642A (en) | 1994-08-31 | 1998-10-27 | Fred Hutchinson Cancer Research Center | Rapid expansion method ("REM") for in vitro propagation of T lymphocytes |
| CA2214649C (en) * | 1995-03-08 | 2007-06-12 | Zeling Cai | Antigen presenting system and methods for activation of t-cells |
| JP2000184880A (ja) * | 1998-10-14 | 2000-07-04 | Kanegafuchi Chem Ind Co Ltd | ガン細胞特異的傷害性ｔ細胞の増殖・活性化誘導方法及びそれに用いるデバイス |
| US6294063B1 (en) | 1999-02-12 | 2001-09-25 | Board Of Regents, The University Of Texas System | Method and apparatus for programmable fluidic processing |
| US6942776B2 (en) | 1999-05-18 | 2005-09-13 | Silicon Biosystems S.R.L. | Method and apparatus for the manipulation of particles by means of dielectrophoresis |
| US7601270B1 (en) | 1999-06-28 | 2009-10-13 | California Institute Of Technology | Microfabricated elastomeric valve and pump systems |
| KR20030032922A (ko) * | 2000-02-24 | 2003-04-26 | 싸이트 테라피스 인코포레이티드 | 세포의 동시 자극 및 농축 |
| US20020044948A1 (en) * | 2000-03-15 | 2002-04-18 | Samir Khleif | Methods and compositions for co-stimulation of immunological responses to peptide antigens |
| US20150329617A1 (en) * | 2001-03-14 | 2015-11-19 | Dynal Biotech Asa | Novel MHC molecule constructs, and methods of employing these constructs for diagnosis and therapy, and uses of MHC molecules |
| US20030170238A1 (en) | 2002-03-07 | 2003-09-11 | Gruenberg Micheal L. | Re-activated T-cells for adoptive immunotherapy |
| US7312085B2 (en) * | 2002-04-01 | 2007-12-25 | Fluidigm Corporation | Microfluidic particle-analysis systems |
| US6958132B2 (en) | 2002-05-31 | 2005-10-25 | The Regents Of The University Of California | Systems and methods for optical actuation of microfluidics based on opto-electrowetting |
| TW200502391A (en) * | 2003-05-08 | 2005-01-16 | Xcyte Therapies Inc | Generation and isolation of antigen-specific t cells |
| WO2005100541A2 (en) | 2004-04-12 | 2005-10-27 | The Regents Of The University Of California | Optoelectronic tweezers for microparticle and cell manipulation |
| EP1814580B1 (en) | 2004-11-24 | 2016-08-10 | Fred Hutchinson Cancer Research Center | Methods of using il-21 for adoptive immunotherapy and identification of tumor antigens |
| PT1739166E (pt) * | 2005-07-01 | 2011-09-22 | Inst Nat Sante Rech Med | Obtenção de células tr1 específicas para um auto-antigénio ou antigénio de alimentos a partir de uma população de pbmc ou de leucócito |
| JP5543207B2 (ja) * | 2006-10-04 | 2014-07-09 | ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ | 不活性化された人工抗原提示細胞の調製および細胞治療におけるそれらの使用 |
| WO2008091848A2 (en) | 2007-01-22 | 2008-07-31 | Advanced Liquid Logic, Inc. | Surface assisted fluid loading and droplet dispensing |
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| US10758487B2 (en) * | 2011-12-09 | 2020-09-01 | The Johns Hopkins University | Artificial antigen presenting cells having a defined and dynamic shape |
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| US11807675B2 (en) * | 2013-10-03 | 2023-11-07 | The University Of Maryland, Baltimore | Nanoparticle based artificial antigen presenting cell mediated activation of NKT cells |
| EP3760703A1 (en) | 2013-10-22 | 2021-01-06 | Berkeley Lights, Inc. | Microfluidic devices having isolation pens and methods of testing biological micro-objects with same |
| US9889445B2 (en) | 2013-10-22 | 2018-02-13 | Berkeley Lights, Inc. | Micro-fluidic devices for assaying biological activity |
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| US20150306599A1 (en) | 2014-04-25 | 2015-10-29 | Berkeley Lights, Inc. | Providing DEP Manipulation Devices And Controllable Electrowetting Devices In The Same Microfluidic Apparatus |
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| WO2016105542A2 (en) * | 2014-12-24 | 2016-06-30 | Neximmune, Inc | Nanoparticle compositions and methods for immunotherapy |
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| WO2016166568A1 (en) * | 2015-04-16 | 2016-10-20 | Juno Therapeutics Gmbh | Methods, kits and apparatus for expanding a population of cells |
| WO2017117521A1 (en) * | 2015-12-31 | 2017-07-06 | Berkeley Lights, Inc. | Tumor infilitrating cells engineered to express a pro-inflammatory polypeptide |
| US12071663B2 (en) | 2016-01-15 | 2024-08-27 | Massachusetts Institute Of Technology | Semi-permeable arrays for analyzing biological systems and methods of using same |
| CN109196094A (zh) * | 2016-03-17 | 2019-01-11 | 伯克利之光生命科技公司 | 微流体装置中t淋巴细胞的选择和克隆 |
| CN115678773A (zh) | 2016-05-26 | 2023-02-03 | 伯克利之光生命科技公司 | 共价修饰的表面、试剂盒及制备方法和用途 |
-
2018
- 2018-07-20 TW TW107125207A patent/TWI832820B/zh not_active IP Right Cessation
- 2018-07-20 SG SG11202000425QA patent/SG11202000425QA/en unknown
- 2018-07-20 CN CN201880058921.XA patent/CN111107871A/zh active Pending
- 2018-07-20 JP JP2020502582A patent/JP2020528747A/ja active Pending
- 2018-07-20 EP EP18836214.9A patent/EP3655027B1/en active Active
- 2018-07-20 EP EP25194457.5A patent/EP4620977A3/en active Pending
- 2018-07-20 WO PCT/US2018/043146 patent/WO2019018801A1/en not_active Ceased
- 2018-07-20 CA CA3070289A patent/CA3070289A1/en active Pending
- 2018-07-20 KR KR1020207005086A patent/KR20200030593A/ko not_active Ceased
- 2018-07-20 AU AU2018304543A patent/AU2018304543A1/en not_active Abandoned
- 2018-07-20 CN CN202410633579.9A patent/CN118846017A/zh active Pending
-
2020
- 2020-01-15 US US16/743,849 patent/US20200299351A1/en not_active Abandoned
- 2020-01-20 IL IL272151A patent/IL272151A/en unknown
-
2023
- 2023-10-23 JP JP2023181879A patent/JP2024020231A/ja not_active Withdrawn
-
2024
- 2024-07-26 US US18/785,725 patent/US20250051417A1/en active Pending
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