SG11202000425QA - Antigen-presenting synthetic surfaces, covalently functionalized surfaces, activated t cells, and uses thereof - Google Patents
Antigen-presenting synthetic surfaces, covalently functionalized surfaces, activated t cells, and uses thereofInfo
- Publication number
- SG11202000425QA SG11202000425QA SG11202000425QA SG11202000425QA SG11202000425QA SG 11202000425Q A SG11202000425Q A SG 11202000425QA SG 11202000425Q A SG11202000425Q A SG 11202000425QA SG 11202000425Q A SG11202000425Q A SG 11202000425QA SG 11202000425Q A SG11202000425Q A SG 11202000425QA
- Authority
- SG
- Singapore
- Prior art keywords
- antigen
- activated
- cells
- covalently functionalized
- presenting synthetic
- Prior art date
Links
- 210000001744 T-lymphocyte Anatomy 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70503—Immunoglobulin superfamily
- C07K14/7051—T-cell receptor (TcR)-CD3 complex
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
- C07K16/2806—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against CD2
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/46—Cellular immunotherapy
- A61K39/461—Cellular immunotherapy characterised by the cell type used
- A61K39/4611—T-cells, e.g. tumor infiltrating lymphocytes [TIL], lymphokine-activated killer cells [LAK] or regulatory T cells [Treg]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/46—Cellular immunotherapy
- A61K39/464—Cellular immunotherapy characterised by the antigen targeted or presented
- A61K39/4643—Vertebrate antigens
- A61K39/4644—Cancer antigens
- A61K39/46449—Melanoma antigens
- A61K39/464491—Melan-A/MART
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
- C07K14/4748—Tumour specific antigens; Tumour rejection antigen precursors [TRAP], e.g. MAGE
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70503—Immunoglobulin superfamily
- C07K14/70539—MHC-molecules, e.g. HLA-molecules
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
- C07K16/2818—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against CD28 or CD152
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
- G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
- G01N33/5044—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics involving specific cell types
- G01N33/5047—Cells of the immune system
- G01N33/505—Cells of the immune system involving T-cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/62—Medicinal preparations containing antigens or antibodies characterised by the link between antigen and carrier
- A61K2039/625—Medicinal preparations containing antigens or antibodies characterised by the link between antigen and carrier binding through the biotin-streptavidin system or similar
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/80—Vaccine for a specifically defined cancer
- A61K2039/876—Skin, melanoma
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
- B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
- B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
- B01L3/50273—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by the means or forces applied to move the fluids
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
- B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
- B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
- B01L3/502761—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip specially adapted for handling suspended solids or molecules independently from the bulk fluid flow, e.g. for trapping or sorting beads, for physically stretching molecules
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
- B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
- B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
- B01L3/502769—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by multiphase flow arrangements
- B01L3/502784—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by multiphase flow arrangements specially adapted for droplet or plug flow, e.g. digital microfluidics
- B01L3/502792—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by multiphase flow arrangements specially adapted for droplet or plug flow, e.g. digital microfluidics for moving individual droplets on a plate, e.g. by locally altering surface tension
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/74—Inducing cell proliferation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/75—Agonist effect on antigen
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Immunology (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Cell Biology (AREA)
- Toxicology (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Microbiology (AREA)
- Engineering & Computer Science (AREA)
- Hematology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Mycology (AREA)
- Epidemiology (AREA)
- Analytical Chemistry (AREA)
- Dispersion Chemistry (AREA)
- Biomedical Technology (AREA)
- Physics & Mathematics (AREA)
- Urology & Nephrology (AREA)
- Clinical Laboratory Science (AREA)
- Oncology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Fluid Mechanics (AREA)
- Food Science & Technology (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Biotechnology (AREA)
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201762535742P | 2017-07-21 | 2017-07-21 | |
US201862660779P | 2018-04-20 | 2018-04-20 | |
US201862664279P | 2018-04-30 | 2018-04-30 | |
PCT/US2018/043146 WO2019018801A1 (en) | 2017-07-21 | 2018-07-20 | Antigen-presenting synthetic surfaces, covalently functionalized surfaces, activated t cells, and uses thereof |
Publications (1)
Publication Number | Publication Date |
---|---|
SG11202000425QA true SG11202000425QA (en) | 2020-02-27 |
Family
ID=65015614
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SG11202000425QA SG11202000425QA (en) | 2017-07-21 | 2018-07-20 | Antigen-presenting synthetic surfaces, covalently functionalized surfaces, activated t cells, and uses thereof |
Country Status (11)
Country | Link |
---|---|
US (1) | US20200299351A1 (en) |
EP (1) | EP3655027A4 (en) |
JP (2) | JP2020528747A (en) |
KR (1) | KR20200030593A (en) |
CN (1) | CN111107871A (en) |
AU (1) | AU2018304543A1 (en) |
CA (1) | CA3070289A1 (en) |
IL (1) | IL272151A (en) |
SG (1) | SG11202000425QA (en) |
TW (1) | TWI832820B (en) |
WO (1) | WO2019018801A1 (en) |
Families Citing this family (7)
Publication number | Priority date | Publication date | Assignee | Title |
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US10799865B2 (en) | 2015-10-27 | 2020-10-13 | Berkeley Lights, Inc. | Microfluidic apparatus having an optimized electrowetting surface and related systems and methods |
SG11201809539RA (en) | 2016-05-26 | 2018-12-28 | Berkeley Lights Inc | Covalently modified surfaces, kits, and methods of preparation and use |
CA3112813A1 (en) * | 2018-09-21 | 2020-03-26 | Berkeley Lights, Inc. | Functionalized well plate, methods of preparation and use thereof |
WO2020092975A2 (en) * | 2018-11-01 | 2020-05-07 | Berkeley Lights, Inc. | Methods for assaying biological cells in a microfluidic device |
CN116174068A (en) | 2019-04-30 | 2023-05-30 | 伯克利之光生命科技公司 | Methods for encapsulating and assaying cells |
US20220348863A1 (en) * | 2021-04-28 | 2022-11-03 | A.U. Vista, Inc. | Tft-based cell isolation device and cell manipulation panel thereof |
WO2023161961A1 (en) * | 2022-02-24 | 2023-08-31 | Lymphon Biologics Pvt. Ltd. | A system and method for t cell activation and immunomodulation |
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US5827642A (en) | 1994-08-31 | 1998-10-27 | Fred Hutchinson Cancer Research Center | Rapid expansion method ("REM") for in vitro propagation of T lymphocytes |
ATE240119T1 (en) * | 1995-03-08 | 2003-05-15 | Scripps Research Inst | ANTIGEN PRESENTATION SYSTEM AND ACTIVATION OF T CELLS |
JP2000184880A (en) * | 1998-10-14 | 2000-07-04 | Kanegafuchi Chem Ind Co Ltd | Propagation and activating induction of cytotoxic t-cell specific to cancer cell and device therefor |
US6294063B1 (en) | 1999-02-12 | 2001-09-25 | Board Of Regents, The University Of Texas System | Method and apparatus for programmable fluidic processing |
US6942776B2 (en) | 1999-05-18 | 2005-09-13 | Silicon Biosystems S.R.L. | Method and apparatus for the manipulation of particles by means of dielectrophoresis |
ATE215673T1 (en) | 1999-06-28 | 2002-04-15 | California Inst Of Techn | ELASTOMERIC MICROPUMP AND MICROVALVE SYSTEMS |
AU4328801A (en) * | 2000-02-24 | 2001-09-03 | Xcyte Therapies Inc | Simultaneous stimulation and concentration of cells |
US20020044948A1 (en) * | 2000-03-15 | 2002-04-18 | Samir Khleif | Methods and compositions for co-stimulation of immunological responses to peptide antigens |
US20150329617A1 (en) * | 2001-03-14 | 2015-11-19 | Dynal Biotech Asa | Novel MHC molecule constructs, and methods of employing these constructs for diagnosis and therapy, and uses of MHC molecules |
US20030170238A1 (en) | 2002-03-07 | 2003-09-11 | Gruenberg Micheal L. | Re-activated T-cells for adoptive immunotherapy |
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US6958132B2 (en) | 2002-05-31 | 2005-10-25 | The Regents Of The University Of California | Systems and methods for optical actuation of microfluidics based on opto-electrowetting |
ATE481476T1 (en) * | 2003-05-08 | 2010-10-15 | Life Technologies Corp | GENERATION AND ISOLATION OF ANTIGEN-SPECIFIC T-CELLS |
WO2005100541A2 (en) | 2004-04-12 | 2005-10-27 | The Regents Of The University Of California | Optoelectronic tweezers for microparticle and cell manipulation |
EP1814580B1 (en) | 2004-11-24 | 2016-08-10 | Fred Hutchinson Cancer Research Center | Methods of using il-21 for adoptive immunotherapy and identification of tumor antigens |
ES2368152T3 (en) * | 2005-07-01 | 2011-11-14 | Txcell S.A. | OBTAINING TR1 CELLS SPECIFIC TO FOOD ANTIGENS OR SELF-ORIGINS FROM A POPULATION OF LEUKOCYTES OR PBMC. |
US8124408B2 (en) * | 2006-10-04 | 2012-02-28 | Janssen Pharmaceutica N.V. | Preparation of inactivated artificial antigen presenting cells and their use in cell therapies |
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WO2008121375A2 (en) * | 2007-03-29 | 2008-10-09 | Pacific Biosciences Of California, Inc. | Modified surfaces for immobilization of active molecules |
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CN103180730B (en) | 2010-05-14 | 2016-03-02 | 综合医院公司 | The composition of qualification tumour-specific neoantigen and method |
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US10758487B2 (en) * | 2011-12-09 | 2020-09-01 | The Johns Hopkins University | Artificial antigen presenting cells having a defined and dynamic shape |
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AU2014245806B2 (en) | 2013-03-28 | 2019-10-31 | The University Of British Columbia | Microfluidic devices and methods for use thereof in multicellular assays of secretion |
EP3052085B1 (en) * | 2013-10-03 | 2019-07-03 | University of Maryland, Baltimore | Nanoparticle based artificial antigen presenting cell mediated activation of nkt cells |
IL283153B2 (en) | 2013-10-22 | 2023-04-01 | Berkeley Lights Inc | Microfluidic devices having isolation pens and methods of testing biological micro-objects with same |
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EP3922716A1 (en) * | 2016-03-17 | 2021-12-15 | Berkeley Lights, Inc. | Selection and cloning of t lymphocytes in a microfluidic device |
SG11201809539RA (en) | 2016-05-26 | 2018-12-28 | Berkeley Lights Inc | Covalently modified surfaces, kits, and methods of preparation and use |
-
2018
- 2018-07-20 AU AU2018304543A patent/AU2018304543A1/en active Pending
- 2018-07-20 KR KR1020207005086A patent/KR20200030593A/en not_active Application Discontinuation
- 2018-07-20 CA CA3070289A patent/CA3070289A1/en active Pending
- 2018-07-20 EP EP18836214.9A patent/EP3655027A4/en active Pending
- 2018-07-20 TW TW107125207A patent/TWI832820B/en active
- 2018-07-20 CN CN201880058921.XA patent/CN111107871A/en active Pending
- 2018-07-20 SG SG11202000425QA patent/SG11202000425QA/en unknown
- 2018-07-20 JP JP2020502582A patent/JP2020528747A/en active Pending
- 2018-07-20 WO PCT/US2018/043146 patent/WO2019018801A1/en unknown
-
2020
- 2020-01-15 US US16/743,849 patent/US20200299351A1/en active Pending
- 2020-01-20 IL IL272151A patent/IL272151A/en unknown
-
2023
- 2023-10-23 JP JP2023181879A patent/JP2024020231A/en active Pending
Also Published As
Publication number | Publication date |
---|---|
TWI832820B (en) | 2024-02-21 |
TW201908336A (en) | 2019-03-01 |
US20200299351A1 (en) | 2020-09-24 |
CN111107871A (en) | 2020-05-05 |
JP2020528747A (en) | 2020-10-01 |
WO2019018801A1 (en) | 2019-01-24 |
EP3655027A4 (en) | 2021-04-21 |
WO2019018801A8 (en) | 2020-09-10 |
EP3655027A1 (en) | 2020-05-27 |
CA3070289A1 (en) | 2019-01-24 |
KR20200030593A (en) | 2020-03-20 |
JP2024020231A (en) | 2024-02-14 |
AU2018304543A1 (en) | 2020-02-13 |
IL272151A (en) | 2020-03-31 |
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