JP2020191868A5 - - Google Patents
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- JP2020191868A5 JP2020191868A5 JP2020102992A JP2020102992A JP2020191868A5 JP 2020191868 A5 JP2020191868 A5 JP 2020191868A5 JP 2020102992 A JP2020102992 A JP 2020102992A JP 2020102992 A JP2020102992 A JP 2020102992A JP 2020191868 A5 JP2020191868 A5 JP 2020191868A5
- Authority
- JP
- Japan
- Prior art keywords
- peptide
- cells
- antigen
- expression vector
- host cell
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 108090000765 processed proteins & peptides Proteins 0.000 claims 20
- 108091008874 T cell receptors Proteins 0.000 claims 8
- 102000016266 T-Cell Antigen Receptors Human genes 0.000 claims 8
- 210000004027 cell Anatomy 0.000 claims 8
- 210000001744 T-lymphocyte Anatomy 0.000 claims 6
- 239000013604 expression vector Substances 0.000 claims 6
- 108700018351 Major Histocompatibility Complex Proteins 0.000 claims 4
- 239000000427 antigen Substances 0.000 claims 4
- 108091007433 antigens Proteins 0.000 claims 4
- 102000036639 antigens Human genes 0.000 claims 4
- 239000003795 chemical substances by application Substances 0.000 claims 4
- 102000039446 nucleic acids Human genes 0.000 claims 4
- 108020004707 nucleic acids Proteins 0.000 claims 4
- 150000007523 nucleic acids Chemical class 0.000 claims 4
- 239000008194 pharmaceutical composition Substances 0.000 claims 4
- 230000020382 suppression by virus of host antigen processing and presentation of peptide antigen via MHC class I Effects 0.000 claims 4
- 206010028980 Neoplasm Diseases 0.000 claims 3
- 125000003275 alpha amino acid group Chemical group 0.000 claims 2
- 210000000612 antigen-presenting cell Anatomy 0.000 claims 2
- 201000011510 cancer Diseases 0.000 claims 2
- 238000000338 in vitro Methods 0.000 claims 2
- 239000003446 ligand Substances 0.000 claims 2
- 239000012931 lyophilized formulation Substances 0.000 claims 2
- 238000004519 manufacturing process Methods 0.000 claims 2
- 239000012528 membrane Substances 0.000 claims 2
- 102100035683 Axin-2 Human genes 0.000 claims 1
- 208000003174 Brain Neoplasms Diseases 0.000 claims 1
- 206010009944 Colon cancer Diseases 0.000 claims 1
- 102000006354 HLA-DR Antigens Human genes 0.000 claims 1
- 108010058597 HLA-DR Antigens Proteins 0.000 claims 1
- 102000008949 Histocompatibility Antigens Class I Human genes 0.000 claims 1
- 108010088652 Histocompatibility Antigens Class I Proteins 0.000 claims 1
- 101000874569 Homo sapiens Axin-2 Proteins 0.000 claims 1
- 208000008839 Kidney Neoplasms Diseases 0.000 claims 1
- 125000001429 N-terminal alpha-amino-acid group Chemical group 0.000 claims 1
- 206010061902 Pancreatic neoplasm Diseases 0.000 claims 1
- 208000015634 Rectal Neoplasms Diseases 0.000 claims 1
- 206010038389 Renal cancer Diseases 0.000 claims 1
- 230000004913 activation Effects 0.000 claims 1
- 239000004480 active ingredient Substances 0.000 claims 1
- 210000001072 colon Anatomy 0.000 claims 1
- 208000029742 colonic neoplasm Diseases 0.000 claims 1
- 238000012258 culturing Methods 0.000 claims 1
- 239000003085 diluting agent Substances 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 108020001507 fusion proteins Proteins 0.000 claims 1
- 102000037865 fusion proteins Human genes 0.000 claims 1
- 206010073071 hepatocellular carcinoma Diseases 0.000 claims 1
- 108010028930 invariant chain Proteins 0.000 claims 1
- 201000010982 kidney cancer Diseases 0.000 claims 1
- 208000032839 leukemia Diseases 0.000 claims 1
- 208000015486 malignant pancreatic neoplasm Diseases 0.000 claims 1
- 238000000034 method Methods 0.000 claims 1
- 230000003278 mimic effect Effects 0.000 claims 1
- 230000002018 overexpression Effects 0.000 claims 1
- 201000002528 pancreatic cancer Diseases 0.000 claims 1
- 208000008443 pancreatic carcinoma Diseases 0.000 claims 1
- 229920001184 polypeptide Polymers 0.000 claims 1
- 102000004196 processed proteins & peptides Human genes 0.000 claims 1
- 206010038038 rectal cancer Diseases 0.000 claims 1
- 201000001275 rectum cancer Diseases 0.000 claims 1
- 150000003839 salts Chemical class 0.000 claims 1
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201462096165P | 2014-12-23 | 2014-12-23 | |
| US62/096,165 | 2014-12-23 | ||
| GB201423016 | 2014-12-23 | ||
| GB1423016.3 | 2014-12-23 | ||
| GBGB1501017.6A GB201501017D0 (en) | 2014-12-23 | 2015-01-21 | Novel peptides and combination of peptides for use in immunotherapy against hepatocellular carcinoma (HCC) and other cancers |
| GB1501017.6 | 2015-01-21 | ||
| JP2017518096A JP6906156B2 (ja) | 2014-12-23 | 2015-12-16 | 肝細胞がん（ｈｃｃ）およびその他のがんに対する免疫療法で使用するための新規ペプチドおよびペプチド組み合わせ |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017518096A Division JP6906156B2 (ja) | 2014-12-23 | 2015-12-16 | 肝細胞がん（ｈｃｃ）およびその他のがんに対する免疫療法で使用するための新規ペプチドおよびペプチド組み合わせ |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2020191868A JP2020191868A (ja) | 2020-12-03 |
| JP2020191868A5 true JP2020191868A5 (https=) | 2021-07-26 |
| JP7346361B2 JP7346361B2 (ja) | 2023-09-19 |
Family
ID=66846825
Family Applications (9)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020102005A Active JP7358299B2 (ja) | 2014-12-23 | 2020-06-12 | 肝細胞がん（ｈｃｃ）およびその他のがんに対する免疫療法で使用するための新規ペプチドおよびペプチド組み合わせ |
| JP2020102004A Expired - Fee Related JP7109801B2 (ja) | 2014-12-23 | 2020-06-12 | 肝細胞がん（ｈｃｃ）およびその他のがんに対する免疫療法で使用するための新規ペプチドおよびペプチド組み合わせ |
| JP2020102006A Pending JP2020191866A (ja) | 2014-12-23 | 2020-06-12 | 肝細胞がん（ｈｃｃ）およびその他のがんに対する免疫療法で使用するための新規ペプチドおよびペプチド組み合わせ |
| JP2020102993A Active JP7448423B2 (ja) | 2014-12-23 | 2020-06-15 | 肝細胞がん（ｈｃｃ）およびその他のがんに対する免疫療法で使用するための新規ペプチドおよびペプチド組み合わせ |
| JP2020102991A Ceased JP2020191867A (ja) | 2014-12-23 | 2020-06-15 | 肝細胞がん（ｈｃｃ）およびその他のがんに対する免疫療法で使用するための新規ペプチドおよびペプチド組み合わせ |
| JP2020102992A Active JP7346361B2 (ja) | 2014-12-23 | 2020-06-15 | 肝細胞がん（ｈｃｃ）およびその他のがんに対する免疫療法で使用するための新規ペプチドおよびペプチド組み合わせ |
| JP2020106475A Expired - Fee Related JP7026411B2 (ja) | 2014-12-23 | 2020-06-19 | 肝細胞がん（ｈｃｃ）およびその他のがんに対する免疫療法で使用するための新規ペプチドおよびペプチド組み合わせ |
| JP2023078113A Pending JP2023100927A (ja) | 2014-12-23 | 2023-05-10 | 肝細胞がん（ｈｃｃ）およびその他のがんに対する免疫療法で使用するための新規ペプチドおよびペプチド組み合わせ |
| JP2025098413A Pending JP2025134788A (ja) | 2014-12-23 | 2025-06-12 | 肝細胞がん（ｈｃｃ）およびその他のがんに対する免疫療法で使用するための新規ペプチドおよびペプチド組み合わせ |
Family Applications Before (5)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020102005A Active JP7358299B2 (ja) | 2014-12-23 | 2020-06-12 | 肝細胞がん（ｈｃｃ）およびその他のがんに対する免疫療法で使用するための新規ペプチドおよびペプチド組み合わせ |
| JP2020102004A Expired - Fee Related JP7109801B2 (ja) | 2014-12-23 | 2020-06-12 | 肝細胞がん（ｈｃｃ）およびその他のがんに対する免疫療法で使用するための新規ペプチドおよびペプチド組み合わせ |
| JP2020102006A Pending JP2020191866A (ja) | 2014-12-23 | 2020-06-12 | 肝細胞がん（ｈｃｃ）およびその他のがんに対する免疫療法で使用するための新規ペプチドおよびペプチド組み合わせ |
| JP2020102993A Active JP7448423B2 (ja) | 2014-12-23 | 2020-06-15 | 肝細胞がん（ｈｃｃ）およびその他のがんに対する免疫療法で使用するための新規ペプチドおよびペプチド組み合わせ |
| JP2020102991A Ceased JP2020191867A (ja) | 2014-12-23 | 2020-06-15 | 肝細胞がん（ｈｃｃ）およびその他のがんに対する免疫療法で使用するための新規ペプチドおよびペプチド組み合わせ |
Family Applications After (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020106475A Expired - Fee Related JP7026411B2 (ja) | 2014-12-23 | 2020-06-19 | 肝細胞がん（ｈｃｃ）およびその他のがんに対する免疫療法で使用するための新規ペプチドおよびペプチド組み合わせ |
| JP2023078113A Pending JP2023100927A (ja) | 2014-12-23 | 2023-05-10 | 肝細胞がん（ｈｃｃ）およびその他のがんに対する免疫療法で使用するための新規ペプチドおよびペプチド組み合わせ |
| JP2025098413A Pending JP2025134788A (ja) | 2014-12-23 | 2025-06-12 | 肝細胞がん（ｈｃｃ）およびその他のがんに対する免疫療法で使用するための新規ペプチドおよびペプチド組み合わせ |
Country Status (29)
| Country | Link |
|---|---|
| US (11) | US12076380B2 (https=) |
| EP (1) | EP4461371A3 (https=) |
| JP (9) | JP7358299B2 (https=) |
| KR (4) | KR102643923B1 (https=) |
| AU (1) | AU2022268329A1 (https=) |
| CL (1) | CL2021001479A1 (https=) |
| CO (1) | CO2017003772A2 (https=) |
| CR (1) | CR20210289A (https=) |
| CY (5) | CY1122491T1 (https=) |
| DK (1) | DK3236985T4 (https=) |
| ES (5) | ES2887107T3 (https=) |
| FI (1) | FI3236985T4 (https=) |
| HR (5) | HRP20211580T1 (https=) |
| HU (5) | HUE056087T2 (https=) |
| IL (1) | IL281752A (https=) |
| LT (5) | LT3616706T (https=) |
| MA (6) | MA49156A (https=) |
| MD (5) | MD3545965T2 (https=) |
| MX (6) | MX2020004757A (https=) |
| MY (2) | MY199068A (https=) |
| PE (1) | PE20211740A1 (https=) |
| PL (4) | PL3545965T3 (https=) |
| PT (5) | PT3626731T (https=) |
| RS (1) | RS62575B1 (https=) |
| SG (2) | SG10202101444UA (https=) |
| SI (2) | SI3626731T1 (https=) |
| TW (3) | TWI794679B (https=) |
| UA (1) | UA124331C2 (https=) |
| ZA (1) | ZA201701762B (https=) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR102643923B1 (ko) * | 2014-12-23 | 2024-03-05 | 이매틱스 바이오테크놀로지스 게엠베하 | 간세포 암종(hcc) 및 기타 암들에 대한 면역요법에서의 사용을 위한 신규 펩티드 및 펩티드의 조합 |
| CN114720691B (zh) * | 2022-05-10 | 2022-12-09 | 深圳粒影生物科技有限公司 | 一种检测生物标志物的试剂盒及其制备方法和应用 |
| CN119391711A (zh) * | 2024-10-17 | 2025-02-07 | 合肥综合性国家科学中心大健康研究院 | 小蛋白UFD1s及其在预防、治疗和诊断非酒精性脂肪性肝炎中的应用 |
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