MA48487B1 - Nouveaux peptides et combinaison de peptides à utiliser dans l'immunothérapie contre le carcinome hépatocellulaire (hcc) et d'autres cancers - Google Patents
Nouveaux peptides et combinaison de peptides à utiliser dans l'immunothérapie contre le carcinome hépatocellulaire (hcc) et d'autres cancersInfo
- Publication number
- MA48487B1 MA48487B1 MA48487A MA48487A MA48487B1 MA 48487 B1 MA48487 B1 MA 48487B1 MA 48487 A MA48487 A MA 48487A MA 48487 A MA48487 A MA 48487A MA 48487 B1 MA48487 B1 MA 48487B1
- Authority
- MA
- Morocco
- Prior art keywords
- cells
- peptides
- present
- relates
- molecules
- Prior art date
Links
- 108090000765 processed proteins & peptides Proteins 0.000 title abstract 8
- 102000004196 processed proteins & peptides Human genes 0.000 title abstract 5
- 206010028980 Neoplasm Diseases 0.000 title abstract 3
- 206010073071 hepatocellular carcinoma Diseases 0.000 title 1
- 231100000844 hepatocellular carcinoma Toxicity 0.000 title 1
- 238000009169 immunotherapy Methods 0.000 title 1
- 210000001744 T-lymphocyte Anatomy 0.000 abstract 2
- 230000005975 antitumor immune response Effects 0.000 abstract 2
- 210000004027 cell Anatomy 0.000 abstract 2
- 239000000203 mixture Substances 0.000 abstract 2
- 210000004881 tumor cell Anatomy 0.000 abstract 2
- 229960005486 vaccine Drugs 0.000 abstract 2
- 108700018351 Major Histocompatibility Complex Proteins 0.000 abstract 1
- 108091008874 T cell receptors Proteins 0.000 abstract 1
- 102000016266 T-Cell Antigen Receptors Human genes 0.000 abstract 1
- 239000008186 active pharmaceutical agent Substances 0.000 abstract 1
- 238000002619 cancer immunotherapy Methods 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 230000001024 immunotherapeutic effect Effects 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 102000039446 nucleic acids Human genes 0.000 abstract 1
- 108020004707 nucleic acids Proteins 0.000 abstract 1
- 150000007523 nucleic acids Chemical class 0.000 abstract 1
- 239000000825 pharmaceutical preparation Substances 0.000 abstract 1
- 229940127557 pharmaceutical product Drugs 0.000 abstract 1
- 108090000623 proteins and genes Proteins 0.000 abstract 1
- 102000004169 proteins and genes Human genes 0.000 abstract 1
- 230000020382 suppression by virus of host antigen processing and presentation of peptide antigen via MHC class I Effects 0.000 abstract 1
Classifications
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- Analytical Chemistry (AREA)
Abstract
La présente invention concerne des peptides, des protéines, des acides nucléiques et des cellules à utiliser dans des méthodes immunothérapeutiques. En particulier, la présente invention concerne l'immunothérapie du cancer. La présente invention concerne en outre des épitopes peptidiques des cellules t associés aux tumeurs, seuls ou en combinaison avec d'autres peptides associés aux tumeurs qui peuvent par exemple servir d'ingrédients pharmaceutiques actifs de compositions vaccinales qui stimulent les réponses immunitaires anti-tumorales, ou pour stimuler les cellules t. Ex vivo et transfert aux patients. Les peptides liés aux molécules du complexe majeur d'histocompatibilité (cmh), ou les peptides en tant que tels, peuvent également être des cibles d'anticorps, de récepteurs de cellules t solubles et d'autres molécules de liaison. En particulier, la présente invention concerne plusieurs nouvelles séquences peptidiques et leurs variantes dérivées de molécules hla de classe i et de classe ii de cellules tumorales humaines qui peuvent être utilisées dans des compositions vaccinales pour déclencher des réponses immunitaires antitumorales ou comme cibles pour le développement de produits pharmaceutiques. / composés et cellules immunologiquement actifs.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
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US201462096165P | 2014-12-23 | 2014-12-23 | |
GB201423016 | 2014-12-23 | ||
GBGB1501017.6A GB201501017D0 (en) | 2014-12-23 | 2015-01-21 | Novel peptides and combination of peptides for use in immunotherapy against hepatocellular carcinoma (HCC) and other cancers |
Publications (2)
Publication Number | Publication Date |
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MA48487A MA48487A (fr) | 2020-03-04 |
MA48487B1 true MA48487B1 (fr) | 2021-11-30 |
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Application Number | Title | Priority Date | Filing Date |
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MA48487A MA48487B1 (fr) | 2014-12-23 | 2015-12-16 | Nouveaux peptides et combinaison de peptides à utiliser dans l'immunothérapie contre le carcinome hépatocellulaire (hcc) et d'autres cancers |
MA049157A MA49157A (fr) | 2014-12-23 | 2015-12-16 | Nouveaux peptides et combinaison de peptides à utiliser dans l'immunothérapie contre le carcinome hépatocellulaire (hcc) et d'autres cancers |
MA49155A MA49155B1 (fr) | 2014-12-23 | 2015-12-16 | Nouveaux peptides et combinaison de peptides à utiliser dans l'immunothérapie contre le carcinome hépatocellulaire (hcc) et d'autres cancers |
MA049156A MA49156A (fr) | 2014-12-23 | 2015-12-16 | Nouveaux peptides et combinaison de peptides à utiliser dans l'immunothérapie contre le carcinome hépatocellulaire (hcc) et d'autres cancers |
MA46913A MA46913B1 (fr) | 2014-12-23 | 2015-12-16 | Nouveaux peptides et combinaison de peptides à utiliser dans l'immunothérapie contre le carcinome hépatocellulaire (hcc) et d'autres cancers |
MA050819A MA50819A (fr) | 2014-12-23 | 2015-12-16 | Nouveaux peptides et combinaison de peptides à utiliser dans l'immunothérapie contre le carcinome hépatocellulaire (hcc) et d'autres cancers |
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Application Number | Title | Priority Date | Filing Date |
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MA049157A MA49157A (fr) | 2014-12-23 | 2015-12-16 | Nouveaux peptides et combinaison de peptides à utiliser dans l'immunothérapie contre le carcinome hépatocellulaire (hcc) et d'autres cancers |
MA49155A MA49155B1 (fr) | 2014-12-23 | 2015-12-16 | Nouveaux peptides et combinaison de peptides à utiliser dans l'immunothérapie contre le carcinome hépatocellulaire (hcc) et d'autres cancers |
MA049156A MA49156A (fr) | 2014-12-23 | 2015-12-16 | Nouveaux peptides et combinaison de peptides à utiliser dans l'immunothérapie contre le carcinome hépatocellulaire (hcc) et d'autres cancers |
MA46913A MA46913B1 (fr) | 2014-12-23 | 2015-12-16 | Nouveaux peptides et combinaison de peptides à utiliser dans l'immunothérapie contre le carcinome hépatocellulaire (hcc) et d'autres cancers |
MA050819A MA50819A (fr) | 2014-12-23 | 2015-12-16 | Nouveaux peptides et combinaison de peptides à utiliser dans l'immunothérapie contre le carcinome hépatocellulaire (hcc) et d'autres cancers |
Country Status (28)
Country | Link |
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US (10) | US20220016227A1 (fr) |
JP (8) | JP2020191866A (fr) |
KR (4) | KR20240033128A (fr) |
AU (1) | AU2022268329A1 (fr) |
CL (1) | CL2021001479A1 (fr) |
CO (1) | CO2017003772A2 (fr) |
CR (1) | CR20210289A (fr) |
CY (5) | CY1122491T1 (fr) |
DK (1) | DK3236985T4 (fr) |
ES (5) | ES2887107T3 (fr) |
FI (1) | FI3236985T4 (fr) |
HR (5) | HRP20211580T1 (fr) |
HU (5) | HUE056087T2 (fr) |
IL (1) | IL281752A (fr) |
LT (5) | LT3236985T (fr) |
MA (6) | MA48487B1 (fr) |
MD (5) | MD3626731T2 (fr) |
MX (6) | MX2020011794A (fr) |
MY (1) | MY178137A (fr) |
PE (1) | PE20211740A1 (fr) |
PL (4) | PL3545965T3 (fr) |
PT (5) | PT3545965T (fr) |
RS (1) | RS62575B1 (fr) |
SG (2) | SG10202101444UA (fr) |
SI (2) | SI3616706T1 (fr) |
TW (3) | TWI754892B (fr) |
UA (1) | UA124331C2 (fr) |
ZA (1) | ZA201701762B (fr) |
Families Citing this family (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
MD3626731T2 (ro) * | 2014-12-23 | 2022-01-31 | Immatics Biotechnologies Gmbh | Noi peptide și combinație de peptide pentru utilizare în imunoterapie împotriva carcinomului hepatocelular (HCC) și a altor cancere |
CN114720691B (zh) * | 2022-05-10 | 2022-12-09 | 深圳粒影生物科技有限公司 | 一种检测生物标志物的试剂盒及其制备方法和应用 |
Family Cites Families (62)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20020177551A1 (en) * | 2000-05-31 | 2002-11-28 | Terman David S. | Compositions and methods for treatment of neoplastic disease |
US20020061552A1 (en) | 1999-12-17 | 2002-05-23 | Dong Yan | Mammalian dishevelled-associated proteins |
AU2001232204A1 (en) | 2000-02-22 | 2001-09-03 | Ahuva Nissim | Chimeric and tcr phage display libraries, chimeric and tcr reagents and methods of use thereof |
AU2001276018A1 (en) | 2000-07-20 | 2002-02-05 | Regents Of The University Of Minnesota | Radiolabeled immunotoxins |
US7919467B2 (en) * | 2000-12-04 | 2011-04-05 | Immunotope, Inc. | Cytotoxic T-lymphocyte-inducing immunogens for prevention, treatment, and diagnosis of cancer |
US20050053918A1 (en) * | 2001-05-16 | 2005-03-10 | Technion Research & Development Foundation Ltd. | Method of identifying peptides capable of binding to MHC molecules, peptides identified thereby and their uses |
US6867283B2 (en) | 2001-05-16 | 2005-03-15 | Technion Research & Development Foundation Ltd. | Peptides capable of binding to MHC molecules, cells presenting such peptides, and pharmaceutical compositions comprising such peptides and/or cells |
US20070134261A1 (en) * | 2001-12-03 | 2007-06-14 | Hancock Robert E | Effectors of innate immunity |
US7311914B2 (en) | 2002-08-13 | 2007-12-25 | Ludwig Institute For Cancer Research | MAGE-A4 antigenic peptides and uses thereof |
US20040091503A1 (en) * | 2002-08-20 | 2004-05-13 | Genitrix, Llc | Lectin compositions and methods for modulating an immune response to an antigen |
TW200413406A (en) * | 2002-08-26 | 2004-08-01 | Kirin Brewery | Peptides and drugs containing the same |
NZ570811A (en) | 2002-11-09 | 2009-11-27 | Immunocore Ltd | T cell receptor display |
US20040096982A1 (en) | 2002-11-19 | 2004-05-20 | International Business Machines Corporation | Methods and apparatus for analysis of mass spectra |
DK1581812T3 (da) | 2003-01-06 | 2008-10-20 | Wyeth Corp | Sammensætninger og fremgangsmåde til diagnosticering og behandling af coloncancere |
US20090233318A1 (en) | 2004-12-28 | 2009-09-17 | Weidanz Jon A | Methods of assaying vaccine potency |
US20090075304A1 (en) | 2004-05-27 | 2009-03-19 | Weidanz Jon A | Methods of assaying vaccine potency |
US20090304679A1 (en) | 2004-05-27 | 2009-12-10 | Weidanz Jon A | Antibodies as T cell receptor mimics, methods of production and uses thereof |
SI1806358T1 (sl) | 2005-09-05 | 2010-06-30 | Immatics Biotechnologies Gmbh | S tumorjem povezani peptidi ki se promiskuitetnovežejo na molekule humanega levkocitnega antigena HLA razreda II |
SI1760089T1 (sl) | 2005-09-05 | 2009-12-31 | Immatics Biotechnologies Gmbh | S tumorjem povezani peptidi, ki se veĹľejo na molekule humanega levkocitnega antigena (HLA) razreda I ali II in ustrezno cepivo proti raku |
AU2007284651B2 (en) | 2006-08-09 | 2014-03-20 | Institute For Systems Biology | Organ-specific proteins and methods of their use |
WO2008156655A2 (fr) * | 2007-06-15 | 2008-12-24 | Genelux Corporation | Microorganismes pour une imagerie et/ou un traitement de tumeurs |
WO2009026547A1 (fr) | 2007-08-22 | 2009-02-26 | Receptor Logi, Ltd. | Procédés d'analyse de l'activité de vaccin |
PT2201100E (pt) | 2007-09-14 | 2016-06-03 | Univ Brussel Vrije | Aperfeiçoamento da capacidade estimulatória de células t das células que apresentam antígeno humano e o seu uso na vacinação |
WO2009108372A2 (fr) | 2008-02-27 | 2009-09-03 | Receptor Logic, Inc. | Anticorps imitant les récepteurs des lymphocytes t, leurs procédés de production et d’utilisation |
WO2009151487A1 (fr) | 2008-06-13 | 2009-12-17 | Receptor Logic, Inc. | Procédés de dosage de la puissance d’un vaccin |
DE102008049136B4 (de) | 2008-09-26 | 2012-10-25 | Leibniz-Institut für Naturstoff-Forschung und Infektionsbiologie e.V. | Neue Regulatoren des angeborenen Immunsystems |
ES2536465T3 (es) * | 2008-10-01 | 2015-05-25 | Immatics Biotechnologies Gmbh | Composición de péptidos tumor-asociados y relacionados con la vacuna contra el cáncer para el tratamiento de glioblastoma (GBM) y otros cánceres |
WO2010059742A1 (fr) * | 2008-11-18 | 2010-05-27 | Collabrx, Inc. | Traitement du cancer individualisé |
EP2499488A1 (fr) | 2009-11-14 | 2012-09-19 | Kuang-Yuh Chyu | Procédés et systèmes d'immunomodulation pour le traitement et/ou la prévention de l'athérosclérose |
US8506964B2 (en) | 2010-02-05 | 2013-08-13 | Cardiovax, Llc | Fusion proteins and related compositions, methods and systems for treatment and/or prevention of atherosclerosis |
JP2013544243A (ja) | 2010-11-12 | 2013-12-12 | シーダース シナイ メディカル センター | 動脈瘤の治療及び/又は予防のための免疫調節方法及びシステム |
WO2012065135A2 (fr) * | 2010-11-12 | 2012-05-18 | Cedars-Sinai Medical Center | Compositions immunomodulatrices, méthodes et systèmes comportant des fragments immunogènes de apob100 |
CN103608035A (zh) | 2010-11-12 | 2014-02-26 | 赛达斯西奈医疗中心 | 用于治疗和/或预防高血压的免疫调节方法和系统 |
CN114262690A (zh) * | 2011-04-15 | 2022-04-01 | 吉恩勒克斯公司 | 减毒的痘苗病毒的克隆毒株及其使用方法 |
US9221876B2 (en) * | 2011-11-11 | 2015-12-29 | Cardiovax, Llc | Methods for treating kidney disease with fragments of ApoB-100 |
GB201208293D0 (en) | 2012-05-11 | 2012-06-20 | Circassia Ltd | Hydrochlorice salt of peptide |
WO2014039675A2 (fr) | 2012-09-05 | 2014-03-13 | University Of Virginia Patent Foundation | Peptides cibles pour la thérapie et les diagnostics du cancer colorectal |
GB201301632D0 (en) | 2013-01-30 | 2013-03-13 | Imp Innovations | Complement System |
US9134326B2 (en) | 2013-03-14 | 2015-09-15 | Battelle Memorial Institute | Biomarkers for liver fibrosis |
CN103739667B (zh) | 2013-09-24 | 2017-08-25 | 上海宇研生物技术有限公司 | 卵巢癌特异的肿瘤抗原肽及其制备方法 |
WO2015136072A1 (fr) | 2014-03-14 | 2015-09-17 | Immunocore Limited | Banques de tcr |
GB201501017D0 (en) | 2014-12-23 | 2015-03-04 | Immatics Biotechnologies Gmbh | Novel peptides and combination of peptides for use in immunotherapy against hepatocellular carcinoma (HCC) and other cancers |
MD3626731T2 (ro) * | 2014-12-23 | 2022-01-31 | Immatics Biotechnologies Gmbh | Noi peptide și combinație de peptide pentru utilizare în imunoterapie împotriva carcinomului hepatocelular (HCC) și a altor cancere |
GB201507719D0 (en) | 2015-05-06 | 2015-06-17 | Immatics Biotechnologies Gmbh | Novel peptides and combination of peptides and scaffolds thereof for use in immunotherapy against colorectal carcinoma (CRC) and other cancers |
US20180179283A1 (en) | 2015-06-08 | 2018-06-28 | Adicet Bio Inc. | T cell receptor like antibodies having fine specificity |
NL2014935B1 (en) | 2015-06-08 | 2017-02-03 | Applied Immune Tech Ltd | T cell receptor like antibodies having fine specificity. |
AU2017248120B2 (en) | 2016-04-08 | 2022-07-21 | Adaptimmune Limited | T cell receptors |
ES2891321T3 (es) | 2016-04-08 | 2022-01-27 | Adaptimmune Ltd | Receptores de células T |
ES2788188T5 (es) | 2016-04-08 | 2023-10-24 | Adaptimmune Ltd | Receptores de linfocitos T |
WO2018022573A1 (fr) | 2016-07-27 | 2018-02-01 | Sharp Laboratories Of America, Inc. | Procédés et appareil de télécommunication sans fil utilisant une étiquette de valeur d'information système |
JP7303750B2 (ja) | 2017-01-24 | 2023-07-05 | ベーリンガー インゲルハイム ファーマシューティカルズ インコーポレイテッド | 癌における非古典的hla-iおよびネオ抗原を含む複合体を標的とするための方法および組成物 |
US20200325244A1 (en) | 2020-05-18 | 2020-10-15 | Abexxa Biologics, Inc. | Antibodies and methods of use thereof |
US11497768B2 (en) | 2017-06-05 | 2022-11-15 | Mie University | Antigen-binding protein that recognizes MAGE-A4-derived peptide |
CN111328287A (zh) | 2017-07-04 | 2020-06-23 | 库瑞瓦格股份公司 | 新型核酸分子 |
CA3072816A1 (fr) | 2017-08-18 | 2019-02-21 | Gritstone Oncology, Inc. | Proteines de liaison d'antigene ciblant des antigenes partages |
US20190201443A1 (en) | 2017-09-06 | 2019-07-04 | California Institute Of Technology | Signaling and antigen-presenting bifunctional receptors (sabr) |
CN111886027A (zh) | 2017-12-28 | 2020-11-03 | 磨石肿瘤生物技术公司 | 靶向共同抗原的抗原结合蛋白 |
EP3784255A4 (fr) | 2018-04-19 | 2022-06-22 | Board of Regents, The University of Texas System | Récepteurs de lymphocytes t spécifiques de mage-b2 et leurs utilisations |
WO2019226941A1 (fr) | 2018-05-23 | 2019-11-28 | Gritstone Oncology, Inc. | Antigènes partagés |
US20200291128A1 (en) | 2020-05-18 | 2020-09-17 | Abexxa Biologics, Inc. | Antibodies and methods of use thereof |
US20200291127A1 (en) | 2020-05-18 | 2020-09-17 | Abexxa Biologics, Inc. | Antibodies and methods of use thereof |
US20200291116A1 (en) | 2020-05-18 | 2020-09-17 | Abexxa Biologics, Inc. | Antibodies and methods of use thereof |
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MA43435B1 (fr) | Nouveaux peptides et combinaison de peptides à utiliser dans l'immunothérapie contre diverses tumeurs (seq id 25 - mrax5-003) | |
MA41393B2 (fr) | Nouveaux peptides et combinaisons de peptides et échafaudages formés de ceux-ci destinés à être utilisés en immunothérapie contre le carcinome colorectal (crc) et d'autres cancers | |
MA42294A (fr) | Nouveaux peptides et combinaison de peptides à utiliser en immunothérapie contre le cancer de l'ovaire et d'autres cancers | |
MA43459A1 (fr) | Nouveaux peptides, combinaisons de peptides et supports pour utilisation dans le traitementimmunothérapeutique de divers cancers | |
MA46508A1 (fr) | Nouveaux épitopes de cellules et nouvelle combinaison d'épitopes de cellules destinés à être utilisés dans l'immunothérapie du myélome et d'autres cancers | |
MA46022A (fr) | Nouveaux peptides et combinaison de peptides à utiliser en immunothérapie contre le cancer de la prostate et d'autres cancers | |
MA43719B1 (fr) | Peptide à utiliser en immunothérapie contre le cancer du poumon non à petites cellules et le cancer du poumon à petites cellules | |
MA48487B1 (fr) | Nouveaux peptides et combinaison de peptides à utiliser dans l'immunothérapie contre le carcinome hépatocellulaire (hcc) et d'autres cancers | |
MA46798A1 (fr) | Nouvelle immunothérapie contre plusieurs tumeurs, tels que le cancer du poumon, comprenant le cancer du poumon à grandes cellules |