HRP20211327T1 - Novi peptidi i kombinacije peptida za upotrebu u imunoterapiji protiv hepatocelularnog karcinoma (hcc) i drugih rakova - Google Patents

Novi peptidi i kombinacije peptida za upotrebu u imunoterapiji protiv hepatocelularnog karcinoma (hcc) i drugih rakova Download PDF

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HRP20211327T1
HRP20211327T1 HRP20211327TT HRP20211327T HRP20211327T1 HR P20211327 T1 HRP20211327 T1 HR P20211327T1 HR P20211327T T HRP20211327T T HR P20211327TT HR P20211327 T HRP20211327 T HR P20211327T HR P20211327 T1 HRP20211327 T1 HR P20211327T1
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Croatia
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peptide
cell
expression vector
tcr
nucleic acid
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HRP20211327TT
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English (en)
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Toni Weinschenk
Andrea Mahr
Jens Fritsche
Phillip Müller
Anita WIEBE
Sarah MISSEL
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Immatics Biotechnologies Gmbh
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Priority claimed from GBGB1501017.6A external-priority patent/GB201501017D0/en
Application filed by Immatics Biotechnologies Gmbh filed Critical Immatics Biotechnologies Gmbh
Publication of HRP20211327T1 publication Critical patent/HRP20211327T1/hr

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Claims (15)

1. Peptid koji sadrži aminokiselinsku sekvencu odabranu iz skupine s ID BR. SEKV 6 ili farmaceutski prihvatljivu sol od nje, pri čemu je navedeni peptid ukupne duljine do 30 aminokiselina, pri čemu navedeni peptid ima sposobnost vezivanja s molekulom glavnog kompleksa gena tkivne podudarnosti (MHC) klase I molekule, i pri čemu ga, kada je navedeni peptid vezan s MHC-om, CD8 T stanice mogu prepoznati.
2. Peptid u skladu s patentnim zahtjevom 1, pri čemu ukupna duljina navedenog peptida iznosi do 16 aminokiselina.
3. Peptid u skladu s patentnim zahtjevom 1 ili 2, pri čemu navedeni peptid uključuje nepeptidne veze, i/ili pri čemu je navedeni peptid dio fuzioniranog proteina koji sadrži N-terminalne aminokiseline HLA-DR invarijantnog lanca vezanog za antigene (Ii).
4. Antitijelo, topljivo ili koje se vezuje za membranu, koje specifično prepoznaje peptid u skladu s bilo kojim od patentnih zahtjeva 1 ili 2, po mogućnosti peptid u skladu s bilo kojim od patentnih zahtjeva 1 ili 2 koji se vezuje za MHC molekulu.
5. T-stanični receptor (TCR), topljiv ili koji se vezuje za membranu, koji reagira sa HLA ligandom, pri čemu navedeni ligand ima najmanje 88% sličnosti s, i po mogućnosti se sastoji od, aminokiselinske sekvence odabrane iz grupe koja se sastoji od ID BR. SEKV 6, pri čemu je opcionalno navedeni TCR dat kao topljiva molekula i nadalje opcionalno nosi daljnju efektorsku funkciju kao što je imunostimulirajuća domena ili toksin.
6. Nukleinska kiselina, koja kodira peptid u skladu s bilo kojim od patentnih zahtjeva od 1 do 3, antitijelo u skladu s patentnim zahtjevom 4, TCR u skladu s patentnim zahtjevom 5, ili ekspresijski vektor koji eksprimira navedenu nukleinsku kiselinu.
7. Stanica domaćina koja sadrži peptid u skladu s bilo kojim od patentnih zahtjeva 1 do 3, ili nukleinsku kiselinu ili ekspresijski vektor u skladu s patentnim zahtjevom 6, pri čemu je navedena stanica domaćin po mogućnosti stanica koja prezentira antigen, kao što je dendritična stanica, ili T stanica ili NK stanica.
8. Metoda za proizvodnju peptida u skladu s bilo kojim od patentnih zahtjeva od 1 do 3, antitijelo u skladu s patentnim zahtjevom 4, ili TCR u skladu s patentnim zahtjevom 5, metoda je koja se sastoji od kultiviranja stanice domaćina u skladu s patentnim zahtjevom 7 koji predstavlja peptid u skladu s bilo kojim od patentnih zahtjeva od 1 do 3, ili eksprimira nukleinsku kiselinu ili ekspresijski vektor u skladu s patentnim zahtjevom 6, i izoliranjem navedenog peptida, navedeno antitijelo ili navedeni TCR iz stanice domaćina i/ili medija za kultiviranje.
9. In vitro metoda za proizvodnju aktiviranih T-limfocita, metoda je koja obuhvaća kontaktiranje in vitro T stanica humanim MHC molekulama klase I s umetnutim antigenima koje se eksprimiraju na površini odgovarajuće stanice koja prezentira antigen ili umjetnog spoja koji oponaša stanicu koja prezentira antigen u vremenskom razdoblju dovoljnom da se aktiviraju navedene T stanice na način svojstven antigenu, pri čemu je navedeni antigen peptid u skladu s patentnim zahtjevom 1 ili 2.
10. Aktivirana T stanica, proizvedena metodom u skladu s patentnim zahtjevom 9, koja selektivno prepoznaje stanicu koja predstavlja polipeptid koji se sastoji od sekvence aminokiselina navedene u patentnom zahtjevu 1 ili 2.
11. Farmaceutska smjesa, koja se sastoji od najmanje jednog aktivnog sastojka odabranog iz grupe koja se sastoji od peptida u skladu s bilo kojim od patentnih zahtjeva od 1 do 3, antitijela u skladu s patentnim zahtjevom 4, TCR u skladu s patentnim zahtjevom 5, nukleinske kiseline ili ekspresijskog vektora u skladu s patentnim zahtjevom 6, stanice domaćina koja se sastoji od ekspresijskog vektora u skladu s patentnim zahtjevom 7, aktivirane T stanice u skladu s patentnim zahtjevom 10, i farmaceutski prihvatljivog nosača, te opcionalno, farmaceutski prihvatljivih pomoćnih supstanci i / ili stabilizatora.
12. Peptid u skladu s bilo kojim od patentnih zahtjeva od 1 do 3, antitijelo u skladu s patentnim zahtjevom 4, TCR u skladu s patentnim zahtjevom 5, nukleinska kiselina ili ekspresijski vektor u skladu s patentnim zahtjevom 6, stanica domaćina koja se sastoji od ekspresijskog vektora u skladu s patentnim zahtjevom 7, aktivirana T stanica u skladu s patentnim zahtjevom 10, ili farmaceutska smjesa u skladu s patentnim zahtjevom 11 za upotrebu u medicini.
13. Peptid u skladu s bilo kojim od patentnih zahtjeva od 1 do 3, antitijelo u skladu s patentnim zahtjevom 4, TCR u skladu s patentnim zahtjevom 5, nukleinska kiselina ili ekspresijski vektor u skladu s patentnim zahtjevom 6, stanica domaćina koja se sastoji od ekspresijskog vektora u skladu s patentnim zahtjevom 7, aktivirana T stanica u skladu s patentnim zahtjevom 10, ili farmaceutska smjesa u skladu s patentnim zahtjevom 11 za upotrebu u liječenju raka.
14. Peptid u skladu s bilo kojim od patentnih zahtjeva od 1 do 3, antitijelo u skladu s patentnim zahtjevom 4, TCR u skladu s patentnim zahtjevom 5, nukleinska kiselina ili ekspresijski vektor u skladu s patentnim zahtjevom 6, stanica domaćina koja se sastoji od ekspresijskog vektora u skladu s patentnim zahtjevom 7, aktivirana T stanica u skladu s patentnim zahtjevom 10, ili farmaceutska smjesa u skladu s patentnim zahtjevom 11 za upotrebu u skladu s patentnim zahtjevom 13, pri čemu je navedeni rak odabran iz grupe HCC, raka mozga, raka bubrega, raka pankreasa, debelog crijeva ili rektalnog raka, ili leukemije i drugih tumora koji pokazuju pretjeranu ekspresiju AXIN2.
15. Komplet koji se sastoji od: (a) posude koja sadrži farmaceutsku smjesu u skladu s patentnim zahtjevom 11, u otopini ili u liofiliziranom obliku; (b) opcionalno, druge posude koja sadrži otapalo ili otopinu za rekonstituciju za liofiliziranu formulaciju; (c) opcionalno, upute za (i) korištenje otapala ili (ii) rekonstituciju i/ili korištenje liofilizirane formulacije i po potrebi; (d) koja se sastoji od jednog ili više od (iii) pafera, (iv) otapala, (v) filtra, (vi) igle, ili (vii) štrcaljke.
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MD3616706T2 (ro) 2022-01-31
HRP20211580T1 (hr) 2022-01-21
HUE056607T2 (hu) 2022-02-28
KR20220118565A (ko) 2022-08-25
JP2020191869A (ja) 2020-12-03
JP2020191867A (ja) 2020-12-03
CY1122491T1 (el) 2020-10-14
FI3236985T4 (fi) 2022-12-15
PL3626731T3 (pl) 2022-05-02
HRP20211753T1 (hr) 2022-04-01
LT3616706T (lt) 2022-02-10
MD3626729T2 (ro) 2021-12-31
US20220054613A1 (en) 2022-02-24
JP7346361B2 (ja) 2023-09-19
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MY178137A (en) 2020-10-05
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