UA124331C2 - Пептид, здатний зв'язуватися з молекулою головного комплексу гістосумісності (mhc) людини i класу - Google Patents

Пептид, здатний зв'язуватися з молекулою головного комплексу гістосумісності (mhc) людини i класу

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Publication number
UA124331C2
UA124331C2 UAA201702214A UAA201702214A UA124331C2 UA 124331 C2 UA124331 C2 UA 124331C2 UA A201702214 A UAA201702214 A UA A201702214A UA A201702214 A UAA201702214 A UA A201702214A UA 124331 C2 UA124331 C2 UA 124331C2
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UA
Ukraine
Prior art keywords
peptide
mhc
bind
molecule
tcr
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UAA201702214A
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English (en)
Inventor
Тоні Вайншенк
Тони Вайншенк
Андреа Мар
Йенс Фрітше
Йенс Фритше
Філіп Мюллер
Филип МЮЛЛЕР
Аніта Вібе
Анита Вибэ
Сара Кучер
Original Assignee
Імматікс Біотекнолоджіс Гмбх
Имматикс Биотекнолоджис Гмбх
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Priority claimed from GBGB1501017.6A external-priority patent/GB201501017D0/en
Application filed by Імматікс Біотекнолоджіс Гмбх, Имматикс Биотекнолоджис Гмбх filed Critical Імматікс Біотекнолоджіс Гмбх
Publication of UA124331C2 publication Critical patent/UA124331C2/uk

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    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
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Abstract

Винахід стосується пептиду, що складається з амінокислотної послідовності SEQ ID NO: 6, або його фармацевтично прийнятної солі, причому згаданий пептид здатний зв'язуватися з молекулою головного комплексу гістосумісності (MHC) людини I класу і згаданий пептид, якщо він зв'язаний з MHC, здатний розпізнаватися CD8 T-клітинами. Також винахід стосується антитіла, Т-клітинного рецептору (ТКР), нуклеїнової кислоти, вектору експресії, клітини-хазяїна, способу отримання пептиду, антитіла або ТКР, способу продукування активованих Т-лімфоцитів in vitro, активованої Т-клітини, фармацевтичної композиції, застосування активованого пептиду, антитіла, ТКР для виробництва лікарського засобу для лікування раку, що виявляє надмірну експресію AXIN2, та терапевтичного комплекту.
UAA201702214A 2014-12-23 2015-12-16 Пептид, здатний зв'язуватися з молекулою головного комплексу гістосумісності (mhc) людини i класу UA124331C2 (uk)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201462096165P 2014-12-23 2014-12-23
GB201423016 2014-12-23
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