MD3626731T2 - Noi peptide și combinație de peptide pentru utilizare în imunoterapie împotriva carcinomului hepatocelular (HCC) și a altor cancere - Google Patents

Noi peptide și combinație de peptide pentru utilizare în imunoterapie împotriva carcinomului hepatocelular (HCC) și a altor cancere

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Publication number
MD3626731T2
MD3626731T2 MDE20200300T MDE20200300T MD3626731T2 MD 3626731 T2 MD3626731 T2 MD 3626731T2 MD E20200300 T MDE20200300 T MD E20200300T MD E20200300 T MDE20200300 T MD E20200300T MD 3626731 T2 MD3626731 T2 MD 3626731T2
Authority
MD
Moldova
Prior art keywords
peptides
cells
relates
present
combination
Prior art date
Application number
MDE20200300T
Other languages
English (en)
Inventor
Toni Weinschenk
Andrea Mahr
Jens Fritsche
Phillip Muller
Anita Wiebe
Sarah Missel
Original Assignee
Immatics Biotechnologies Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB1501017.6A external-priority patent/GB201501017D0/en
Application filed by Immatics Biotechnologies Gmbh filed Critical Immatics Biotechnologies Gmbh
Publication of MD3626731T2 publication Critical patent/MD3626731T2/ro

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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/14—Blood; Artificial blood
    • A61K35/17—Lymphocytes; B-cells; T-cells; Natural killer cells; Interferon-activated or cytokine-activated lymphocytes
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K38/00—Medicinal preparations containing peptides
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    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/19—Cytokines; Lymphokines; Interferons
    • A61K38/20—Interleukins [IL]
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    • C—CHEMISTRY; METALLURGY
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    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
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    • C07—ORGANIC CHEMISTRY
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    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
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    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503—Immunoglobulin superfamily
    • C07K14/7051—T-cell receptor (TcR)-CD3 complex
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    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
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    • C—CHEMISTRY; METALLURGY
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    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
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    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
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    • A61K51/10—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody
    • A61K51/1045—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody against animal or human tumor cells or tumor cell determinants
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Abstract

Prezenta invenţie se referă la peptide, proteine, acizi nucleici şi celule pentru utilizare în metode imunoterapeutice. În mod special, prezenta invenţie se referă la imunoterapia cancerului. În plus, prezenta invenţie se referă la epitopii peptidici ai celulelor T citotoxice asociate tumorii, singuri sau asociaţi cu alte peptide asociate tumorii, care pot servi, de exemplu, drept componente farmaceutice active ale formulelor de vaccin care stimulează răspunsurile imunitare antitumorale sau pentru stimularea celulelor T ex vivo şi transferarea la paciente. Peptidele legate de molecule ale complexului major de histocompatibilitate (MHC), sau peptidele ca atare, pot fi, de asemenea, ţinte ale anticorpilor, ale receptorilor solubili ai celulelor T şi ale altor molecule de legare. În special, prezenta invenţie se referă la mai multe secvenţe peptidice noi şi variantele acestora derivate din moleculele HLA de clasă I şi de clasă II ale celulelor tumorale umane care se pot folosi în formule de vaccin pentru inducerea de răspunsuri imunitar antitumorale sau drept ţinte pentru dezvoltarea de compuşi sau celule active din punct de vedere farmaceuticIimunologic.
MDE20200300T 2014-12-23 2015-12-16 Noi peptide și combinație de peptide pentru utilizare în imunoterapie împotriva carcinomului hepatocelular (HCC) și a altor cancere MD3626731T2 (ro)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201462096165P 2014-12-23 2014-12-23
GB201423016 2014-12-23
GBGB1501017.6A GB201501017D0 (en) 2014-12-23 2015-01-21 Novel peptides and combination of peptides for use in immunotherapy against hepatocellular carcinoma (HCC) and other cancers

Publications (1)

Publication Number Publication Date
MD3626731T2 true MD3626731T2 (ro) 2022-01-31

Family

ID=66846825

Family Applications (5)

Application Number Title Priority Date Filing Date
MDE20170224T MD3236985T3 (ro) 2014-12-23 2015-12-16 Noi peptide și combinații de peptide pentru utilizare în imunoterapie împotriva carcinomului hepatocelular (HCC) și altor tipuri de cancere
MDE20200300T MD3626731T2 (ro) 2014-12-23 2015-12-16 Noi peptide și combinație de peptide pentru utilizare în imunoterapie împotriva carcinomului hepatocelular (HCC) și a altor cancere
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