MA42294A - Nouveaux peptides et combinaison de peptides à utiliser en immunothérapie contre le cancer de l'ovaire et d'autres cancers - Google Patents
Nouveaux peptides et combinaison de peptides à utiliser en immunothérapie contre le cancer de l'ovaire et d'autres cancersInfo
- Publication number
- MA42294A MA42294A MA042294A MA42294A MA42294A MA 42294 A MA42294 A MA 42294A MA 042294 A MA042294 A MA 042294A MA 42294 A MA42294 A MA 42294A MA 42294 A MA42294 A MA 42294A
- Authority
- MA
- Morocco
- Prior art keywords
- peptides
- cells
- combination
- tumor
- present
- Prior art date
Links
- 108090000765 processed proteins & peptides Proteins 0.000 title abstract 7
- 102000004196 processed proteins & peptides Human genes 0.000 title abstract 6
- 206010028980 Neoplasm Diseases 0.000 title abstract 3
- 201000011510 cancer Diseases 0.000 title 1
- 238000009169 immunotherapy Methods 0.000 title 1
- 230000002611 ovarian Effects 0.000 title 1
- 210000001744 T-lymphocyte Anatomy 0.000 abstract 2
- 230000005975 antitumor immune response Effects 0.000 abstract 2
- 108700018351 Major Histocompatibility Complex Proteins 0.000 abstract 1
- 108091008874 T cell receptors Proteins 0.000 abstract 1
- 102000016266 T-Cell Antigen Receptors Human genes 0.000 abstract 1
- 239000004480 active ingredient Substances 0.000 abstract 1
- 238000002619 cancer immunotherapy Methods 0.000 abstract 1
- 210000004027 cell Anatomy 0.000 abstract 1
- 230000001024 immunotherapeutic effect Effects 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 102000039446 nucleic acids Human genes 0.000 abstract 1
- 108020004707 nucleic acids Proteins 0.000 abstract 1
- 150000007523 nucleic acids Chemical class 0.000 abstract 1
- 108090000623 proteins and genes Proteins 0.000 abstract 1
- 102000004169 proteins and genes Human genes 0.000 abstract 1
- 230000000638 stimulation Effects 0.000 abstract 1
- 230000020382 suppression by virus of host antigen processing and presentation of peptide antigen via MHC class I Effects 0.000 abstract 1
- 229960005486 vaccine Drugs 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
- C07K14/4748—Tumour specific antigens; Tumour rejection antigen precursors [TRAP], e.g. MAGE
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/14—Blood; Artificial blood
- A61K35/17—Lymphocytes; B-cells; T-cells; Natural killer cells; Interferon-activated or cytokine-activated lymphocytes
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/1703—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- A61K38/1709—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
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- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/19—Cytokines; Lymphokines; Interferons
- A61K38/20—Interleukins [IL]
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- A61K39/461—Cellular immunotherapy characterised by the cell type used
- A61K39/4611—T-cells, e.g. tumor infiltrating lymphocytes [TIL], lymphokine-activated killer cells [LAK] or regulatory T cells [Treg]
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- A61K47/6801—Drug-antibody or immunoglobulin conjugates defined by the pharmacologically or therapeutically active agent
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- A61K48/005—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the 'active' part of the composition delivered, i.e. the nucleic acid delivered
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- A61P37/02—Immunomodulators
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- C—CHEMISTRY; METALLURGY
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- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
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- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
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- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
- C07K14/4702—Regulators; Modulating activity
- C07K14/4705—Regulators; Modulating activity stimulating, promoting or activating activity
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
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- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
- C07K14/4738—Cell cycle regulated proteins, e.g. cyclin, CDC, INK-CCR
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
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- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
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- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
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- C07K14/70503—Immunoglobulin superfamily
- C07K14/7051—T-cell receptor (TcR)-CD3 complex
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
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- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70503—Immunoglobulin superfamily
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- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
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- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
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- C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
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- C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
- C07K16/3015—Breast
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- C—CHEMISTRY; METALLURGY
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- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
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- C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
- C07K16/3023—Lung
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- C—CHEMISTRY; METALLURGY
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- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
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- C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
- C07K16/303—Liver or Pancreas
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
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- C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
- C07K16/3038—Kidney, bladder
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- C—CHEMISTRY; METALLURGY
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- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
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- C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
- C07K16/3046—Stomach, Intestines
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- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
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- C07K16/3053—Skin, nerves, brain
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- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
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- C07K16/3069—Reproductive system, e.g. ovaria, uterus, testes, prostate
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- C—CHEMISTRY; METALLURGY
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- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
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- C07K7/08—Linear peptides containing only normal peptide links having 12 to 20 amino acids
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- C12N15/115—Aptamers, i.e. nucleic acids binding a target molecule specifically and with high affinity without hybridising therewith ; Nucleic acids binding to non-nucleic acids, e.g. aptamers
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Abstract
La présente invention concerne des peptides, des protéines, des acides nucléiques et des cellules destinés à être utilisés dans des procédés immunothérapeutiques. La présente invention concerne en particulier l'immunothérapie du cancer. La présente invention porte en outre sur des épitopes peptidiques tumoraux de cellules t, seuls ou combinés à d'autres peptides tumoraux, qui peuvent par exemple servir en tant que principes actifs pharmaceutiques de compositions de vaccin qui stimulent des réponses immunitaires antitumorales, ou sur la stimulation ex vivo des cellules t et leur transfert aux patients. Des peptides liés aux molécules du complexe majeur d'histocompatibilité (cmh), ou des peptides tels quels, peuvent également être des cibles d'anticorps, des récepteurs de cellules t solubles, et d'autres molécules de liaison.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
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US201562187507P | 2015-07-01 | 2015-07-01 | |
GBGB1511546.2A GB201511546D0 (en) | 2015-07-01 | 2015-07-01 | Novel peptides and combination of peptides for use in immunotherapy against ovarian cancer and other cancers |
PCT/EP2016/065166 WO2017001491A2 (fr) | 2015-07-01 | 2016-06-29 | Nouveaux peptides et combinaison de peptides à utiliser en immunothérapie contre le cancer de l'ovaire et d'autres cancers |
Publications (2)
Publication Number | Publication Date |
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MA42294A true MA42294A (fr) | 2018-05-09 |
MA42294B1 MA42294B1 (fr) | 2020-11-30 |
Family
ID=56292721
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
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MA42294A MA42294B1 (fr) | 2015-07-01 | 2016-06-29 | Nouveaux peptides et combinaison de peptides à utiliser en immunothérapie contre le cancer de l'ovaire et d'autres cancers |
MA054884A MA54884A (fr) | 2015-07-01 | 2016-06-29 | Neuartige peptide und kombination aus peptiden zur verwendung in der immuntherapie gegen ovarialkarzinom und andere karzinome |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
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MA054884A MA54884A (fr) | 2015-07-01 | 2016-06-29 | Neuartige peptide und kombination aus peptiden zur verwendung in der immuntherapie gegen ovarialkarzinom und andere karzinome |
Country Status (18)
Country | Link |
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US (8) | US11230581B2 (fr) |
EP (1) | EP3919507A3 (fr) |
JP (1) | JP2024037858A (fr) |
CN (1) | CN108026154B (fr) |
AU (1) | AU2022215208A1 (fr) |
CL (1) | CL2017003362A1 (fr) |
CO (1) | CO2017012891A2 (fr) |
CY (1) | CY1123635T1 (fr) |
HK (1) | HK1252868A1 (fr) |
HR (1) | HRP20202019T1 (fr) |
IL (2) | IL308735A (fr) |
MA (2) | MA42294B1 (fr) |
MX (1) | MX2021013147A (fr) |
MY (1) | MY191654A (fr) |
PE (1) | PE20230321A1 (fr) |
PH (1) | PH12017502261A1 (fr) |
TW (2) | TWI751973B (fr) |
ZA (1) | ZA201707942B (fr) |
Families Citing this family (20)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB201521746D0 (en) * | 2015-12-10 | 2016-01-27 | Immatics Biotechnologies Gmbh | Novel peptides and combination of peptides for use in immunotherapy against CLL and other cancers |
EP3727467A4 (fr) * | 2017-12-22 | 2021-12-01 | Centivax, Inc. | Compositions du complexe majeur d'histocompatibilité (cmh) et procédés d'utilisation correspondants |
CN110531077B (zh) * | 2018-05-25 | 2023-07-07 | 荣昌生物制药(烟台)股份有限公司 | 间皮素免疫组化检测试剂盒 |
CN110835623B (zh) * | 2018-08-15 | 2022-08-30 | 复旦大学附属肿瘤医院 | 一种原发性铂耐药的人卵巢癌细胞系fdovl、其制备方法和应用 |
CN109633156B (zh) * | 2018-12-19 | 2022-02-22 | 湖南中南大学湘雅口腔医院 | 生物标志物在评估口腔鳞癌危险程度中的应用 |
CN109856400B (zh) * | 2019-01-22 | 2022-02-01 | 上海交通大学医学院附属仁济医院 | 神经酰胺c24作为生物标记物在诊断胆囊癌中的用途 |
CN110018316B (zh) * | 2019-04-16 | 2022-04-05 | 福建师范大学 | Ddx20在制备肾透明细胞癌术后预后评估试剂盒中的应用 |
CN110412273B (zh) * | 2019-06-26 | 2022-09-09 | 四川大学华西医院 | Caap1自身抗体检测试剂在制备肺癌筛查试剂盒中的用途 |
CN112409449B (zh) * | 2019-08-19 | 2023-12-15 | 辽宁中健医药科技有限公司 | Hla-a0201限定性kif15特异性抗肿瘤ctl优势表位肽及应用 |
EP4073242A4 (fr) * | 2019-12-12 | 2024-01-03 | Kumquat Biosciences Inc. | Compositions et procédés pour potentialiser l'activité immunitaire |
CN113105528B (zh) * | 2020-01-13 | 2023-12-08 | 辽宁中健医药科技有限公司 | 一条肿瘤相关抗原ctl表位肽及其应用 |
CN111610331B (zh) * | 2020-06-01 | 2021-01-15 | 郑州大学第一附属医院 | 一种用于早期食管癌筛查的血清学检测试纸条 |
CN112216388A (zh) * | 2020-09-29 | 2021-01-12 | 北京大学第三医院(北京大学第三临床医学院) | 一种子宫内膜异位症相关卵巢癌的风险预测模型和风险预测系统 |
CN112691195B (zh) * | 2021-02-02 | 2023-03-14 | 黑龙江省科学院高技术研究院 | Prpf8表达抑制剂在制备治疗肺癌的药物中的应用 |
CN113041342A (zh) * | 2021-03-24 | 2021-06-29 | 深圳先进技术研究院 | 一种纳米人工抗原呈递细胞及其制备方法和应用 |
CN113209313A (zh) * | 2021-06-25 | 2021-08-06 | 华中科技大学同济医学院附属同济医院 | Tgfbr2在制备卵巢功能保护药物方面中的应用 |
CN114592006A (zh) * | 2022-04-29 | 2022-06-07 | 昆明理工大学 | Memo1基因的新用途 |
CN114875030A (zh) * | 2022-06-06 | 2022-08-09 | 中国水产科学研究院黑龙江水产研究所 | 虹鳟ccne1基因的dsRNA及其应用 |
CN114751961B (zh) * | 2022-06-14 | 2022-09-20 | 中山大学孙逸仙纪念医院 | circ0005199-173aa蛋白及其在制备食管癌诊断产品中的应用 |
CN117805381B (zh) * | 2024-02-29 | 2024-05-28 | 首都医科大学附属北京积水潭医院 | 检测Gasdermin蛋白家族的物质在制备检测骨肉瘤的产品中的应用 |
Family Cites Families (77)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4440859A (en) | 1977-05-27 | 1984-04-03 | The Regents Of The University Of California | Method for producing recombinant bacterial plasmids containing the coding sequences of higher organisms |
US4704362A (en) | 1977-11-08 | 1987-11-03 | Genentech, Inc. | Recombinant cloning vehicle microbial polypeptide expression |
DD147855A5 (de) | 1978-12-22 | 1981-04-22 | Biogen Nv | Verfahren zur erzeugung mindestens eines hbv-antigenwirkung aufweisenden polypeptids |
US4530901A (en) | 1980-01-08 | 1985-07-23 | Biogen N.V. | Recombinant DNA molecules and their use in producing human interferon-like polypeptides |
US4342566A (en) | 1980-02-22 | 1982-08-03 | Scripps Clinic & Research Foundation | Solid phase anti-C3 assay for detection of immune complexes |
US4678751A (en) | 1981-09-25 | 1987-07-07 | Genentech, Inc. | Hybrid human leukocyte interferons |
US4766075A (en) | 1982-07-14 | 1988-08-23 | Genentech, Inc. | Human tissue plasminogen activator |
US4582800A (en) | 1982-07-12 | 1986-04-15 | Hoffmann-La Roche Inc. | Novel vectors and method for controlling interferon expression |
US4816567A (en) | 1983-04-08 | 1989-03-28 | Genentech, Inc. | Recombinant immunoglobin preparations |
US4757006A (en) | 1983-10-28 | 1988-07-12 | Genetics Institute, Inc. | Human factor VIII:C gene and recombinant methods for production |
US4677063A (en) | 1985-05-02 | 1987-06-30 | Cetus Corporation | Human tumor necrosis factor |
US4810648A (en) | 1986-01-08 | 1989-03-07 | Rhone Poulenc Agrochimie | Haloarylnitrile degrading gene, its use, and cells containing the gene |
US4897445A (en) | 1986-06-27 | 1990-01-30 | The Administrators Of The Tulane Educational Fund | Method for synthesizing a peptide containing a non-peptide bond |
US6193969B1 (en) | 1993-06-03 | 2001-02-27 | Protherics Inc. | Antibody fragments in therapy |
AUPM322393A0 (en) | 1993-12-24 | 1994-01-27 | Austin Research Institute, The | Mucin carbohydrate compounds and their use in immunotherapy |
DK0879282T3 (da) | 1996-01-17 | 2003-10-20 | Imp College Innovations Ltd | Immunterapi ved anvendelse af cytotoksiske T-lymfocytter (CTL) |
US5849589A (en) | 1996-03-11 | 1998-12-15 | Duke University | Culturing monocytes with IL-4, TNF-α and GM-CSF TO induce differentiation to dendric cells |
US6406705B1 (en) | 1997-03-10 | 2002-06-18 | University Of Iowa Research Foundation | Use of nucleic acids containing unmethylated CpG dinucleotide as an adjuvant |
US20020119158A1 (en) | 1998-12-17 | 2002-08-29 | Corixa Corporation | Compositions and methods for the therapy and diagnosis of ovarian cancer |
US6858710B2 (en) | 1998-12-17 | 2005-02-22 | Corixa Corporation | Compositions and methods for the therapy and diagnosis of ovarian cancer |
CA2395926A1 (fr) | 1999-12-28 | 2001-07-05 | Curagen Corporation | Acides nucleiques contenant des polymorphismes mononucleotidiques et procedes d'utilisation correspondants |
CA2404489A1 (fr) | 2000-03-27 | 2001-10-04 | Technion Research And Development Foundation Ltd. | Complexes majeurs d'histocompatibilite monocatenaires de classe 1, constructions les codant et leurs methodes de production |
US20040191260A1 (en) | 2003-03-26 | 2004-09-30 | Technion Research & Development Foundation Ltd. | Compositions capable of specifically binding particular human antigen presenting molecule/pathogen-derived antigen complexes and uses thereof |
US6436703B1 (en) | 2000-03-31 | 2002-08-20 | Hyseq, Inc. | Nucleic acids and polypeptides |
ES2659376T3 (es) | 2000-06-05 | 2018-03-15 | Altor Bioscience Corporation | Proteínas de fusión del receptor de linfocitos T y conjugados y procedimientos de uso de las mismas |
WO2003020884A2 (fr) | 2001-08-14 | 2003-03-13 | The Government Of The United States Of America As Represented By The Secretary Of Health And Human Services | Procede de generation rapide de cellules dentritique matures |
US20040142325A1 (en) | 2001-09-14 | 2004-07-22 | Liat Mintz | Methods and systems for annotating biomolecular sequences |
US6992176B2 (en) | 2002-02-13 | 2006-01-31 | Technion Research & Development Foundation Ltd. | Antibody having a T-cell receptor-like specificity, yet higher affinity, and the use of same in the detection and treatment of cancer, viral infection and autoimmune disease |
WO2003070752A2 (fr) | 2002-02-20 | 2003-08-28 | Dyax Corporation | Ligands de liaison au complexe mhc-peptide |
DE10225144A1 (de) | 2002-05-29 | 2003-12-18 | Immatics Biotechnologies Gmbh | An MHC-Moleküle bindende Tumor-assoziierte Peptide |
US20070073047A1 (en) | 2002-06-10 | 2007-03-29 | Biogen Idec Ma Inc. | Genes overexpressed by ovarian cancer and their use in developing novel therapeutics |
EP1536814A4 (fr) | 2002-07-03 | 2006-02-15 | Immunogen Inc | Anticorps contre muc1 et muc16 non liberees et leurs utilisations |
WO2004033685A1 (fr) | 2002-10-09 | 2004-04-22 | Avidex Ltd | Recepteurs de lymphocytes t de recombinaison a chaine unique |
DE60327795D1 (de) | 2002-11-09 | 2009-07-09 | Immunocore Ltd | T zell rezeptor "display" |
GB0304068D0 (en) | 2003-02-22 | 2003-03-26 | Avidex Ltd | Substances |
US7348007B2 (en) | 2004-02-09 | 2008-03-25 | Ludwig Institute For Cancer Research | Mage C2 antigenic peptides and uses thereof |
DE102004026135A1 (de) | 2004-05-25 | 2006-01-05 | Immatics Biotechnologies Gmbh | An MHC-Moleküle bindende Tumor-assoziierte Peptide |
CA2579558A1 (fr) | 2004-09-08 | 2006-03-16 | Ludwig Institute For Cancer Research | Antigenes du cancer du testicule |
WO2006106912A1 (fr) | 2005-03-31 | 2006-10-12 | Chugai Seiyaku Kabushiki Kaisha | Peptide analogue d’antigene associe au cancer et son utilisation |
JP4962687B2 (ja) | 2005-08-30 | 2012-06-27 | Nok株式会社 | 密封構造 |
DE602005020047D1 (de) | 2005-09-05 | 2010-04-29 | Immatics Biotechnologies Gmbh | Tumor-assoziierte Peptide, welche an unterschiedliche menschliche Leukozytenantigene der Klasse II binden |
DE602005016112D1 (de) | 2005-09-05 | 2009-10-01 | Immatics Biotechnologies Gmbh | Tumorassoziierte Peptide, die HLA Klasse I oder II-Moleküle binden, und anti-Tumor Impfstoffe |
US8216582B2 (en) | 2006-06-23 | 2012-07-10 | Alethia Biotherapeutics Inc. | Polynucleotides and polypeptide sequences involved in cancer |
WO2008127285A2 (fr) * | 2006-10-05 | 2008-10-23 | The Board Of Trustees Of The University Of Arkansas | Peptides cibles pour immunothérapie du cancer des ovaires |
CA2682827A1 (fr) | 2007-04-05 | 2008-10-16 | Source Precision Medicine, Inc., D/B/A Source Mdx | Profilage d'expression genique pour l'identification, la surveillance et le traitement du cancer des ovaires |
JP6008461B2 (ja) | 2007-07-27 | 2016-10-19 | イマティクス バイオテクノロジーズ ゲーエムベーハー | 神経細胞性脳腫瘍に対する新規免疫療法 |
EP2178557B1 (fr) | 2007-07-27 | 2017-03-01 | Immatics Biotechnologies GmbH | Composition de peptides associés à des tumeurs et vaccin anti-cancer connexe |
HUE026776T2 (en) | 2007-07-27 | 2016-08-29 | Immatics Biotechnologies Gmbh | New immunogenic epitope for immunotherapy |
WO2009067546A2 (fr) | 2007-11-19 | 2009-05-28 | Celera Corpration | Marqueurs de cancer du poumon et leurs utilisations |
US20090263574A1 (en) | 2008-04-21 | 2009-10-22 | Quinn Daniel E | Method of restoring an article |
HUE024541T2 (hu) * | 2008-05-14 | 2016-01-28 | Immatics Biotechnologies Gmbh | Szurvivinbõl és neurocanból származó új és hatásos II-es osztályú MHC peptidek |
EP2733222A1 (fr) * | 2008-07-09 | 2014-05-21 | Celera Corporation | Polymorphismes génétiques associés à des maladies cardiovasculaires, procédés de détection et utilisations associées |
US20100029748A1 (en) | 2008-08-04 | 2010-02-04 | Sloan-Kettering Institute For Cancer Research | Metastasis Promoting Genes and Proteins |
EP2172211B1 (fr) | 2008-10-01 | 2014-12-03 | Immatics Biotechnologies GmbH | Composition de peptide associé aux tumeurs et vaccin anti-cancer associé pour le traitement de glioblastome (GBM) et autres cancers |
WO2010088688A2 (fr) | 2009-02-02 | 2010-08-05 | Biotheranostics, Inc. | Diagnostic de cancer du sein in situ et invasif |
KR20120034593A (ko) | 2009-03-09 | 2012-04-12 | 유니버시티 오브 조지아 리서치 파운데이션 인코퍼레이티드 | 위암 진단용 단백질 마커의 동정 |
GB201004551D0 (en) | 2010-03-19 | 2010-05-05 | Immatics Biotechnologies Gmbh | NOvel immunotherapy against several tumors including gastrointestinal and gastric cancer |
WO2013040142A2 (fr) | 2011-09-16 | 2013-03-21 | Iogenetics, Llc | Procédés bio-informatiques de détermination de liaisons peptidiques |
PT2552959T (pt) | 2010-03-26 | 2017-04-21 | Memorial Sloan Kettering Cancer Center | Anticorpos para muc16 e métodos de utilização dos mesmos |
GB201006360D0 (en) | 2010-04-16 | 2010-06-02 | Immatics Biotechnologies Gmbh | Method for differentially quantifying naturally processed HLA-restricted peptides for cancer, autoimmune and infectious diseases immunotherapy development |
WO2011143361A2 (fr) | 2010-05-11 | 2011-11-17 | Veracyte, Inc. | Méthodes et compositions utilisées dans le cadre du diagnostic de maladies |
GB201009222D0 (en) | 2010-06-02 | 2010-07-21 | Immatics Biotechnologies Gmbh | Improved cancer therapy based on tumour associated antigens derived from cyclin D1 |
CN102372773B (zh) | 2010-08-11 | 2013-06-05 | 中国科学院生物物理研究所 | 人膀胱癌肿瘤标志物及其抗体和应用 |
CA2816225A1 (fr) | 2010-10-26 | 2012-05-03 | Technion Research & Development Foundation Ltd. | Anticorps qui se lient a des ligands de recepteurs de lymphocytes t solubles |
CA2838086A1 (fr) | 2011-06-02 | 2012-12-06 | Almac Diagnostics Limited | Test de diagnostic moleculaire pour un cancer |
CA2838728A1 (fr) | 2011-06-07 | 2012-12-13 | Caris Life Sciences Luxembourg Holdings, S.A.R.L. | Biomarqueurs circulants pour le cancer |
WO2013057586A1 (fr) | 2011-10-19 | 2013-04-25 | Oslo Universitetssykehus Hf | Compositions et procédés de production de récepteurs solubles des lymphocytes t |
CN104080797A (zh) | 2011-11-11 | 2014-10-01 | 弗雷德哈钦森癌症研究中心 | 针对癌症的靶向细胞周期蛋白a1的t细胞免疫疗法 |
US9688991B2 (en) | 2012-07-13 | 2017-06-27 | Albert Einstein College Of Medicine, Inc. | Aptamer-targetted antigen delivery |
EP2895864B1 (fr) | 2012-09-17 | 2021-03-10 | AIT Austrian Institute of Technology GmbH | Mathode et moyen de diagnostic du cancer du côlon |
ES2603589T3 (es) | 2012-11-08 | 2017-02-28 | F. Hoffmann-La Roche Ag | Ácidos nucleicos que codifican polipéptidos quiméricos para la identificación sistemática de bibliotecas |
EP2808392A1 (fr) | 2013-05-28 | 2014-12-03 | Rheinische Friedrich-Wilhelms-Universität Bonn | Aptamères et utilisation de ces aptamères dans le diagnostic et le traitement du cancer |
TWI777196B (zh) | 2013-08-05 | 2022-09-11 | 德商伊瑪提克斯生物科技有限公司 | 新穎肽類,細胞及其用於治療多種腫瘤的用途,其製造方法及包含其等之醫藥組成物(五) |
LT3149048T (lt) | 2014-05-28 | 2020-05-11 | Nono Inc. | Tat-nr2b9c chlorido druska |
CA3116369A1 (fr) | 2014-12-03 | 2016-06-09 | Verik Bio, Inc. | Identification, selection et utilisation d'epitopes de cellule t a haut potentiel curatif |
GB201507030D0 (en) | 2015-04-24 | 2015-06-10 | Immatics Biotechnologies Gmbh | Immunotherapy against lung cancers, in particular NSCLC |
GB201511546D0 (en) | 2015-07-01 | 2015-08-12 | Immatics Biotechnologies Gmbh | Novel peptides and combination of peptides for use in immunotherapy against ovarian cancer and other cancers |
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