MX2022012147A - Metodos para cultivar celulas y kits y aparatos para ello. - Google Patents

Metodos para cultivar celulas y kits y aparatos para ello.

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Publication number
MX2022012147A
MX2022012147A MX2022012147A MX2022012147A MX2022012147A MX 2022012147 A MX2022012147 A MX 2022012147A MX 2022012147 A MX2022012147 A MX 2022012147A MX 2022012147 A MX2022012147 A MX 2022012147A MX 2022012147 A MX2022012147 A MX 2022012147A
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Mexico
Prior art keywords
methods
agents
cells
reagents
multimerized
Prior art date
Application number
MX2022012147A
Other languages
English (en)
Inventor
Lothar Germeroth
Christian Stemberger
Keenan Bashour
Patricia Gräf
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Juno Therapeutics Gmbh
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Publication date
Application filed by Juno Therapeutics Gmbh filed Critical Juno Therapeutics Gmbh
Publication of MX2022012147A publication Critical patent/MX2022012147A/es

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    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503—Immunoglobulin superfamily
    • C07K14/7051—T-cell receptor (TcR)-CD3 complex
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/14—Blood; Artificial blood
    • A61K35/17—Lymphocytes; B-cells; T-cells; Natural killer cells; Interferon-activated or cytokine-activated lymphocytes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/0005—Vertebrate antigens
    • A61K39/0011—Cancer antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/46—Cellular immunotherapy
    • A61K39/461—Cellular immunotherapy characterised by the cell type used
    • A61K39/4611—T-cells, e.g. tumor infiltrating lymphocytes [TIL], lymphokine-activated killer cells [LAK] or regulatory T cells [Treg]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/46—Cellular immunotherapy
    • A61K39/463—Cellular immunotherapy characterised by recombinant expression
    • A61K39/4631—Chimeric Antigen Receptors [CAR]
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K39/464—Cellular immunotherapy characterised by the antigen targeted or presented
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    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
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    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
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    • C12N5/0634—Cells from the blood or the immune system
    • C12N5/0646—Natural killers cells [NK], NKT cells
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    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
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    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
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  • Gastroenterology & Hepatology (AREA)
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  • Peptides Or Proteins (AREA)
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Abstract

Se proporcionan en la presente métodos que se relacionan, en algunos aspectos, a la incubación o cultivo, tal como para inducir estimulación de expansión (proliferación), activación, coestimulación y/o supervivencia, de una composición de células, tal como una población de linfocitos. En algunos aspectos, se proporcionan métodos y reactivos para la estimulación, por ejemplo, de expansión (proliferación), supervivencia o persistencia, activación, coestimulación u otro efecto, de poblaciones celulares que involucran el enlace de agentes a una molécula sobre la superficie de las células, para de esta manera proporcionar una o más señales a las células. En algunos casos, los reactivos son reactivos que contienen una pluralidad de sitios de enlace para agentes, tales como reactivos de multimerización, y de esta manera el uno o más agentes se multimerizan mediante el enlace reversiblemente al reactivo, por ejemplo, para de esta manera crear un reactivo estimulador (agente multimerizado) que tienen agentes estimuladores multimerizados sobre el mismo. En algunos aspectos, el agente multimerizado puede proporcionar expansión o proliferación u otra estimulación de una población de células, y luego tales agentes estimuladores se pueden remover mediante la interrupción del enlace reversible. También se proporcionan composiciones, aparato y métodos de uso de los mismos.
MX2022012147A 2015-10-22 2018-04-19 Metodos para cultivar celulas y kits y aparatos para ello. MX2022012147A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201562245252P 2015-10-22 2015-10-22
US201562245261P 2015-10-22 2015-10-22

Publications (1)

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MX2022012147A true MX2022012147A (es) 2023-03-01

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ID=57394616

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MX2018004874A MX2018004874A (es) 2015-10-22 2016-10-20 Metodos para cultivar celulas y kits y aparatos para ello.
MX2022012148A MX2022012148A (es) 2015-10-22 2018-04-19 Metodos para cultivar celulas y kits y aparatos para ello.
MX2022012147A MX2022012147A (es) 2015-10-22 2018-04-19 Metodos para cultivar celulas y kits y aparatos para ello.

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MX2018004874A MX2018004874A (es) 2015-10-22 2016-10-20 Metodos para cultivar celulas y kits y aparatos para ello.
MX2022012148A MX2022012148A (es) 2015-10-22 2018-04-19 Metodos para cultivar celulas y kits y aparatos para ello.

Country Status (16)

Country Link
US (2) US11466253B2 (es)
EP (1) EP3365434A1 (es)
JP (3) JP6895959B2 (es)
KR (1) KR20180100110A (es)
CN (2) CN108431210B (es)
AU (1) AU2016341529B2 (es)
BR (1) BR112018008081A2 (es)
CA (1) CA3002745A1 (es)
HK (1) HK1258931A1 (es)
IL (2) IL258844B2 (es)
MA (1) MA45488A (es)
MX (3) MX2018004874A (es)
PH (1) PH12018500860A1 (es)
RU (1) RU2761557C2 (es)
SG (1) SG11201803330WA (es)
WO (1) WO2017068421A1 (es)

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