MX2022012148A - Metodos para cultivar celulas y kits y aparatos para ello. - Google Patents

Metodos para cultivar celulas y kits y aparatos para ello.

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Publication number
MX2022012148A
MX2022012148A MX2022012148A MX2022012148A MX2022012148A MX 2022012148 A MX2022012148 A MX 2022012148A MX 2022012148 A MX2022012148 A MX 2022012148A MX 2022012148 A MX2022012148 A MX 2022012148A MX 2022012148 A MX2022012148 A MX 2022012148A
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MX
Mexico
Prior art keywords
methods
agents
cells
reagents
multimerized
Prior art date
Application number
MX2022012148A
Other languages
English (en)
Inventor
Lothar Germeroth
Christian Stemberger
Keenan Bashour
Patricia Gräf
Original Assignee
Juno Therapeutics Gmbh
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Publication date
Application filed by Juno Therapeutics Gmbh filed Critical Juno Therapeutics Gmbh
Publication of MX2022012148A publication Critical patent/MX2022012148A/es

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    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
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    • C12N5/0636—T lymphocytes
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    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503—Immunoglobulin superfamily
    • C07K14/7051—T-cell receptor (TcR)-CD3 complex
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    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
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    • A61K35/17—Lymphocytes; B-cells; T-cells; Natural killer cells; Interferon-activated or cytokine-activated lymphocytes
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    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
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    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0634—Cells from the blood or the immune system
    • C12N5/0646—Natural killers cells [NK], NKT cells
    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
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    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/20—Cytokines; Chemokines
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    • C12N2501/50—Cell markers; Cell surface determinants
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    • C12N2533/00—Supports or coatings for cell culture, characterised by material
    • C12N2533/50—Proteins

Abstract

Se proporcionan en la presente métodos que se relacionan, en algunos aspectos, a la incubación o cultivo, tal como para inducir estimulación de expansión (proliferación), activación, coestimulación y/o supervivencia, de una composición de células, tal como una población de linfocitos. En algunos aspectos, se proporcionan métodos y reactivos para la estimulación, por ejemplo, de expansión (proliferación), supervivencia o persistencia, activación, coestimulación u otro efecto, de poblaciones celulares que involucran el enlace de agentes a una molécula sobre la superficie de las células, para de esta manera proporcionar una o más señales a las células. En algunos casos, los reactivos son reactivos que contienen una pluralidad de sitios de enlace para agentes, tales como reactivos de multimerización, y de esta manera el uno o más agentes se multimerizan mediante el enlace reversiblemente al reactivo, por ejemplo, para de esta manera crear un reactivo estimulador (agente multimerizado) que tienen agentes estimuladores multimerizados sobre el mismo. En algunos aspectos, el agente multimerizado puede proporcionar expansión o proliferación u otra estimulación de una población de células, y luego tales agentes estimuladores se pueden remover mediante la interrupción del enlace reversible. También se proporcionan composiciones, aparato y métodos de uso de los mismos.
MX2022012148A 2015-10-22 2018-04-19 Metodos para cultivar celulas y kits y aparatos para ello. MX2022012148A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201562245261P 2015-10-22 2015-10-22
US201562245252P 2015-10-22 2015-10-22

Publications (1)

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MX2022012148A true MX2022012148A (es) 2023-03-01

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MX2018004874A MX2018004874A (es) 2015-10-22 2016-10-20 Metodos para cultivar celulas y kits y aparatos para ello.
MX2022012148A MX2022012148A (es) 2015-10-22 2018-04-19 Metodos para cultivar celulas y kits y aparatos para ello.
MX2022012147A MX2022012147A (es) 2015-10-22 2018-04-19 Metodos para cultivar celulas y kits y aparatos para ello.

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US (2) US11466253B2 (es)
EP (1) EP3365434A1 (es)
JP (3) JP6895959B2 (es)
KR (1) KR20180100110A (es)
CN (2) CN108431210B (es)
AU (1) AU2016341529B2 (es)
BR (1) BR112018008081A2 (es)
CA (1) CA3002745A1 (es)
HK (1) HK1258931A1 (es)
IL (2) IL258844B2 (es)
MA (1) MA45488A (es)
MX (3) MX2018004874A (es)
NZ (1) NZ741878A (es)
PH (1) PH12018500860A1 (es)
RU (1) RU2761557C2 (es)
SG (1) SG11201803330WA (es)
WO (1) WO2017068421A1 (es)

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MX2018006789A (es) 2015-12-03 2019-02-13 Juno Therapeutics Inc Receptores quimericos modificados y composiciones y metodos relacionados.
JP2020505034A (ja) 2017-01-20 2020-02-20 ジュノ セラピューティクス ゲーエムベーハー 細胞表面コンジュゲートならびに関連する細胞組成物および方法
KR102606210B1 (ko) 2017-04-27 2023-11-24 주노 테라퓨틱스 게엠베하 올리고머 입자 시약 및 이의 사용 방법
JP2021533746A (ja) 2018-08-09 2021-12-09 ジュノー セラピューティクス インコーポレイテッド 操作された細胞およびその組成物を生成するための方法
JP2022512872A (ja) 2018-10-31 2022-02-07 ジュノ セラピューティクス ゲーエムベーハー 細胞の選択および刺激のための方法ならびにそのための装置

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IL258844B1 (en) 2023-11-01
MA45488A (fr) 2018-08-29
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JP6895959B2 (ja) 2021-06-30
MX2018004874A (es) 2018-12-12
RU2018118575A (ru) 2019-11-27
RU2761557C2 (ru) 2021-12-09
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CN117106716A (zh) 2023-11-24
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AU2016341529A1 (en) 2018-05-10
BR112018008081A2 (pt) 2018-11-13
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