JP2018529634A5 - - Google Patents
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- JP2018529634A5 JP2018529634A5 JP2018501163A JP2018501163A JP2018529634A5 JP 2018529634 A5 JP2018529634 A5 JP 2018529634A5 JP 2018501163 A JP2018501163 A JP 2018501163A JP 2018501163 A JP2018501163 A JP 2018501163A JP 2018529634 A5 JP2018529634 A5 JP 2018529634A5
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- 125000003275 alpha amino acid group Chemical group 0.000 claims description 61
- 239000012634 fragment Substances 0.000 claims description 60
- 239000000427 antigen Substances 0.000 claims description 47
- 102000036639 antigens Human genes 0.000 claims description 47
- 108091007433 antigens Proteins 0.000 claims description 47
- 208000018737 Parkinson disease Diseases 0.000 claims description 21
- 239000008194 pharmaceutical composition Substances 0.000 claims description 17
- 208000024827 Alzheimer disease Diseases 0.000 claims description 10
- 206010067889 Dementia with Lewy bodies Diseases 0.000 claims description 10
- 208000009829 Lewy Body Disease Diseases 0.000 claims description 10
- 208000015872 Gaucher disease Diseases 0.000 claims description 6
- 101000834898 Homo sapiens Alpha-synuclein Proteins 0.000 claims description 6
- 208000032859 Synucleinopathies Diseases 0.000 claims description 6
- 210000004558 lewy body Anatomy 0.000 claims description 5
- 208000001089 Multiple system atrophy Diseases 0.000 claims description 4
- 150000001413 amino acids Chemical class 0.000 claims description 4
- 238000002560 therapeutic procedure Methods 0.000 claims description 4
- 230000002567 autonomic effect Effects 0.000 claims description 3
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims description 2
- 102000001706 Immunoglobulin Fab Fragments Human genes 0.000 claims description 2
- 108010054477 Immunoglobulin Fab Fragments Proteins 0.000 claims description 2
- 102000017727 Immunoglobulin Variable Region Human genes 0.000 claims description 2
- 108010067060 Immunoglobulin Variable Region Proteins 0.000 claims description 2
- 150000007523 nucleic acids Chemical class 0.000 claims description 2
- 102000039446 nucleic acids Human genes 0.000 claims description 2
- 108020004707 nucleic acids Proteins 0.000 claims description 2
- 102000003802 alpha-Synuclein Human genes 0.000 description 25
- 108090000185 alpha-Synuclein Proteins 0.000 description 25
- 238000002360 preparation method Methods 0.000 description 21
- 210000004027 cell Anatomy 0.000 description 9
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- 241000699660 Mus musculus Species 0.000 description 3
- 108091005804 Peptidases Proteins 0.000 description 3
- 239000004365 Protease Substances 0.000 description 3
- 102100037486 Reverse transcriptase/ribonuclease H Human genes 0.000 description 3
- 238000009825 accumulation Methods 0.000 description 3
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- 230000006735 deficit Effects 0.000 description 3
- 210000001320 hippocampus Anatomy 0.000 description 3
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- 238000000338 in vitro Methods 0.000 description 3
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- 238000011552 rat model Methods 0.000 description 3
- 230000007017 scission Effects 0.000 description 3
- 230000005062 synaptic transmission Effects 0.000 description 3
- 238000011830 transgenic mouse model Methods 0.000 description 3
- 238000011282 treatment Methods 0.000 description 3
- 208000023328 Basedow disease Diseases 0.000 description 2
- 208000015023 Graves' disease Diseases 0.000 description 2
- 102000019355 Synuclein Human genes 0.000 description 2
- 108050006783 Synuclein Proteins 0.000 description 2
- 229940079593 drug Drugs 0.000 description 2
- 210000005260 human cell Anatomy 0.000 description 2
- 238000011503 in vivo imaging Methods 0.000 description 2
- 238000011866 long-term treatment Methods 0.000 description 2
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- 241000272814 Anser sp. Species 0.000 description 1
- 206010003840 Autonomic nervous system imbalance Diseases 0.000 description 1
- 102000004190 Enzymes Human genes 0.000 description 1
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- 201000008808 Fibrosarcoma Diseases 0.000 description 1
- 241000238631 Hexapoda Species 0.000 description 1
- 206010035226 Plasma cell myeloma Diseases 0.000 description 1
- 240000004808 Saccharomyces cerevisiae Species 0.000 description 1
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- 210000001124 body fluid Anatomy 0.000 description 1
- 239000010839 body fluid Substances 0.000 description 1
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- 210000004978 chinese hamster ovary cell Anatomy 0.000 description 1
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- 239000003937 drug carrier Substances 0.000 description 1
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- 238000000569 multi-angle light scattering Methods 0.000 description 1
- 201000000050 myeloid neoplasm Diseases 0.000 description 1
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Priority Applications (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2021136539A JP7138322B2 (ja) | 2015-07-13 | 2021-08-24 | シヌクレイノパチーの治療のための薬剤、使用および方法 |
| JP2022136108A JP7608404B2 (ja) | 2015-07-13 | 2022-08-29 | シヌクレイノパチーの治療のための薬剤、使用および方法 |
| JP2024221962A JP2025041734A (ja) | 2015-07-13 | 2024-12-18 | シヌクレイノパチーの治療のための薬剤、使用および方法 |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB1512203.9A GB201512203D0 (en) | 2015-07-13 | 2015-07-13 | Agents,uses and methods |
| GB1512203.9 | 2015-07-13 | ||
| PCT/EP2016/066476 WO2017009312A1 (en) | 2015-07-13 | 2016-07-12 | Agents, uses and methods for the treatment of synucleinopathy |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021136539A Division JP7138322B2 (ja) | 2015-07-13 | 2021-08-24 | シヌクレイノパチーの治療のための薬剤、使用および方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2018529634A JP2018529634A (ja) | 2018-10-11 |
| JP2018529634A5 true JP2018529634A5 (enExample) | 2019-08-15 |
| JP7012004B2 JP7012004B2 (ja) | 2022-02-10 |
Family
ID=54013851
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018501163A Active JP7012004B2 (ja) | 2015-07-13 | 2016-07-12 | シヌクレイノパチーの治療のための薬剤、使用および方法 |
| JP2021136539A Active JP7138322B2 (ja) | 2015-07-13 | 2021-08-24 | シヌクレイノパチーの治療のための薬剤、使用および方法 |
| JP2022136108A Active JP7608404B2 (ja) | 2015-07-13 | 2022-08-29 | シヌクレイノパチーの治療のための薬剤、使用および方法 |
| JP2024221962A Pending JP2025041734A (ja) | 2015-07-13 | 2024-12-18 | シヌクレイノパチーの治療のための薬剤、使用および方法 |
Family Applications After (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021136539A Active JP7138322B2 (ja) | 2015-07-13 | 2021-08-24 | シヌクレイノパチーの治療のための薬剤、使用および方法 |
| JP2022136108A Active JP7608404B2 (ja) | 2015-07-13 | 2022-08-29 | シヌクレイノパチーの治療のための薬剤、使用および方法 |
| JP2024221962A Pending JP2025041734A (ja) | 2015-07-13 | 2024-12-18 | シヌクレイノパチーの治療のための薬剤、使用および方法 |
Country Status (40)
Families Citing this family (30)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB201512203D0 (en) | 2015-07-13 | 2015-08-19 | Lundbeck & Co As H | Agents,uses and methods |
| US11542332B2 (en) | 2016-03-26 | 2023-01-03 | Bioatla, Inc. | Anti-CTLA4 antibodies, antibody fragments, their immunoconjugates and uses thereof |
| MA46836A (fr) | 2016-11-15 | 2019-09-25 | H Lundbeck As | Agents, utilisations et procédés pour le traitement d'une synucléinopathie |
| EP3555127B1 (en) | 2016-12-16 | 2024-12-18 | H. Lundbeck A/S | Agents, uses and methods |
| US10364286B2 (en) | 2016-12-22 | 2019-07-30 | H. Lundbeck A/S | Monoclonal anti-alpha-synuclein antibodies for preventing tau aggregation |
| MX2019008029A (es) | 2017-01-06 | 2019-12-11 | Abl Bio Inc | Anticuerpo anti-alfa-sinucleina y su uso. |
| EA201991720A1 (ru) | 2017-02-17 | 2020-01-20 | Бристол-Маерс Сквибб Компани | Антитела к альфа-синуклеину и их применения |
| EP3600291A4 (en) | 2017-03-27 | 2020-12-23 | Chase Therapeutics Corporation | COMPOSITIONS AND METHODS OF TREATMENT OF SYNUCLEINOPATHIES |
| WO2018204352A1 (en) | 2017-05-01 | 2018-11-08 | The Trustees Of The University Of Pennsylvania | Monoclonal antibodies against alpha-synuclein fibrils |
| EP3672635A4 (en) | 2017-08-23 | 2021-05-12 | The Trustees of The University of Pennsylvania | MONOCLONAL ANTIBODIES AGAINST PATHOLOGICAL ALPHA-SYNUCLEIN AND METHOD OF USING THEREOF |
| AU2018370279B2 (en) * | 2017-11-17 | 2022-11-03 | Abl Bio Inc. | Antibodies to a-synuclein and uses thereof |
| CN111886251A (zh) | 2017-12-14 | 2020-11-03 | Abl生物公司 | 抗a-syn/igf1r的双特异性抗体及其用途 |
| GB201720975D0 (en) | 2017-12-15 | 2018-01-31 | Ucb Biopharma Sprl | Anti-alpha synuclein antibodies |
| GB201720970D0 (en) | 2017-12-15 | 2018-01-31 | Ucb Biopharma Sprl | Antibodies |
| JP2021511829A (ja) * | 2018-01-26 | 2021-05-13 | クアンタム−エスアイ インコーポレイテッドＱｕａｎｔｕｍ−Ｓｉ Ｉｎｃｏｒｐｏｒａｔｅｄ | シークエンシングデバイスに関する機械学習可能なパルス決定および塩基決定 |
| US20210032369A1 (en) * | 2018-02-12 | 2021-02-04 | The Scripps Research Institute | Methods related to parkinson?s disease and synucleinopathies |
| EP3833435B1 (en) * | 2018-08-09 | 2025-09-24 | F. Hoffmann-La Roche AG | Determination of parkinson's disease |
| TWI734279B (zh) * | 2018-12-14 | 2021-07-21 | 美商美國禮來大藥廠 | 抗α-突觸核蛋白抗體及其用途 |
| KR20210154179A (ko) * | 2019-04-18 | 2021-12-20 | 에이씨 이뮨 에스.에이. | 치료 및 진단용 신규한 분자 |
| EP3962492A4 (en) * | 2019-04-29 | 2023-05-31 | Thomas Jefferson University | METHODS OF TREATMENT OF NEURODEGENERATIVE DISEASES |
| US20250340623A1 (en) * | 2019-12-04 | 2025-11-06 | Ac Immune Sa | Novel Molecules for Therapy and Diagnosis |
| KR102466943B1 (ko) * | 2020-04-02 | 2022-11-14 | 한국과학기술연구원 | 갭을 갖는 바이오 센서를 이용한 파킨슨병 모니터링 방법 및 시스템 |
| CN111537738A (zh) * | 2020-05-18 | 2020-08-14 | 南通大学附属医院 | 用于超早期帕金森病检测的试剂盒 |
| MX2024002684A (es) * | 2021-09-01 | 2024-05-16 | Vaxxinity Inc | Metodos para la prevencion y tratamiento de sinucleinopatias. |
| CA3230055A1 (en) | 2021-09-16 | 2023-03-23 | Josefine Nielsen Soderberg | Compositions and methods for treating synucleinopathies |
| CN117430686B (zh) * | 2022-07-22 | 2025-07-01 | 深圳市安群生物工程有限公司 | α-突触核蛋白抗原表位肽及测定唾液中SNCA试剂盒和在帕金森病诊断中的应用 |
| WO2024177999A2 (en) * | 2023-02-21 | 2024-08-29 | The Regents Of The University Of Michigan | Human aggregated alpha-synuclein binding molecules |
| CN116077524A (zh) * | 2023-02-27 | 2023-05-09 | 广西馨海药业科技有限公司 | 氯化铷在制备治疗帕金森综合征的药物中的用途 |
| WO2025076635A1 (en) * | 2023-10-12 | 2025-04-17 | Universite Laval | Anti-alpha-synuclein antibodies and uses thereof |
| US20250282855A1 (en) | 2024-03-05 | 2025-09-11 | H. Lundbeck A/S | Compositions and methods for treating multiple system atrophy (msa) |
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