JP2018525333A5 - - Google Patents

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Publication number
JP2018525333A5
JP2018525333A5 JP2017565189A JP2017565189A JP2018525333A5 JP 2018525333 A5 JP2018525333 A5 JP 2018525333A5 JP 2017565189 A JP2017565189 A JP 2017565189A JP 2017565189 A JP2017565189 A JP 2017565189A JP 2018525333 A5 JP2018525333 A5 JP 2018525333A5
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JP
Japan
Prior art keywords
tnfα
trimer
compound
antibody
binding
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JP2017565189A
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English (en)
Japanese (ja)
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JP6948954B2 (ja
JP2018525333A (ja
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Priority claimed from GBGB1510758.4A external-priority patent/GB201510758D0/en
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Publication of JP2018525333A publication Critical patent/JP2018525333A/ja
Publication of JP2018525333A5 publication Critical patent/JP2018525333A5/ja
Priority to JP2021095909A priority Critical patent/JP2021153592A/ja
Application granted granted Critical
Publication of JP6948954B2 publication Critical patent/JP6948954B2/ja
Active legal-status Critical Current
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JP2017565189A 2015-06-18 2015-10-22 抗体エピトープ Active JP6948954B2 (ja)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP2021095909A JP2021153592A (ja) 2015-06-18 2021-06-08 抗体エピトープ

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB1510758.4 2015-06-18
GBGB1510758.4A GB201510758D0 (en) 2015-06-18 2015-06-18 Novel TNFa structure for use in therapy
PCT/EP2015/074532 WO2016202415A1 (en) 2015-06-18 2015-10-22 Antibody epitope

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2021095909A Division JP2021153592A (ja) 2015-06-18 2021-06-08 抗体エピトープ

Publications (3)

Publication Number Publication Date
JP2018525333A JP2018525333A (ja) 2018-09-06
JP2018525333A5 true JP2018525333A5 (https=) 2018-11-29
JP6948954B2 JP6948954B2 (ja) 2021-10-13

Family

ID=53784155

Family Applications (12)

Application Number Title Priority Date Filing Date
JP2017565189A Active JP6948954B2 (ja) 2015-06-18 2015-10-22 抗体エピトープ
JP2017565114A Active JP7336178B2 (ja) 2015-06-18 2015-10-22 治療における使用のための新規のTNFα構造
JP2017565173A Active JP6659030B2 (ja) 2015-06-18 2015-10-22 作用機構
JP2017565155A Active JP6781718B2 (ja) 2015-06-18 2015-10-22 モジュレータアッセイ
JP2017565174A Active JP6951256B2 (ja) 2015-06-18 2015-10-22 抗体
JP2019154528A Active JP6752344B2 (ja) 2015-06-18 2019-08-27 作用機構
JP2020174314A Pending JP2021038222A (ja) 2015-06-18 2020-10-16 モジュレータアッセイ
JP2021020352A Pending JP2021109880A (ja) 2015-06-18 2021-02-12 治療における使用のための新規のTNFα構造
JP2021095909A Abandoned JP2021153592A (ja) 2015-06-18 2021-06-08 抗体エピトープ
JP2021155537A Active JP7159420B2 (ja) 2015-06-18 2021-09-24 抗体
JP2023001089A Pending JP2023052250A (ja) 2015-06-18 2023-01-06 モジュレータアッセイ
JP2023046164A Pending JP2023100010A (ja) 2015-06-18 2023-03-23 治療における使用のための新規のTNFα構造

Family Applications After (11)

Application Number Title Priority Date Filing Date
JP2017565114A Active JP7336178B2 (ja) 2015-06-18 2015-10-22 治療における使用のための新規のTNFα構造
JP2017565173A Active JP6659030B2 (ja) 2015-06-18 2015-10-22 作用機構
JP2017565155A Active JP6781718B2 (ja) 2015-06-18 2015-10-22 モジュレータアッセイ
JP2017565174A Active JP6951256B2 (ja) 2015-06-18 2015-10-22 抗体
JP2019154528A Active JP6752344B2 (ja) 2015-06-18 2019-08-27 作用機構
JP2020174314A Pending JP2021038222A (ja) 2015-06-18 2020-10-16 モジュレータアッセイ
JP2021020352A Pending JP2021109880A (ja) 2015-06-18 2021-02-12 治療における使用のための新規のTNFα構造
JP2021095909A Abandoned JP2021153592A (ja) 2015-06-18 2021-06-08 抗体エピトープ
JP2021155537A Active JP7159420B2 (ja) 2015-06-18 2021-09-24 抗体
JP2023001089A Pending JP2023052250A (ja) 2015-06-18 2023-01-06 モジュレータアッセイ
JP2023046164A Pending JP2023100010A (ja) 2015-06-18 2023-03-23 治療における使用のための新規のTNFα構造

Country Status (16)

Country Link
US (12) US10705094B2 (https=)
EP (8) EP3311170B1 (https=)
JP (12) JP6948954B2 (https=)
KR (2) KR102599907B1 (https=)
CN (6) CN108290945B (https=)
AU (2) AU2015398984B2 (https=)
CA (4) CA2988723A1 (https=)
CL (2) CL2017003189A1 (https=)
EA (4) EA201890080A1 (https=)
ES (5) ES2895486T3 (https=)
GB (1) GB201510758D0 (https=)
IL (2) IL256099B2 (https=)
MX (2) MX2017015481A (https=)
PL (4) PL3311170T3 (https=)
PT (4) PT3311171T (https=)
WO (5) WO2016202413A1 (https=)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JOP20200043A1 (ar) 2011-05-10 2017-06-16 Amgen Inc طرق معالجة أو منع الاضطرابات المختصة بالكوليسترول
DK3277719T3 (da) 2015-03-31 2022-05-02 Sorriso Pharmaceuticals Inc Polypeptider
WO2016156468A1 (en) 2015-03-31 2016-10-06 Vhsquared Limited Polypeptides
HK1250011A1 (zh) 2015-03-31 2018-11-23 Sorriso Pharmaceuticals, Inc. 具有蛋白酶可切割接头的肽构建体
US9879016B2 (en) 2015-04-17 2018-01-30 Abbvie Inc. Indazolones as modulators of TNF signaling
EP3288939A1 (en) 2015-04-17 2018-03-07 AbbVie Inc. Tricyclic modulators of tnf signaling
WO2016168633A1 (en) 2015-04-17 2016-10-20 Abbvie Inc. Indazolones as modulators of tnf signaling
GB201510758D0 (en) 2015-06-18 2015-08-05 Ucb Biopharma Sprl Novel TNFa structure for use in therapy
GB201522394D0 (en) 2015-12-18 2016-02-03 Ucb Biopharma Sprl Antibodies
EP3519438A1 (en) 2016-09-30 2019-08-07 VHsquared Limited Compositions
WO2018119142A1 (en) 2016-12-21 2018-06-28 Amgen Inc. Anti-tnf alpha antibody formulations
GB201621907D0 (en) 2016-12-21 2017-02-01 Ucb Biopharma Sprl And Sanofi Antibody epitope
CN116462666B (zh) * 2017-01-10 2025-07-15 瑞士苏黎世联邦理工学院 细胞保护性化合物及其用途
WO2020254827A1 (en) 2019-06-21 2020-12-24 Vhsquared Limited Polypeptides
KR20220063148A (ko) 2019-06-21 2022-05-17 소리소 파마슈티컬스 인크. 조성물
JP7680377B2 (ja) 2019-06-21 2025-05-20 ソリッソ ファーマシューティカルズ,インク. ポリペプチド
JP7561364B2 (ja) * 2020-04-30 2024-10-04 国立大学法人東北大学 蛍光偏光免疫分析法

Family Cites Families (125)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0288088B1 (en) 1987-04-24 1994-03-09 Teijin Limited Detection of tumor necrosis factor; monoclonal antibody and kit
EP0436597B1 (en) 1988-09-02 1997-04-02 Protein Engineering Corporation Generation and selection of recombinant varied binding proteins
US5223409A (en) 1988-09-02 1993-06-29 Protein Engineering Corp. Directed evolution of novel binding proteins
GB8823869D0 (en) 1988-10-12 1988-11-16 Medical Res Council Production of antibodies
US4908372A (en) 1988-10-13 1990-03-13 Merrell Dow Pharmaceuticals Inc. Antihistaminic piperidinyl benzimidazoles
DE3843534A1 (de) 1988-12-23 1990-07-12 Basf Ag Neue tnf-polypeptide
US6448380B2 (en) 1989-08-07 2002-09-10 Peptech Limited Tumor necrosis factor antibodies
GB8928874D0 (en) 1989-12-21 1990-02-28 Celltech Ltd Humanised antibodies
WO1991010737A1 (en) 1990-01-11 1991-07-25 Molecular Affinities Corporation Production of antibodies using gene libraries
US5780225A (en) 1990-01-12 1998-07-14 Stratagene Method for generating libaries of antibody genes comprising amplification of diverse antibody DNAs and methods for using these libraries for the production of diverse antigen combining molecules
EP1690934A3 (en) 1990-01-12 2008-07-30 Abgenix, Inc. Generation of xenogeneic antibodies
US5427908A (en) 1990-05-01 1995-06-27 Affymax Technologies N.V. Recombinant library screening methods
GB9015198D0 (en) 1990-07-10 1990-08-29 Brien Caroline J O Binding substance
EP0542810A1 (en) 1990-08-02 1993-05-26 B.R. Centre Limited Methods for the production of proteins with a desired function
US5545806A (en) 1990-08-29 1996-08-13 Genpharm International, Inc. Ransgenic non-human animals for producing heterologous antibodies
US5770429A (en) 1990-08-29 1998-06-23 Genpharm International, Inc. Transgenic non-human animals capable of producing heterologous antibodies
US5625126A (en) 1990-08-29 1997-04-29 Genpharm International, Inc. Transgenic non-human animals for producing heterologous antibodies
US5661016A (en) 1990-08-29 1997-08-26 Genpharm International Inc. Transgenic non-human animals capable of producing heterologous antibodies of various isotypes
ATE300615T1 (de) 1990-08-29 2005-08-15 Genpharm Int Transgene mäuse fähig zur produktion heterologer antikörper
US5633425A (en) 1990-08-29 1997-05-27 Genpharm International, Inc. Transgenic non-human animals capable of producing heterologous antibodies
US5698426A (en) 1990-09-28 1997-12-16 Ixsys, Incorporated Surface expression libraries of heteromeric receptors
CA2405246A1 (en) 1990-12-03 1992-06-11 Genentech, Inc. Enrichment method for variant proteins with alterred binding properties
GB9028123D0 (en) 1990-12-28 1991-02-13 Erba Carlo Spa Monoclonal antibodies against human tumor necrosis factor alpha
DK0580737T3 (da) 1991-04-10 2004-11-01 Scripps Research Inst Heterodimere receptorbiblioteker ved anvendelse af phagemider
GB9113120D0 (en) 1991-06-18 1991-08-07 Kodak Ltd Photographic processing apparatus
IT1249708B (it) 1991-09-23 1995-03-09 Tecnogen Scpa Metodo per la determinazione del fattore di necrosi tumorale (tnf) in forma biologicamente attiva.
ES2341666T3 (es) 1991-12-02 2010-06-24 Medimmune Limited Produccion de autoanticuerpos de repertorios de segmentos de anticue rpos expresados en la superficie de fagos.
AU3347493A (en) 1992-01-09 1993-08-03 Janssen Pharmaceutica N.V. Pharmaceutically active substituted benzimidazole derivatives
US5733743A (en) 1992-03-24 1998-03-31 Cambridge Antibody Technology Limited Methods for producing members of specific binding pairs
WO1994018325A1 (en) 1993-02-03 1994-08-18 N.V. Innogenetics S.A. Tnf-alpha muteins and a process for preparing them
CA2119089A1 (en) 1993-03-29 1994-09-30 David Banner Tumor necrosis factor muteins
EP0733070A1 (en) 1993-12-08 1996-09-25 Genzyme Corporation Process for generating specific antibodies
PT1231268E (pt) 1994-01-31 2005-11-30 Univ Boston Bancos de anticorpos policlonais
US5516637A (en) 1994-06-10 1996-05-14 Dade International Inc. Method involving display of protein binding pairs on the surface of bacterial pili and bacteriophage
DE4440613C1 (de) 1994-11-14 1996-07-25 Leica Ag Vorrichtung und Verfahren zur Detektion und Demodulation eines intensitätsmodulierten Strahlungsfeldes
TW453995B (en) 1995-12-15 2001-09-11 Novartis Ag Certain alpha-substituted arylsulfonamido acetohydroxamic acids
JP2978435B2 (ja) 1996-01-24 1999-11-15 チッソ株式会社 アクリロキシプロピルシランの製造方法
CN1204230A (zh) 1997-12-08 1999-01-06 李建安 一种手提电话机用防护罩及其制做方法
US20040009535A1 (en) 1998-11-27 2004-01-15 Celltech R&D, Inc. Compositions and methods for increasing bone mineralization
GB9828628D0 (en) * 1998-12-23 1999-02-17 Glaxo Group Ltd Novel ligand
US7101974B2 (en) * 2000-03-02 2006-09-05 Xencor TNF-αvariants
AU8704101A (en) 2000-09-01 2002-03-13 Biogen Inc Novel cd40:cd154 binding interruptor compounds and use thereof to treat immunological complications
AU2002310156A1 (en) 2001-06-05 2002-12-16 Boehringer Ingelheim Pharmaceuticals, Inc. 1,4-disubstituted benzo-fused cycloalkyl urea compounds
US6632810B2 (en) 2001-06-29 2003-10-14 Kowa Co., Ltd. Cyclic diamine compound with condensed-ring groups
JP2003040888A (ja) 2001-07-30 2003-02-13 Sankyo Co Ltd イミダゾール誘導体
WO2004012673A2 (en) 2002-08-01 2004-02-12 Wyeth, Methods and reagents relating to inflammation and apoptosis
US7993864B2 (en) 2002-12-03 2011-08-09 Ucb Pharma S.A. Assay for identifying antibody producing cells
NZ543976A (en) 2003-05-09 2008-04-30 Pharmexa As Immunogenic human TNF alpha analogues with reduced cytotoxicity and methods of their preparation
GB0312481D0 (en) 2003-05-30 2003-07-09 Celltech R&D Ltd Antibodies
GB0315450D0 (en) 2003-07-01 2003-08-06 Celltech R&D Ltd Biological products
GB0315457D0 (en) 2003-07-01 2003-08-06 Celltech R&D Ltd Biological products
ES2551439T5 (es) 2003-07-01 2018-11-08 Ucb Biopharma Sprl Fragmentos Fab de anticuerpos modificados
CN102408483B (zh) 2003-07-15 2016-06-08 安姆根有限公司 作为选择性ngf途径抑制剂的人抗ngf中和抗体
US7268116B2 (en) 2003-10-02 2007-09-11 Genhunter Corp. Methods and compositions for producing secreted trimeric receptor analogs and biologically active fusion proteins
TW200526780A (en) * 2004-01-06 2005-08-16 Hayashibara Biochem Lab TNF antagonists and TNF inhibitors comprising the same as the active ingredient
GB0411186D0 (en) 2004-05-19 2004-06-23 Celltech R&D Ltd Biological products
WO2006122787A1 (en) * 2005-05-18 2006-11-23 Ablynx Nv Serum albumin binding proteins
DE102005023617A1 (de) 2005-05-21 2006-11-23 Aspre Ag Verfahren zum Mischen von Farben in einem Display
WO2007060411A1 (en) 2005-11-24 2007-05-31 Ucb Pharma S.A. Anti-tnf alpha antibodies which selectively inhibit tnf alpha signalling through the p55r
TW201531484A (zh) 2007-05-21 2015-08-16 Alder Biopharmaceuticals Inc 抗TNF-α之抗體及其用途
KR20170036814A (ko) 2007-05-21 2017-04-03 앨더바이오 홀딩스 엘엘씨 신규한 래빗 항체 인간화 방법 및 인간화된 래빗 항체
CL2008002278A1 (es) * 2007-08-03 2009-07-17 Alcon Res Ltd Metodo para el tratamiento de una enfermedad ocular relacionada al tnfalfa; metodo para la atenuacion de la expresion del arnm de tace o tnfr1 en el ojo de un paciente.
WO2009040562A1 (en) 2007-09-26 2009-04-02 Ucb Pharma S.A. Dual specificity antibody fusions
US9365644B2 (en) 2008-04-23 2016-06-14 Epitomics, Inc. Anti-TNFα antibody
MX345039B (es) 2008-06-25 2017-01-16 Esbatech Alcon Biomed Res Unit Anticuerpos estables y solubles que inhiben el tnfa.
CA2744365A1 (en) 2008-11-20 2010-05-27 Panacea Biotec Ltd. Tumor necrosis factor alpha inhibiting peptides and uses thereof
JP2010172307A (ja) 2009-01-30 2010-08-12 Saitama Medical Univ 関節リウマチに対する可溶性TNFα/LTαレセプター薬の薬効予測方法、及び薬効予測装置
WO2010118404A2 (en) 2009-04-09 2010-10-14 California Institute Of Technology Methods for creating or identifying compounds that bind tumor necrosis factor alpha
US8722860B2 (en) 2009-04-16 2014-05-13 Abbvie Biotherapeutics Inc. Anti-TNF-α antibodies and their uses
WO2011127141A1 (en) 2010-04-07 2011-10-13 Abbott Laboratories TNF-α BINDING PROTEINS
US8377441B2 (en) * 2010-08-03 2013-02-19 National Cheng Kung University Treating breast cancer with anti-IL-19 antibody
WO2012058649A1 (en) * 2010-10-30 2012-05-03 Kindex Therapeutics, Llc Cis 3,4-dihydroxy-2-(3-methylbutanoyl)-5-(-3-methylbutyl)-4-(4-methylpentanoyl)cyclopent-2-en-1-one derivatives, substantially enantiomerically pure compositions and methods
AR084210A1 (es) 2010-12-08 2013-05-02 Abbott Lab PROTEINAS DE UNION AL TNF-a
WO2012172070A1 (en) 2011-06-17 2012-12-20 Glaxo Group Limited Tumour necrosis factor receptor 1 antagonists
WO2013024040A2 (en) 2011-08-12 2013-02-21 B.S.R.C. Alexander Fleming Tnf superfamily trimerization inhibitors
US9550737B2 (en) * 2012-06-11 2017-01-24 Ucb Biopharma Sprl TNF -α modulating benzimidazoles
WO2014001557A1 (en) 2012-06-28 2014-01-03 Ucb Pharma S.A. A method for identifying compounds of therapeutic interest
GB201212513D0 (en) 2012-07-13 2012-08-29 Ucb Pharma Sa Therapeutic agents
CN104619709B (zh) * 2012-07-13 2016-11-09 Ucb生物制药私人有限公司 作为tnf活性调节剂的咪唑并吡啶衍生物
WO2014040076A1 (en) 2012-09-10 2014-03-13 Xencor Methods of treating neurological diseases
KR101759687B1 (ko) 2013-01-25 2017-07-19 타이몬, 엘엘씨 순환하는 생물활성 가용성 tnf의 선택적 감소를 위한 조성물 및 tnf-매개 질환의 치료 방법
EP2969209A2 (en) 2013-03-12 2016-01-20 Anellotech, Inc. Regeneration of catalytic fast pyrolysis catalyst
US9908944B2 (en) * 2013-07-15 2018-03-06 Novo Nordisk A/S Antibodies that bind urokinase plasminogen activator
GB201321746D0 (en) 2013-12-09 2014-01-22 Ucb Pharma Sa Therapeutic agents
GB201321730D0 (en) 2013-12-09 2014-01-22 Ucb Pharma Sa Therapeutic agents
GB201321743D0 (en) 2013-12-09 2014-01-22 Ucb Pharma Sa Therapeutic agents
GB201321728D0 (en) 2013-12-09 2014-01-22 Ucb Pharma Sa Therapeutic agents
GB201321742D0 (en) 2013-12-09 2014-01-22 Ucb Pharma Sa Therapeutic agents
GB201321741D0 (en) 2013-12-09 2014-01-22 Ucb Pharma Sa Therapeutic agents
US9920052B2 (en) 2013-12-09 2018-03-20 Ucb Biopharma Sprl Imidazopyridine derivatives as modulators of TNF activity
GB201321734D0 (en) 2013-12-09 2014-01-22 Ucb Pharma Sa Therapeutic Agents
GB201321737D0 (en) 2013-12-09 2014-01-22 Ucb Pharma Sa Therapeutic Agents
GB201321735D0 (en) 2013-12-09 2014-01-22 Ucb Pharma Sa Therapeutic Agents
GB201321739D0 (en) 2013-12-09 2014-01-22 Ucb Pharma Sa Therapeutic agents
GB201321749D0 (en) 2013-12-09 2014-01-22 Ucb Pharma Sa Therapeutic agents
GB201321732D0 (en) 2013-12-09 2014-01-22 Ucb Pharma Sa Therapeutic agents
GB201321738D0 (en) 2013-12-09 2014-01-22 Ucb Pharma Sa Therapeutic Agents
GB201321733D0 (en) 2013-12-09 2014-01-22 Ucb Pharma Sa Therapeutic agents
RU2685234C1 (ru) 2013-12-09 2019-04-17 Юсб Байофарма Спрл Конденсированные бициклические гетероароматические производные в качестве модуляторов активности tnf
GB201321744D0 (en) 2013-12-09 2014-01-22 Ucb Pharma Sa Therapeutic agents
GB201321729D0 (en) 2013-12-09 2014-01-22 Ucb Pharma Sa Therapeutic agents
GB201321736D0 (en) 2013-12-09 2014-01-22 Ucb Pharma Sa Therapeutic agents
GB201321745D0 (en) 2013-12-09 2014-01-22 Ucb Pharma Sa Therapeutic agents
GB201321731D0 (en) 2013-12-09 2014-01-22 Ucb Pharma Sa Therapeutic agents
GB201321740D0 (en) 2013-12-09 2014-01-22 Ucb Pharma Sa Therapeutic agents
GB201321748D0 (en) 2013-12-09 2014-01-22 Ucb Pharma Sa Therapeutic agents
MX380578B (es) 2014-10-03 2025-03-12 Ucb Biopharma Sprl Derivados de imidazol pentaciclicos fusionados.
BR112017015661A2 (pt) 2015-01-30 2018-03-20 Saitama Medical University anticorpo anti-alk2
CN107635993B (zh) 2015-03-18 2020-05-22 百时美施贵宝公司 取代的三环杂环化合物
WO2016149439A1 (en) 2015-03-18 2016-09-22 Bristol-Myers Squibb Company Heterocyclic compounds useful as inhibitors of tnf
ES2797685T3 (es) 2015-03-18 2020-12-03 Bristol Myers Squibb Co Compuestos heterocíclicos tricíclicos útiles como inhibidores de TNF
EP3288939A1 (en) 2015-04-17 2018-03-07 AbbVie Inc. Tricyclic modulators of tnf signaling
WO2016168633A1 (en) 2015-04-17 2016-10-20 Abbvie Inc. Indazolones as modulators of tnf signaling
US9879016B2 (en) 2015-04-17 2018-01-30 Abbvie Inc. Indazolones as modulators of TNF signaling
GB201509893D0 (en) 2015-06-08 2015-07-22 Ucb Biopharma Sprl Therapeutic agents
GB201509888D0 (en) 2015-06-08 2015-07-22 Ucb Biopharma Sprl Therapeutic agents
GB201509885D0 (en) 2015-06-08 2015-07-22 Ucb Biopharma Sprl Therapeutic agents
GB201510758D0 (en) 2015-06-18 2015-08-05 Ucb Biopharma Sprl Novel TNFa structure for use in therapy
BR112018001980A2 (pt) 2015-08-03 2018-09-18 Bristol Myers Squibb Co compostos cíclicos úteis como moduladores de tnf alfa
PE20181366A1 (es) 2015-08-03 2018-08-27 Bristol Myers Squibb Co Compuestos heterociclicos utiles como moduladores de factor de necrosis tumoral (tnf) alfa
US10766906B2 (en) 2016-04-01 2020-09-08 UCB Biopharma SRL Fused hexacyclic imidazole derivatives as modulators of TNF activity
EP3436458B1 (en) 2016-04-01 2021-06-02 UCB Biopharma SRL Fused pentacyclic imidazole derivatives as modulators of tnf activity
EA201892153A1 (ru) 2016-04-01 2019-04-30 Юсб Байофарма Спрл Конденсированные пентациклические производные имидазола в качестве модуляторов активности tnf
JP6968090B2 (ja) 2016-04-01 2021-11-17 ユーシービー バイオファルマ エスアールエル Tnf活性のモジュレーターとしての縮合五環式イミダゾール誘導体
GB201621907D0 (en) 2016-12-21 2017-02-01 Ucb Biopharma Sprl And Sanofi Antibody epitope

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