JP2018515071A5 - - Google Patents
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- Publication number
- JP2018515071A5 JP2018515071A5 JP2017554283A JP2017554283A JP2018515071A5 JP 2018515071 A5 JP2018515071 A5 JP 2018515071A5 JP 2017554283 A JP2017554283 A JP 2017554283A JP 2017554283 A JP2017554283 A JP 2017554283A JP 2018515071 A5 JP2018515071 A5 JP 2018515071A5
- Authority
- JP
- Japan
- Prior art keywords
- seq
- antibody
- sequence
- heavy chain
- light chain
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 6
- 238000001514 detection method Methods 0.000 claims 6
- 238000000034 method Methods 0.000 claims 5
- 108090000765 processed proteins & peptides Proteins 0.000 claims 5
- 101100112922 Candida albicans CDR3 gene Proteins 0.000 claims 4
- 102100035360 Cerebellar degeneration-related antigen 1 Human genes 0.000 claims 4
- 102100035361 Cerebellar degeneration-related protein 2 Human genes 0.000 claims 4
- 101000737793 Homo sapiens Cerebellar degeneration-related antigen 1 Proteins 0.000 claims 4
- 101000737796 Homo sapiens Cerebellar degeneration-related protein 2 Proteins 0.000 claims 4
- 239000012634 fragment Substances 0.000 claims 4
- 206010028980 Neoplasm Diseases 0.000 claims 2
- 125000003275 alpha amino acid group Chemical group 0.000 claims 2
- 150000001413 amino acids Chemical class 0.000 claims 2
- 238000001917 fluorescence detection Methods 0.000 claims 2
- 230000003053 immunization Effects 0.000 claims 2
- 241001465754 Metazoa Species 0.000 claims 1
- 241000283973 Oryctolagus cuniculus Species 0.000 claims 1
- 239000002299 complementary DNA Substances 0.000 claims 1
- 230000002163 immunogen Effects 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562149239P | 2015-04-17 | 2015-04-17 | |
| US62/149,239 | 2015-04-17 | ||
| PCT/EP2016/058135 WO2016166169A1 (en) | 2015-04-17 | 2016-04-13 | Antibodies, compositions, and immunohistochemistry methods for detecting c4.4a |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2018515071A JP2018515071A (ja) | 2018-06-14 |
| JP2018515071A5 true JP2018515071A5 (https=) | 2019-03-07 |
| JP6720208B2 JP6720208B2 (ja) | 2020-07-08 |
Family
ID=55702016
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017554283A Active JP6720208B2 (ja) | 2015-04-17 | 2016-04-13 | Ｃ４．４ａを検出するための抗体、組成物、及び免疫組織化学法 |
Country Status (6)
| Country | Link |
|---|---|
| US (2) | US10948493B2 (https=) |
| EP (1) | EP3283522A1 (https=) |
| JP (1) | JP6720208B2 (https=) |
| AU (1) | AU2016249839B2 (https=) |
| CA (1) | CA2982536C (https=) |
| WO (1) | WO2016166169A1 (https=) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2016166169A1 (en) * | 2015-04-17 | 2016-10-20 | Spring Bioscience Corporation | Antibodies, compositions, and immunohistochemistry methods for detecting c4.4a |
| CN111349164B (zh) * | 2018-12-21 | 2023-05-26 | 艾比玛特医药科技（上海）有限公司 | 糖基磷脂酰肌醇锚定糖蛋白（c4.4a）的单克隆抗体及其应用 |
| EP4351602A4 (en) * | 2021-06-11 | 2025-07-30 | Memorial Sloan Kettering Cancer Center | UPAR-TARGETING ANTIGEN-RECOGNIZING RECEPTORS AND THEIR USES |
| IL315431A (en) * | 2022-03-16 | 2024-11-01 | Pentixapharm Ag | Antibodies against lypd3 |
| EP4536278A2 (en) | 2022-06-07 | 2025-04-16 | Actinium Pharmaceuticals, Inc. | Bifunctional chelators and conjugates |
| CN116086919B (zh) * | 2023-02-20 | 2024-01-26 | 深圳裕策生物科技有限公司 | 一种肺癌和/或胰腺癌样本的染色方法及试剂盒 |
| WO2025149667A1 (en) | 2024-01-12 | 2025-07-17 | Pheon Therapeutics Ltd | Antibody drug conjugates and uses thereof |
Family Cites Families (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1220919A2 (en) | 1999-09-29 | 2002-07-10 | Deutsches Krebsforschungszentrum Stiftung des öffentlichen Rechts | Metastasis-associated antigen c4.4a |
| US6649138B2 (en) | 2000-10-13 | 2003-11-18 | Quantum Dot Corporation | Surface-modified semiconductive and metallic nanoparticles having enhanced dispersibility in aqueous media |
| US20020083888A1 (en) | 2000-12-28 | 2002-07-04 | Zehnder Donald A. | Flow synthesis of quantum dot nanocrystals |
| US6670113B2 (en) | 2001-03-30 | 2003-12-30 | Nanoprobes | Enzymatic deposition and alteration of metals |
| EP1409240B1 (en) | 2001-07-20 | 2012-05-09 | Life Technologies Corporation | Luminescent nanoparticles and methods for their preparation |
| EP1532175B1 (en) | 2002-03-22 | 2012-10-17 | Aprogen, Inc. | Humanized antibody and process for preparing the same |
| US7642064B2 (en) | 2003-06-24 | 2010-01-05 | Ventana Medical Systems, Inc. | Enzyme-catalyzed metal deposition for the enhanced detection of analytes of interest |
| DK1636586T3 (da) | 2003-06-24 | 2009-11-23 | Ventana Med Syst Inc | Enzymkatalyseret metaldeponering til foröget in situ-detektion af immunhistokemisker epitoper og nucleinsyresekvenser |
| WO2008063378A2 (en) | 2006-11-01 | 2008-05-29 | Ventana Medical Systems, Inc. | Haptens, hapten conjugates, compositions thereof and method for their preparation and use |
| KR20170036814A (ko) * | 2007-05-21 | 2017-04-03 | 앨더바이오 홀딩스 엘엘씨 | 신규한 래빗 항체 인간화 방법 및 인간화된 래빗 항체 |
| WO2009040562A1 (en) * | 2007-09-26 | 2009-04-02 | Ucb Pharma S.A. | Dual specificity antibody fusions |
| PT2510012T (pt) * | 2009-12-09 | 2017-07-13 | Bayer Pharma AG | Anticorpos anti-c4.4a e utilizações dos mesmos |
| WO2011158883A1 (ja) | 2010-06-15 | 2011-12-22 | 国立大学法人大阪大学 | 癌予後判定可能な抗体、および癌予後判定方法 |
| KR102023496B1 (ko) | 2011-04-21 | 2019-09-20 | 시애틀 지네틱스, 인크. | 신규 결합제-약물 콘주게이트 (adc) 및 그의 용도 |
| CA2834535A1 (en) * | 2011-04-29 | 2012-11-01 | Celgene Corporation | Methods for the treatment of cancer and inflammatory diseases using cereblon as a predictor |
| US20120295803A1 (en) | 2011-05-16 | 2012-11-22 | The Regents Of The University Of Michigan | Lung cancer signature |
| KR20150013935A (ko) | 2012-06-08 | 2015-02-05 | 갓코 호진 긴키 다이가쿠 | 트랜스포터에 대한 항체 및 이의 용도 |
| WO2014183119A1 (en) | 2013-05-10 | 2014-11-13 | H. Lee Moffitt Cancer Center And Research Institute, Inc. | Molecular imaging probes for lung cancer inoperative guidance |
| WO2014186878A1 (en) * | 2013-05-24 | 2014-11-27 | Cashman Neil R | Cell senescence markers as diagnostic and therapeutic targets |
| US10428159B2 (en) * | 2014-09-09 | 2019-10-01 | Board Of Regents, The University Of Texas System | Blocking monoclonal antibodies to AGR2 and its receptor C4.4A |
| WO2016166169A1 (en) * | 2015-04-17 | 2016-10-20 | Spring Bioscience Corporation | Antibodies, compositions, and immunohistochemistry methods for detecting c4.4a |
-
2016
- 2016-04-13 WO PCT/EP2016/058135 patent/WO2016166169A1/en not_active Ceased
- 2016-04-13 CA CA2982536A patent/CA2982536C/en active Active
- 2016-04-13 AU AU2016249839A patent/AU2016249839B2/en active Active
- 2016-04-13 EP EP16715595.1A patent/EP3283522A1/en not_active Withdrawn
- 2016-04-13 JP JP2017554283A patent/JP6720208B2/ja active Active
-
2017
- 2017-10-12 US US15/782,804 patent/US10948493B2/en active Active
-
2021
- 2021-02-05 US US17/248,767 patent/US11719699B2/en active Active
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