JP2018521663A5 - - Google Patents
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- Publication number
- JP2018521663A5 JP2018521663A5 JP2018503642A JP2018503642A JP2018521663A5 JP 2018521663 A5 JP2018521663 A5 JP 2018521663A5 JP 2018503642 A JP2018503642 A JP 2018503642A JP 2018503642 A JP2018503642 A JP 2018503642A JP 2018521663 A5 JP2018521663 A5 JP 2018521663A5
- Authority
- JP
- Japan
- Prior art keywords
- immune response
- response cell
- cell according
- binding element
- receptor
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2021114022A JP2021168675A (ja) | 2015-07-31 | 2021-07-09 | 治療薬 |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB1513540.3A GB201513540D0 (en) | 2015-07-31 | 2015-07-31 | Therapeutic agents |
| GB1513540.3 | 2015-07-31 | ||
| PCT/GB2016/052324 WO2017021701A1 (en) | 2015-07-31 | 2016-07-28 | Therapeutic agents |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021114022A Division JP2021168675A (ja) | 2015-07-31 | 2021-07-09 | 治療薬 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2018521663A JP2018521663A (ja) | 2018-08-09 |
| JP2018521663A5 true JP2018521663A5 (enExample) | 2019-08-29 |
| JP7053037B2 JP7053037B2 (ja) | 2022-04-12 |
Family
ID=54062973
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018503642A Active JP7053037B2 (ja) | 2015-07-31 | 2016-07-28 | 治療薬 |
| JP2021114022A Pending JP2021168675A (ja) | 2015-07-31 | 2021-07-09 | 治療薬 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021114022A Pending JP2021168675A (ja) | 2015-07-31 | 2021-07-09 | 治療薬 |
Country Status (14)
| Country | Link |
|---|---|
| US (6) | US10703794B2 (enExample) |
| EP (2) | EP3328880B1 (enExample) |
| JP (2) | JP7053037B2 (enExample) |
| KR (1) | KR102411571B1 (enExample) |
| CN (1) | CN107735407B (enExample) |
| AU (1) | AU2016303355B2 (enExample) |
| DK (1) | DK3328880T3 (enExample) |
| ES (1) | ES2883633T3 (enExample) |
| GB (1) | GB201513540D0 (enExample) |
| IL (1) | IL256511B (enExample) |
| MX (1) | MX2018001009A (enExample) |
| RU (1) | RU2747733C1 (enExample) |
| SG (1) | SG10201912416QA (enExample) |
| WO (1) | WO2017021701A1 (enExample) |
Families Citing this family (44)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SG11201505858VA (en) | 2013-01-28 | 2015-09-29 | St Jude Childrens Res Hospital | A chimeric receptor with nkg2d specificity for use in cell therapy against cancer and infectious disease |
| EP3805371A1 (en) | 2014-05-15 | 2021-04-14 | National University of Singapore | Modified natural killer cells and uses thereof |
| GB201513540D0 (en) | 2015-07-31 | 2015-09-16 | King S College London | Therapeutic agents |
| GB201514874D0 (en) | 2015-08-20 | 2015-10-07 | Autolus Ltd | Cell |
| US11590167B2 (en) | 2016-12-03 | 2023-02-28 | Juno Therapeutic, Inc. | Methods and compositions for use of therapeutic T cells in combination with kinase inhibitors |
| EP3336107A1 (en) * | 2016-12-15 | 2018-06-20 | Miltenyi Biotec GmbH | Immune cells expressing an antigen binding receptor and a chimeric costimulatory receptor |
| WO2018115485A1 (en) | 2016-12-22 | 2018-06-28 | Pierfrancesco Tassone | A monoclonal antibody targeting a unique sialoglycosilated cancer-associated epitope of cd43 |
| MX2019011570A (es) | 2017-03-27 | 2019-11-18 | Nat Univ Singapore | Lineas celulares estimuladoras para expansion y activacion ex vivo de celulas asesinas naturales. |
| CN117363636A (zh) | 2017-03-27 | 2024-01-09 | 新加坡国立大学 | 一种编码嵌合受体的多核苷酸 |
| IL327498A (en) | 2017-06-02 | 2026-05-01 | Juno Therapeutics Inc | Articles of manufacture and methods for treatment using adoptive cell therapy |
| EP3658578A1 (en) * | 2017-07-26 | 2020-06-03 | Cellectis | Methods of antigen-dependent chimeric antigen receptor (car) immune cell selection |
| CN109971724B (zh) * | 2017-12-28 | 2023-10-31 | 上海细胞治疗研究院 | 靶向ErbB受体家族且自表达PD-1抗体的CAR-T细胞及其用途 |
| JP7360174B2 (ja) | 2018-02-09 | 2023-10-12 | ナショナル ユニヴァーシティー オブ シンガポール | ナチュラルキラー細胞免疫療法における活性化キメラ受容体及びその使用 |
| US12441787B2 (en) | 2018-04-02 | 2025-10-14 | National University Of Singapore | Neutralization of human cytokines with membrane-bound anti-cytokine non-signaling binders expressed in immune cells |
| CN110615842B (zh) * | 2018-06-20 | 2023-05-09 | 上海隆耀生物科技有限公司 | 一种包含共刺激受体的嵌合抗原受体及应用 |
| EP3587454A1 (en) * | 2018-06-27 | 2020-01-01 | Albert-Ludwigs-Universität Freiburg | Chimeric antigen receptors that bind to prostate specific membrane antigen |
| WO2020044239A1 (en) | 2018-08-29 | 2020-03-05 | National University Of Singapore | A method to specifically stimulate survival and expansion of genetically-modified immune cells |
| CN113226340A (zh) | 2018-11-26 | 2021-08-06 | 恩卡尔塔公司 | 同时扩增多种免疫细胞类型的方法、相关组合物及其在癌症免疫疗法中的用途 |
| GB201900858D0 (en) * | 2019-01-22 | 2019-03-13 | Price Nicola Kaye | Receptors providing targeted costimulation for adoptive cell therapy |
| GB201902277D0 (en) | 2019-02-19 | 2019-04-03 | King S College London | Therapeutic agents |
| KR20210137085A (ko) | 2019-03-05 | 2021-11-17 | 엔카르타, 인크. | Cd19 유도된 키메라 항원 수용체 및 면역 요법에서 이의 용도 |
| EP3937974A1 (en) * | 2019-03-11 | 2022-01-19 | Leucid Bio Ltd | Muc1 parallel car (pcar) therapeutic agents |
| JP7711945B2 (ja) | 2019-04-30 | 2025-07-23 | センティ バイオサイエンシズ インコーポレイテッド | キメラ受容体及びその使用方法 |
| CN114555791B (zh) * | 2019-08-13 | 2026-07-14 | 伦敦国王学院 | Il-1超家族时空限制性活性细胞因子铠装的免疫应答细胞 |
| JP7723420B2 (ja) * | 2019-08-28 | 2025-08-14 | キングス・カレッジ・ロンドン | Ｂ細胞標的化並列ＣＡＲ（ｐＣＡＲ）治療的薬剤 |
| GB202003277D0 (en) | 2020-03-06 | 2020-04-22 | King S College London | Therapeutic agents |
| EP4136119A4 (en) * | 2020-04-17 | 2024-09-11 | Regeneron Pharmaceuticals, Inc. | MODIFIED CCR POLYPEPTIDES AND USES THEREOF |
| WO2022020456A2 (en) * | 2020-07-21 | 2022-01-27 | Allogene Therapeutics, Inc. | Chimeric antigen receptors with enhanced signaling and activities and uses thereof |
| WO2022036495A1 (en) | 2020-08-17 | 2022-02-24 | Utc Therapeutics Inc. | Lymphocytes-antigen presenting cells co-stimulators and uses thereof |
| WO2022083668A1 (en) * | 2020-10-21 | 2022-04-28 | Nanjing Legend Biotech Co., Ltd. | Use of a chimeric co-stimulatory receptor for cell therapy |
| EP4384211A1 (en) * | 2021-08-13 | 2024-06-19 | Ludwig-Maximilians-Universität München | Anti-csf1r car expressing lymphocytes for targeted tumor therapy |
| KR20240055733A (ko) * | 2021-08-18 | 2024-04-29 | 레전드 바이오테크 아일랜드 리미티드 | Tlr 수용체를 발현하는 변형된 면역 세포 |
| JP7732839B2 (ja) * | 2021-10-14 | 2025-09-02 | 株式会社三共 | 遊技機 |
| JP7732840B2 (ja) * | 2021-10-14 | 2025-09-02 | 株式会社三共 | 遊技機 |
| JP7732841B2 (ja) * | 2021-10-14 | 2025-09-02 | 株式会社三共 | 遊技機 |
| JP7732842B2 (ja) * | 2021-10-14 | 2025-09-02 | 株式会社三共 | 遊技機 |
| JP7732843B2 (ja) * | 2021-10-14 | 2025-09-02 | 株式会社三共 | 遊技機 |
| JP2024541081A (ja) | 2021-11-15 | 2024-11-06 | ネオジン セラピューティクス ビー．ブイ． | 低下したｔｇｆ－ベータ受容体シグナル伝達を有する遺伝子操作されたｔ細胞 |
| JP2025503546A (ja) | 2021-12-30 | 2025-02-04 | ティーアール１エックス，インコーポレーテッド | Ｉｌ－１０およびキメラ抗原受容体を発現するｃｄ４＋ｔ細胞およびその使用 |
| WO2023217062A1 (zh) * | 2022-05-10 | 2023-11-16 | 星尘生物科技(上海)有限公司 | 一种嵌合抗原受体及其应用 |
| CN116804210A (zh) * | 2022-12-08 | 2023-09-26 | 复旦大学附属中山医院 | 一种肠道病毒载体及其应用 |
| WO2024209084A1 (en) | 2023-04-05 | 2024-10-10 | Kings College London | Parallel chimeric antigen receptors (pcars) and adaptor chimeric antigen receptors comprising alternative signalling domains and methods of use thereof |
| GB202403718D0 (en) | 2024-03-14 | 2024-05-01 | King S College London | Therapeutic agents |
| WO2026015450A1 (en) | 2024-07-06 | 2026-01-15 | Tr1X, Inc. | Cd4+ t cells expressing il-10 and chimeric antigen receptors and uses thereof |
Family Cites Families (33)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU708339B2 (en) * | 1995-02-24 | 1999-08-05 | General Hospital Corporation, The | Redirection of cellular immunity by receptor chimeras |
| US7446190B2 (en) | 2002-05-28 | 2008-11-04 | Sloan-Kettering Institute For Cancer Research | Nucleic acids encoding chimeric T cell receptors |
| GB0520068D0 (en) | 2005-10-03 | 2005-11-09 | Cancer Res Technology | av peptide ligand |
| US8389282B2 (en) | 2007-03-30 | 2013-03-05 | Memorial Sloan-Kettering Cancer Center | Constitutive expression of costimulatory ligands on adoptively transferred T lymphocytes |
| EP2389443B1 (en) | 2009-01-23 | 2018-11-14 | Roger Williams Hospital | Retroviral vectors encoding multiple highly homologous non-viral polypeptides and the use of same |
| JP5934099B2 (ja) | 2009-10-01 | 2016-06-15 | アメリカ合衆国 | 抗血管内皮増殖因子受容体−２キメラ抗原受容体及び癌の治療のためのその使用 |
| WO2012129514A1 (en) | 2011-03-23 | 2012-09-27 | Fred Hutchinson Cancer Research Center | Method and compositions for cellular immunotherapy |
| MX2014001222A (es) | 2011-07-29 | 2014-09-15 | Univ Pennsylvania | Receptores coestimuladores de cambio. |
| US9833476B2 (en) | 2011-08-31 | 2017-12-05 | The Trustees Of Dartmouth College | NKP30 receptor targeted therapeutics |
| BR112014020502A2 (pt) | 2012-02-22 | 2019-09-24 | Univ Pennsylvania | sequência de ácido nucleico isolada, receptor quimérico de antígeno isolado, célula, vetor, e, métodos para estimular uma resposta imune, para fornecer uma imunidade antitumoral, para tratamento de um mamífero, para gerar e para expandir uma população de células - t, e para modular a quantidade de citocina secretada por uma célula -t |
| EP2817330B1 (en) | 2012-02-22 | 2020-07-08 | The Trustees of the University of Pennsylvania | Use of icos-based cars to enhance antitumor activity and car persistence |
| CN103483452B (zh) | 2012-06-12 | 2021-08-13 | 上海细胞治疗集团有限公司 | 双信号独立的嵌合抗原受体及其用途 |
| AU2013312838B2 (en) | 2012-09-04 | 2018-11-29 | Cellectis | Multi-chain chimeric antigen receptor and uses thereof |
| WO2014055442A2 (en) | 2012-10-01 | 2014-04-10 | The Trustees Of The University Of Pennsylvania | Compositions and methods for targeting stromal cells for the treatment of cancer |
| RU2729401C2 (ru) | 2012-10-02 | 2020-08-06 | Мемориал Слоан-Кеттеринг Кэнсер Сентер | Композиции и способы для иммунотерапии |
| US10117896B2 (en) | 2012-10-05 | 2018-11-06 | The Trustees Of The University Of Pennsylvania | Use of a trans-signaling approach in chimeric antigen receptors |
| SG11201507026WA (en) | 2013-02-06 | 2015-10-29 | Anthrogenesis Corp | Modified t lymphocytes having improved specificity |
| IL305629A (en) | 2013-02-15 | 2023-11-01 | Univ California | Chimeric antigen receptor and methods of using it |
| WO2014138348A1 (en) | 2013-03-06 | 2014-09-12 | The Trustees Of The University Of Pennsylvania | Iikaros inhibition to augment adoptive t cell transfer |
| US20160015750A1 (en) | 2013-03-09 | 2016-01-21 | Baylor College Of Medicine | Vascular-targeted t-cell therapy |
| CA2905352A1 (en) | 2013-03-14 | 2014-09-25 | Bellicum Pharmaceuticals, Inc. | Methods for controlling t cell proliferation |
| WO2014172584A1 (en) | 2013-04-17 | 2014-10-23 | Baylor College Of Medicine | IMMUNOSUPPRESSIVE TGF-β SIGNAL CONVERTER |
| US20160250258A1 (en) | 2013-10-31 | 2016-09-01 | Fred Hutchinson Cancer Research Center | Modified hematopoietic stem/progenitor and non-t effector cells, and uses thereof |
| EP3858379A1 (en) | 2013-11-21 | 2021-08-04 | Autolus Limited | Cell |
| WO2015090229A1 (en) | 2013-12-20 | 2015-06-25 | Novartis Ag | Regulatable chimeric antigen receptor |
| EP3090214A4 (en) * | 2013-12-26 | 2017-12-06 | Agrawal, Avichal | A fluid handling device and a method of heating or cooling a fluid flow |
| US20170233452A1 (en) | 2014-04-23 | 2017-08-17 | Immusoft Corporation | Chimeric antigen receptors specific to avb6 integrin and methods of use thereof to treat cancer |
| US10738278B2 (en) * | 2014-07-15 | 2020-08-11 | Juno Therapeutics, Inc. | Engineered cells for adoptive cell therapy |
| AU2015292744C1 (en) | 2014-07-21 | 2021-01-21 | Novartis Ag | Treatment of cancer using humanized anti-BCMA chimeric antigen receptor |
| AU2015380397B2 (en) | 2015-01-31 | 2021-10-21 | The Trustees Of The University Of Pennsylvania | Compositions and methods for T cell delivery of therapeutic molecules |
| MX2017015239A (es) | 2015-05-29 | 2018-02-19 | Juno Therapeutics Inc | Composicion y metodos para regular interacciones inhibitorias en celulas geneticamente modificadas. |
| GB201513540D0 (en) * | 2015-07-31 | 2015-09-16 | King S College London | Therapeutic agents |
| EP3937974A1 (en) * | 2019-03-11 | 2022-01-19 | Leucid Bio Ltd | Muc1 parallel car (pcar) therapeutic agents |
-
2015
- 2015-07-31 GB GBGB1513540.3A patent/GB201513540D0/en not_active Ceased
-
2016
- 2016-07-28 ES ES16750211T patent/ES2883633T3/es active Active
- 2016-07-28 EP EP16750211.1A patent/EP3328880B1/en active Active
- 2016-07-28 RU RU2018105137A patent/RU2747733C1/ru active
- 2016-07-28 MX MX2018001009A patent/MX2018001009A/es unknown
- 2016-07-28 KR KR1020187005607A patent/KR102411571B1/ko active Active
- 2016-07-28 AU AU2016303355A patent/AU2016303355B2/en active Active
- 2016-07-28 EP EP21177321.3A patent/EP3939992A1/en not_active Withdrawn
- 2016-07-28 DK DK16750211.1T patent/DK3328880T3/da active
- 2016-07-28 US US15/749,016 patent/US10703794B2/en active Active
- 2016-07-28 CN CN201680039617.1A patent/CN107735407B/zh active Active
- 2016-07-28 JP JP2018503642A patent/JP7053037B2/ja active Active
- 2016-07-28 SG SG10201912416QA patent/SG10201912416QA/en unknown
- 2016-07-28 WO PCT/GB2016/052324 patent/WO2017021701A1/en not_active Ceased
-
2017
- 2017-12-24 IL IL256511A patent/IL256511B/en unknown
-
2020
- 2020-05-18 US US16/877,035 patent/US10865231B2/en active Active
- 2020-05-18 US US16/877,008 patent/US10899818B2/en active Active
- 2020-12-10 US US17/118,045 patent/US11802143B2/en active Active
-
2021
- 2021-07-09 JP JP2021114022A patent/JP2021168675A/ja active Pending
-
2023
- 2023-09-22 US US18/472,441 patent/US12612445B2/en active Active
-
2024
- 2024-01-22 US US18/418,864 patent/US12509499B2/en active Active
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