JP2018521663A5 - - Google Patents
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- Publication number
- JP2018521663A5 JP2018521663A5 JP2018503642A JP2018503642A JP2018521663A5 JP 2018521663 A5 JP2018521663 A5 JP 2018521663A5 JP 2018503642 A JP2018503642 A JP 2018503642A JP 2018503642 A JP2018503642 A JP 2018503642A JP 2018521663 A5 JP2018521663 A5 JP 2018521663A5
- Authority
- JP
- Japan
- Prior art keywords
- immune response
- response cell
- cell according
- binding element
- receptor
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 210000004027 cell Anatomy 0.000 claims 28
- 230000028993 immune response Effects 0.000 claims 24
- 230000027455 binding Effects 0.000 claims 12
- 101000914514 Homo sapiens T-cell-specific surface glycoprotein CD28 Proteins 0.000 claims 4
- 102100027213 T-cell-specific surface glycoprotein CD28 Human genes 0.000 claims 4
- 230000000139 costimulatory effect Effects 0.000 claims 4
- 108020004707 nucleic acids Proteins 0.000 claims 4
- 150000007523 nucleic acids Chemical class 0.000 claims 4
- 102000039446 nucleic acids Human genes 0.000 claims 4
- 230000011664 signaling Effects 0.000 claims 4
- 101000851370 Homo sapiens Tumor necrosis factor receptor superfamily member 9 Proteins 0.000 claims 3
- 102100036856 Tumor necrosis factor receptor superfamily member 9 Human genes 0.000 claims 3
- 239000000427 antigen Substances 0.000 claims 3
- 102000036639 antigens Human genes 0.000 claims 3
- 108091007433 antigens Proteins 0.000 claims 3
- 239000011230 binding agent Substances 0.000 claims 3
- 108010057085 cytokine receptors Proteins 0.000 claims 3
- 102000003675 cytokine receptors Human genes 0.000 claims 3
- 102000006495 integrins Human genes 0.000 claims 3
- 108010044426 integrins Proteins 0.000 claims 3
- 230000009870 specific binding Effects 0.000 claims 3
- 102100027207 CD27 antigen Human genes 0.000 claims 2
- 108010019670 Chimeric Antigen Receptors Proteins 0.000 claims 2
- 101000914511 Homo sapiens CD27 antigen Proteins 0.000 claims 2
- 102100028198 Macrophage colony-stimulating factor 1 receptor Human genes 0.000 claims 2
- 210000001744 T-lymphocyte Anatomy 0.000 claims 2
- 102100022153 Tumor necrosis factor receptor superfamily member 4 Human genes 0.000 claims 2
- 101710165473 Tumor necrosis factor receptor superfamily member 4 Proteins 0.000 claims 2
- 108091008034 costimulatory receptors Proteins 0.000 claims 2
- 238000000034 method Methods 0.000 claims 2
- 230000019491 signal transduction Effects 0.000 claims 2
- 239000013598 vector Substances 0.000 claims 2
- 101150013553 CD40 gene Proteins 0.000 claims 1
- 108090000695 Cytokines Proteins 0.000 claims 1
- 102000004127 Cytokines Human genes 0.000 claims 1
- 101000916644 Homo sapiens Macrophage colony-stimulating factor 1 receptor Proteins 0.000 claims 1
- 101000801234 Homo sapiens Tumor necrosis factor receptor superfamily member 18 Proteins 0.000 claims 1
- 101000851376 Homo sapiens Tumor necrosis factor receptor superfamily member 8 Proteins 0.000 claims 1
- -1 ICOS Proteins 0.000 claims 1
- 108010046938 Macrophage Colony-Stimulating Factor Proteins 0.000 claims 1
- 102100028123 Macrophage colony-stimulating factor 1 Human genes 0.000 claims 1
- 101710150918 Macrophage colony-stimulating factor 1 receptor Proteins 0.000 claims 1
- 108010061593 Member 14 Tumor Necrosis Factor Receptors Proteins 0.000 claims 1
- 102100028785 Tumor necrosis factor receptor superfamily member 14 Human genes 0.000 claims 1
- 102100033728 Tumor necrosis factor receptor superfamily member 18 Human genes 0.000 claims 1
- 102100040245 Tumor necrosis factor receptor superfamily member 5 Human genes 0.000 claims 1
- 102100036857 Tumor necrosis factor receptor superfamily member 8 Human genes 0.000 claims 1
- 230000008878 coupling Effects 0.000 claims 1
- 238000010168 coupling process Methods 0.000 claims 1
- 238000005859 coupling reaction Methods 0.000 claims 1
- 239000000539 dimer Substances 0.000 claims 1
- 230000003834 intracellular effect Effects 0.000 claims 1
- 230000021633 leukocyte mediated immunity Effects 0.000 claims 1
- 239000003446 ligand Substances 0.000 claims 1
- 230000035755 proliferation Effects 0.000 claims 1
- 102000005962 receptors Human genes 0.000 claims 1
- 108020003175 receptors Proteins 0.000 claims 1
- 230000000638 stimulation Effects 0.000 claims 1
- 230000002463 transducing effect Effects 0.000 claims 1
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2021114022A JP2021168675A (ja) | 2015-07-31 | 2021-07-09 | 治療薬 |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB1513540.3A GB201513540D0 (en) | 2015-07-31 | 2015-07-31 | Therapeutic agents |
| GB1513540.3 | 2015-07-31 | ||
| PCT/GB2016/052324 WO2017021701A1 (en) | 2015-07-31 | 2016-07-28 | Therapeutic agents |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021114022A Division JP2021168675A (ja) | 2015-07-31 | 2021-07-09 | 治療薬 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2018521663A JP2018521663A (ja) | 2018-08-09 |
| JP2018521663A5 true JP2018521663A5 (enExample) | 2019-08-29 |
| JP7053037B2 JP7053037B2 (ja) | 2022-04-12 |
Family
ID=54062973
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018503642A Active JP7053037B2 (ja) | 2015-07-31 | 2016-07-28 | 治療薬 |
| JP2021114022A Pending JP2021168675A (ja) | 2015-07-31 | 2021-07-09 | 治療薬 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021114022A Pending JP2021168675A (ja) | 2015-07-31 | 2021-07-09 | 治療薬 |
Country Status (15)
| Country | Link |
|---|---|
| US (6) | US10703794B2 (enExample) |
| EP (2) | EP3939992A1 (enExample) |
| JP (2) | JP7053037B2 (enExample) |
| KR (1) | KR102411571B1 (enExample) |
| CN (1) | CN107735407B (enExample) |
| AU (1) | AU2016303355B2 (enExample) |
| CA (1) | CA2993746A1 (enExample) |
| DK (1) | DK3328880T3 (enExample) |
| ES (1) | ES2883633T3 (enExample) |
| GB (1) | GB201513540D0 (enExample) |
| IL (1) | IL256511B (enExample) |
| MX (1) | MX2018001009A (enExample) |
| RU (1) | RU2747733C1 (enExample) |
| SG (1) | SG10201912416QA (enExample) |
| WO (1) | WO2017021701A1 (enExample) |
Families Citing this family (41)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SG11201505858VA (en) | 2013-01-28 | 2015-09-29 | St Jude Childrens Res Hospital | A chimeric receptor with nkg2d specificity for use in cell therapy against cancer and infectious disease |
| EP3143134B1 (en) | 2014-05-15 | 2020-10-28 | National University of Singapore | Modified natural killer cells and uses thereof |
| GB201513540D0 (en) | 2015-07-31 | 2015-09-16 | King S College London | Therapeutic agents |
| GB201514874D0 (en) | 2015-08-20 | 2015-10-07 | Autolus Ltd | Cell |
| MA46995A (fr) | 2016-12-03 | 2019-10-09 | Acerta Pharma Bv | Méthodes et compositions pour l'utilisation de lymphocytes t thérapeutiques en association avec des inhibiteurs de kinase |
| EP3336107A1 (en) * | 2016-12-15 | 2018-06-20 | Miltenyi Biotec GmbH | Immune cells expressing an antigen binding receptor and a chimeric costimulatory receptor |
| EA201991204A1 (ru) | 2016-12-22 | 2019-12-30 | Университа Дельи Студи Манья Греча Катандзаро | Моноклональное антитело против уникального сиалогликозилированного опухолеассоциированного эпитопа cd43 |
| SG11201908492PA (en) | 2017-03-27 | 2019-10-30 | Nat Univ Singapore | Truncated nkg2d chimeric receptors and uses thereof in natural killer cell immunotherapy |
| EP3601537A4 (en) | 2017-03-27 | 2021-01-13 | National University of Singapore | STIMULATING CELL LINES FOR EX VIVO EXPANSION AND ACTIVATION OF NATURAL KILLER CELLS |
| KR20200054160A (ko) | 2017-06-02 | 2020-05-19 | 주노 쎄러퓨티크스 인코퍼레이티드 | 입양 세포 요법을 사용한 치료를 위한 물품 제조 및 방법 |
| EP3658578A1 (en) * | 2017-07-26 | 2020-06-03 | Cellectis | Methods of antigen-dependent chimeric antigen receptor (car) immune cell selection |
| CN109971724B (zh) * | 2017-12-28 | 2023-10-31 | 上海细胞治疗研究院 | 靶向ErbB受体家族且自表达PD-1抗体的CAR-T细胞及其用途 |
| CN111801348A (zh) | 2018-02-09 | 2020-10-20 | 新加坡国立大学 | 活化性嵌合受体及其在自然杀伤细胞免疫疗法中的用途 |
| KR20200138741A (ko) | 2018-04-02 | 2020-12-10 | 내셔널 유니버시티 오브 싱가포르 | 면역 세포에서 발현되는 막-결합 항-사이토카인 비-신호전달 결합제를 이용한 인간 사이토카인의 중화 |
| CN110615842B (zh) * | 2018-06-20 | 2023-05-09 | 上海隆耀生物科技有限公司 | 一种包含共刺激受体的嵌合抗原受体及应用 |
| EP3587454A1 (en) * | 2018-06-27 | 2020-01-01 | Albert-Ludwigs-Universität Freiburg | Chimeric antigen receptors that bind to prostate specific membrane antigen |
| JP7560882B2 (ja) | 2018-08-29 | 2024-10-03 | ナショナル ユニヴァーシティー オブ シンガポール | 遺伝子修飾免疫細胞の生存及び増加を特異的に刺激するための方法 |
| GB201900858D0 (en) * | 2019-01-22 | 2019-03-13 | Price Nicola Kaye | Receptors providing targeted costimulation for adoptive cell therapy |
| GB201902277D0 (en) | 2019-02-19 | 2019-04-03 | King S College London | Therapeutic agents |
| EP3773918A4 (en) | 2019-03-05 | 2022-01-05 | Nkarta, Inc. | ANTI-CD19 CHEMERIC ANTIGEN RECEPTORS AND THEIR USE IN IMMUNOTHERAPY |
| CN113811327A (zh) * | 2019-03-11 | 2021-12-17 | 卢西德生物有限公司 | MUC1平行CAR(pCAR)治疗剂 |
| SG11202111130SA (en) | 2019-04-30 | 2021-11-29 | Senti Biosciences Inc | Chimeric receptors and methods of use thereof |
| US20230000913A1 (en) * | 2019-08-13 | 2023-01-05 | King's College London | Immunoresponsive cells armoured with spatiotemporally restricted activity of cytokines of the il-1 superfamily |
| JP7723420B2 (ja) * | 2019-08-28 | 2025-08-14 | キングス・カレッジ・ロンドン | Ｂ細胞標的化並列ＣＡＲ（ｐＣＡＲ）治療的薬剤 |
| GB202003277D0 (en) | 2020-03-06 | 2020-04-22 | King S College London | Therapeutic agents |
| JP2023522038A (ja) * | 2020-04-17 | 2023-05-26 | ２セブンティ バイオ インコーポレイテッド | 修飾ｃｃｒポリペプチド及びその使用 |
| AU2021312871A1 (en) * | 2020-07-21 | 2023-02-09 | Allogene Therapeutics, Inc. | Chimeric antigen receptors with enhanced signaling and activities and uses thereof |
| WO2022036495A1 (en) | 2020-08-17 | 2022-02-24 | Utc Therapeutics Inc. | Lymphocytes-antigen presenting cells co-stimulators and uses thereof |
| WO2022083668A1 (en) * | 2020-10-21 | 2022-04-28 | Nanjing Legend Biotech Co., Ltd. | Use of a chimeric co-stimulatory receptor for cell therapy |
| AU2022327766A1 (en) * | 2021-08-13 | 2023-12-14 | Ludwig-Maximilians-Universität München | Anti-csf1r car expressing lymphocytes for targeted tumor therapy |
| US20240350545A1 (en) * | 2021-08-18 | 2024-10-24 | Legend Biotech Ireland Limited | Modified immune cells expressing tlr receptors |
| JP7732839B2 (ja) * | 2021-10-14 | 2025-09-02 | 株式会社三共 | 遊技機 |
| JP7732840B2 (ja) * | 2021-10-14 | 2025-09-02 | 株式会社三共 | 遊技機 |
| JP7732843B2 (ja) * | 2021-10-14 | 2025-09-02 | 株式会社三共 | 遊技機 |
| JP7732841B2 (ja) * | 2021-10-14 | 2025-09-02 | 株式会社三共 | 遊技機 |
| JP7732842B2 (ja) * | 2021-10-14 | 2025-09-02 | 株式会社三共 | 遊技機 |
| CA3237754A1 (en) | 2021-11-15 | 2023-05-19 | Neogene Therapeutics B.V. | Engineered t cells with reduced tgf-beta receptor signaling |
| US20250108113A1 (en) | 2021-12-30 | 2025-04-03 | Tr1X, Inc. | Cd4+ t cells expressing il-10 and chimeric antigen receptors and uses thereof |
| CN118510814A (zh) * | 2022-05-10 | 2024-08-16 | 星尘生物科技(上海)有限公司 | 一种嵌合抗原受体及其应用 |
| WO2024209084A1 (en) | 2023-04-05 | 2024-10-10 | Kings College London | Parallel chimeric antigen receptors (pcars) and adaptor chimeric antigen receptors comprising alternative signalling domains and methods of use thereof |
| GB202403718D0 (en) | 2024-03-14 | 2024-05-01 | King S College London | Therapeutic agents |
Family Cites Families (33)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1996025953A1 (en) * | 1995-02-24 | 1996-08-29 | The General Hospital Corporation | Redirection of cellular immunity by receptor chimeras |
| US7446190B2 (en) | 2002-05-28 | 2008-11-04 | Sloan-Kettering Institute For Cancer Research | Nucleic acids encoding chimeric T cell receptors |
| GB0520068D0 (en) | 2005-10-03 | 2005-11-09 | Cancer Res Technology | av peptide ligand |
| PT2856876T (pt) | 2007-03-30 | 2018-03-28 | Memorial Sloan Kettering Cancer Center | Expressão constitutiva de ligantes co-estimulatórios em linfócitos t adotivamente transferidos |
| US9206440B2 (en) | 2009-01-23 | 2015-12-08 | Roger Williams Hospital | Viral vectors encoding multiple highly homologus non-viral polypeptides and the use of same |
| EP2483301A1 (en) | 2009-10-01 | 2012-08-08 | The United States Of America, As Represented By The Secretary, Department of Health and Human Services | Anti-vascular endothelial growth factor receptor-2 chimeric antigen receptors and use of same for the treatment of cancer |
| KR101976882B1 (ko) | 2011-03-23 | 2019-05-09 | 프레드 헛친슨 켄서 리서치 센터 | 세포 면역요법용 방법 및 조성물 |
| PE20141520A1 (es) | 2011-07-29 | 2014-11-17 | Univ Pennsylvania | Receptores coestimuladores de cambio |
| US9833476B2 (en) | 2011-08-31 | 2017-12-05 | The Trustees Of Dartmouth College | NKP30 receptor targeted therapeutics |
| MX2014010185A (es) | 2012-02-22 | 2014-11-14 | Univ Pennsylvania | Uso de dominio de señalizacion cd2 en receptores de antigeno quimericos de segunda generacion. |
| EP2817330B1 (en) | 2012-02-22 | 2020-07-08 | The Trustees of the University of Pennsylvania | Use of icos-based cars to enhance antitumor activity and car persistence |
| CN103483452B (zh) | 2012-06-12 | 2021-08-13 | 上海细胞治疗集团有限公司 | 双信号独立的嵌合抗原受体及其用途 |
| AU2013312838B2 (en) | 2012-09-04 | 2018-11-29 | Cellectis | Multi-chain chimeric antigen receptor and uses thereof |
| US9365641B2 (en) | 2012-10-01 | 2016-06-14 | The Trustees Of The University Of Pennsylvania | Compositions and methods for targeting stromal cells for the treatment of cancer |
| RU2729401C2 (ru) * | 2012-10-02 | 2020-08-06 | Мемориал Слоан-Кеттеринг Кэнсер Сентер | Композиции и способы для иммунотерапии |
| WO2014055657A1 (en) | 2012-10-05 | 2014-04-10 | The Trustees Of The University Of Pennsylvania | Use of a trans-signaling approach in chimeric antigen receptors |
| WO2014124143A1 (en) | 2013-02-06 | 2014-08-14 | Anthrogenesis Corporation | Modified t lymphocytes having improved specificity |
| LT2956175T (lt) | 2013-02-15 | 2017-12-11 | The Regents Of The University Of California | Chimerinis antigeno receptorius ir jo panaudojimo būdai |
| US20160017286A1 (en) | 2013-03-06 | 2016-01-21 | The Trustees Of The University Of Pennsylvania | Ikaros inhibition to augment adoptive t cell transfer |
| US20160015750A1 (en) | 2013-03-09 | 2016-01-21 | Baylor College Of Medicine | Vascular-targeted t-cell therapy |
| KR20150131218A (ko) | 2013-03-14 | 2015-11-24 | 벨리쿰 파마슈티컬스, 인크. | T 세포 증식의 제어 방법 |
| WO2014172584A1 (en) | 2013-04-17 | 2014-10-23 | Baylor College Of Medicine | IMMUNOSUPPRESSIVE TGF-β SIGNAL CONVERTER |
| AU2014342020C1 (en) | 2013-10-31 | 2019-09-05 | Fred Hutchinson Cancer Research Center | Modified hematopoietic stem/progenitor and non-T effector cells, and uses thereof |
| WO2015075468A1 (en) | 2013-11-21 | 2015-05-28 | Ucl Business Plc | Cell |
| EP3087101B1 (en) | 2013-12-20 | 2024-06-05 | Novartis AG | Regulatable chimeric antigen receptor |
| CN106164599B (zh) * | 2013-12-26 | 2019-07-05 | 巍然科技私人有限公司 | 加热或冷却流体流的流体处理装置和方法 |
| US20170233452A1 (en) | 2014-04-23 | 2017-08-17 | Immusoft Corporation | Chimeric antigen receptors specific to avb6 integrin and methods of use thereof to treat cancer |
| MX2017000646A (es) | 2014-07-15 | 2017-04-27 | Juno Therapeutics Inc | Celulas geneticamente modificadas para terapia celular adoptiva. |
| WO2016014565A2 (en) | 2014-07-21 | 2016-01-28 | Novartis Ag | Treatment of cancer using humanized anti-bcma chimeric antigen receptor |
| AU2015380397B2 (en) | 2015-01-31 | 2021-10-21 | The Trustees Of The University Of Pennsylvania | Compositions and methods for T cell delivery of therapeutic molecules |
| WO2016196388A1 (en) | 2015-05-29 | 2016-12-08 | Juno Therapeutics, Inc. | Composition and methods for regulating inhibitory interactions in genetically engineered cells |
| GB201513540D0 (en) * | 2015-07-31 | 2015-09-16 | King S College London | Therapeutic agents |
| CN113811327A (zh) * | 2019-03-11 | 2021-12-17 | 卢西德生物有限公司 | MUC1平行CAR(pCAR)治疗剂 |
-
2015
- 2015-07-31 GB GBGB1513540.3A patent/GB201513540D0/en not_active Ceased
-
2016
- 2016-07-28 RU RU2018105137A patent/RU2747733C1/ru active
- 2016-07-28 EP EP21177321.3A patent/EP3939992A1/en not_active Withdrawn
- 2016-07-28 MX MX2018001009A patent/MX2018001009A/es unknown
- 2016-07-28 WO PCT/GB2016/052324 patent/WO2017021701A1/en not_active Ceased
- 2016-07-28 KR KR1020187005607A patent/KR102411571B1/ko active Active
- 2016-07-28 US US15/749,016 patent/US10703794B2/en active Active
- 2016-07-28 CN CN201680039617.1A patent/CN107735407B/zh active Active
- 2016-07-28 SG SG10201912416QA patent/SG10201912416QA/en unknown
- 2016-07-28 DK DK16750211.1T patent/DK3328880T3/da active
- 2016-07-28 CA CA2993746A patent/CA2993746A1/en active Pending
- 2016-07-28 EP EP16750211.1A patent/EP3328880B1/en active Active
- 2016-07-28 ES ES16750211T patent/ES2883633T3/es active Active
- 2016-07-28 AU AU2016303355A patent/AU2016303355B2/en active Active
- 2016-07-28 JP JP2018503642A patent/JP7053037B2/ja active Active
-
2017
- 2017-12-24 IL IL256511A patent/IL256511B/en unknown
-
2020
- 2020-05-18 US US16/877,008 patent/US10899818B2/en active Active
- 2020-05-18 US US16/877,035 patent/US10865231B2/en active Active
- 2020-12-10 US US17/118,045 patent/US11802143B2/en active Active
-
2021
- 2021-07-09 JP JP2021114022A patent/JP2021168675A/ja active Pending
-
2023
- 2023-09-22 US US18/472,441 patent/US20240076348A1/en active Pending
-
2024
- 2024-01-22 US US18/418,864 patent/US20240228576A1/en active Pending
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