JP2021500882A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2021500882A5 JP2021500882A5 JP2020521861A JP2020521861A JP2021500882A5 JP 2021500882 A5 JP2021500882 A5 JP 2021500882A5 JP 2020521861 A JP2020521861 A JP 2020521861A JP 2020521861 A JP2020521861 A JP 2020521861A JP 2021500882 A5 JP2021500882 A5 JP 2021500882A5
- Authority
- JP
- Japan
- Prior art keywords
- chimeric polypeptide
- region
- stalk
- polypeptide according
- cell
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 108090000765 processed proteins & peptides Proteins 0.000 claims description 92
- 229920001184 polypeptide Polymers 0.000 claims description 91
- 102000004196 processed proteins & peptides Human genes 0.000 claims description 91
- 108010019670 Chimeric Antigen Receptors Proteins 0.000 claims description 46
- 210000004027 cell Anatomy 0.000 claims description 25
- 210000001744 T-lymphocyte Anatomy 0.000 claims description 20
- 239000000427 antigen Substances 0.000 claims description 20
- 108091007433 antigens Proteins 0.000 claims description 20
- 102000036639 antigens Human genes 0.000 claims description 20
- 239000013598 vector Substances 0.000 claims description 20
- 238000000034 method Methods 0.000 claims description 15
- 230000011664 signaling Effects 0.000 claims description 15
- -1 EGP-40 Proteins 0.000 claims description 14
- 101000914514 Homo sapiens T-cell-specific surface glycoprotein CD28 Proteins 0.000 claims description 13
- 102100027213 T-cell-specific surface glycoprotein CD28 Human genes 0.000 claims description 13
- 238000006471 dimerization reaction Methods 0.000 claims description 13
- 125000003275 alpha amino acid group Chemical group 0.000 claims description 12
- 108091008874 T cell receptors Proteins 0.000 claims description 10
- 102000016266 T-Cell Antigen Receptors Human genes 0.000 claims description 10
- 125000006850 spacer group Chemical group 0.000 claims description 10
- 150000007523 nucleic acids Chemical group 0.000 claims description 9
- 210000000822 natural killer cell Anatomy 0.000 claims description 8
- 240000007019 Oxalis corniculata Species 0.000 claims description 7
- 102100022005 B-lymphocyte antigen CD20 Human genes 0.000 claims description 6
- 108010021064 CTLA-4 Antigen Proteins 0.000 claims description 6
- 229940045513 CTLA4 antagonist Drugs 0.000 claims description 6
- 101000897405 Homo sapiens B-lymphocyte antigen CD20 Proteins 0.000 claims description 6
- 101001012157 Homo sapiens Receptor tyrosine-protein kinase erbB-2 Proteins 0.000 claims description 6
- 102100030086 Receptor tyrosine-protein kinase erbB-2 Human genes 0.000 claims description 6
- 102100029986 Receptor tyrosine-protein kinase erbB-3 Human genes 0.000 claims description 6
- 101710100969 Receptor tyrosine-protein kinase erbB-3 Proteins 0.000 claims description 6
- 102000052116 epidermal growth factor receptor activity proteins Human genes 0.000 claims description 6
- 108700015053 epidermal growth factor receptor activity proteins Proteins 0.000 claims description 6
- YOHYSYJDKVYCJI-UHFFFAOYSA-N n-[3-[[6-[3-(trifluoromethyl)anilino]pyrimidin-4-yl]amino]phenyl]cyclopropanecarboxamide Chemical compound FC(F)(F)C1=CC=CC(NC=2N=CN=C(NC=3C=C(NC(=O)C4CC4)C=CC=3)C=2)=C1 YOHYSYJDKVYCJI-UHFFFAOYSA-N 0.000 claims description 6
- 102100024222 B-lymphocyte antigen CD19 Human genes 0.000 claims description 5
- 101000980825 Homo sapiens B-lymphocyte antigen CD19 Proteins 0.000 claims description 5
- 108091028043 Nucleic acid sequence Proteins 0.000 claims description 5
- 235000001014 amino acid Nutrition 0.000 claims description 5
- 239000012634 fragment Substances 0.000 claims description 5
- 101001103039 Homo sapiens Inactive tyrosine-protein kinase transmembrane receptor ROR1 Proteins 0.000 claims description 4
- 101000623901 Homo sapiens Mucin-16 Proteins 0.000 claims description 4
- 101001103036 Homo sapiens Nuclear receptor ROR-alpha Proteins 0.000 claims description 4
- 101000851370 Homo sapiens Tumor necrosis factor receptor superfamily member 9 Proteins 0.000 claims description 4
- 102100039615 Inactive tyrosine-protein kinase transmembrane receptor ROR1 Human genes 0.000 claims description 4
- 102100023123 Mucin-16 Human genes 0.000 claims description 4
- 102000008579 Transposases Human genes 0.000 claims description 4
- 108010020764 Transposases Proteins 0.000 claims description 4
- 102100022153 Tumor necrosis factor receptor superfamily member 4 Human genes 0.000 claims description 4
- 102100036856 Tumor necrosis factor receptor superfamily member 9 Human genes 0.000 claims description 4
- 150000001413 amino acids Chemical class 0.000 claims description 4
- 210000004102 animal cell Anatomy 0.000 claims description 4
- 239000013604 expression vector Substances 0.000 claims description 4
- 210000005260 human cell Anatomy 0.000 claims description 4
- 108020004707 nucleic acids Proteins 0.000 claims description 4
- 102000039446 nucleic acids Human genes 0.000 claims description 4
- 108091033319 polynucleotide Proteins 0.000 claims description 4
- 102000040430 polynucleotide Human genes 0.000 claims description 4
- 239000002157 polynucleotide Substances 0.000 claims description 4
- 239000013603 viral vector Substances 0.000 claims description 4
- BGFTWECWAICPDG-UHFFFAOYSA-N 2-[bis(4-chlorophenyl)methyl]-4-n-[3-[bis(4-chlorophenyl)methyl]-4-(dimethylamino)phenyl]-1-n,1-n-dimethylbenzene-1,4-diamine Chemical compound C1=C(C(C=2C=CC(Cl)=CC=2)C=2C=CC(Cl)=CC=2)C(N(C)C)=CC=C1NC(C=1)=CC=C(N(C)C)C=1C(C=1C=CC(Cl)=CC=1)C1=CC=C(Cl)C=C1 BGFTWECWAICPDG-UHFFFAOYSA-N 0.000 claims description 3
- 102100031585 ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1 Human genes 0.000 claims description 3
- 101001005269 Arabidopsis thaliana Ceramide synthase 1 LOH3 Proteins 0.000 claims description 3
- 101001005312 Arabidopsis thaliana Ceramide synthase LOH1 Proteins 0.000 claims description 3
- 101100067974 Arabidopsis thaliana POP2 gene Proteins 0.000 claims description 3
- 102000006942 B-Cell Maturation Antigen Human genes 0.000 claims description 3
- 108010008014 B-Cell Maturation Antigen Proteins 0.000 claims description 3
- 102100038080 B-cell receptor CD22 Human genes 0.000 claims description 3
- 102100026094 C-type lectin domain family 12 member A Human genes 0.000 claims description 3
- 101710188619 C-type lectin domain family 12 member A Proteins 0.000 claims description 3
- 108700012439 CA9 Proteins 0.000 claims description 3
- 102100032912 CD44 antigen Human genes 0.000 claims description 3
- 108010058905 CD44v6 antigen Proteins 0.000 claims description 3
- 102100028801 Calsyntenin-1 Human genes 0.000 claims description 3
- 102100024423 Carbonic anhydrase 9 Human genes 0.000 claims description 3
- 102100028757 Chondroitin sulfate proteoglycan 4 Human genes 0.000 claims description 3
- 102000001301 EGF receptor Human genes 0.000 claims description 3
- 108010055196 EphA2 Receptor Proteins 0.000 claims description 3
- 102100030340 Ephrin type-A receptor 2 Human genes 0.000 claims description 3
- 102100031940 Epithelial cell adhesion molecule Human genes 0.000 claims description 3
- 101710088083 Glomulin Proteins 0.000 claims description 3
- 102100041003 Glutamate carboxypeptidase 2 Human genes 0.000 claims description 3
- 102100032530 Glypican-3 Human genes 0.000 claims description 3
- 101000893701 Homo sapiens 3-galactosyl-N-acetylglucosaminide 4-alpha-L-fucosyltransferase FUT3 Proteins 0.000 claims description 3
- 101000777636 Homo sapiens ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1 Proteins 0.000 claims description 3
- 101000884305 Homo sapiens B-cell receptor CD22 Proteins 0.000 claims description 3
- 101000868273 Homo sapiens CD44 antigen Proteins 0.000 claims description 3
- 101000914324 Homo sapiens Carcinoembryonic antigen-related cell adhesion molecule 5 Proteins 0.000 claims description 3
- 101000914321 Homo sapiens Carcinoembryonic antigen-related cell adhesion molecule 7 Proteins 0.000 claims description 3
- 101000916489 Homo sapiens Chondroitin sulfate proteoglycan 4 Proteins 0.000 claims description 3
- 101100118549 Homo sapiens EGFR gene Proteins 0.000 claims description 3
- 101000920667 Homo sapiens Epithelial cell adhesion molecule Proteins 0.000 claims description 3
- 101000892862 Homo sapiens Glutamate carboxypeptidase 2 Proteins 0.000 claims description 3
- 101001014668 Homo sapiens Glypican-3 Proteins 0.000 claims description 3
- 101000998120 Homo sapiens Interleukin-3 receptor subunit alpha Proteins 0.000 claims description 3
- 101000934338 Homo sapiens Myeloid cell surface antigen CD33 Proteins 0.000 claims description 3
- 101000617725 Homo sapiens Pregnancy-specific beta-1-glycoprotein 2 Proteins 0.000 claims description 3
- 101001136592 Homo sapiens Prostate stem cell antigen Proteins 0.000 claims description 3
- 101000633784 Homo sapiens SLAM family member 7 Proteins 0.000 claims description 3
- 101000874179 Homo sapiens Syndecan-1 Proteins 0.000 claims description 3
- 101000851376 Homo sapiens Tumor necrosis factor receptor superfamily member 8 Proteins 0.000 claims description 3
- 102100034256 Mucin-1 Human genes 0.000 claims description 3
- 108010008707 Mucin-1 Proteins 0.000 claims description 3
- 102100025243 Myeloid cell surface antigen CD33 Human genes 0.000 claims description 3
- 102100036735 Prostate stem cell antigen Human genes 0.000 claims description 3
- 101100123851 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) HER1 gene Proteins 0.000 claims description 3
- 101000668858 Spinacia oleracea 30S ribosomal protein S1, chloroplastic Proteins 0.000 claims description 3
- 101000898746 Streptomyces clavuligerus Clavaminate synthase 1 Proteins 0.000 claims description 3
- 101001051488 Takifugu rubripes Neural cell adhesion molecule L1 Proteins 0.000 claims description 3
- 102100036857 Tumor necrosis factor receptor superfamily member 8 Human genes 0.000 claims description 3
- 108010087914 epidermal growth factor receptor VIII Proteins 0.000 claims description 3
- 102000006815 folate receptor Human genes 0.000 claims description 3
- 108020005243 folate receptor Proteins 0.000 claims description 3
- 229960000304 folic acid Drugs 0.000 claims description 3
- 239000011724 folic acid Substances 0.000 claims description 3
- 102000036215 folic acid binding proteins Human genes 0.000 claims description 3
- 108091011001 folic acid binding proteins Proteins 0.000 claims description 3
- 230000031146 intracellular signal transduction Effects 0.000 claims description 3
- 229920001481 poly(stearyl methacrylate) Polymers 0.000 claims description 3
- 102000005962 receptors Human genes 0.000 claims description 3
- 108020003175 receptors Proteins 0.000 claims description 3
- 230000001177 retroviral effect Effects 0.000 claims description 3
- 101150047061 tag-72 gene Proteins 0.000 claims description 3
- 102100027207 CD27 antigen Human genes 0.000 claims description 2
- 102100029360 Hematopoietic cell signal transducer Human genes 0.000 claims description 2
- 101000914511 Homo sapiens CD27 antigen Proteins 0.000 claims description 2
- 101000990188 Homo sapiens Hematopoietic cell signal transducer Proteins 0.000 claims description 2
- 101000809875 Homo sapiens TYRO protein tyrosine kinase-binding protein Proteins 0.000 claims description 2
- 101000679851 Homo sapiens Tumor necrosis factor receptor superfamily member 4 Proteins 0.000 claims description 2
- 102100038717 TYRO protein tyrosine kinase-binding protein Human genes 0.000 claims description 2
- 101710165473 Tumor necrosis factor receptor superfamily member 4 Proteins 0.000 claims description 2
- 230000004913 activation Effects 0.000 claims description 2
- 125000000151 cysteine group Chemical group N[C@@H](CS)C(=O)* 0.000 claims description 2
- 230000006698 induction Effects 0.000 claims description 2
- 230000004068 intracellular signaling Effects 0.000 claims description 2
- 230000021633 leukocyte mediated immunity Effects 0.000 claims description 2
- 238000004519 manufacturing process Methods 0.000 claims description 2
- 230000001404 mediated effect Effects 0.000 claims description 2
- 239000008194 pharmaceutical composition Substances 0.000 claims description 2
- 230000035755 proliferation Effects 0.000 claims description 2
- 230000004936 stimulating effect Effects 0.000 claims description 2
- 102000008203 CTLA-4 Antigen Human genes 0.000 claims 2
- 230000000139 costimulatory effect Effects 0.000 claims 2
- 102100022019 Pregnancy-specific beta-1-glycoprotein 2 Human genes 0.000 claims 1
- 108010019530 Vascular Endothelial Growth Factors Proteins 0.000 claims 1
- 102000005789 Vascular Endothelial Growth Factors Human genes 0.000 claims 1
- 102100039498 Cytotoxic T-lymphocyte protein 4 Human genes 0.000 description 4
- 238000006467 substitution reaction Methods 0.000 description 4
- 102100025475 Carcinoembryonic antigen-related cell adhesion molecule 5 Human genes 0.000 description 2
- 125000000539 amino acid group Chemical group 0.000 description 2
- 210000001151 cytotoxic T lymphocyte Anatomy 0.000 description 2
- 239000012528 membrane Substances 0.000 description 2
- 238000012986 modification Methods 0.000 description 2
- 230000004048 modification Effects 0.000 description 2
- 102100025570 Cancer/testis antigen 1 Human genes 0.000 description 1
- 108010002947 Connectin Proteins 0.000 description 1
- 101000856237 Homo sapiens Cancer/testis antigen 1 Proteins 0.000 description 1
- 101000578784 Homo sapiens Melanoma antigen recognized by T-cells 1 Proteins 0.000 description 1
- 102100028389 Melanoma antigen recognized by T-cells 1 Human genes 0.000 description 1
- 108060006580 PRAME Proteins 0.000 description 1
- 102000036673 PRAME Human genes 0.000 description 1
- 102100026260 Titin Human genes 0.000 description 1
- 230000005754 cellular signaling Effects 0.000 description 1
- 239000003085 diluting agent Substances 0.000 description 1
- 239000003937 drug carrier Substances 0.000 description 1
- 230000003834 intracellular effect Effects 0.000 description 1
- 238000012737 microarray-based gene expression Methods 0.000 description 1
- 238000012243 multiplex automated genomic engineering Methods 0.000 description 1
- 239000000546 pharmaceutical excipient Substances 0.000 description 1
- 210000003289 regulatory T cell Anatomy 0.000 description 1
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2023118889A JP2023153866A (ja) | 2017-10-18 | 2023-07-21 | スペーサーを含むポリペプチド組成物 |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201762574061P | 2017-10-18 | 2017-10-18 | |
| US62/574,061 | 2017-10-18 | ||
| PCT/US2018/056334 WO2019079486A1 (en) | 2017-10-18 | 2018-10-17 | POLYPEPTIDE COMPOSITIONS COMPRISING SPACERS |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2023118889A Division JP2023153866A (ja) | 2017-10-18 | 2023-07-21 | スペーサーを含むポリペプチド組成物 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2021500882A JP2021500882A (ja) | 2021-01-14 |
| JP2021500882A5 true JP2021500882A5 (enExample) | 2021-11-25 |
Family
ID=66096807
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020521861A Pending JP2021500882A (ja) | 2017-10-18 | 2018-10-17 | スペーサーを含むポリペプチド組成物 |
| JP2023118889A Pending JP2023153866A (ja) | 2017-10-18 | 2023-07-21 | スペーサーを含むポリペプチド組成物 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2023118889A Pending JP2023153866A (ja) | 2017-10-18 | 2023-07-21 | スペーサーを含むポリペプチド組成物 |
Country Status (10)
| Country | Link |
|---|---|
| US (2) | US11771718B2 (enExample) |
| EP (1) | EP3697438A4 (enExample) |
| JP (2) | JP2021500882A (enExample) |
| KR (2) | KR20250010043A (enExample) |
| CN (1) | CN111511391B (enExample) |
| AU (2) | AU2018352984B2 (enExample) |
| CA (1) | CA3079264A1 (enExample) |
| IL (2) | IL273961B2 (enExample) |
| SG (1) | SG11202003543WA (enExample) |
| WO (1) | WO2019079486A1 (enExample) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2021530217A (ja) * | 2018-07-10 | 2021-11-11 | プレシゲン，インコーポレイテッド | Ｒｏｒ−１特異的キメラ抗原受容体およびその使用 |
| CA3110858A1 (en) * | 2018-08-31 | 2020-03-05 | Seattle Children's Hospital (dba Seattle Children's Research Institute) | Methods and compositions comprising b7h3 chimeric antigen receptors |
| US20220073585A1 (en) * | 2018-11-06 | 2022-03-10 | Washington University | Chimeric antigen receptor memory-like (carml) nk cells and methods of making and using same |
| CN114008076B (zh) * | 2019-04-19 | 2025-08-15 | 艾洛基治疗公司 | 针对4g7衍生的嵌合抗原受体的抗体 |
| SG11202111130SA (en) | 2019-04-30 | 2021-11-29 | Senti Biosciences Inc | Chimeric receptors and methods of use thereof |
| SE544015C2 (en) * | 2019-06-18 | 2021-11-02 | Tx Medic Ab | Allogenic car-t cell therapy |
| CN114222763A (zh) * | 2019-06-19 | 2022-03-22 | 尤利乌斯·马克西米利安维尔茨堡大学 | 在嵌合抗原受体设计中实现的超模块化IgG3间隔区结构域和多功能位点 |
| IL307609B2 (en) * | 2019-09-24 | 2025-03-01 | Univ California | Notch receptors with hinge domain |
| CN112111014A (zh) * | 2020-09-22 | 2020-12-22 | 廖文强 | 一种抗氧化嵌合型抗原受体和免疫细胞 |
| KR20230143140A (ko) * | 2021-01-11 | 2023-10-11 | 프레시전 인코포레이티드 | 키메라 수용체 요법 |
| EP4288073A4 (en) * | 2021-02-05 | 2025-03-26 | University of Utah Research Foundation | Compositions and methods for treating with car cells |
| AU2022227686A1 (en) | 2021-02-25 | 2023-07-27 | Lyell Immunopharma, Inc. | Ror1 targeting chimeric antigen receptor |
| BR112023022765A2 (pt) | 2021-05-05 | 2024-01-02 | Immatics Biotechnologies Gmbh | Proteínas de ligação ao antígeno que ligam especificamente o prame |
| WO2025038646A1 (en) * | 2023-08-14 | 2025-02-20 | Intellia Therapeutics, Inc. | Cd70 car-t compositions and methods for cell-based therapy |
Family Cites Families (27)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL300733B1 (en) | 2010-03-05 | 2025-10-01 | Univ Johns Hopkins | Compositions and methods for antibodies and fusion proteins targeted for immune modulation |
| US9212229B2 (en) * | 2010-09-08 | 2015-12-15 | Chemotherapeutisches Forschungsinstitut Georg-Speyer-Haus | Chimeric antigen receptors with an optimized hinge region |
| WO2013059593A1 (en) | 2011-10-20 | 2013-04-25 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Anti-cd22 chimeric antigen receptors |
| AU2013211824B2 (en) * | 2012-01-27 | 2017-06-01 | Gliknik Inc. | Fusion proteins comprising IgG2 hinge domains |
| PL2884999T3 (pl) | 2012-08-20 | 2021-07-05 | Fred Hutchinson Cancer Research Center | Sposób i kompozycje do immunoterapii komórkowej |
| KR102238226B1 (ko) | 2013-05-14 | 2021-04-09 | 보드 오브 리전츠, 더 유니버시티 오브 텍사스 시스템 | 가공된 키메라 항원 수용체 (ｃａｒ) ｔ-세포의 인간 적용 |
| EP3087101B1 (en) * | 2013-12-20 | 2024-06-05 | Novartis AG | Regulatable chimeric antigen receptor |
| HRP20201906T1 (hr) | 2013-12-20 | 2021-04-02 | Fred Hutchinson Cancer Research Center | Označene kimerne efektorske molekule i njihovi receptori |
| KR102375998B1 (ko) * | 2014-02-14 | 2022-03-21 | 더 보드 오브 리젠츠 오브 더 유니버시티 오브 텍사스 시스템 | 키메라 항원 수용체 및 제조방법 |
| EP3243831A1 (en) * | 2014-02-27 | 2017-11-15 | Ucl Business Plc | Variants of the proliferation-inducing ligand (april) |
| SG11201608393TA (en) | 2014-04-10 | 2016-11-29 | Seattle Children S Hospital Dba Seattle Children S Res Inst | Transgene genetic tags and methods of use |
| UA123764C2 (uk) | 2014-09-15 | 2021-06-02 | МОЛМЕД СпА | Химерний рецептор антигену та його застосування при лікуванні пухлин, які експресують cd44 |
| AU2015330017A1 (en) * | 2014-10-07 | 2017-04-27 | Cellectis | Method for modulating car-induced immune cells activity |
| WO2016168769A1 (en) | 2015-04-15 | 2016-10-20 | The California Institute For Biomedical Research | Chimeric receptor t cell switches for her2 |
| KR20240013282A (ko) | 2015-06-10 | 2024-01-30 | 이뮤너티바이오, 인크. | 암을 치료하기 위한 변형된 nk-92 세포 |
| US10822419B2 (en) | 2015-06-26 | 2020-11-03 | University Of Southern California | Masking chimeric antigen receptor T cells for tumor-specific activation |
| US11458167B2 (en) | 2015-08-07 | 2022-10-04 | Seattle Children's Hospital | Bispecific CAR T-cells for solid tumor targeting |
| WO2017088012A1 (en) * | 2015-11-27 | 2017-06-01 | Cartherics Pty. Ltd. | Genetically modified cells and uses thereof |
| MA45341A (fr) | 2016-06-06 | 2019-04-10 | Hutchinson Fred Cancer Res | Procédés de traitement de malignités de lymphocytes b au moyen d'une thérapie cellulaire adoptive |
| US11787848B2 (en) * | 2016-06-08 | 2023-10-17 | Precigen, Inc. | CD33 specific chimeric antigen receptors |
| KR20240128814A (ko) * | 2017-01-10 | 2024-08-27 | 프레시전 인코포레이티드 | 신규의 유전자 스위치 발현 시스템을 통한 폴리펩티드의 발현 조절 |
| AU2018281316B2 (en) * | 2017-06-07 | 2024-05-30 | Precigen, Inc. | Expression of novel cell tags |
| CA3101641A1 (en) * | 2018-06-04 | 2019-12-12 | Intrexon Corporation | Muc16 specific chimeric antigen receptors and uses thereof |
| US11535669B2 (en) * | 2018-07-09 | 2022-12-27 | Precigen, Inc. | Fusion constructs and methods of using thereof |
| JP2021530217A (ja) * | 2018-07-10 | 2021-11-11 | プレシゲン，インコーポレイテッド | Ｒｏｒ−１特異的キメラ抗原受容体およびその使用 |
| WO2022011256A1 (en) * | 2020-07-10 | 2022-01-13 | Precigen, Inc. | Fusion constructs and methods of using thereof |
| KR20230143140A (ko) * | 2021-01-11 | 2023-10-11 | 프레시전 인코포레이티드 | 키메라 수용체 요법 |
-
2018
- 2018-10-17 AU AU2018352984A patent/AU2018352984B2/en active Active
- 2018-10-17 IL IL273961A patent/IL273961B2/en unknown
- 2018-10-17 WO PCT/US2018/056334 patent/WO2019079486A1/en not_active Ceased
- 2018-10-17 KR KR1020247040963A patent/KR20250010043A/ko active Pending
- 2018-10-17 SG SG11202003543WA patent/SG11202003543WA/en unknown
- 2018-10-17 JP JP2020521861A patent/JP2021500882A/ja active Pending
- 2018-10-17 CA CA3079264A patent/CA3079264A1/en active Pending
- 2018-10-17 KR KR1020207013590A patent/KR102742741B1/ko active Active
- 2018-10-17 EP EP18869303.0A patent/EP3697438A4/en active Pending
- 2018-10-17 IL IL316522A patent/IL316522A/en unknown
- 2018-10-17 US US16/163,233 patent/US11771718B2/en active Active
- 2018-10-17 CN CN201880082078.9A patent/CN111511391B/zh active Active
-
2023
- 2023-06-29 US US18/344,421 patent/US20230414661A1/en active Pending
- 2023-07-21 JP JP2023118889A patent/JP2023153866A/ja active Pending
- 2023-12-13 AU AU2023282226A patent/AU2023282226B2/en active Active