JP2018516851A5 - - Google Patents
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- JP2018516851A5 JP2018516851A5 JP2017550548A JP2017550548A JP2018516851A5 JP 2018516851 A5 JP2018516851 A5 JP 2018516851A5 JP 2017550548 A JP2017550548 A JP 2017550548A JP 2017550548 A JP2017550548 A JP 2017550548A JP 2018516851 A5 JP2018516851 A5 JP 2018516851A5
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- 0 CC(C)[C@@](C(N[C@@](CCCNC(N)=O)C(C)=O)=O)NC(*(C)(C)N(C(CC1C)=O)C1=O)=O Chemical compound CC(C)[C@@](C(N[C@@](CCCNC(N)=O)C(C)=O)=O)NC(*(C)(C)N(C(CC1C)=O)C1=O)=O 0.000 description 3
- ROEXBULBZKICBC-KRQJBFIFSA-N C[C@@H](C(O[C@@H](CC(N(C)c(cc(C/C(/C)=C/C=C/[C@H]([C@@](C[C@H](C)[C@@H](C)[C@@H]1C)(NC(O)=O)O)OC)cc2OC)c2Cl)=O)[C@]1(C)O)=O)N(C)C(c(cc1)cc(S(C)(=O)=O)c1NNC)=O Chemical compound C[C@@H](C(O[C@@H](CC(N(C)c(cc(C/C(/C)=C/C=C/[C@H]([C@@](C[C@H](C)[C@@H](C)[C@@H]1C)(NC(O)=O)O)OC)cc2OC)c2Cl)=O)[C@]1(C)O)=O)N(C)C(c(cc1)cc(S(C)(=O)=O)c1NNC)=O ROEXBULBZKICBC-KRQJBFIFSA-N 0.000 description 1
- LHKUAZUPONJFED-BJWVSRTKSA-N C[C@@H](C(O[C@@H](CC(N(C)c(cc(C/C(/C)=C/C=C/[C@H]1OC)cc2OC)c2Cl)=O)[C@@H](C)[C@@H](C)[C@H](C)[C@@H](C)C[C@]1(NC(O)=O)O)=O)NC Chemical compound C[C@@H](C(O[C@@H](CC(N(C)c(cc(C/C(/C)=C/C=C/[C@H]1OC)cc2OC)c2Cl)=O)[C@@H](C)[C@@H](C)[C@H](C)[C@@H](C)C[C@]1(NC(O)=O)O)=O)NC LHKUAZUPONJFED-BJWVSRTKSA-N 0.000 description 1
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2021044152A JP2021113191A (ja) | 2015-03-27 | 2021-03-17 | メイタンシノイド誘導体、そのコンジュゲート、及び使用方法 |
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562139044P | 2015-03-27 | 2015-03-27 | |
| US62/139,044 | 2015-03-27 | ||
| US201562252239P | 2015-11-06 | 2015-11-06 | |
| US62/252,239 | 2015-11-06 | ||
| PCT/US2016/024343 WO2016160615A1 (en) | 2015-03-27 | 2016-03-25 | Maytansinoid derivatives, conjugates thereof, and methods of use |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021044152A Division JP2021113191A (ja) | 2015-03-27 | 2021-03-17 | メイタンシノイド誘導体、そのコンジュゲート、及び使用方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2018516851A JP2018516851A (ja) | 2018-06-28 |
| JP2018516851A5 true JP2018516851A5 (https=) | 2019-05-23 |
| JP6948950B2 JP6948950B2 (ja) | 2021-10-13 |
Family
ID=55650789
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017550548A Active JP6948950B2 (ja) | 2015-03-27 | 2016-03-25 | メイタンシノイド誘導体、そのコンジュゲート、及び使用方法 |
| JP2021044152A Withdrawn JP2021113191A (ja) | 2015-03-27 | 2021-03-17 | メイタンシノイド誘導体、そのコンジュゲート、及び使用方法 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021044152A Withdrawn JP2021113191A (ja) | 2015-03-27 | 2021-03-17 | メイタンシノイド誘導体、そのコンジュゲート、及び使用方法 |
Country Status (17)
| Country | Link |
|---|---|
| US (4) | US20160375147A1 (https=) |
| EP (1) | EP3273998B1 (https=) |
| JP (2) | JP6948950B2 (https=) |
| KR (2) | KR20240142591A (https=) |
| CN (2) | CN115645543A (https=) |
| AU (1) | AU2016243527B2 (https=) |
| BR (1) | BR112017020149A8 (https=) |
| CA (1) | CA2978340C (https=) |
| CL (1) | CL2017002422A1 (https=) |
| CO (1) | CO2017010890A2 (https=) |
| EA (1) | EA034950B1 (https=) |
| IL (1) | IL254267B (https=) |
| MX (2) | MX386328B (https=) |
| PH (1) | PH12017501780A1 (https=) |
| SG (1) | SG11201707148PA (https=) |
| WO (1) | WO2016160615A1 (https=) |
| ZA (1) | ZA201706040B (https=) |
Families Citing this family (27)
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| JP6948708B2 (ja) | 2015-06-19 | 2021-10-13 | センチュリオン バイオファーマ コーポレイション | 薬物制御放出のための送達系 |
| IL296285A (en) | 2015-07-06 | 2022-11-01 | Regeneron Pharma | Multispecific antigen-binding molecules and uses thereof |
| BR112018014759B1 (pt) | 2016-01-25 | 2024-02-27 | Regeneron Pharmaceuticals, Inc | Compostos derivados de maitasinoide e seus conjugados, composição compreendendo os mesmos, seus métodos de fabricação e uso |
| EP3448891A1 (en) | 2016-04-28 | 2019-03-06 | Regeneron Pharmaceuticals, Inc. | Methods of making multispecific antigen-binding molecules |
| JP7066690B2 (ja) | 2016-09-23 | 2022-05-13 | リジェネロン・ファーマシューティカルズ・インコーポレイテッド | 抗ｍｕｃ１６（ムチン１６）抗体 |
| MY199468A (en) | 2016-09-23 | 2023-10-31 | Regeneron Pharma | Anti-steap2 antibodies, antibody-drug conjugates, and bispecific antigen-binding molecules that bind steap2 and cd3, and uses thereof |
| TWI782930B (zh) * | 2016-11-16 | 2022-11-11 | 美商再生元醫藥公司 | 抗ｍｅｔ抗體，結合ｍｅｔ之雙特異性抗原結合分子及其使用方法 |
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| KR20200007905A (ko) | 2017-05-18 | 2020-01-22 | 리제너론 파마슈티칼스 인코포레이티드 | 사이클로덱스트린 단백질 약물 접합체 |
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| KR102871690B1 (ko) | 2018-04-30 | 2025-10-16 | 리제너론 파마슈티칼스 인코포레이티드 | Her2 및/또는 aplp2에 결합하는 항체 및 이중특이적 항원-결합 분자 및 접합체 그리고 이들의 용도 |
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| US11814428B2 (en) * | 2019-09-19 | 2023-11-14 | Regeneron Pharmaceuticals, Inc. | Anti-PTCRA antibody-drug conjugates and uses thereof |
| EP4058024A1 (en) | 2019-11-15 | 2022-09-21 | Seagen Inc. | Methods of treating her2 positive breast cancer with tucatinib in combination with an anti-her2 antibody-drug conjugate |
| CN113292574B (zh) * | 2020-02-21 | 2022-05-03 | 四川大学 | 一类手性多环的托品烷化合物及其制备方法和用途 |
| KR20220148200A (ko) | 2020-02-28 | 2022-11-04 | 리제너론 파마슈티칼스 인코포레이티드 | Her2에 결합하는 이중특이적 항원 결합 분자 및 이의 사용 방법 |
| CN115968304A (zh) | 2020-04-16 | 2023-04-14 | 瑞泽恩制药公司 | 狄尔斯-阿尔德缀合方法 |
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| BR112017020149A8 (pt) | 2015-03-27 | 2023-05-02 | Regeneron Pharma | Derivados de maitansinoide, conjugados dos mesmos e métodos de uso |
| BR112018014759B1 (pt) | 2016-01-25 | 2024-02-27 | Regeneron Pharmaceuticals, Inc | Compostos derivados de maitasinoide e seus conjugados, composição compreendendo os mesmos, seus métodos de fabricação e uso |
| MY199468A (en) | 2016-09-23 | 2023-10-31 | Regeneron Pharma | Anti-steap2 antibodies, antibody-drug conjugates, and bispecific antigen-binding molecules that bind steap2 and cd3, and uses thereof |
| US11814428B2 (en) | 2019-09-19 | 2023-11-14 | Regeneron Pharmaceuticals, Inc. | Anti-PTCRA antibody-drug conjugates and uses thereof |
-
2016
- 2016-03-25 BR BR112017020149A patent/BR112017020149A8/pt not_active Application Discontinuation
- 2016-03-25 KR KR1020247030839A patent/KR20240142591A/ko active Pending
- 2016-03-25 US US15/081,759 patent/US20160375147A1/en not_active Abandoned
- 2016-03-25 WO PCT/US2016/024343 patent/WO2016160615A1/en not_active Ceased
- 2016-03-25 CA CA2978340A patent/CA2978340C/en active Active
- 2016-03-25 MX MX2017012380A patent/MX386328B/es unknown
- 2016-03-25 KR KR1020177030678A patent/KR102708103B1/ko active Active
- 2016-03-25 CN CN202210829028.0A patent/CN115645543A/zh active Pending
- 2016-03-25 EA EA201700464A patent/EA034950B1/ru unknown
- 2016-03-25 AU AU2016243527A patent/AU2016243527B2/en active Active
- 2016-03-25 JP JP2017550548A patent/JP6948950B2/ja active Active
- 2016-03-25 CN CN201680030443.2A patent/CN107995912A/zh active Pending
- 2016-03-25 EP EP16714199.3A patent/EP3273998B1/en active Active
- 2016-03-25 SG SG11201707148PA patent/SG11201707148PA/en unknown
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2017
- 2017-09-01 IL IL254267A patent/IL254267B/en active IP Right Grant
- 2017-09-05 ZA ZA2017/06040A patent/ZA201706040B/en unknown
- 2017-09-26 CL CL2017002422A patent/CL2017002422A1/es unknown
- 2017-09-27 PH PH12017501780A patent/PH12017501780A1/en unknown
- 2017-09-27 MX MX2021008101A patent/MX2021008101A/es unknown
- 2017-10-26 CO CONC2017/0010890A patent/CO2017010890A2/es unknown
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2019
- 2019-12-12 US US16/712,941 patent/US20200385402A1/en not_active Abandoned
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2021
- 2021-03-17 JP JP2021044152A patent/JP2021113191A/ja not_active Withdrawn
- 2021-11-16 US US17/528,144 patent/US12297207B2/en active Active
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2025
- 2025-03-28 US US19/093,440 patent/US20250223299A1/en active Pending
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