MX2021008101A - Derivados de maitansinoide, conjugados de los mismos, y metodos de uso. - Google Patents
Derivados de maitansinoide, conjugados de los mismos, y metodos de uso.Info
- Publication number
- MX2021008101A MX2021008101A MX2021008101A MX2021008101A MX2021008101A MX 2021008101 A MX2021008101 A MX 2021008101A MX 2021008101 A MX2021008101 A MX 2021008101A MX 2021008101 A MX2021008101 A MX 2021008101A MX 2021008101 A MX2021008101 A MX 2021008101A
- Authority
- MX
- Mexico
- Prior art keywords
- conjugates
- methods
- maytansinoid derivatives
- maytansinoid
- derivatives
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5365—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines ortho- or peri-condensed with heterocyclic ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
- C07D498/18—Bridged systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
- A61K47/6801—Drug-antibody or immunoglobulin conjugates defined by the pharmacologically or therapeutically active agent
- A61K47/6803—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
- A61K47/6835—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site
- A61K47/6849—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site the antibody targeting a receptor, a cell surface antigen or a cell surface determinant
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
- A61K47/6889—Conjugates wherein the antibody being the modifying agent and wherein the linker, binder or spacer confers particular properties to the conjugates, e.g. peptidic enzyme-labile linkers or acid-labile linkers, providing for an acid-labile immuno conjugate wherein the drug may be released from its antibody conjugated part in an acidic, e.g. tumoural or environment
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/08—Bridged systems
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Immunology (AREA)
- Cell Biology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
En este documento se proporcionan derivados de maitansinoides, conjugados de los mismos y métodos para tratar o evitar enfermedades proliferativas con los mismos.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201562139044P | 2015-03-27 | 2015-03-27 | |
US201562252239P | 2015-11-06 | 2015-11-06 |
Publications (1)
Publication Number | Publication Date |
---|---|
MX2021008101A true MX2021008101A (es) | 2021-08-05 |
Family
ID=55650789
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2017012380A MX2017012380A (es) | 2015-03-27 | 2016-03-25 | Derivados de maitansinoide, conjugados de los mismos, y metodos de uso. |
MX2021008101A MX2021008101A (es) | 2015-03-27 | 2017-09-27 | Derivados de maitansinoide, conjugados de los mismos, y metodos de uso. |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2017012380A MX2017012380A (es) | 2015-03-27 | 2016-03-25 | Derivados de maitansinoide, conjugados de los mismos, y metodos de uso. |
Country Status (17)
Country | Link |
---|---|
US (3) | US20160375147A1 (es) |
EP (1) | EP3273998B1 (es) |
JP (2) | JP6948950B2 (es) |
KR (1) | KR20170131587A (es) |
CN (2) | CN107995912A (es) |
AU (1) | AU2016243527B2 (es) |
BR (1) | BR112017020149A8 (es) |
CA (1) | CA2978340A1 (es) |
CL (1) | CL2017002422A1 (es) |
CO (1) | CO2017010890A2 (es) |
EA (1) | EA034950B1 (es) |
IL (1) | IL254267B (es) |
MX (2) | MX2017012380A (es) |
PH (1) | PH12017501780A1 (es) |
SG (1) | SG11201707148PA (es) |
WO (1) | WO2016160615A1 (es) |
ZA (1) | ZA201706040B (es) |
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CN105188766B (zh) | 2013-03-15 | 2019-07-12 | 瑞泽恩制药公司 | 生物活性分子、其偶联物及治疗用途 |
EP3038624A1 (en) | 2013-08-26 | 2016-07-06 | Regeneron Pharmaceuticals, Inc. | Pharmaceutical compositions comprising macrolide diastereomers, methods of their synthesis and therapeutic uses |
US20160375147A1 (en) * | 2015-03-27 | 2016-12-29 | Regeneron Pharmaceuticals, Inc. | Maytansinoid derivatives, conjugates thereof, and methods of use |
MY189159A (en) | 2015-07-06 | 2022-01-29 | Regeneron Pharma | Multispecific antigen-binding molecules and uses thereof |
MY198605A (en) | 2016-01-25 | 2023-09-08 | Regeneron Pharma | Maytansinoid derivatives conjugates thereof, and methods of use |
WO2017190079A1 (en) | 2016-04-28 | 2017-11-02 | Regeneron Pharmaceuticals, Inc. | Methods of making multispecific antigen-binding molecules |
SG10202102617QA (en) | 2016-09-23 | 2021-04-29 | Regeneron Pharma | Anti-steap2 antibodies, antibody-drug conjugates, and bispecific antigen-binding molecules that bind steap2 and cd3, and uses thereof |
WO2018067331A1 (en) | 2016-09-23 | 2018-04-12 | Regeneron Pharmaceuticals, Inc. | Bi specific anti-muc16-cd3 antibodies and nti-muc16 drug conjugates |
TWI782930B (zh) | 2016-11-16 | 2022-11-11 | 美商再生元醫藥公司 | 抗met抗體,結合met之雙特異性抗原結合分子及其使用方法 |
MX2019006131A (es) | 2016-11-29 | 2019-08-21 | Regeneron Pharma | Metodos para tratar cancer de mama positivo para prlr. |
MX2019013690A (es) | 2017-05-18 | 2020-01-27 | Regeneron Pharma | Conjugados de farmaco-proteina con ciclodextrina. |
JP7442821B2 (ja) * | 2017-11-30 | 2024-03-05 | センチュリオン バイオファーマ コーポレイション | メイタンシノイド系薬物送達システム |
CA3097711A1 (en) | 2018-04-30 | 2019-11-07 | Regeneron Pharmaceuticals, Inc. | Antibodies, and bispecific antigen-binding molecules that bind her2 and/or aplp2, conjugates, and uses thereof |
EA202091135A1 (ru) | 2018-05-09 | 2020-10-14 | Регенерон Фармасьютикалз, Инк. | Гидрофильные линкеры для конъюгатов антитело-лекарственное средство |
US20210079109A1 (en) | 2018-05-17 | 2021-03-18 | Regeneron Pharmaceuticals, Inc. | Anti-cd63 antibodies, conjugates, and uses thereof |
CN112638426B (zh) * | 2018-09-21 | 2023-06-16 | 中国人民解放军军事科学院军事医学研究院 | 基于芳硝基的连接子、含连接子的抗体偶联药物及连接子的用途 |
AU2020224136A1 (en) | 2019-02-21 | 2021-09-02 | Regeneron Pharmaceuticals, Inc. | Methods of treating ocular cancer using anti-MET antibodies and bispecific antigen binding molecules that bind MET |
CA3146933A1 (en) | 2019-09-16 | 2021-03-25 | Marcus KELLY | Radiolabeled met binding proteins for immuno-pet imaging |
US11814428B2 (en) * | 2019-09-19 | 2023-11-14 | Regeneron Pharmaceuticals, Inc. | Anti-PTCRA antibody-drug conjugates and uses thereof |
JP2023502929A (ja) | 2019-11-15 | 2023-01-26 | シージェン インコーポレイテッド | Her2陽性乳がんを抗her2抗体-薬物コンジュゲートと併用してツカチニブで治療する方法 |
CN113292574B (zh) * | 2020-02-21 | 2022-05-03 | 四川大学 | 一类手性多环的托品烷化合物及其制备方法和用途 |
CA3166619A1 (en) | 2020-02-28 | 2021-09-02 | Julian Andreev | Bispecific antigen binding molecules that bind her2, and methods of use thereof |
JP2023521885A (ja) | 2020-04-16 | 2023-05-25 | リジェネロン・ファーマシューティカルズ・インコーポレイテッド | ディールス-アルダーコンジュゲーション方法 |
CN116406379A (zh) | 2020-10-22 | 2023-07-07 | 瑞泽恩制药公司 | 抗fgfr2抗体和其使用方法 |
MX2023004935A (es) | 2020-11-10 | 2023-07-07 | Regeneron Pharma | Conjugados de anticuerpos y selenio. |
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-
2016
- 2016-03-25 US US15/081,759 patent/US20160375147A1/en not_active Abandoned
- 2016-03-25 BR BR112017020149A patent/BR112017020149A8/pt not_active Application Discontinuation
- 2016-03-25 CA CA2978340A patent/CA2978340A1/en active Granted
- 2016-03-25 KR KR1020177030678A patent/KR20170131587A/ko not_active Application Discontinuation
- 2016-03-25 WO PCT/US2016/024343 patent/WO2016160615A1/en active Application Filing
- 2016-03-25 MX MX2017012380A patent/MX2017012380A/es unknown
- 2016-03-25 CN CN201680030443.2A patent/CN107995912A/zh active Pending
- 2016-03-25 SG SG11201707148PA patent/SG11201707148PA/en unknown
- 2016-03-25 JP JP2017550548A patent/JP6948950B2/ja active Active
- 2016-03-25 EP EP16714199.3A patent/EP3273998B1/en active Active
- 2016-03-25 AU AU2016243527A patent/AU2016243527B2/en active Active
- 2016-03-25 EA EA201700464A patent/EA034950B1/ru unknown
- 2016-03-25 CN CN202210829028.0A patent/CN115645543A/zh active Pending
-
2017
- 2017-09-01 IL IL254267A patent/IL254267B/en active IP Right Grant
- 2017-09-05 ZA ZA2017/06040A patent/ZA201706040B/en unknown
- 2017-09-26 CL CL2017002422A patent/CL2017002422A1/es unknown
- 2017-09-27 PH PH12017501780A patent/PH12017501780A1/en unknown
- 2017-09-27 MX MX2021008101A patent/MX2021008101A/es unknown
- 2017-10-26 CO CONC2017/0010890A patent/CO2017010890A2/es unknown
-
2019
- 2019-12-12 US US16/712,941 patent/US20200385402A1/en not_active Abandoned
-
2021
- 2021-03-17 JP JP2021044152A patent/JP2021113191A/ja not_active Withdrawn
- 2021-11-16 US US17/528,144 patent/US20220259225A1/en active Pending
Also Published As
Publication number | Publication date |
---|---|
EP3273998A1 (en) | 2018-01-31 |
WO2016160615A1 (en) | 2016-10-06 |
PH12017501780A1 (en) | 2018-04-30 |
MX2017012380A (es) | 2018-04-11 |
EA201700464A1 (ru) | 2018-11-30 |
IL254267B (en) | 2021-03-25 |
BR112017020149A8 (pt) | 2023-05-02 |
IL254267A (en) | 2018-06-28 |
EA034950B1 (ru) | 2020-04-09 |
CN115645543A (zh) | 2023-01-31 |
ZA201706040B (en) | 2020-05-27 |
US20220259225A1 (en) | 2022-08-18 |
JP2021113191A (ja) | 2021-08-05 |
CN107995912A (zh) | 2018-05-04 |
SG11201707148PA (en) | 2017-10-30 |
EP3273998B1 (en) | 2019-09-04 |
KR20170131587A (ko) | 2017-11-29 |
US20200385402A1 (en) | 2020-12-10 |
JP6948950B2 (ja) | 2021-10-13 |
CA2978340A1 (en) | 2016-10-06 |
JP2018516851A (ja) | 2018-06-28 |
AU2016243527A1 (en) | 2017-09-21 |
CO2017010890A2 (es) | 2020-04-13 |
US20160375147A1 (en) | 2016-12-29 |
AU2016243527B2 (en) | 2021-04-29 |
CL2017002422A1 (es) | 2018-03-16 |
BR112017020149A2 (pt) | 2018-09-11 |
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