JP2018514549A5 - - Google Patents
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- JP2018514549A5 JP2018514549A5 JP2017556627A JP2017556627A JP2018514549A5 JP 2018514549 A5 JP2018514549 A5 JP 2018514549A5 JP 2017556627 A JP2017556627 A JP 2017556627A JP 2017556627 A JP2017556627 A JP 2017556627A JP 2018514549 A5 JP2018514549 A5 JP 2018514549A5
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- Prior art keywords
- agent according
- cancer
- drug
- rad1901
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- Prior art date
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- 239000003795 chemical substances by application Substances 0.000 claims 20
- 239000003814 drug Substances 0.000 claims 9
- 229940079593 drug Drugs 0.000 claims 8
- 206010028980 Neoplasm Diseases 0.000 claims 7
- SIFNOOUKXBRGGB-AREMUKBSSA-N (6r)-6-[2-[ethyl-[[4-[2-(ethylamino)ethyl]phenyl]methyl]amino]-4-methoxyphenyl]-5,6,7,8-tetrahydronaphthalen-2-ol Chemical compound C1=CC(CCNCC)=CC=C1CN(CC)C1=CC(OC)=CC=C1[C@H]1CC2=CC=C(O)C=C2CC1 SIFNOOUKXBRGGB-AREMUKBSSA-N 0.000 claims 6
- 150000003839 salts Chemical class 0.000 claims 6
- -1 DDR2 Proteins 0.000 claims 5
- HKVAMNSJSFKALM-GKUWKFKPSA-N Everolimus Chemical compound C1C[C@@H](OCCO)[C@H](OC)C[C@@H]1C[C@@H](C)[C@H]1OC(=O)[C@@H]2CCCCN2C(=O)C(=O)[C@](O)(O2)[C@H](C)CC[C@H]2C[C@H](OC)/C(C)=C/C=C/C=C/[C@@H](C)C[C@@H](C)C(=O)[C@H](OC)[C@H](O)/C(C)=C/[C@@H](C)C(=O)C1 HKVAMNSJSFKALM-GKUWKFKPSA-N 0.000 claims 5
- 201000011510 cancer Diseases 0.000 claims 5
- 229960005167 everolimus Drugs 0.000 claims 5
- 239000003112 inhibitor Substances 0.000 claims 5
- 239000012453 solvate Substances 0.000 claims 5
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- 206010006187 Breast cancer Diseases 0.000 claims 3
- 208000026310 Breast neoplasm Diseases 0.000 claims 3
- 229940046836 anti-estrogen Drugs 0.000 claims 3
- 230000001833 anti-estrogenic effect Effects 0.000 claims 3
- 239000003886 aromatase inhibitor Substances 0.000 claims 3
- 239000000328 estrogen antagonist Substances 0.000 claims 3
- 108091007854 Cdh1/Fizzy-related Proteins 0.000 claims 2
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- 108010011536 PTEN Phosphohydrolase Proteins 0.000 claims 2
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- 239000004480 active ingredient Substances 0.000 claims 2
- 229940046844 aromatase inhibitors Drugs 0.000 claims 2
- 230000035772 mutation Effects 0.000 claims 2
- XGFHYCAZOCBCRQ-FBHGDYMESA-N (6r)-6-[2-[ethyl-[[4-[2-(ethylamino)ethyl]phenyl]methyl]amino]-4-methoxyphenyl]-5,6,7,8-tetrahydronaphthalen-2-ol;dihydrochloride Chemical group Cl.Cl.C1=CC(CCNCC)=CC=C1CN(CC)C1=CC(OC)=CC=C1[C@H]1CC2=CC=C(O)C=C2CC1 XGFHYCAZOCBCRQ-FBHGDYMESA-N 0.000 claims 1
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- 108010024491 DNA Methyltransferase 3A Proteins 0.000 claims 1
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- VWUXBMIQPBEWFH-WCCTWKNTSA-N Fulvestrant Chemical compound OC1=CC=C2[C@H]3CC[C@](C)([C@H](CC4)O)[C@@H]4[C@@H]3[C@H](CCCCCCCCCS(=O)CCCC(F)(F)C(F)(F)F)CC2=C1 VWUXBMIQPBEWFH-WCCTWKNTSA-N 0.000 claims 1
- 102100024165 G1/S-specific cyclin-D1 Human genes 0.000 claims 1
- 102100024185 G1/S-specific cyclin-D2 Human genes 0.000 claims 1
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- 101000779641 Homo sapiens ALK tyrosine kinase receptor Proteins 0.000 claims 1
- 101000924266 Homo sapiens AT-rich interactive domain-containing protein 1A Proteins 0.000 claims 1
- 101000924577 Homo sapiens Adenomatous polyposis coli protein Proteins 0.000 claims 1
- 101000933320 Homo sapiens Breakpoint cluster region protein Proteins 0.000 claims 1
- 101000945515 Homo sapiens CCAAT/enhancer-binding protein alpha Proteins 0.000 claims 1
- 101000916173 Homo sapiens Catenin beta-1 Proteins 0.000 claims 1
- 101000980937 Homo sapiens Cyclin-dependent kinase 8 Proteins 0.000 claims 1
- 101000968658 Homo sapiens DNA mismatch repair protein Msh6 Proteins 0.000 claims 1
- 101001115395 Homo sapiens Dual specificity mitogen-activated protein kinase kinase 4 Proteins 0.000 claims 1
- 101001095815 Homo sapiens E3 ubiquitin-protein ligase RING2 Proteins 0.000 claims 1
- 101001057929 Homo sapiens Echinoderm microtubule-associated protein-like 4 Proteins 0.000 claims 1
- 101001060267 Homo sapiens Fibroblast growth factor 5 Proteins 0.000 claims 1
- 101000818410 Homo sapiens Fibroblast growth factor receptor substrate 2 Proteins 0.000 claims 1
- 101000980741 Homo sapiens G1/S-specific cyclin-D2 Proteins 0.000 claims 1
- 101000738559 Homo sapiens G1/S-specific cyclin-D3 Proteins 0.000 claims 1
- 101000738568 Homo sapiens G1/S-specific cyclin-E1 Proteins 0.000 claims 1
- 101000584633 Homo sapiens GTPase HRas Proteins 0.000 claims 1
- 101000744505 Homo sapiens GTPase NRas Proteins 0.000 claims 1
- 101000795643 Homo sapiens Hamartin Proteins 0.000 claims 1
- 101000632178 Homo sapiens Homeobox protein Nkx-2.1 Proteins 0.000 claims 1
- 101001046870 Homo sapiens Hypoxia-inducible factor 1-alpha Proteins 0.000 claims 1
- 101001056180 Homo sapiens Induced myeloid leukemia cell differentiation protein Mcl-1 Proteins 0.000 claims 1
- 101001034652 Homo sapiens Insulin-like growth factor 1 receptor Proteins 0.000 claims 1
- 101000960234 Homo sapiens Isocitrate dehydrogenase [NADP] cytoplasmic Proteins 0.000 claims 1
- 101000599886 Homo sapiens Isocitrate dehydrogenase [NADP], mitochondrial Proteins 0.000 claims 1
- 101001050559 Homo sapiens Kinesin-1 heavy chain Proteins 0.000 claims 1
- 101001025967 Homo sapiens Lysine-specific demethylase 6A Proteins 0.000 claims 1
- 101001057193 Homo sapiens Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 Proteins 0.000 claims 1
- 101000653374 Homo sapiens Methylcytosine dioxygenase TET2 Proteins 0.000 claims 1
- 101001120056 Homo sapiens Phosphatidylinositol 3-kinase regulatory subunit alpha Proteins 0.000 claims 1
- 101000605639 Homo sapiens Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform Proteins 0.000 claims 1
- 101001126417 Homo sapiens Platelet-derived growth factor receptor alpha Proteins 0.000 claims 1
- 101000728236 Homo sapiens Polycomb group protein ASXL1 Proteins 0.000 claims 1
- 101000573199 Homo sapiens Protein PML Proteins 0.000 claims 1
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- 101000779418 Homo sapiens RAC-alpha serine/threonine-protein kinase Proteins 0.000 claims 1
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- 101000823316 Homo sapiens Tyrosine-protein kinase ABL1 Proteins 0.000 claims 1
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- 101000740048 Homo sapiens Ubiquitin carboxyl-terminal hydrolase BAP1 Proteins 0.000 claims 1
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- 101000740049 Latilactobacillus curvatus Bioactive peptide 1 Proteins 0.000 claims 1
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- 102100030803 Methylcytosine dioxygenase TET2 Human genes 0.000 claims 1
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- 102100026169 Phosphatidylinositol 3-kinase regulatory subunit alpha Human genes 0.000 claims 1
- 102100038332 Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform Human genes 0.000 claims 1
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- 239000000333 selective estrogen receptor modulator Substances 0.000 claims 1
- 229940095743 selective estrogen receptor modulator Drugs 0.000 claims 1
- QFJCIRLUMZQUOT-HPLJOQBZSA-N sirolimus Chemical compound C1C[C@@H](O)[C@H](OC)C[C@@H]1C[C@@H](C)[C@H]1OC(=O)[C@@H]2CCCCN2C(=O)C(=O)[C@](O)(O2)[C@H](C)CC[C@H]2C[C@H](OC)/C(C)=C/C=C/C=C/[C@@H](C)C[C@@H](C)C(=O)[C@H](OC)[C@H](O)/C(C)=C/[C@@H](C)C(=O)C1 QFJCIRLUMZQUOT-HPLJOQBZSA-N 0.000 claims 1
- 229960002930 sirolimus Drugs 0.000 claims 1
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Applications Claiming Priority (27)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562154699P | 2015-04-29 | 2015-04-29 | |
| US62/154,699 | 2015-04-29 | ||
| US201562155451P | 2015-04-30 | 2015-04-30 | |
| US62/155,451 | 2015-04-30 | ||
| US201562158469P | 2015-05-07 | 2015-05-07 | |
| US62/158,469 | 2015-05-07 | ||
| US201562192944P | 2015-07-15 | 2015-07-15 | |
| US201562192940P | 2015-07-15 | 2015-07-15 | |
| US62/192,940 | 2015-07-15 | ||
| US62/192,944 | 2015-07-15 | ||
| US201562252085P | 2015-11-06 | 2015-11-06 | |
| US62/252,085 | 2015-11-06 | ||
| US201562252916P | 2015-11-09 | 2015-11-09 | |
| US62/252,916 | 2015-11-09 | ||
| US201562265658P | 2015-12-10 | 2015-12-10 | |
| US201562265774P | 2015-12-10 | 2015-12-10 | |
| US201562265696P | 2015-12-10 | 2015-12-10 | |
| US201562265663P | 2015-12-10 | 2015-12-10 | |
| US62/265,658 | 2015-12-10 | ||
| US62/265,774 | 2015-12-10 | ||
| US62/265,696 | 2015-12-10 | ||
| US62/265,663 | 2015-12-10 | ||
| US201662323576P | 2016-04-15 | 2016-04-15 | |
| US201662323572P | 2016-04-15 | 2016-04-15 | |
| US62/323,576 | 2016-04-15 | ||
| US62/323,572 | 2016-04-15 | ||
| PCT/US2016/030316 WO2016176664A1 (en) | 2015-04-29 | 2016-04-29 | Methods for treating cancer |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2018514549A JP2018514549A (ja) | 2018-06-07 |
| JP2018514549A5 true JP2018514549A5 (enExample) | 2019-05-30 |
| JP7019422B2 JP7019422B2 (ja) | 2022-02-15 |
Family
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| JP2018509732A Active JP6926066B2 (ja) | 2015-04-29 | 2016-04-29 | 癌を治療するための方法 |
| JP2018509731A Active JP6926065B2 (ja) | 2015-04-29 | 2016-04-29 | 癌を治療するための方法 |
| JP2021052305A Active JP7146992B2 (ja) | 2015-04-29 | 2021-03-25 | 癌を治療するための方法 |
| JP2021073337A Active JP7262508B2 (ja) | 2015-04-29 | 2021-04-23 | 癌を治療するための方法 |
| JP2022150560A Active JP7516472B2 (ja) | 2015-04-29 | 2022-09-21 | 癌を治療するための方法 |
| JP2023009598A Active JP7696378B2 (ja) | 2015-04-29 | 2023-01-25 | 癌を治療するための方法 |
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| JP2025153179A Pending JP2025170141A (ja) | 2015-04-29 | 2025-09-16 | 癌を治療するための方法 |
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| JP2018509732A Active JP6926066B2 (ja) | 2015-04-29 | 2016-04-29 | 癌を治療するための方法 |
| JP2018509731A Active JP6926065B2 (ja) | 2015-04-29 | 2016-04-29 | 癌を治療するための方法 |
| JP2021052305A Active JP7146992B2 (ja) | 2015-04-29 | 2021-03-25 | 癌を治療するための方法 |
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