JPWO2020118202A5 - - Google Patents
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- Publication number
- JPWO2020118202A5 JPWO2020118202A5 JP2021531817A JP2021531817A JPWO2020118202A5 JP WO2020118202 A5 JPWO2020118202 A5 JP WO2020118202A5 JP 2021531817 A JP2021531817 A JP 2021531817A JP 2021531817 A JP2021531817 A JP 2021531817A JP WO2020118202 A5 JPWO2020118202 A5 JP WO2020118202A5
- Authority
- JP
- Japan
- Prior art keywords
- pharmaceutical composition
- subject
- elasestrant
- estrogen receptor
- day
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000008194 pharmaceutical composition Substances 0.000 claims 20
- 102100038595 Estrogen receptor Human genes 0.000 claims 8
- 108010007005 Estrogen Receptor alpha Proteins 0.000 claims 7
- 206010028980 Neoplasm Diseases 0.000 claims 7
- 201000011510 cancer Diseases 0.000 claims 6
- 206010006187 Breast cancer Diseases 0.000 claims 4
- -1 DDR2 Proteins 0.000 claims 4
- 239000003886 aromatase inhibitor Substances 0.000 claims 4
- 150000003839 salts Chemical class 0.000 claims 4
- 239000012453 solvate Substances 0.000 claims 4
- 229940122815 Aromatase inhibitor Drugs 0.000 claims 3
- 208000026310 Breast neoplasm Diseases 0.000 claims 3
- 230000035772 mutation Effects 0.000 claims 3
- 108010025464 Cyclin-Dependent Kinase 4 Proteins 0.000 claims 2
- 108010025468 Cyclin-Dependent Kinase 6 Proteins 0.000 claims 2
- 102100036252 Cyclin-dependent kinase 4 Human genes 0.000 claims 2
- 102100026804 Cyclin-dependent kinase 6 Human genes 0.000 claims 2
- 101001120056 Homo sapiens Phosphatidylinositol 3-kinase regulatory subunit alpha Proteins 0.000 claims 2
- 101000605639 Homo sapiens Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform Proteins 0.000 claims 2
- 101000779418 Homo sapiens RAC-alpha serine/threonine-protein kinase Proteins 0.000 claims 2
- 101000798015 Homo sapiens RAC-beta serine/threonine-protein kinase Proteins 0.000 claims 2
- 101000984753 Homo sapiens Serine/threonine-protein kinase B-raf Proteins 0.000 claims 2
- 101150097381 Mtor gene Proteins 0.000 claims 2
- 102100026169 Phosphatidylinositol 3-kinase regulatory subunit alpha Human genes 0.000 claims 2
- 102100038332 Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform Human genes 0.000 claims 2
- 102100033810 RAC-alpha serine/threonine-protein kinase Human genes 0.000 claims 2
- 102100032315 RAC-beta serine/threonine-protein kinase Human genes 0.000 claims 2
- 102100027103 Serine/threonine-protein kinase B-raf Human genes 0.000 claims 2
- 102100023085 Serine/threonine-protein kinase mTOR Human genes 0.000 claims 2
- NKANXQFJJICGDU-QPLCGJKRSA-N Tamoxifen Chemical compound C=1C=CC=CC=1C(/CC)=C(C=1C=CC(OCCN(C)C)=CC=1)/C1=CC=CC=C1 NKANXQFJJICGDU-QPLCGJKRSA-N 0.000 claims 2
- 229940046836 anti-estrogen Drugs 0.000 claims 2
- 230000001833 anti-estrogenic effect Effects 0.000 claims 2
- 239000000328 estrogen antagonist Substances 0.000 claims 2
- 238000000034 method Methods 0.000 claims 2
- 108090000623 proteins and genes Proteins 0.000 claims 2
- 239000000333 selective estrogen receptor modulator Substances 0.000 claims 2
- 229940095743 selective estrogen receptor modulator Drugs 0.000 claims 2
- 102100034580 AT-rich interactive domain-containing protein 1A Human genes 0.000 claims 1
- 102000000872 ATM Human genes 0.000 claims 1
- BFYIZQONLCFLEV-DAELLWKTSA-N Aromasine Chemical compound O=C1C=C[C@]2(C)[C@H]3CC[C@](C)(C(CC4)=O)[C@@H]4[C@@H]3CC(=C)C2=C1 BFYIZQONLCFLEV-DAELLWKTSA-N 0.000 claims 1
- 108010004586 Ataxia Telangiectasia Mutated Proteins Proteins 0.000 claims 1
- 102000004000 Aurora Kinase A Human genes 0.000 claims 1
- 108090000461 Aurora Kinase A Proteins 0.000 claims 1
- 108700020463 BRCA1 Proteins 0.000 claims 1
- 102000036365 BRCA1 Human genes 0.000 claims 1
- 101150072950 BRCA1 gene Proteins 0.000 claims 1
- 108700020462 BRCA2 Proteins 0.000 claims 1
- 102000052609 BRCA2 Human genes 0.000 claims 1
- 108010040168 Bcl-2-Like Protein 11 Proteins 0.000 claims 1
- 102000001765 Bcl-2-Like Protein 11 Human genes 0.000 claims 1
- 101001042041 Bos taurus Isocitrate dehydrogenase [NAD] subunit beta, mitochondrial Proteins 0.000 claims 1
- 101150008921 Brca2 gene Proteins 0.000 claims 1
- 102100026008 Breakpoint cluster region protein Human genes 0.000 claims 1
- 206010055113 Breast cancer metastatic Diseases 0.000 claims 1
- 102100034808 CCAAT/enhancer-binding protein alpha Human genes 0.000 claims 1
- 102100028914 Catenin beta-1 Human genes 0.000 claims 1
- ZEOWTGPWHLSLOG-UHFFFAOYSA-N Cc1ccc(cc1-c1ccc2c(n[nH]c2c1)-c1cnn(c1)C1CC1)C(=O)Nc1cccc(c1)C(F)(F)F Chemical compound Cc1ccc(cc1-c1ccc2c(n[nH]c2c1)-c1cnn(c1)C1CC1)C(=O)Nc1cccc(c1)C(F)(F)F ZEOWTGPWHLSLOG-UHFFFAOYSA-N 0.000 claims 1
- 108091007854 Cdh1/Fizzy-related Proteins 0.000 claims 1
- 102100025064 Cellular tumor antigen p53 Human genes 0.000 claims 1
- 108010043471 Core Binding Factor Alpha 2 Subunit Proteins 0.000 claims 1
- 108010058546 Cyclin D1 Proteins 0.000 claims 1
- 102000009512 Cyclin-Dependent Kinase Inhibitor p15 Human genes 0.000 claims 1
- 108010009356 Cyclin-Dependent Kinase Inhibitor p15 Proteins 0.000 claims 1
- 108010009392 Cyclin-Dependent Kinase Inhibitor p16 Proteins 0.000 claims 1
- 108010016788 Cyclin-Dependent Kinase Inhibitor p21 Proteins 0.000 claims 1
- 102000000577 Cyclin-Dependent Kinase Inhibitor p27 Human genes 0.000 claims 1
- 108010016777 Cyclin-Dependent Kinase Inhibitor p27 Proteins 0.000 claims 1
- 102100024456 Cyclin-dependent kinase 8 Human genes 0.000 claims 1
- 102100033270 Cyclin-dependent kinase inhibitor 1 Human genes 0.000 claims 1
- 102100024812 DNA (cytosine-5)-methyltransferase 3A Human genes 0.000 claims 1
- 108010024491 DNA Methyltransferase 3A Proteins 0.000 claims 1
- 102100021147 DNA mismatch repair protein Msh6 Human genes 0.000 claims 1
- 102100031480 Dual specificity mitogen-activated protein kinase kinase 1 Human genes 0.000 claims 1
- 102100023274 Dual specificity mitogen-activated protein kinase kinase 4 Human genes 0.000 claims 1
- 102000012199 E3 ubiquitin-protein ligase Mdm2 Human genes 0.000 claims 1
- 108050002772 E3 ubiquitin-protein ligase Mdm2 Proteins 0.000 claims 1
- 101150097734 EPHB2 gene Proteins 0.000 claims 1
- 102100027100 Echinoderm microtubule-associated protein-like 4 Human genes 0.000 claims 1
- 102100031968 Ephrin type-B receptor 2 Human genes 0.000 claims 1
- 102100028138 F-box/WD repeat-containing protein 7 Human genes 0.000 claims 1
- 101710105178 F-box/WD repeat-containing protein 7 Proteins 0.000 claims 1
- 102100028072 Fibroblast growth factor 4 Human genes 0.000 claims 1
- 102100023593 Fibroblast growth factor receptor 1 Human genes 0.000 claims 1
- 101710182386 Fibroblast growth factor receptor 1 Proteins 0.000 claims 1
- 102100023600 Fibroblast growth factor receptor 2 Human genes 0.000 claims 1
- 101710182389 Fibroblast growth factor receptor 2 Proteins 0.000 claims 1
- 102100027842 Fibroblast growth factor receptor 3 Human genes 0.000 claims 1
- 101710182396 Fibroblast growth factor receptor 3 Proteins 0.000 claims 1
- 102100021066 Fibroblast growth factor receptor substrate 2 Human genes 0.000 claims 1
- 102100040859 Fizzy-related protein homolog Human genes 0.000 claims 1
- VWUXBMIQPBEWFH-WCCTWKNTSA-N Fulvestrant Chemical compound OC1=CC=C2[C@H]3CC[C@](C)([C@H](CC4)O)[C@@H]4[C@@H]3[C@H](CCCCCCCCCS(=O)CCCC(F)(F)C(F)(F)F)CC2=C1 VWUXBMIQPBEWFH-WCCTWKNTSA-N 0.000 claims 1
- 102100024165 G1/S-specific cyclin-D1 Human genes 0.000 claims 1
- 102100024185 G1/S-specific cyclin-D2 Human genes 0.000 claims 1
- 102100037859 G1/S-specific cyclin-D3 Human genes 0.000 claims 1
- 102100037858 G1/S-specific cyclin-E1 Human genes 0.000 claims 1
- 102100029974 GTPase HRas Human genes 0.000 claims 1
- 102100030708 GTPase KRas Human genes 0.000 claims 1
- 102100039788 GTPase NRas Human genes 0.000 claims 1
- 102100027893 Homeobox protein Nkx-2.1 Human genes 0.000 claims 1
- 101000924266 Homo sapiens AT-rich interactive domain-containing protein 1A Proteins 0.000 claims 1
- 101000933320 Homo sapiens Breakpoint cluster region protein Proteins 0.000 claims 1
- 101000945515 Homo sapiens CCAAT/enhancer-binding protein alpha Proteins 0.000 claims 1
- 101000916173 Homo sapiens Catenin beta-1 Proteins 0.000 claims 1
- 101000980937 Homo sapiens Cyclin-dependent kinase 8 Proteins 0.000 claims 1
- 101000968658 Homo sapiens DNA mismatch repair protein Msh6 Proteins 0.000 claims 1
- 101001115395 Homo sapiens Dual specificity mitogen-activated protein kinase kinase 4 Proteins 0.000 claims 1
- 101001095815 Homo sapiens E3 ubiquitin-protein ligase RING2 Proteins 0.000 claims 1
- 101001057929 Homo sapiens Echinoderm microtubule-associated protein-like 4 Proteins 0.000 claims 1
- 101000882584 Homo sapiens Estrogen receptor Proteins 0.000 claims 1
- 101001060274 Homo sapiens Fibroblast growth factor 4 Proteins 0.000 claims 1
- 101000818410 Homo sapiens Fibroblast growth factor receptor substrate 2 Proteins 0.000 claims 1
- 101000980741 Homo sapiens G1/S-specific cyclin-D2 Proteins 0.000 claims 1
- 101000738559 Homo sapiens G1/S-specific cyclin-D3 Proteins 0.000 claims 1
- 101000738568 Homo sapiens G1/S-specific cyclin-E1 Proteins 0.000 claims 1
- 101000584633 Homo sapiens GTPase HRas Proteins 0.000 claims 1
- 101000584612 Homo sapiens GTPase KRas Proteins 0.000 claims 1
- 101000744505 Homo sapiens GTPase NRas Proteins 0.000 claims 1
- 101000632178 Homo sapiens Homeobox protein Nkx-2.1 Proteins 0.000 claims 1
- 101001046870 Homo sapiens Hypoxia-inducible factor 1-alpha Proteins 0.000 claims 1
- 101001056180 Homo sapiens Induced myeloid leukemia cell differentiation protein Mcl-1 Proteins 0.000 claims 1
- 101001034652 Homo sapiens Insulin-like growth factor 1 receptor Proteins 0.000 claims 1
- 101000960234 Homo sapiens Isocitrate dehydrogenase [NADP] cytoplasmic Proteins 0.000 claims 1
- 101000599886 Homo sapiens Isocitrate dehydrogenase [NADP], mitochondrial Proteins 0.000 claims 1
- 101001050559 Homo sapiens Kinesin-1 heavy chain Proteins 0.000 claims 1
- 101000984620 Homo sapiens Low-density lipoprotein receptor-related protein 1B Proteins 0.000 claims 1
- 101001025967 Homo sapiens Lysine-specific demethylase 6A Proteins 0.000 claims 1
- 101001057193 Homo sapiens Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 Proteins 0.000 claims 1
- 101000653374 Homo sapiens Methylcytosine dioxygenase TET2 Proteins 0.000 claims 1
- 101001126417 Homo sapiens Platelet-derived growth factor receptor alpha Proteins 0.000 claims 1
- 101000728236 Homo sapiens Polycomb group protein ASXL1 Proteins 0.000 claims 1
- 101000573199 Homo sapiens Protein PML Proteins 0.000 claims 1
- 101000686031 Homo sapiens Proto-oncogene tyrosine-protein kinase ROS Proteins 0.000 claims 1
- 101000579425 Homo sapiens Proto-oncogene tyrosine-protein kinase receptor Ret Proteins 0.000 claims 1
- 101100087590 Homo sapiens RICTOR gene Proteins 0.000 claims 1
- 101001012157 Homo sapiens Receptor tyrosine-protein kinase erbB-2 Proteins 0.000 claims 1
- 101000932478 Homo sapiens Receptor-type tyrosine-protein kinase FLT3 Proteins 0.000 claims 1
- 101000606537 Homo sapiens Receptor-type tyrosine-protein phosphatase delta Proteins 0.000 claims 1
- 101000742859 Homo sapiens Retinoblastoma-associated protein Proteins 0.000 claims 1
- 101001112293 Homo sapiens Retinoic acid receptor alpha Proteins 0.000 claims 1
- 101000628562 Homo sapiens Serine/threonine-protein kinase STK11 Proteins 0.000 claims 1
- 101000702545 Homo sapiens Transcription activator BRG1 Proteins 0.000 claims 1
- 101000904150 Homo sapiens Transcription factor E2F3 Proteins 0.000 claims 1
- 101000687905 Homo sapiens Transcription factor SOX-2 Proteins 0.000 claims 1
- 101000823316 Homo sapiens Tyrosine-protein kinase ABL1 Proteins 0.000 claims 1
- 101000997832 Homo sapiens Tyrosine-protein kinase JAK2 Proteins 0.000 claims 1
- 101000740048 Homo sapiens Ubiquitin carboxyl-terminal hydrolase BAP1 Proteins 0.000 claims 1
- 102100022875 Hypoxia-inducible factor 1-alpha Human genes 0.000 claims 1
- 102100026539 Induced myeloid leukemia cell differentiation protein Mcl-1 Human genes 0.000 claims 1
- 102100039688 Insulin-like growth factor 1 receptor Human genes 0.000 claims 1
- 102100039905 Isocitrate dehydrogenase [NADP] cytoplasmic Human genes 0.000 claims 1
- 102100037845 Isocitrate dehydrogenase [NADP], mitochondrial Human genes 0.000 claims 1
- 102100023422 Kinesin-1 heavy chain Human genes 0.000 claims 1
- 101000740049 Latilactobacillus curvatus Bioactive peptide 1 Proteins 0.000 claims 1
- 102100027121 Low-density lipoprotein receptor-related protein 1B Human genes 0.000 claims 1
- 102100037462 Lysine-specific demethylase 6A Human genes 0.000 claims 1
- 108010068342 MAP Kinase Kinase 1 Proteins 0.000 claims 1
- 102000017274 MDM4 Human genes 0.000 claims 1
- 108050005300 MDM4 Proteins 0.000 claims 1
- 102100027240 Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 Human genes 0.000 claims 1
- 206010027476 Metastases Diseases 0.000 claims 1
- 102100025825 Methylated-DNA-protein-cysteine methyltransferase Human genes 0.000 claims 1
- 102100030803 Methylcytosine dioxygenase TET2 Human genes 0.000 claims 1
- 102100025725 Mothers against decapentaplegic homolog 4 Human genes 0.000 claims 1
- 101710143112 Mothers against decapentaplegic homolog 4 Proteins 0.000 claims 1
- 102100027096 Nucleotide exchange factor SIL1 Human genes 0.000 claims 1
- 206010033128 Ovarian cancer Diseases 0.000 claims 1
- 206010061535 Ovarian neoplasm Diseases 0.000 claims 1
- 108010011536 PTEN Phosphohydrolase Proteins 0.000 claims 1
- 102000014160 PTEN Phosphohydrolase Human genes 0.000 claims 1
- 208000007913 Pituitary Neoplasms Diseases 0.000 claims 1
- 102100030485 Platelet-derived growth factor receptor alpha Human genes 0.000 claims 1
- 102100029799 Polycomb group protein ASXL1 Human genes 0.000 claims 1
- 102100026375 Protein PML Human genes 0.000 claims 1
- 102100023347 Proto-oncogene tyrosine-protein kinase ROS Human genes 0.000 claims 1
- 102100028286 Proto-oncogene tyrosine-protein kinase receptor Ret Human genes 0.000 claims 1
- 102000004229 RNA-binding protein EWS Human genes 0.000 claims 1
- 108090000740 RNA-binding protein EWS Proteins 0.000 claims 1
- 108700019586 Rapamycin-Insensitive Companion of mTOR Proteins 0.000 claims 1
- 102000046941 Rapamycin-Insensitive Companion of mTOR Human genes 0.000 claims 1
- 102100030086 Receptor tyrosine-protein kinase erbB-2 Human genes 0.000 claims 1
- 102100029986 Receptor tyrosine-protein kinase erbB-3 Human genes 0.000 claims 1
- 101710100969 Receptor tyrosine-protein kinase erbB-3 Proteins 0.000 claims 1
- 102100020718 Receptor-type tyrosine-protein kinase FLT3 Human genes 0.000 claims 1
- 102100039666 Receptor-type tyrosine-protein phosphatase delta Human genes 0.000 claims 1
- 108010029031 Regulatory-Associated Protein of mTOR Proteins 0.000 claims 1
- 102100040969 Regulatory-associated protein of mTOR Human genes 0.000 claims 1
- 102100038042 Retinoblastoma-associated protein Human genes 0.000 claims 1
- 102100023606 Retinoic acid receptor alpha Human genes 0.000 claims 1
- 102100025373 Runt-related transcription factor 1 Human genes 0.000 claims 1
- 102100026715 Serine/threonine-protein kinase STK11 Human genes 0.000 claims 1
- 101710145783 TATA-box-binding protein Proteins 0.000 claims 1
- 102100031027 Transcription activator BRG1 Human genes 0.000 claims 1
- 102100024027 Transcription factor E2F3 Human genes 0.000 claims 1
- 102100024270 Transcription factor SOX-2 Human genes 0.000 claims 1
- 108010078814 Tumor Suppressor Protein p53 Proteins 0.000 claims 1
- 102100033254 Tumor suppressor ARF Human genes 0.000 claims 1
- 102100022596 Tyrosine-protein kinase ABL1 Human genes 0.000 claims 1
- 102100033444 Tyrosine-protein kinase JAK2 Human genes 0.000 claims 1
- 208000002495 Uterine Neoplasms Diseases 0.000 claims 1
- 108010053099 Vascular Endothelial Growth Factor Receptor-2 Proteins 0.000 claims 1
- 102100033177 Vascular endothelial growth factor receptor 2 Human genes 0.000 claims 1
- 229960002932 anastrozole Drugs 0.000 claims 1
- YBBLVLTVTVSKRW-UHFFFAOYSA-N anastrozole Chemical compound N#CC(C)(C)C1=CC(C(C)(C#N)C)=CC(CN2N=CN=C2)=C1 YBBLVLTVTVSKRW-UHFFFAOYSA-N 0.000 claims 1
- 229940046844 aromatase inhibitors Drugs 0.000 claims 1
- 210000004556 brain Anatomy 0.000 claims 1
- 230000000593 degrading effect Effects 0.000 claims 1
- 229940079593 drug Drugs 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 102000052116 epidermal growth factor receptor activity proteins Human genes 0.000 claims 1
- 108700015053 epidermal growth factor receptor activity proteins Proteins 0.000 claims 1
- 229960000255 exemestane Drugs 0.000 claims 1
- 229960002258 fulvestrant Drugs 0.000 claims 1
- 230000002401 inhibitory effect Effects 0.000 claims 1
- 229960003881 letrozole Drugs 0.000 claims 1
- HPJKCIUCZWXJDR-UHFFFAOYSA-N letrozole Chemical compound C1=CC(C#N)=CC=C1C(N1N=CN=C1)C1=CC=C(C#N)C=C1 HPJKCIUCZWXJDR-UHFFFAOYSA-N 0.000 claims 1
- 231100000682 maximum tolerated dose Toxicity 0.000 claims 1
- 230000009401 metastasis Effects 0.000 claims 1
- 108040008770 methylated-DNA-[protein]-cysteine S-methyltransferase activity proteins Proteins 0.000 claims 1
- YOHYSYJDKVYCJI-UHFFFAOYSA-N n-[3-[[6-[3-(trifluoromethyl)anilino]pyrimidin-4-yl]amino]phenyl]cyclopropanecarboxamide Chemical compound FC(F)(F)C1=CC=CC(NC=2N=CN=C(NC=3C=C(NC(=O)C4CC4)C=CC=3)C=2)=C1 YOHYSYJDKVYCJI-UHFFFAOYSA-N 0.000 claims 1
- 201000002511 pituitary cancer Diseases 0.000 claims 1
- 229960001603 tamoxifen Drugs 0.000 claims 1
- 229960005026 toremifene Drugs 0.000 claims 1
- XFCLJVABOIYOMF-QPLCGJKRSA-N toremifene Chemical compound C1=CC(OCCN(C)C)=CC=C1C(\C=1C=CC=CC=1)=C(\CCCl)C1=CC=CC=C1 XFCLJVABOIYOMF-QPLCGJKRSA-N 0.000 claims 1
- 206010046766 uterine cancer Diseases 0.000 claims 1
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2024086821A JP2024101017A (ja) | 2018-12-06 | 2024-05-29 | Ｅｓｒ１変異を含むモデルにおいて癌を治療するための方法 |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201862776338P | 2018-12-06 | 2018-12-06 | |
| US62/776,338 | 2018-12-06 | ||
| PCT/US2019/064980 WO2020118202A1 (en) | 2018-12-06 | 2019-12-06 | Methods for treating cancer in models harboring esr1 mutations |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2024086821A Division JP2024101017A (ja) | 2018-12-06 | 2024-05-29 | Ｅｓｒ１変異を含むモデルにおいて癌を治療するための方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2022511497A JP2022511497A (ja) | 2022-01-31 |
| JPWO2020118202A5 true JPWO2020118202A5 (enExample) | 2022-12-19 |
| JP7497353B2 JP7497353B2 (ja) | 2024-06-10 |
Family
ID=69158304
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021531817A Active JP7497353B2 (ja) | 2018-12-06 | 2019-12-06 | Ｅｓｒ１変異を含むモデルにおいて癌を治療するための方法 |
| JP2024086821A Pending JP2024101017A (ja) | 2018-12-06 | 2024-05-29 | Ｅｓｒ１変異を含むモデルにおいて癌を治療するための方法 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2024086821A Pending JP2024101017A (ja) | 2018-12-06 | 2024-05-29 | Ｅｓｒ１変異を含むモデルにおいて癌を治療するための方法 |
Country Status (17)
| Country | Link |
|---|---|
| US (2) | US20220016052A1 (enExample) |
| EP (1) | EP3890835A1 (enExample) |
| JP (2) | JP7497353B2 (enExample) |
| KR (1) | KR20210100135A (enExample) |
| AU (1) | AU2019392908B2 (enExample) |
| BR (1) | BR112021010141A2 (enExample) |
| CA (1) | CA3121918A1 (enExample) |
| EA (1) | EA202191256A1 (enExample) |
| IL (1) | IL283655A (enExample) |
| JO (1) | JOP20210138A1 (enExample) |
| MA (1) | MA54393A (enExample) |
| MX (1) | MX2021006412A (enExample) |
| MY (1) | MY208702A (enExample) |
| PH (1) | PH12021551327A1 (enExample) |
| SG (1) | SG11202105915UA (enExample) |
| UA (1) | UA129588C2 (enExample) |
| WO (1) | WO2020118202A1 (enExample) |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SMT202300072T1 (it) * | 2014-03-28 | 2023-05-12 | Univ Duke | Cancro della mammella mediante l'utilizzo di modulatori selettivi del recetiore degli estrogeni |
| MX393599B (es) * | 2015-04-29 | 2025-03-19 | Radius Pharmaceuticals Inc | Rad1901 para usarse en el tratamiento de cancer en sujetos con cancer positivo a receptor de estrogeno alfa resistente a farmaco |
-
2019
- 2019-12-06 MA MA054393A patent/MA54393A/fr unknown
- 2019-12-06 KR KR1020217020309A patent/KR20210100135A/ko not_active Ceased
- 2019-12-06 MY MYPI2021003130A patent/MY208702A/en unknown
- 2019-12-06 MX MX2021006412A patent/MX2021006412A/es unknown
- 2019-12-06 CA CA3121918A patent/CA3121918A1/en active Pending
- 2019-12-06 EA EA202191256A patent/EA202191256A1/ru unknown
- 2019-12-06 WO PCT/US2019/064980 patent/WO2020118202A1/en not_active Ceased
- 2019-12-06 BR BR112021010141-1A patent/BR112021010141A2/pt unknown
- 2019-12-06 UA UAA202103001A patent/UA129588C2/uk unknown
- 2019-12-06 US US17/299,361 patent/US20220016052A1/en not_active Abandoned
- 2019-12-06 PH PH1/2021/551327A patent/PH12021551327A1/en unknown
- 2019-12-06 JP JP2021531817A patent/JP7497353B2/ja active Active
- 2019-12-06 JO JOP/2021/0138A patent/JOP20210138A1/ar unknown
- 2019-12-06 AU AU2019392908A patent/AU2019392908B2/en active Active
- 2019-12-06 SG SG11202105915UA patent/SG11202105915UA/en unknown
- 2019-12-06 EP EP19835569.5A patent/EP3890835A1/en not_active Withdrawn
-
2021
- 2021-06-02 IL IL283655A patent/IL283655A/en unknown
-
2024
- 2024-05-29 JP JP2024086821A patent/JP2024101017A/ja active Pending
-
2025
- 2025-04-21 US US19/184,210 patent/US20250241875A1/en active Pending
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