JP2018518529A5 - - Google Patents
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- JP2018518529A5 JP2018518529A5 JP2018509732A JP2018509732A JP2018518529A5 JP 2018518529 A5 JP2018518529 A5 JP 2018518529A5 JP 2018509732 A JP2018509732 A JP 2018509732A JP 2018509732 A JP2018509732 A JP 2018509732A JP 2018518529 A5 JP2018518529 A5 JP 2018518529A5
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- JP
- Japan
- Prior art keywords
- agent according
- cancer
- drug
- rad1901
- group
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 239000003795 chemical substances by application Substances 0.000 claims 22
- 239000003814 drug Substances 0.000 claims 9
- 229940079593 drug Drugs 0.000 claims 8
- 206010028980 Neoplasm Diseases 0.000 claims 7
- SIFNOOUKXBRGGB-AREMUKBSSA-N (6r)-6-[2-[ethyl-[[4-[2-(ethylamino)ethyl]phenyl]methyl]amino]-4-methoxyphenyl]-5,6,7,8-tetrahydronaphthalen-2-ol Chemical compound C1=CC(CCNCC)=CC=C1CN(CC)C1=CC(OC)=CC=C1[C@H]1CC2=CC=C(O)C=C2CC1 SIFNOOUKXBRGGB-AREMUKBSSA-N 0.000 claims 6
- 150000003839 salts Chemical class 0.000 claims 6
- -1 DDR2 Proteins 0.000 claims 5
- 201000011510 cancer Diseases 0.000 claims 5
- 239000012453 solvate Substances 0.000 claims 5
- 229940124297 CDK 4/6 inhibitor Drugs 0.000 claims 4
- 108010007005 Estrogen Receptor alpha Proteins 0.000 claims 4
- 102100038595 Estrogen receptor Human genes 0.000 claims 4
- 206010006187 Breast cancer Diseases 0.000 claims 3
- 208000026310 Breast neoplasm Diseases 0.000 claims 3
- 229940046836 anti-estrogen Drugs 0.000 claims 3
- 230000001833 anti-estrogenic effect Effects 0.000 claims 3
- 239000003886 aromatase inhibitor Substances 0.000 claims 3
- 239000000328 estrogen antagonist Substances 0.000 claims 3
- 108091007854 Cdh1/Fizzy-related Proteins 0.000 claims 2
- 102100040859 Fizzy-related protein homolog Human genes 0.000 claims 2
- 108010011536 PTEN Phosphohydrolase Proteins 0.000 claims 2
- 102000014160 PTEN Phosphohydrolase Human genes 0.000 claims 2
- NKANXQFJJICGDU-QPLCGJKRSA-N Tamoxifen Chemical compound C=1C=CC=CC=1C(/CC)=C(C=1C=CC(OCCN(C)C)=CC=1)/C1=CC=CC=C1 NKANXQFJJICGDU-QPLCGJKRSA-N 0.000 claims 2
- 239000004480 active ingredient Substances 0.000 claims 2
- 229940046844 aromatase inhibitors Drugs 0.000 claims 2
- 230000035772 mutation Effects 0.000 claims 2
- XGFHYCAZOCBCRQ-FBHGDYMESA-N (6r)-6-[2-[ethyl-[[4-[2-(ethylamino)ethyl]phenyl]methyl]amino]-4-methoxyphenyl]-5,6,7,8-tetrahydronaphthalen-2-ol;dihydrochloride Chemical group Cl.Cl.C1=CC(CCNCC)=CC=C1CN(CC)C1=CC(OC)=CC=C1[C@H]1CC2=CC=C(O)C=C2CC1 XGFHYCAZOCBCRQ-FBHGDYMESA-N 0.000 claims 1
- 102100033793 ALK tyrosine kinase receptor Human genes 0.000 claims 1
- 102100034580 AT-rich interactive domain-containing protein 1A Human genes 0.000 claims 1
- 102000000872 ATM Human genes 0.000 claims 1
- 102100034540 Adenomatous polyposis coli protein Human genes 0.000 claims 1
- 229940122815 Aromatase inhibitor Drugs 0.000 claims 1
- 108010004586 Ataxia Telangiectasia Mutated Proteins Proteins 0.000 claims 1
- 102000004000 Aurora Kinase A Human genes 0.000 claims 1
- 108090000461 Aurora Kinase A Proteins 0.000 claims 1
- 108700020463 BRCA1 Proteins 0.000 claims 1
- 102000036365 BRCA1 Human genes 0.000 claims 1
- 101150072950 BRCA1 gene Proteins 0.000 claims 1
- 108700020462 BRCA2 Proteins 0.000 claims 1
- 102000052609 BRCA2 Human genes 0.000 claims 1
- 108010040168 Bcl-2-Like Protein 11 Proteins 0.000 claims 1
- 102000001765 Bcl-2-Like Protein 11 Human genes 0.000 claims 1
- 101001042041 Bos taurus Isocitrate dehydrogenase [NAD] subunit beta, mitochondrial Proteins 0.000 claims 1
- 101150008921 Brca2 gene Proteins 0.000 claims 1
- 102100026008 Breakpoint cluster region protein Human genes 0.000 claims 1
- 102100034808 CCAAT/enhancer-binding protein alpha Human genes 0.000 claims 1
- 101100005789 Caenorhabditis elegans cdk-4 gene Proteins 0.000 claims 1
- 102100028914 Catenin beta-1 Human genes 0.000 claims 1
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- 108010043471 Core Binding Factor Alpha 2 Subunit Proteins 0.000 claims 1
- 108010058546 Cyclin D1 Proteins 0.000 claims 1
- 108010025464 Cyclin-Dependent Kinase 4 Proteins 0.000 claims 1
- 108010025468 Cyclin-Dependent Kinase 6 Proteins 0.000 claims 1
- 102000009512 Cyclin-Dependent Kinase Inhibitor p15 Human genes 0.000 claims 1
- 108010009356 Cyclin-Dependent Kinase Inhibitor p15 Proteins 0.000 claims 1
- 108010009392 Cyclin-Dependent Kinase Inhibitor p16 Proteins 0.000 claims 1
- 102000000577 Cyclin-Dependent Kinase Inhibitor p27 Human genes 0.000 claims 1
- 108010016777 Cyclin-Dependent Kinase Inhibitor p27 Proteins 0.000 claims 1
- 102100036252 Cyclin-dependent kinase 4 Human genes 0.000 claims 1
- 102100026804 Cyclin-dependent kinase 6 Human genes 0.000 claims 1
- 102100024456 Cyclin-dependent kinase 8 Human genes 0.000 claims 1
- 102100024812 DNA (cytosine-5)-methyltransferase 3A Human genes 0.000 claims 1
- 108010024491 DNA Methyltransferase 3A Proteins 0.000 claims 1
- 102100021147 DNA mismatch repair protein Msh6 Human genes 0.000 claims 1
- 102100031480 Dual specificity mitogen-activated protein kinase kinase 1 Human genes 0.000 claims 1
- 102100023274 Dual specificity mitogen-activated protein kinase kinase 4 Human genes 0.000 claims 1
- 102000012199 E3 ubiquitin-protein ligase Mdm2 Human genes 0.000 claims 1
- 108050002772 E3 ubiquitin-protein ligase Mdm2 Proteins 0.000 claims 1
- 101150097734 EPHB2 gene Proteins 0.000 claims 1
- 102100027100 Echinoderm microtubule-associated protein-like 4 Human genes 0.000 claims 1
- 102100031968 Ephrin type-B receptor 2 Human genes 0.000 claims 1
- 102100028138 F-box/WD repeat-containing protein 7 Human genes 0.000 claims 1
- 101710105178 F-box/WD repeat-containing protein 7 Proteins 0.000 claims 1
- 102100028073 Fibroblast growth factor 5 Human genes 0.000 claims 1
- 102100021066 Fibroblast growth factor receptor substrate 2 Human genes 0.000 claims 1
- VWUXBMIQPBEWFH-WCCTWKNTSA-N Fulvestrant Chemical compound OC1=CC=C2[C@H]3CC[C@](C)([C@H](CC4)O)[C@@H]4[C@@H]3[C@H](CCCCCCCCCS(=O)CCCC(F)(F)C(F)(F)F)CC2=C1 VWUXBMIQPBEWFH-WCCTWKNTSA-N 0.000 claims 1
- 102100024165 G1/S-specific cyclin-D1 Human genes 0.000 claims 1
- 102100024185 G1/S-specific cyclin-D2 Human genes 0.000 claims 1
- 102100037859 G1/S-specific cyclin-D3 Human genes 0.000 claims 1
- 102100037858 G1/S-specific cyclin-E1 Human genes 0.000 claims 1
- 102100029974 GTPase HRas Human genes 0.000 claims 1
- 102100039788 GTPase NRas Human genes 0.000 claims 1
- 102100031561 Hamartin Human genes 0.000 claims 1
- 102100027893 Homeobox protein Nkx-2.1 Human genes 0.000 claims 1
- 101000779641 Homo sapiens ALK tyrosine kinase receptor Proteins 0.000 claims 1
- 101000924266 Homo sapiens AT-rich interactive domain-containing protein 1A Proteins 0.000 claims 1
- 101000924577 Homo sapiens Adenomatous polyposis coli protein Proteins 0.000 claims 1
- 101000933320 Homo sapiens Breakpoint cluster region protein Proteins 0.000 claims 1
- 101000945515 Homo sapiens CCAAT/enhancer-binding protein alpha Proteins 0.000 claims 1
- 101000916173 Homo sapiens Catenin beta-1 Proteins 0.000 claims 1
- 101000980937 Homo sapiens Cyclin-dependent kinase 8 Proteins 0.000 claims 1
- 101000968658 Homo sapiens DNA mismatch repair protein Msh6 Proteins 0.000 claims 1
- 101001115395 Homo sapiens Dual specificity mitogen-activated protein kinase kinase 4 Proteins 0.000 claims 1
- 101001095815 Homo sapiens E3 ubiquitin-protein ligase RING2 Proteins 0.000 claims 1
- 101001057929 Homo sapiens Echinoderm microtubule-associated protein-like 4 Proteins 0.000 claims 1
- 101001060267 Homo sapiens Fibroblast growth factor 5 Proteins 0.000 claims 1
- 101000818410 Homo sapiens Fibroblast growth factor receptor substrate 2 Proteins 0.000 claims 1
- 101000980741 Homo sapiens G1/S-specific cyclin-D2 Proteins 0.000 claims 1
- 101000738559 Homo sapiens G1/S-specific cyclin-D3 Proteins 0.000 claims 1
- 101000738568 Homo sapiens G1/S-specific cyclin-E1 Proteins 0.000 claims 1
- 101000584633 Homo sapiens GTPase HRas Proteins 0.000 claims 1
- 101000744505 Homo sapiens GTPase NRas Proteins 0.000 claims 1
- 101000795643 Homo sapiens Hamartin Proteins 0.000 claims 1
- 101000632178 Homo sapiens Homeobox protein Nkx-2.1 Proteins 0.000 claims 1
- 101001046870 Homo sapiens Hypoxia-inducible factor 1-alpha Proteins 0.000 claims 1
- 101001056180 Homo sapiens Induced myeloid leukemia cell differentiation protein Mcl-1 Proteins 0.000 claims 1
- 101001034652 Homo sapiens Insulin-like growth factor 1 receptor Proteins 0.000 claims 1
- 101000960234 Homo sapiens Isocitrate dehydrogenase [NADP] cytoplasmic Proteins 0.000 claims 1
- 101000599886 Homo sapiens Isocitrate dehydrogenase [NADP], mitochondrial Proteins 0.000 claims 1
- 101001050559 Homo sapiens Kinesin-1 heavy chain Proteins 0.000 claims 1
- 101001025967 Homo sapiens Lysine-specific demethylase 6A Proteins 0.000 claims 1
- 101001057193 Homo sapiens Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 Proteins 0.000 claims 1
- 101000653374 Homo sapiens Methylcytosine dioxygenase TET2 Proteins 0.000 claims 1
- 101001120056 Homo sapiens Phosphatidylinositol 3-kinase regulatory subunit alpha Proteins 0.000 claims 1
- 101000605639 Homo sapiens Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform Proteins 0.000 claims 1
- 101001126417 Homo sapiens Platelet-derived growth factor receptor alpha Proteins 0.000 claims 1
- 101000728236 Homo sapiens Polycomb group protein ASXL1 Proteins 0.000 claims 1
- 101000573199 Homo sapiens Protein PML Proteins 0.000 claims 1
- 101000686031 Homo sapiens Proto-oncogene tyrosine-protein kinase ROS Proteins 0.000 claims 1
- 101000579425 Homo sapiens Proto-oncogene tyrosine-protein kinase receptor Ret Proteins 0.000 claims 1
- 101000779418 Homo sapiens RAC-alpha serine/threonine-protein kinase Proteins 0.000 claims 1
- 101000798015 Homo sapiens RAC-beta serine/threonine-protein kinase Proteins 0.000 claims 1
- 101100087590 Homo sapiens RICTOR gene Proteins 0.000 claims 1
- 101001012157 Homo sapiens Receptor tyrosine-protein kinase erbB-2 Proteins 0.000 claims 1
- 101000742859 Homo sapiens Retinoblastoma-associated protein Proteins 0.000 claims 1
- 101001112293 Homo sapiens Retinoic acid receptor alpha Proteins 0.000 claims 1
- 101000984753 Homo sapiens Serine/threonine-protein kinase B-raf Proteins 0.000 claims 1
- 101000628562 Homo sapiens Serine/threonine-protein kinase STK11 Proteins 0.000 claims 1
- 101000702545 Homo sapiens Transcription activator BRG1 Proteins 0.000 claims 1
- 101000904150 Homo sapiens Transcription factor E2F3 Proteins 0.000 claims 1
- 101000687905 Homo sapiens Transcription factor SOX-2 Proteins 0.000 claims 1
- 101000795659 Homo sapiens Tuberin Proteins 0.000 claims 1
- 101000823316 Homo sapiens Tyrosine-protein kinase ABL1 Proteins 0.000 claims 1
- 101000997832 Homo sapiens Tyrosine-protein kinase JAK2 Proteins 0.000 claims 1
- 101000740048 Homo sapiens Ubiquitin carboxyl-terminal hydrolase BAP1 Proteins 0.000 claims 1
- 102100022875 Hypoxia-inducible factor 1-alpha Human genes 0.000 claims 1
- 102100026539 Induced myeloid leukemia cell differentiation protein Mcl-1 Human genes 0.000 claims 1
- 102100039688 Insulin-like growth factor 1 receptor Human genes 0.000 claims 1
- 102100039905 Isocitrate dehydrogenase [NADP] cytoplasmic Human genes 0.000 claims 1
- 102100037845 Isocitrate dehydrogenase [NADP], mitochondrial Human genes 0.000 claims 1
- 102100023422 Kinesin-1 heavy chain Human genes 0.000 claims 1
- 101000740049 Latilactobacillus curvatus Bioactive peptide 1 Proteins 0.000 claims 1
- 102100037462 Lysine-specific demethylase 6A Human genes 0.000 claims 1
- 108010068342 MAP Kinase Kinase 1 Proteins 0.000 claims 1
- 102000017274 MDM4 Human genes 0.000 claims 1
- 108050005300 MDM4 Proteins 0.000 claims 1
- 102100027240 Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 Human genes 0.000 claims 1
- 102100025825 Methylated-DNA-protein-cysteine methyltransferase Human genes 0.000 claims 1
- 102100030803 Methylcytosine dioxygenase TET2 Human genes 0.000 claims 1
- 102100025725 Mothers against decapentaplegic homolog 4 Human genes 0.000 claims 1
- 101710143112 Mothers against decapentaplegic homolog 4 Proteins 0.000 claims 1
- 101150097381 Mtor gene Proteins 0.000 claims 1
- 102100027096 Nucleotide exchange factor SIL1 Human genes 0.000 claims 1
- 206010033128 Ovarian cancer Diseases 0.000 claims 1
- 206010061535 Ovarian neoplasm Diseases 0.000 claims 1
- 102100026169 Phosphatidylinositol 3-kinase regulatory subunit alpha Human genes 0.000 claims 1
- 102100038332 Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform Human genes 0.000 claims 1
- 208000007913 Pituitary Neoplasms Diseases 0.000 claims 1
- 102100030485 Platelet-derived growth factor receptor alpha Human genes 0.000 claims 1
- 102100029799 Polycomb group protein ASXL1 Human genes 0.000 claims 1
- 102100026375 Protein PML Human genes 0.000 claims 1
- 102100023347 Proto-oncogene tyrosine-protein kinase ROS Human genes 0.000 claims 1
- 102100028286 Proto-oncogene tyrosine-protein kinase receptor Ret Human genes 0.000 claims 1
- 102100033810 RAC-alpha serine/threonine-protein kinase Human genes 0.000 claims 1
- 102100032315 RAC-beta serine/threonine-protein kinase Human genes 0.000 claims 1
- 102000004229 RNA-binding protein EWS Human genes 0.000 claims 1
- 108090000740 RNA-binding protein EWS Proteins 0.000 claims 1
- 108700019586 Rapamycin-Insensitive Companion of mTOR Proteins 0.000 claims 1
- 102000046941 Rapamycin-Insensitive Companion of mTOR Human genes 0.000 claims 1
- 102100030086 Receptor tyrosine-protein kinase erbB-2 Human genes 0.000 claims 1
- 102100029986 Receptor tyrosine-protein kinase erbB-3 Human genes 0.000 claims 1
- 101710100969 Receptor tyrosine-protein kinase erbB-3 Proteins 0.000 claims 1
- 108010029031 Regulatory-Associated Protein of mTOR Proteins 0.000 claims 1
- 102100040969 Regulatory-associated protein of mTOR Human genes 0.000 claims 1
- 102100038042 Retinoblastoma-associated protein Human genes 0.000 claims 1
- 102100023606 Retinoic acid receptor alpha Human genes 0.000 claims 1
- 102100025373 Runt-related transcription factor 1 Human genes 0.000 claims 1
- 102100027103 Serine/threonine-protein kinase B-raf Human genes 0.000 claims 1
- 102100026715 Serine/threonine-protein kinase STK11 Human genes 0.000 claims 1
- 102100023085 Serine/threonine-protein kinase mTOR Human genes 0.000 claims 1
- 101710145783 TATA-box-binding protein Proteins 0.000 claims 1
- 102100031027 Transcription activator BRG1 Human genes 0.000 claims 1
- 102100024027 Transcription factor E2F3 Human genes 0.000 claims 1
- 102100024270 Transcription factor SOX-2 Human genes 0.000 claims 1
- 102100031638 Tuberin Human genes 0.000 claims 1
- 108010078814 Tumor Suppressor Protein p53 Proteins 0.000 claims 1
- 102100033254 Tumor suppressor ARF Human genes 0.000 claims 1
- 102100022596 Tyrosine-protein kinase ABL1 Human genes 0.000 claims 1
- 102100033444 Tyrosine-protein kinase JAK2 Human genes 0.000 claims 1
- 208000002495 Uterine Neoplasms Diseases 0.000 claims 1
- 108010053099 Vascular Endothelial Growth Factor Receptor-2 Proteins 0.000 claims 1
- 102100033177 Vascular endothelial growth factor receptor 2 Human genes 0.000 claims 1
- 229960002932 anastrozole Drugs 0.000 claims 1
- YBBLVLTVTVSKRW-UHFFFAOYSA-N anastrozole Chemical compound N#CC(C)(C)C1=CC(C(C)(C#N)C)=CC(CN2N=CN=C2)=C1 YBBLVLTVTVSKRW-UHFFFAOYSA-N 0.000 claims 1
- 102000052116 epidermal growth factor receptor activity proteins Human genes 0.000 claims 1
- 108700015053 epidermal growth factor receptor activity proteins Proteins 0.000 claims 1
- 229960002258 fulvestrant Drugs 0.000 claims 1
- 239000003112 inhibitor Substances 0.000 claims 1
- 230000002401 inhibitory effect Effects 0.000 claims 1
- 229960003881 letrozole Drugs 0.000 claims 1
- HPJKCIUCZWXJDR-UHFFFAOYSA-N letrozole Chemical compound C1=CC(C#N)=CC=C1C(N1N=CN=C1)C1=CC=C(C#N)C=C1 HPJKCIUCZWXJDR-UHFFFAOYSA-N 0.000 claims 1
- 238000005259 measurement Methods 0.000 claims 1
- 208000037819 metastatic cancer Diseases 0.000 claims 1
- 208000011575 metastatic malignant neoplasm Diseases 0.000 claims 1
- 108040008770 methylated-DNA-[protein]-cysteine S-methyltransferase activity proteins Proteins 0.000 claims 1
- YOHYSYJDKVYCJI-UHFFFAOYSA-N n-[3-[[6-[3-(trifluoromethyl)anilino]pyrimidin-4-yl]amino]phenyl]cyclopropanecarboxamide Chemical compound FC(F)(F)C1=CC=CC(NC=2N=CN=C(NC=3C=C(NC(=O)C4CC4)C=CC=3)C=2)=C1 YOHYSYJDKVYCJI-UHFFFAOYSA-N 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 201000002511 pituitary cancer Diseases 0.000 claims 1
- 108090000623 proteins and genes Proteins 0.000 claims 1
- 239000000333 selective estrogen receptor modulator Substances 0.000 claims 1
- 229940095743 selective estrogen receptor modulator Drugs 0.000 claims 1
- 229960001603 tamoxifen Drugs 0.000 claims 1
- 238000002560 therapeutic procedure Methods 0.000 claims 1
- 229960005026 toremifene Drugs 0.000 claims 1
- XFCLJVABOIYOMF-QPLCGJKRSA-N toremifene Chemical compound C1=CC(OCCN(C)C)=CC=C1C(\C=1C=CC=CC=1)=C(\CCCl)C1=CC=CC=C1 XFCLJVABOIYOMF-QPLCGJKRSA-N 0.000 claims 1
- 230000004614 tumor growth Effects 0.000 claims 1
- 206010046766 uterine cancer Diseases 0.000 claims 1
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2021052305A JP7146992B2 (ja) | 2015-04-29 | 2021-03-25 | 癌を治療するための方法 |
Applications Claiming Priority (27)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562154699P | 2015-04-29 | 2015-04-29 | |
| US62/154,699 | 2015-04-29 | ||
| US201562155451P | 2015-04-30 | 2015-04-30 | |
| US62/155,451 | 2015-04-30 | ||
| US201562158469P | 2015-05-07 | 2015-05-07 | |
| US62/158,469 | 2015-05-07 | ||
| US201562192940P | 2015-07-15 | 2015-07-15 | |
| US201562192944P | 2015-07-15 | 2015-07-15 | |
| US62/192,940 | 2015-07-15 | ||
| US62/192,944 | 2015-07-15 | ||
| US201562252085P | 2015-11-06 | 2015-11-06 | |
| US62/252,085 | 2015-11-06 | ||
| US201562252916P | 2015-11-09 | 2015-11-09 | |
| US62/252,916 | 2015-11-09 | ||
| US201562265774P | 2015-12-10 | 2015-12-10 | |
| US201562265658P | 2015-12-10 | 2015-12-10 | |
| US201562265696P | 2015-12-10 | 2015-12-10 | |
| US201562265663P | 2015-12-10 | 2015-12-10 | |
| US62/265,663 | 2015-12-10 | ||
| US62/265,658 | 2015-12-10 | ||
| US62/265,774 | 2015-12-10 | ||
| US62/265,696 | 2015-12-10 | ||
| US201662323572P | 2016-04-15 | 2016-04-15 | |
| US201662323576P | 2016-04-15 | 2016-04-15 | |
| US62/323,576 | 2016-04-15 | ||
| US62/323,572 | 2016-04-15 | ||
| PCT/US2016/030321 WO2016176666A1 (en) | 2015-04-29 | 2016-04-29 | Methods of treating cancer |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021052305A Division JP7146992B2 (ja) | 2015-04-29 | 2021-03-25 | 癌を治療するための方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2018518529A JP2018518529A (ja) | 2018-07-12 |
| JP2018518529A5 true JP2018518529A5 (enExample) | 2019-05-30 |
| JP6926066B2 JP6926066B2 (ja) | 2021-08-25 |
Family
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Family Applications (9)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018509731A Active JP6926065B2 (ja) | 2015-04-29 | 2016-04-29 | 癌を治療するための方法 |
| JP2017556627A Active JP7019422B2 (ja) | 2015-04-29 | 2016-04-29 | 癌を治療するための方法 |
| JP2018509732A Active JP6926066B2 (ja) | 2015-04-29 | 2016-04-29 | 癌を治療するための方法 |
| JP2021052305A Active JP7146992B2 (ja) | 2015-04-29 | 2021-03-25 | 癌を治療するための方法 |
| JP2021073337A Active JP7262508B2 (ja) | 2015-04-29 | 2021-04-23 | 癌を治療するための方法 |
| JP2022150560A Active JP7516472B2 (ja) | 2015-04-29 | 2022-09-21 | 癌を治療するための方法 |
| JP2023009598A Active JP7696378B2 (ja) | 2015-04-29 | 2023-01-25 | 癌を治療するための方法 |
| JP2024107407A Active JP7745708B2 (ja) | 2015-04-29 | 2024-07-03 | 癌を治療するための方法 |
| JP2025153179A Pending JP2025170141A (ja) | 2015-04-29 | 2025-09-16 | 癌を治療するための方法 |
Family Applications Before (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018509731A Active JP6926065B2 (ja) | 2015-04-29 | 2016-04-29 | 癌を治療するための方法 |
| JP2017556627A Active JP7019422B2 (ja) | 2015-04-29 | 2016-04-29 | 癌を治療するための方法 |
Family Applications After (6)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021052305A Active JP7146992B2 (ja) | 2015-04-29 | 2021-03-25 | 癌を治療するための方法 |
| JP2021073337A Active JP7262508B2 (ja) | 2015-04-29 | 2021-04-23 | 癌を治療するための方法 |
| JP2022150560A Active JP7516472B2 (ja) | 2015-04-29 | 2022-09-21 | 癌を治療するための方法 |
| JP2023009598A Active JP7696378B2 (ja) | 2015-04-29 | 2023-01-25 | 癌を治療するための方法 |
| JP2024107407A Active JP7745708B2 (ja) | 2015-04-29 | 2024-07-03 | 癌を治療するための方法 |
| JP2025153179A Pending JP2025170141A (ja) | 2015-04-29 | 2025-09-16 | 癌を治療するための方法 |
Country Status (14)
| Country | Link |
|---|---|
| US (12) | US20180153828A1 (enExample) |
| EP (4) | EP3288382A4 (enExample) |
| JP (9) | JP6926065B2 (enExample) |
| KR (9) | KR20250152678A (enExample) |
| CN (5) | CN113750091B (enExample) |
| AU (3) | AU2016256469B2 (enExample) |
| BR (3) | BR112017023228A2 (enExample) |
| CA (2) | CA2984200C (enExample) |
| HK (3) | HK1251409A1 (enExample) |
| IL (10) | IL297369B2 (enExample) |
| MX (6) | MX384605B (enExample) |
| RU (3) | RU2747228C2 (enExample) |
| SG (4) | SG11201708858WA (enExample) |
| WO (3) | WO2016176666A1 (enExample) |
Families Citing this family (48)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2939940T3 (es) | 2014-03-28 | 2023-04-28 | Univ Duke | Tratamiento del cáncer de mama utilizando moduladores selectivos de los receptores de estrógenos |
| US9421264B2 (en) | 2014-03-28 | 2016-08-23 | Duke University | Method of treating cancer using selective estrogen receptor modulators |
| MX384605B (es) | 2015-04-29 | 2025-03-14 | Radius Pharmaceuticals Inc | Combinación de palbociclib y rad1901 para usarse en el tratamiento de cáncer de mama en un sujeto con cáncer positivo a receptor de estrógeno. |
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