EA202191256A1 - Способы лечения рака на моделях, имеющих мутации esr1 - Google Patents
Способы лечения рака на моделях, имеющих мутации esr1Info
- Publication number
- EA202191256A1 EA202191256A1 EA202191256A EA202191256A EA202191256A1 EA 202191256 A1 EA202191256 A1 EA 202191256A1 EA 202191256 A EA202191256 A EA 202191256A EA 202191256 A EA202191256 A EA 202191256A EA 202191256 A1 EA202191256 A1 EA 202191256A1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- cancer
- estrogen receptor
- receptor alpha
- methods
- models
- Prior art date
Links
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
- A61K31/137—Arylalkylamines, e.g. amphetamine, epinephrine, salbutamol, ephedrine or methadone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/01—Hydrocarbons
- A61K31/015—Hydrocarbons carbocyclic
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
- A61K31/138—Aryloxyalkylamines, e.g. propranolol, tamoxifen, phenoxybenzamine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4196—1,2,4-Triazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
- A61K31/566—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol having an oxo group in position 17, e.g. estrone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Epidemiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Emergency Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
В настоящем документе раскрываются способы лечения устойчивого к лекарственному средству положительного по рецептору эстрогена альфа рака у субъекта, имеющего мутантный рецептор эстрогена альфа, при этом способ предусматривает введение субъекту терапевтически эффективного количества элацестранта или его фармацевтически приемлемых соли или сольвата, при этом мутантный рецептор эстрогена альфа содержит одну или несколько мутаций, выбранных из группы, состоящей из D538G, Y537X1, L536X2, P535H, V534E, S463P, V392I, E380Q и их комбинаций, при этом X1 представляет собой S, N или C; и X2 представляет собой R или Q. Согласно некоторым вариантам осуществления устойчивый к лекарственному средству положительный по рецептору эстрогена альфа рак выбран из группы, состоящей из рака молочной железы, рака матки, рака яичника и рака гипофиза.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201862776338P | 2018-12-06 | 2018-12-06 | |
PCT/US2019/064980 WO2020118202A1 (en) | 2018-12-06 | 2019-12-06 | Methods for treating cancer in models harboring esr1 mutations |
Publications (1)
Publication Number | Publication Date |
---|---|
EA202191256A1 true EA202191256A1 (ru) | 2021-10-06 |
Family
ID=69158304
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EA202191256A EA202191256A1 (ru) | 2018-12-06 | 2019-12-06 | Способы лечения рака на моделях, имеющих мутации esr1 |
Country Status (13)
Country | Link |
---|---|
US (1) | US20220016052A1 (ru) |
EP (1) | EP3890835A1 (ru) |
KR (1) | KR20210100135A (ru) |
AU (1) | AU2019392908A1 (ru) |
BR (1) | BR112021010141A2 (ru) |
CA (1) | CA3121918A1 (ru) |
EA (1) | EA202191256A1 (ru) |
IL (1) | IL283655A (ru) |
JO (1) | JOP20210138A1 (ru) |
MA (1) | MA54393A (ru) |
MX (1) | MX2021006412A (ru) |
SG (1) | SG11202105915UA (ru) |
WO (1) | WO2020118202A1 (ru) |
Family Cites Families (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP7019422B2 (ja) * | 2015-04-29 | 2022-02-15 | ラジウス ファーマシューティカルズ,インコーポレイテッド | 癌を治療するための方法 |
-
2019
- 2019-12-06 MX MX2021006412A patent/MX2021006412A/es unknown
- 2019-12-06 BR BR112021010141-1A patent/BR112021010141A2/pt unknown
- 2019-12-06 CA CA3121918A patent/CA3121918A1/en active Pending
- 2019-12-06 EA EA202191256A patent/EA202191256A1/ru unknown
- 2019-12-06 US US17/299,361 patent/US20220016052A1/en active Pending
- 2019-12-06 AU AU2019392908A patent/AU2019392908A1/en active Pending
- 2019-12-06 JO JOP/2021/0138A patent/JOP20210138A1/ar unknown
- 2019-12-06 EP EP19835569.5A patent/EP3890835A1/en active Pending
- 2019-12-06 KR KR1020217020309A patent/KR20210100135A/ko active Search and Examination
- 2019-12-06 SG SG11202105915UA patent/SG11202105915UA/en unknown
- 2019-12-06 MA MA054393A patent/MA54393A/fr unknown
- 2019-12-06 WO PCT/US2019/064980 patent/WO2020118202A1/en unknown
-
2021
- 2021-06-02 IL IL283655A patent/IL283655A/en unknown
Also Published As
Publication number | Publication date |
---|---|
WO2020118202A1 (en) | 2020-06-11 |
CA3121918A1 (en) | 2020-06-11 |
US20220016052A1 (en) | 2022-01-20 |
SG11202105915UA (en) | 2021-07-29 |
BR112021010141A2 (pt) | 2021-08-24 |
MX2021006412A (es) | 2021-07-21 |
MA54393A (fr) | 2021-10-13 |
EP3890835A1 (en) | 2021-10-13 |
JP2022511497A (ja) | 2022-01-31 |
KR20210100135A (ko) | 2021-08-13 |
IL283655A (en) | 2021-07-29 |
AU2019392908A1 (en) | 2021-06-10 |
JOP20210138A1 (ar) | 2023-01-30 |
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