JP2018512145A5 - - Google Patents
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- JP2018512145A5 JP2018512145A5 JP2017551301A JP2017551301A JP2018512145A5 JP 2018512145 A5 JP2018512145 A5 JP 2018512145A5 JP 2017551301 A JP2017551301 A JP 2017551301A JP 2017551301 A JP2017551301 A JP 2017551301A JP 2018512145 A5 JP2018512145 A5 JP 2018512145A5
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- amino acid
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- acid sequence
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- 125000003275 alpha amino acid group Chemical group 0.000 claims description 58
- 102000013529 alpha-Fetoproteins Human genes 0.000 claims description 28
- 108010026331 alpha-Fetoproteins Proteins 0.000 claims description 28
- 238000006467 substitution reaction Methods 0.000 claims description 24
- 210000004027 cell Anatomy 0.000 claims description 17
- 201000010099 disease Diseases 0.000 claims description 16
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 16
- 238000000034 method Methods 0.000 claims description 16
- 108090000765 processed proteins & peptides Proteins 0.000 claims description 13
- 102000043129 MHC class I family Human genes 0.000 claims description 10
- 108091054437 MHC class I family Proteins 0.000 claims description 10
- 239000012636 effector Substances 0.000 claims description 9
- 230000004068 intracellular signaling Effects 0.000 claims description 9
- 206010028980 Neoplasm Diseases 0.000 claims description 7
- 239000000427 antigen Substances 0.000 claims description 7
- 108091007433 antigens Proteins 0.000 claims description 7
- 102000036639 antigens Human genes 0.000 claims description 7
- 201000011510 cancer Diseases 0.000 claims description 7
- 206010073071 hepatocellular carcinoma Diseases 0.000 claims description 7
- 231100000844 hepatocellular carcinoma Toxicity 0.000 claims description 7
- 239000008194 pharmaceutical composition Substances 0.000 claims description 7
- 101000946860 Homo sapiens T-cell surface glycoprotein CD3 epsilon chain Proteins 0.000 claims description 6
- 101000914514 Homo sapiens T-cell-specific surface glycoprotein CD28 Proteins 0.000 claims description 6
- 102100035794 T-cell surface glycoprotein CD3 epsilon chain Human genes 0.000 claims description 6
- 102100027213 T-cell-specific surface glycoprotein CD28 Human genes 0.000 claims description 6
- 150000001413 amino acids Chemical class 0.000 claims description 6
- 239000003814 drug Substances 0.000 claims description 4
- 230000009977 dual effect Effects 0.000 claims description 4
- 229940127121 immunoconjugate Drugs 0.000 claims description 4
- 102000039446 nucleic acids Human genes 0.000 claims description 4
- 108020004707 nucleic acids Proteins 0.000 claims description 4
- 150000007523 nucleic acids Chemical class 0.000 claims description 4
- 102000004196 processed proteins & peptides Human genes 0.000 claims description 4
- 102000004169 proteins and genes Human genes 0.000 claims description 4
- 108090000623 proteins and genes Proteins 0.000 claims description 4
- 108010047041 Complementarity Determining Regions Proteins 0.000 claims description 3
- 101000851370 Homo sapiens Tumor necrosis factor receptor superfamily member 9 Proteins 0.000 claims description 3
- 102100036856 Tumor necrosis factor receptor superfamily member 9 Human genes 0.000 claims description 3
- 229940079593 drug Drugs 0.000 claims description 3
- 238000002347 injection Methods 0.000 claims description 3
- 239000007924 injection Substances 0.000 claims description 3
- 230000002601 intratumoral effect Effects 0.000 claims description 3
- 238000001990 intravenous administration Methods 0.000 claims description 3
- 108700028369 Alleles Proteins 0.000 claims description 2
- 206010006187 Breast cancer Diseases 0.000 claims description 2
- 208000026310 Breast neoplasm Diseases 0.000 claims description 2
- 102100027207 CD27 antigen Human genes 0.000 claims description 2
- 102000017420 CD3 protein, epsilon/gamma/delta subunit Human genes 0.000 claims description 2
- 108050005493 CD3 protein, epsilon/gamma/delta subunit Proteins 0.000 claims description 2
- -1 CD3ζ Proteins 0.000 claims description 2
- 108010029697 CD40 Ligand Proteins 0.000 claims description 2
- 102100032937 CD40 ligand Human genes 0.000 claims description 2
- 208000021309 Germ cell tumor Diseases 0.000 claims description 2
- 102100028972 HLA class I histocompatibility antigen, A alpha chain Human genes 0.000 claims description 2
- 108010075704 HLA-A Antigens Proteins 0.000 claims description 2
- 101000914511 Homo sapiens CD27 antigen Proteins 0.000 claims description 2
- 101000801234 Homo sapiens Tumor necrosis factor receptor superfamily member 18 Proteins 0.000 claims description 2
- 108010061593 Member 14 Tumor Necrosis Factor Receptors Proteins 0.000 claims description 2
- 208000034176 Neoplasms, Germ Cell and Embryonal Diseases 0.000 claims description 2
- 210000001744 T-lymphocyte Anatomy 0.000 claims description 2
- 102100028785 Tumor necrosis factor receptor superfamily member 14 Human genes 0.000 claims description 2
- 102100033728 Tumor necrosis factor receptor superfamily member 18 Human genes 0.000 claims description 2
- 102100022153 Tumor necrosis factor receptor superfamily member 4 Human genes 0.000 claims description 2
- 101710165473 Tumor necrosis factor receptor superfamily member 4 Proteins 0.000 claims description 2
- 210000004899 c-terminal region Anatomy 0.000 claims description 2
- 230000001394 metastastic effect Effects 0.000 claims description 2
- 206010061289 metastatic neoplasm Diseases 0.000 claims description 2
- 229920001184 polypeptide Polymers 0.000 claims description 2
- 239000003053 toxin Substances 0.000 claims description 2
- 231100000765 toxin Toxicity 0.000 claims description 2
- 108700012359 toxins Proteins 0.000 claims description 2
- 239000000203 mixture Substances 0.000 claims 9
- 230000000139 costimulatory effect Effects 0.000 claims 2
- 230000011664 signaling Effects 0.000 claims 2
- 238000000338 in vitro Methods 0.000 claims 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 1
- 230000002285 radioactive effect Effects 0.000 claims 1
- 108020003175 receptors Proteins 0.000 claims 1
- 102000005962 receptors Human genes 0.000 claims 1
- 229940124597 therapeutic agent Drugs 0.000 claims 1
- 108010019670 Chimeric Antigen Receptors Proteins 0.000 description 1
- 206010027476 Metastases Diseases 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 230000009401 metastasis Effects 0.000 description 1
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2021055296A JP2021101723A (ja) | 2015-04-03 | 2021-03-29 | Ａｆｐペプチド／ｍｈｃ複合体を標的化する構築物およびその使用 |
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562142958P | 2015-04-03 | 2015-04-03 | |
| US62/142,958 | 2015-04-03 | ||
| US201562244653P | 2015-10-21 | 2015-10-21 | |
| US62/244,653 | 2015-10-21 | ||
| US201662304915P | 2016-03-07 | 2016-03-07 | |
| US62/304,915 | 2016-03-07 | ||
| PCT/US2016/025755 WO2016161390A1 (en) | 2015-04-03 | 2016-04-01 | Constructs targeting afp peptide/mhc complexes and uses thereof |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021055296A Division JP2021101723A (ja) | 2015-04-03 | 2021-03-29 | Ａｆｐペプチド／ｍｈｃ複合体を標的化する構築物およびその使用 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2018512145A JP2018512145A (ja) | 2018-05-17 |
| JP2018512145A5 true JP2018512145A5 (OSRAM) | 2019-05-09 |
| JP6903587B2 JP6903587B2 (ja) | 2021-07-14 |
Family
ID=57004627
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017551301A Active JP6903587B2 (ja) | 2015-04-03 | 2016-04-01 | Ａｆｐペプチド／ｍｈｃ複合体を標的化する構築物およびその使用 |
| JP2021055296A Pending JP2021101723A (ja) | 2015-04-03 | 2021-03-29 | Ａｆｐペプチド／ｍｈｃ複合体を標的化する構築物およびその使用 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021055296A Pending JP2021101723A (ja) | 2015-04-03 | 2021-03-29 | Ａｆｐペプチド／ｍｈｃ複合体を標的化する構築物およびその使用 |
Country Status (15)
| Country | Link |
|---|---|
| US (3) | US20180208658A1 (OSRAM) |
| EP (1) | EP3277314A4 (OSRAM) |
| JP (2) | JP6903587B2 (OSRAM) |
| KR (1) | KR102721595B1 (OSRAM) |
| CN (3) | CN114456272A (OSRAM) |
| AU (2) | AU2016243026B2 (OSRAM) |
| CA (1) | CA2979732A1 (OSRAM) |
| HK (1) | HK1249048A1 (OSRAM) |
| IL (2) | IL254852B (OSRAM) |
| MX (1) | MX2017012352A (OSRAM) |
| MY (1) | MY186708A (OSRAM) |
| RU (2) | RU2754041C2 (OSRAM) |
| SG (2) | SG10201913158PA (OSRAM) |
| TW (2) | TW202313691A (OSRAM) |
| WO (1) | WO2016161390A1 (OSRAM) |
Families Citing this family (44)
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| KR101602870B1 (ko) | 2014-07-22 | 2016-03-21 | 아주대학교산학협력단 | 완전한 이뮤노글로불린 형태의 항체를 세포막을 투과하여 세포질에 위치시키는 방법 및 그의 이용 |
| KR101602876B1 (ko) | 2014-07-22 | 2016-03-11 | 아주대학교산학협력단 | 완전한 이뮤노글로불린 형태의 세포질 침투능을 갖는 항체를 이용하여 세포내 활성화된 ras를 억제하는 방법 및 그의 이용 |
| CN114456272A (zh) * | 2015-04-03 | 2022-05-10 | 优瑞科生物技术公司 | 靶向afp肽/mhc复合体的构建体及其用途 |
| NL2014935B1 (en) | 2015-06-08 | 2017-02-03 | Applied Immune Tech Ltd | T cell receptor like antibodies having fine specificity. |
| RU2767209C2 (ru) | 2015-10-23 | 2022-03-16 | Еурека Терапьютикс, Инк. | Химерные конструкции антитело/т-клеточный рецептор и их применения |
| BR112018074275A2 (pt) | 2016-05-27 | 2019-10-01 | Orum Therapeutics Inc | anticorpo de penetração no citosol e método de produção do mesmo |
| US20190201496A1 (en) * | 2016-09-16 | 2019-07-04 | The Brigham And Women's Hospital, Inc. | Blockade of alphafetoprotein (afp) interactions with beta2-microglobulin associated molecules |
| JP2020506971A (ja) | 2017-02-08 | 2020-03-05 | ドラゴンフライ セラピューティクス， インコーポレイテッド | ナチュラルキラー細胞の活性化のための多重特異性結合タンパク質およびがんを処置するためのその治療的使用 |
| WO2018148447A1 (en) * | 2017-02-08 | 2018-08-16 | Adimab, Llc | Antibody heavy chain variable domains targeting the nkg2d receptor |
| SG11201907646YA (en) | 2017-02-20 | 2019-09-27 | Dragonfly Therapeutics Inc | Proteins binding her2, nkg2d and cd16 |
| US20210122831A1 (en) * | 2017-03-27 | 2021-04-29 | Noile-Immune Biotech, Inc. | Chimeric antigen receptor |
| CN110753555A (zh) | 2017-04-19 | 2020-02-04 | 得克萨斯州大学系统董事会 | 表达工程化抗原受体的免疫细胞 |
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| EP3755349A4 (en) | 2018-02-21 | 2021-11-17 | Board of Regents, The University of Texas System | PROCESS FOR ACTIVATION AND EXPANSION OF NATURAL KILLER CELLS AND THEIR USES |
| WO2019192432A1 (zh) * | 2018-04-02 | 2019-10-10 | 上海博威生物医药有限公司 | 结合淋巴细胞活化基因-3(lag-3)的抗体及其用途 |
| CN110407927B (zh) * | 2018-04-26 | 2022-09-09 | 香雪生命科学技术（广东）有限公司 | 一种识别afp抗原的tcr |
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| CN110776562B (zh) * | 2018-07-30 | 2022-06-17 | 香雪生命科学技术（广东）有限公司 | 一种识别afp抗原的t细胞受体 |
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| JP7482363B2 (ja) | 2018-08-08 | 2024-05-14 | ドラゴンフライ セラピューティクス， インコーポレイテッド | Ｎｋｇ２ｄ、ｃｄ１６及び腫瘍関連抗原に結合するタンパク質 |
| EA202091888A1 (ru) | 2018-08-08 | 2020-10-23 | Драгонфлай Терапьютикс, Инк. | Вариабельные домены антител, нацеленные на рецептор nkg2d |
| CN110872346A (zh) * | 2018-08-30 | 2020-03-10 | 天津天锐生物科技有限公司 | 一种识别hla-a2分子与fmnkfiyei短肽形成的复合物的单域抗体 |
| US12275773B2 (en) * | 2018-09-21 | 2025-04-15 | Xlifesc, Ltd. | High affinity cell receptor for recognizing AFP antigen |
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| CN114057864B (zh) * | 2020-07-30 | 2023-12-15 | 香雪生命科学技术（广东）有限公司 | 一种识别afp的高亲和力tcr |
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