JP2018509395A5 - - Google Patents

Info

Publication number

JP2018509395A5

JP2018509395A5 JP2017541619A JP2017541619A JP2018509395A5 JP 2018509395 A5 JP2018509395 A5 JP 2018509395A5 JP 2017541619 A JP2017541619 A JP 2017541619A JP 2017541619 A JP2017541619 A JP 2017541619A JP 2018509395 A5 JP2018509395 A5 JP 2018509395A5

Authority

JP

Japan

Prior art keywords

pharmaceutical composition

composition according

muscle

compared

administered

Prior art date

2016-02-09

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Granted

Links

• Espacenet
• Global Dossier
• Discuss

• 239000008194 pharmaceutical composition Substances 0.000 claims 100
• 208000021642 Muscular disease Diseases 0.000 claims 14
• 201000009623 Myopathy Diseases 0.000 claims 14
• 210000003205 muscle Anatomy 0.000 claims 14
• 108010003205 Vasoactive Intestinal Peptide Proteins 0.000 claims 11
• 102400000015 Vasoactive intestinal peptide Human genes 0.000 claims 10
• VBUWHHLIZKOSMS-RIWXPGAOSA-N invicorp Chemical compound C([C@@H](C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CO)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(O)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCCN)NC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](CCSC)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(O)=O)NC(=O)[C@@H](NC(=O)[C@H](CC=1C=CC=CC=1)NC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](N)CC=1NC=NC=1)C(C)C)[C@@H](C)O)[C@@H](C)O)C(C)C)C1=CC=C(O)C=C1 VBUWHHLIZKOSMS-RIWXPGAOSA-N 0.000 claims 10
• 201000006938 muscular dystrophy Diseases 0.000 claims 10
• 208000031229 Cardiomyopathies Diseases 0.000 claims 6
• 206010013801 Duchenne Muscular Dystrophy Diseases 0.000 claims 6
• 210000000663 muscle cell Anatomy 0.000 claims 5
• 210000000107 myocyte Anatomy 0.000 claims 5
• 108090000765 processed proteins & peptides Proteins 0.000 claims 5
• 206010048654 Muscle fibrosis Diseases 0.000 claims 4
• 150000001413 amino acids Chemical group 0.000 claims 4
• 238000004904 shortening Methods 0.000 claims 3
• 102000008186 Collagen Human genes 0.000 claims 2
• 108010035532 Collagen Proteins 0.000 claims 2
• 201000002481 Myositis Diseases 0.000 claims 2
• 201000011212 X-linked dilated cardiomyopathy Diseases 0.000 claims 2
• 229920001436 collagen Polymers 0.000 claims 2
• 210000002865 immune cell Anatomy 0.000 claims 2
• 210000002540 macrophage Anatomy 0.000 claims 2
• 230000004118 muscle contraction Effects 0.000 claims 2
• 210000004165 myocardium Anatomy 0.000 claims 2
• 102000004196 processed proteins & peptides Human genes 0.000 claims 2
• 230000002861 ventricular Effects 0.000 claims 2
• 201000006935 Becker muscular dystrophy Diseases 0.000 claims 1
• 101000666868 Homo sapiens Vasoactive intestinal polypeptide receptor 2 Proteins 0.000 claims 1
• 102100022745 Laminin subunit alpha-2 Human genes 0.000 claims 1
• 201000009342 Limb-girdle muscular dystrophy Diseases 0.000 claims 1
• 102100038388 Vasoactive intestinal polypeptide receptor 1 Human genes 0.000 claims 1
• 101710137655 Vasoactive intestinal polypeptide receptor 1 Proteins 0.000 claims 1
• 102100038286 Vasoactive intestinal polypeptide receptor 2 Human genes 0.000 claims 1
• 210000004413 cardiac myocyte Anatomy 0.000 claims 1
• 201000006815 congenital muscular dystrophy Diseases 0.000 claims 1
• 230000003111 delayed effect Effects 0.000 claims 1
• 201000001981 dermatomyositis Diseases 0.000 claims 1
• 230000001815 facial effect Effects 0.000 claims 1
• 201000008319 inclusion body myositis Diseases 0.000 claims 1
• 238000007918 intramuscular administration Methods 0.000 claims 1
• 238000001990 intravenous administration Methods 0.000 claims 1
• 230000003274 myotonic effect Effects 0.000 claims 1
• 230000002093 peripheral effect Effects 0.000 claims 1
• 208000005987 polymyositis Diseases 0.000 claims 1
• 208000000943 scapulohumeral muscular dystrophy Diseases 0.000 claims 1
• 210000002027 skeletal muscle Anatomy 0.000 claims 1
• 210000002363 skeletal muscle cell Anatomy 0.000 claims 1
• 238000013268 sustained release Methods 0.000 claims 1
• 239000012730 sustained-release form Substances 0.000 claims 1
• 230000003442 weekly effect Effects 0.000 claims 1