JP6824888B2 - 筋肉の疾患および障害を治療するための方法および組成物 - Google Patents
筋肉の疾患および障害を治療するための方法および組成物 Download PDFInfo
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- JP6824888B2 JP6824888B2 JP2017541619A JP2017541619A JP6824888B2 JP 6824888 B2 JP6824888 B2 JP 6824888B2 JP 2017541619 A JP2017541619 A JP 2017541619A JP 2017541619 A JP2017541619 A JP 2017541619A JP 6824888 B2 JP6824888 B2 JP 6824888B2
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/39—Connective tissue peptides, e.g. collagen, elastin, laminin, fibronectin, vitronectin, cold insoluble globulin [CIG]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/2278—Vasoactive intestinal peptide [VIP]; Related peptides (e.g. Exendin)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/02—Inorganic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Immunology (AREA)
- Gastroenterology & Hepatology (AREA)
- Zoology (AREA)
- Vascular Medicine (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Endocrinology (AREA)
- Biomedical Technology (AREA)
- Urology & Nephrology (AREA)
- Inorganic Chemistry (AREA)
- Dermatology (AREA)
- Neurology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562113943P | 2015-02-09 | 2015-02-09 | |
| US62/113,943 | 2015-02-09 | ||
| US201562145770P | 2015-04-10 | 2015-04-10 | |
| US62/145,770 | 2015-04-10 | ||
| US201562150679P | 2015-04-21 | 2015-04-21 | |
| US62/150,679 | 2015-04-21 | ||
| PCT/US2016/017102 WO2016130518A2 (en) | 2015-02-09 | 2016-02-09 | Methods and compositions for treating muscle disease and disorders |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2018509395A JP2018509395A (ja) | 2018-04-05 |
| JP2018509395A5 JP2018509395A5 (enExample) | 2019-03-07 |
| JP6824888B2 true JP6824888B2 (ja) | 2021-02-03 |
Family
ID=56614686
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017541619A Active JP6824888B2 (ja) | 2015-02-09 | 2016-02-09 | 筋肉の疾患および障害を治療するための方法および組成物 |
Country Status (8)
| Country | Link |
|---|---|
| US (4) | US10688156B2 (enExample) |
| EP (1) | EP3256151B1 (enExample) |
| JP (1) | JP6824888B2 (enExample) |
| CN (2) | CN107427556B (enExample) |
| AU (1) | AU2016219513B2 (enExample) |
| CA (1) | CA2976038A1 (enExample) |
| ES (1) | ES2822598T3 (enExample) |
| WO (1) | WO2016130518A2 (enExample) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9561262B2 (en) | 2011-06-06 | 2017-02-07 | Phasebio Pharmaceuticals, Inc. | Use of modified vasoactive intestinal peptides in the treatment of hypertension |
| EP3139949B1 (en) | 2014-05-08 | 2020-07-29 | Phasebio Pharmaceuticals, Inc. | Compositions comprising a vip-elp fusion protein for use in treating cystic fibrosis |
| WO2016130518A2 (en) | 2015-02-09 | 2016-08-18 | Phasebio Pharmaceuticals, Inc. | Methods and compositions for treating muscle disease and disorders |
Family Cites Families (149)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4132746A (en) | 1976-07-09 | 1979-01-02 | University Of Alabama, Birmingham Medical & Education Foundation | Synthetic elastomeric insoluble cross-linked polypentapeptide |
| US4187852A (en) | 1976-07-09 | 1980-02-12 | The University Of Alabama | Synthetic elastomeric insoluble cross-linked polypentapeptide |
| US4500700A (en) | 1981-10-02 | 1985-02-19 | The Board Of Trustees Of The University Of Alabama For The University Of Alabama In Birmingham | Elastomeric composite material comprising a polypentapeptide having an amino acid of opposite chirality in position three |
| US4474851A (en) | 1981-10-02 | 1984-10-02 | The University Of Alabama In Birmingham | Elastomeric composite material comprising a polypeptide |
| US4589882A (en) | 1983-09-19 | 1986-05-20 | Urry Dan W | Enzymatically crosslinked bioelastomers |
| US4752638A (en) | 1983-11-10 | 1988-06-21 | Genetic Systems Corporation | Synthesis and use of polymers containing integral binding-pair members |
| US4749647A (en) | 1984-06-22 | 1988-06-07 | Genetic Systems Corporation | Polymerization-induced separation assay using recognition pairs |
| US4605641A (en) | 1984-10-09 | 1986-08-12 | Hoffmann-La Roche Inc. | Synthetic vasoactive intestinal peptide analogs |
| US4734400A (en) | 1984-10-09 | 1988-03-29 | Hoffmann-La Roche Inc. | Synthetic vasoactive intestinal peptide analogs |
| US4783523A (en) | 1986-08-27 | 1988-11-08 | Urry Dan W | Temperature correlated force and structure development of elastin polytetrapeptides and polypentapeptides |
| US4870055A (en) | 1986-04-17 | 1989-09-26 | University Of Alabama At Birmingham | Segmented polypeptide bioelastomers to modulate elastic modulus |
| US7138486B2 (en) | 1986-05-05 | 2006-11-21 | The General Hospital Corporation | Insulinotropic hormone derivatives and uses thereof |
| US4898926A (en) | 1987-06-15 | 1990-02-06 | The University Of Alabama At Birmingham/Research Foundation | Bioelastomer containing tetra/penta-peptide units |
| US5496712A (en) | 1990-11-06 | 1996-03-05 | Protein Polymer | High molecular weight collagen-like protein polymers |
| US5641648A (en) | 1986-11-04 | 1997-06-24 | Protein Polymer Technologies, Inc. | Methods for preparing synthetic repetitive DNA |
| US5770697A (en) | 1986-11-04 | 1998-06-23 | Protein Polymer Technologies, Inc. | Peptides comprising repetitive units of amino acids and DNA sequences encoding the same |
| US5514581A (en) | 1986-11-04 | 1996-05-07 | Protein Polymer Technologies, Inc. | Functional recombinantly prepared synthetic protein polymer |
| US5830713A (en) | 1986-11-04 | 1998-11-03 | Protein Polymer Technologies, Inc. | Methods for preparing synthetic repetitive DNA |
| US6184348B1 (en) | 1986-11-04 | 2001-02-06 | Protein Polymer Technologies | Functional recombinantly prepared synthetic protein polymer |
| US5243038A (en) | 1986-11-04 | 1993-09-07 | Protein Polymer Technologies, Inc. | Construction of synthetic DNA and its use in large polypeptide synthesis |
| US6018030A (en) | 1986-11-04 | 2000-01-25 | Protein Polymer Technologies, Inc. | Peptides comprising repetitive units of amino acids and DNA sequences encoding the same |
| US5773249A (en) | 1986-11-04 | 1998-06-30 | Protein Polymer Technologies, Inc. | High molecular weight collagen-like protein polymers |
| US4939224A (en) | 1987-02-26 | 1990-07-03 | The Salk Institute Biotechnology/Industrial Associates, Inc. | Vasoactive intestinal peptide analogs |
| US4835252A (en) | 1987-02-26 | 1989-05-30 | The Salk Institute Biotechnology/Industrial Associates, Inc. | Vasoactive intestinal peptide analogs |
| US5606019A (en) | 1987-10-29 | 1997-02-25 | Protien Polymer Technologies, Inc. | Synthetic protein as implantables |
| IL87055A (en) | 1988-07-08 | 1994-06-24 | Illana Gozes | Conjugates of vasoactive intestinal peptide (vip) and of fragments thereof and pharmaceutical compositions comprising them |
| US5766883A (en) | 1989-04-29 | 1998-06-16 | Delta Biotechnology Limited | Polypeptides |
| US5143854A (en) | 1989-06-07 | 1992-09-01 | Affymax Technologies N.V. | Large scale photolithographic solid phase synthesis of polypeptides and receptor binding screening thereof |
| US5234907A (en) | 1989-06-30 | 1993-08-10 | Hoffmann-La Roche Inc. | Synthetic vasoactive intestinal peptide analogs |
| US5141924A (en) | 1989-06-30 | 1992-08-25 | Hoffmann-La Roche, Inc. | Synthetic vasoactive intestinal peptide analogs |
| US5236904A (en) | 1989-09-18 | 1993-08-17 | Senetek, Plc | Erection-inducing methods and compositions |
| US5447912A (en) | 1989-09-18 | 1995-09-05 | Senetek, Plc | Erection-inducing methods and compositions |
| ATE114458T1 (de) | 1990-03-27 | 1994-12-15 | Bioelastics Res Ltd | Bioelastomeres arzneimittelabgabesystem. |
| DE69101187T2 (de) | 1990-06-26 | 1994-09-29 | Sanwa Kagaku Kenkyusho Co | VIP-Analogen und ihre Verwendung. |
| JPH07108232B2 (ja) | 1990-10-09 | 1995-11-22 | エム・ディ・リサーチ株式会社 | ペプチド又は蛋白質の製造方法 |
| US5235041A (en) | 1990-12-28 | 1993-08-10 | Protein Polymer Technologies, Inc. | Purification of structurally ordered recombinant protein polymers |
| US5595732A (en) | 1991-03-25 | 1997-01-21 | Hoffmann-La Roche Inc. | Polyethylene-protein conjugates |
| US5393602A (en) | 1991-04-19 | 1995-02-28 | Bioelastics Research Ltd. | Superabsorbent materials and uses thereof |
| JPH05238950A (ja) | 1991-04-22 | 1993-09-17 | Sanwa Kagaku Kenkyusho Co Ltd | 易吸収性vip製剤 |
| US5958881A (en) | 1991-04-25 | 1999-09-28 | Korman; Louis Y. | Composition containing VIP for injection and a method of enhancing visualization of tissues during medical procedures |
| AU656230B2 (en) | 1991-10-11 | 1995-01-27 | F. Hoffmann-La Roche Ag | Cyclic vasoactive peptides |
| US5681816A (en) | 1992-04-24 | 1997-10-28 | Korman; Louis Y. | Method of inducing temporary paralysis of the gastrointestinal tract during medical procedure |
| US5288514A (en) | 1992-09-14 | 1994-02-22 | The Regents Of The University Of California | Solid phase and combinatorial synthesis of benzodiazepine compounds on a solid support |
| US5972883A (en) | 1993-03-16 | 1999-10-26 | Yeda Research And Development Co. Ltd. | Method for the treatment of neurodegenerative diseases by administering VIP, an analogue, fragment or a conjugate thereof |
| US5545617A (en) | 1993-11-12 | 1996-08-13 | The Schepens Eye Research Institute, Inc. | Therapeutic regulation of abnormal conjunctival goblet cell mucous secretion |
| US5705483A (en) | 1993-12-09 | 1998-01-06 | Eli Lilly And Company | Glucagon-like insulinotropic peptides, compositions and methods |
| US5900405A (en) | 1994-01-24 | 1999-05-04 | Bioelastics Research, Ltd. | Polymers responsive to electrical energy |
| JPH10502333A (ja) | 1994-04-07 | 1998-03-03 | プロティーンニックス カンパニー | バソアクティブ・インテスティナル・ポリペプチド |
| US5527610A (en) | 1994-05-20 | 1996-06-18 | The Uab Research Foundation | Elastomeric polypeptide matrices for preventing adhesion of biological materials |
| US6004782A (en) | 1995-04-14 | 1999-12-21 | Bioelastics Research Ltd. | Hyperexpression of bioelastic polypeptides |
| US5972406A (en) | 1995-04-14 | 1999-10-26 | Bioelastics Research Ltd. | Bioelastomers suitable as food product additives |
| US5854387A (en) | 1995-04-14 | 1998-12-29 | Bioelastics Research, Ltd. | Simple method for the purification of a bioelastic polymer |
| US5624711A (en) | 1995-04-27 | 1997-04-29 | Affymax Technologies, N.V. | Derivatization of solid supports and methods for oligomer synthesis |
| US6037321A (en) | 1995-05-03 | 2000-03-14 | Biostar Inc. | Fusion proteins comprising vasoactive intestinal peptide or PACAP |
| EP0851768B1 (en) | 1995-09-01 | 2002-04-24 | University of Washington | Interactive molecular conjugates |
| US5702717A (en) | 1995-10-25 | 1997-12-30 | Macromed, Inc. | Thermosensitive biodegradable polymers based on poly(ether-ester)block copolymers |
| EP0879246B1 (en) | 1996-02-09 | 2006-05-31 | F. Hoffmann-La Roche Ag | Synthesis of vip analog |
| DE69721548T2 (de) | 1996-02-09 | 2004-04-01 | Abbott Laboratories(Bermuda)Ltd. | HUMANE ANTIKÖRPER WELCHE AN HUMANEN TNFalpha BINDEN |
| US6063061A (en) | 1996-08-27 | 2000-05-16 | Fusion Medical Technologies, Inc. | Fragmented polymeric compositions and methods for their use |
| US5816259A (en) | 1997-01-13 | 1998-10-06 | Rose; Samuel | Method for the diagnosis and treatment of cancer by the accumulation of radioactive precipitates in targeted cells |
| US20020099003A1 (en) | 1997-10-28 | 2002-07-25 | Wilson Leland F. | Treatment of female sexual dysfunction with vasoactive agents, particularly vasoactive intestinal polypeptide and agonists thereof |
| US6703359B1 (en) | 1998-02-13 | 2004-03-09 | Amylin Pharmaceuticals, Inc. | Inotropic and diuretic effects of exendin and GLP-1 |
| EP1056413A4 (en) | 1998-02-27 | 2003-08-20 | Bioelastics Res Ltd | INJECTABLE IMPLANTS FOR TISSUE ENHANCEMENT AND RESTORATION |
| US6998387B1 (en) | 1998-03-19 | 2006-02-14 | Amylin Pharmaceuticals, Inc. | Human appetite control by glucagon-like peptide receptor binding compounds |
| FR2776520B1 (fr) | 1998-03-25 | 2000-05-05 | Sod Conseils Rech Applic | Nouvelles compositions pharmaceutiques destinees a la liberation prolongee de peptides et leur procede de preparation |
| ES2138561B1 (es) | 1998-04-17 | 2000-07-01 | Univ Madrid Complutense | Uso de los peptidos vip y pacap en el tratamiento del shock endotoxico en mamiferos. |
| US6153655A (en) | 1998-04-17 | 2000-11-28 | Enzon, Inc. | Terminally-branched polymeric linkers and polymeric conjugates containing the same |
| US20020151458A1 (en) | 1998-04-17 | 2002-10-17 | Perez Gomariz Rosa Maria | Method for treating and preventing septic shock with VPAC1R, VPAC2R and PAC1R agonists |
| US6200598B1 (en) | 1998-06-18 | 2001-03-13 | Duke University | Temperature-sensitive liposomal formulation |
| US6541033B1 (en) | 1998-06-30 | 2003-04-01 | Amgen Inc. | Thermosensitive biodegradable hydrogels for sustained delivery of leptin |
| US6406921B1 (en) | 1998-07-14 | 2002-06-18 | Zyomyx, Incorporated | Protein arrays for high-throughput screening |
| WO2000056774A1 (en) | 1999-03-19 | 2000-09-28 | Duke University | Methods of using bioelastomers |
| US20090175821A1 (en) | 1999-05-17 | 2009-07-09 | Bridon Dominique P | Modified therapeutic peptides with extended half-lives in vivo |
| CA2391448A1 (en) | 1999-11-12 | 2001-05-17 | Leo Rubin | Use of vasoactive intestinal peptides and kits therefor |
| US6235264B1 (en) | 1999-12-01 | 2001-05-22 | General Electric Company | Medical imaging method for characterizing tumor angiogenesis using polymeric contrast agents |
| JP2001161363A (ja) | 1999-12-03 | 2001-06-19 | Hisamitsu Pharmaceut Co Inc | 新規な小胞体局在タンパク質およびそれを含む糖タンパク質異常症治療薬、並びに該タンパク質をコードするdnaおよびそれを含む糖タンパク質異常症治療のための遺伝子治療薬。 |
| US6593394B1 (en) | 2000-01-03 | 2003-07-15 | Prosperous Kingdom Limited | Bioactive and osteoporotic bone cement |
| US7833992B2 (en) | 2001-05-18 | 2010-11-16 | Merck Sharpe & Dohme | Conjugates and compositions for cellular delivery |
| WO2001060862A1 (en) | 2000-02-18 | 2001-08-23 | Dabur Research Foundation | Vasoactive intestinal peptide analogs |
| ATE355304T1 (de) | 2000-02-18 | 2006-03-15 | Dabur Res Foundation | Radiomarkierte vip-analoge zur diagnose und therapie |
| US6852834B2 (en) | 2000-03-20 | 2005-02-08 | Ashutosh Chilkoti | Fusion peptides isolatable by phase transition |
| US20050255554A1 (en) | 2000-03-20 | 2005-11-17 | Ashutosh Chilkoti | Fusion peptides isolatable by phase transition |
| BR0111562A (pt) | 2000-06-16 | 2003-04-15 | Lilly Co Eli | Análogos de peptìdeo 1 semelhantes ao glucagon |
| CN1487952A (zh) | 2000-11-28 | 2004-04-07 | �ɶ����\��ʵ���� | 具有血管活性肠肽的生物学活性的用于治疗肺动脉和小动脉高压的化合物 |
| DK1355942T3 (da) | 2000-12-07 | 2008-11-17 | Lilly Co Eli | GLP-1-fusionsproteiner |
| US7259233B2 (en) | 2000-12-13 | 2007-08-21 | Eli Lilly And Company | Chronic treatment regimen using glucagon-like insulinotropic peptides |
| EP1542712A2 (en) | 2001-06-01 | 2005-06-22 | Eli Lilly And Company | Glp-1 formulations with protracted time action |
| CA2455884C (en) | 2001-08-15 | 2015-09-22 | Justin R. Fallon | Treatment of muscular dystrophies and related disorders |
| US7101843B2 (en) | 2001-08-23 | 2006-09-05 | Eli Lilly And Company | Glucagon-like peptide-1 analogs |
| US7176278B2 (en) | 2001-08-30 | 2007-02-13 | Biorexis Technology, Inc. | Modified transferrin fusion proteins |
| WO2003039577A1 (en) | 2001-11-06 | 2003-05-15 | Senju Pharmaceutical Co., Ltd. | Remedies for dry eye and diseases associated with dry eye |
| AU2002364586A1 (en) | 2001-12-21 | 2003-07-30 | Delta Biotechnology Limited | Albumin fusion proteins |
| CN1313149C (zh) | 2002-06-10 | 2007-05-02 | 蒙杜生物科技安斯塔特实验室 | 具有血管活性肠肽的生物学活性的化合物在治疗结节病中的用途 |
| KR20050067439A (ko) | 2002-11-27 | 2005-07-01 | 이토햄 가부시키가이샤 | 펩티드 및 이를 포함하는 의약조성물 |
| US20040234609A1 (en) | 2003-05-14 | 2004-11-25 | Collier Katherine D. | Repeat sequence protein polymer active agent congjugates, methods and uses |
| PL1633391T3 (pl) | 2003-06-03 | 2012-03-30 | Novo Nordisk As | Stabilizowane farmaceutycznie kompozycje peptydowe |
| CA2532135A1 (en) | 2003-07-14 | 2005-01-20 | Mondobiotech Laboratories Anstalt | Biologically active substance of a vasoactive intestinal peptide for treating interstitial lung infections |
| WO2005014030A1 (en) | 2003-07-24 | 2005-02-17 | Lutz-Henning Block | Method for treating lung diseases associated with ventilation-perfusion mismatches |
| US7928059B2 (en) | 2004-02-24 | 2011-04-19 | Wisconsin Alumni Research Foundation | Use of neuropeptides for traumatic cartilage injury |
| US7776815B2 (en) | 2004-02-24 | 2010-08-17 | Wisconsin Alumni Research Foundation | Use of neuropeptides for ligament healing |
| US20050203009A1 (en) | 2004-03-12 | 2005-09-15 | Bayer Pharmaceuticals Corporation | VPAC1 selective antagonists and their pharmacological methods of use |
| WO2005097158A1 (en) | 2004-03-29 | 2005-10-20 | The Arizona Board Of Regents On Behalf Of The University Of Arizona | Amphipathic glycopeptides |
| CA2567635A1 (en) | 2004-05-21 | 2005-12-01 | Eli Lilly And Company | Selective vpac2 receptor peptide agonists |
| BRPI0511367B8 (pt) | 2004-06-11 | 2021-05-25 | Vectus Biosystems Ltd | uso de uma composição,composição, uso de vip e/ou de um fragmento ativo do mesmo |
| EP1768686A4 (en) | 2004-06-12 | 2007-11-14 | Bayer Pharmaceuticals Corp | PEGYLATION OF VASOACTIVE INTESTINAL PEPTIDE (VIP) / HYPOPHYDE-ADENYLATE CYCLASE-ACTIVATING PEPTIDE (PACAP) RECEPTOR 2 (VPAC2) AGONISTS AND METHOD OF USE |
| US20080085860A1 (en) | 2004-08-18 | 2008-04-10 | Eli Lilly And Company | Selective Vpac2 Receptor Peptide Agonists |
| CA2576755A1 (en) | 2004-08-18 | 2006-03-02 | Eli Lilly And Company | Selective vpac2 receptor peptide agonists |
| JP2008515437A (ja) | 2004-10-08 | 2008-05-15 | フォーブス メディ−テック(リサーチ) インコーポレーテッド | 血管活性腸管ポリペプチド医薬品 |
| WO2006078629A2 (en) * | 2005-01-18 | 2006-07-27 | Duke University | In-situ crosslinkable elastin-like polypeptides for defect filling in cartilaginous tissue repair |
| US7723472B2 (en) | 2005-02-28 | 2010-05-25 | The Regents Of The University Of California | Extracellular matrix binding chimeric proteins and methods of use thereof |
| US20070009602A1 (en) | 2005-06-24 | 2007-01-11 | Setton Lori A | Direct drug delivery system based on thermally responsive biopolymers |
| US7846445B2 (en) | 2005-09-27 | 2010-12-07 | Amunix Operating, Inc. | Methods for production of unstructured recombinant polymers and uses thereof |
| BRPI0617740A2 (pt) | 2005-10-26 | 2011-08-02 | Lilly Co Eli | agonistas seletivos peptìdicos do receptor vpac2, composição farmacêutica e uso dos referidos agonistas |
| US20100184651A1 (en) | 2005-11-18 | 2010-07-22 | Dabur Pharma Limited | Targeted fusion proteins for cancer therapy |
| AU2006322656B2 (en) * | 2005-12-09 | 2012-03-08 | Vectus Biosystems Limited | VIP fragments and methods of use |
| EP1971355B1 (en) | 2005-12-20 | 2020-03-11 | Duke University | Methods and compositions for delivering active agents with enhanced pharmacological properties |
| US20130172274A1 (en) | 2005-12-20 | 2013-07-04 | Duke University | Methods and compositions for delivering active agents with enhanced pharmacological properties |
| US8841255B2 (en) | 2005-12-20 | 2014-09-23 | Duke University | Therapeutic agents comprising fusions of vasoactive intestinal peptide and elastic peptides |
| US7709227B2 (en) | 2006-01-04 | 2010-05-04 | Phasebio Pharmaceuticals, Inc. | Multimeric ELP fusion constructs |
| US8367626B2 (en) | 2006-05-12 | 2013-02-05 | Wisconsin Alumni Research Foundation | Elastin-like polymer delivery vehicles |
| CN103230598A (zh) | 2006-09-06 | 2013-08-07 | 费斯生物制药公司 | 融合肽治疗组合物 |
| CA2687602C (en) | 2007-05-21 | 2014-07-15 | Res International Sarl | Peptides with improved properties having the biological activity of vasoactive intestinal peptide (vip) and their use for the treatment of lung diseases |
| DE602008005596D1 (de) | 2007-06-21 | 2011-04-28 | Univ Muenchen Tech | Biologisch aktive proteine mit erhöhter in-vivo- und/oder in-vitro-stabilität |
| BRPI0815416A2 (pt) | 2007-08-15 | 2014-10-21 | Amunix Inc | Composições e métodos para modificar propriedades de polipeptídeos biologicamente ativos |
| US20110207673A1 (en) | 2007-11-20 | 2011-08-25 | Ashutosh Chilkoti | Methods and compositions for modulating drug-polymer architecture, pharmacokinetics and biodistribution |
| WO2009135184A2 (en) * | 2008-05-01 | 2009-11-05 | The Trustees Of Columbia University In The City Of New York | Methods for treating and/or preventing cardiomyopathies by erk or jnk inhibition |
| JP2011526303A (ja) | 2008-06-27 | 2011-10-06 | デューク ユニバーシティ | エラスチン様ペプチドを含む治療剤 |
| US20110219462A1 (en) | 2008-07-15 | 2011-09-08 | Bayer Schering Pharma Aktiengesellschaft | G-Protein Coupled Receptor 30 (GPR30) transgenic animals as a model for cardiovascular diseases |
| US9333235B2 (en) | 2008-10-22 | 2016-05-10 | Trustees Of Dartmouth College | Combination therapy and kit for the prevention and treatment of cystic fibrosis |
| US8314239B2 (en) | 2008-10-23 | 2012-11-20 | Vertex Pharmaceutical Incorporated | Modulators of cystic fibrosis transmembrane conductance regulator |
| US20110288001A1 (en) | 2008-12-18 | 2011-11-24 | Homayoun Sadeghi | Biologically active proteins activatable by peptidase |
| MX366935B (es) * | 2009-08-14 | 2019-07-31 | Phasebio Pharmaceuticals Inc | Peptidos intestinales vasoactivos modificados. |
| CN102883739B (zh) | 2009-11-02 | 2015-11-25 | 图兰恩教育基金管理人 | 垂体腺苷酸环化酶激活多肽(pacap)的类似物和它们的应用方法 |
| US20130116184A1 (en) | 2010-04-02 | 2013-05-09 | The Regents Of The University Of Michigan | RFamide-Related Peptides and Methods Thereof |
| CN103260647A (zh) | 2010-11-30 | 2013-08-21 | 伦敦健康科学中心研究公司 | 用于治疗心脏病的egfr拮抗剂 |
| CA2826663A1 (en) | 2011-02-07 | 2012-08-16 | Mochida Pharmaceutical Co., Ltd. | Therapeutic agent for diastolic congestive heart failure |
| HUE047354T2 (hu) | 2011-05-18 | 2020-04-28 | Vertex Pharmaceuticals Europe Ltd | Ivacaftor deuterizált származékai |
| US9561262B2 (en) | 2011-06-06 | 2017-02-07 | Phasebio Pharmaceuticals, Inc. | Use of modified vasoactive intestinal peptides in the treatment of hypertension |
| CA2846209C (en) | 2011-08-24 | 2022-04-05 | Phasebio Pharmaceuticals, Inc. | Systemic sustained release formulation comprising elastinlike peptide repeating sequence and protein active agent |
| SG11201402661TA (en) | 2011-11-28 | 2014-08-28 | Phasebio Pharmaceuticals Inc | Therapeutic agents comprising insulin amino acid sequences |
| EP2664326B1 (en) | 2012-05-17 | 2017-11-01 | I.E.R.F.C. European Institute for Cystic Fibrosis Research | Combined therapy for cystic fibrosis |
| WO2013177428A1 (en) | 2012-05-23 | 2013-11-28 | Valerion Therapeutics, Inc. | Methods for increasing muscle contractility |
| US10159741B2 (en) | 2012-05-25 | 2018-12-25 | National Cheng Kung University | Methods and compositions comprising hyaluronan for enhancing bone marrow cell therapy |
| US9605186B2 (en) | 2012-09-19 | 2017-03-28 | Exxonmobil Chemical Patents Inc. | Adhesive compositions of ethylene-based and propylene-based polymers |
| US20150290328A1 (en) | 2012-11-20 | 2015-10-15 | Phasebio Pharmaceuticals, Inc. | Formulations of active agents for sustained release |
| EP2945643A4 (en) | 2013-01-15 | 2017-04-26 | Phasebio Pharmaceuticals, Inc. | Therapeutic agents, compositions, and methods for glycemic control |
| EP3139949B1 (en) * | 2014-05-08 | 2020-07-29 | Phasebio Pharmaceuticals, Inc. | Compositions comprising a vip-elp fusion protein for use in treating cystic fibrosis |
| JP7075757B2 (ja) * | 2014-11-21 | 2022-05-26 | フェーズバイオ ファーマシューティカルズ,インコーポレイテッド | 制御放出および持続的放出のためのelp融合タンパク質 |
| WO2016130518A2 (en) | 2015-02-09 | 2016-08-18 | Phasebio Pharmaceuticals, Inc. | Methods and compositions for treating muscle disease and disorders |
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| CA2976038A1 (en) | 2016-08-18 |
| CN107427556B (zh) | 2022-02-25 |
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| US10688156B2 (en) | 2020-06-23 |
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| EP3256151B1 (en) | 2020-08-05 |
| EP3256151A4 (en) | 2018-08-22 |
| CN107427556A (zh) | 2017-12-01 |
| AU2016219513B2 (en) | 2021-09-30 |
| US11266719B2 (en) | 2022-03-08 |
| ES2822598T3 (es) | 2021-05-04 |
| AU2016219513A1 (en) | 2017-08-17 |
| CN114652817A (zh) | 2022-06-24 |
| WO2016130518A2 (en) | 2016-08-18 |
| HK1249402A1 (zh) | 2018-11-02 |
| US20180333467A1 (en) | 2018-11-22 |
| JP2018509395A (ja) | 2018-04-05 |
| US20220288170A1 (en) | 2022-09-15 |
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