JP2016516073A5 - - Google Patents
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- Publication number
- JP2016516073A5 JP2016516073A5 JP2016503371A JP2016503371A JP2016516073A5 JP 2016516073 A5 JP2016516073 A5 JP 2016516073A5 JP 2016503371 A JP2016503371 A JP 2016503371A JP 2016503371 A JP2016503371 A JP 2016503371A JP 2016516073 A5 JP2016516073 A5 JP 2016516073A5
- Authority
- JP
- Japan
- Prior art keywords
- composition
- esterase inhibitor
- hae
- administration
- esterase
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000000203 mixture Substances 0.000 claims description 42
- 229940009550 c1 esterase inhibitor Drugs 0.000 claims description 21
- 206010019860 Hereditary angioedema Diseases 0.000 claims description 11
- KRKNYBCHXYNGOX-UHFFFAOYSA-K Citrate Chemical compound [O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O KRKNYBCHXYNGOX-UHFFFAOYSA-K 0.000 claims description 3
- 229910019142 PO4 Inorganic materials 0.000 claims description 3
- 239000000872 buffer Substances 0.000 claims description 3
- 239000010452 phosphate Substances 0.000 claims description 3
- 238000011282 treatment Methods 0.000 claims description 3
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 claims description 2
- 125000003275 alpha amino acid group Chemical group 0.000 claims 2
- 239000008280 blood Substances 0.000 claims 2
- 210000004369 blood Anatomy 0.000 claims 2
- 230000036765 blood level Effects 0.000 claims 2
- 229940122601 Esterase inhibitor Drugs 0.000 claims 1
- 239000006172 buffering agent Substances 0.000 claims 1
- 239000002329 esterase inhibitor Substances 0.000 claims 1
- 239000012669 liquid formulation Substances 0.000 claims 1
- 239000008176 lyophilized powder Substances 0.000 claims 1
- 125000002467 phosphate group Chemical group [H]OP(=O)(O[H])O[*] 0.000 claims 1
- 238000011321 prophylaxis Methods 0.000 claims 1
- 238000002560 therapeutic procedure Methods 0.000 claims 1
- 238000000034 method Methods 0.000 description 10
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 3
- 101001081555 Homo sapiens Plasma protease C1 inhibitor Proteins 0.000 description 2
- 229940088950 c1 esterase inhibitor (human) Drugs 0.000 description 2
- 239000003937 drug carrier Substances 0.000 description 2
- 102000016917 Complement C1 Human genes 0.000 description 1
- 108010028774 Complement C1 Proteins 0.000 description 1
- 230000007812 deficiency Effects 0.000 description 1
- 238000001990 intravenous administration Methods 0.000 description 1
- 230000002265 prevention Effects 0.000 description 1
- 238000007920 subcutaneous administration Methods 0.000 description 1
- 230000001629 suppression Effects 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361791399P | 2013-03-15 | 2013-03-15 | |
| US61/791,399 | 2013-03-15 | ||
| PCT/US2014/030309 WO2014145519A2 (en) | 2013-03-15 | 2014-03-17 | C1-inh compositions and methods for the prevention and treatment of disorders associated with c1 esterase inhibitor deficency |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017051361A Division JP6422520B2 (ja) | 2013-03-15 | 2017-03-16 | Ｃ１エステラーゼ抑制因子欠乏に関連する障害の予防及び治療のためのｃ１−ｉｎｈ組成物ならびに方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2016516073A JP2016516073A (ja) | 2016-06-02 |
| JP2016516073A5 true JP2016516073A5 (enExample) | 2017-04-20 |
| JP6184581B2 JP6184581B2 (ja) | 2017-08-23 |
Family
ID=51538486
Family Applications (9)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016503371A Active JP6184581B2 (ja) | 2013-03-15 | 2014-03-17 | Ｃ１エステラーゼ抑制因子欠乏に関連する障害の予防及び治療のためのｃ１−ｉｎｈ組成物ならびに方法 |
| JP2017051361A Active JP6422520B2 (ja) | 2013-03-15 | 2017-03-16 | Ｃ１エステラーゼ抑制因子欠乏に関連する障害の予防及び治療のためのｃ１−ｉｎｈ組成物ならびに方法 |
| JP2018073691A Active JP6473536B2 (ja) | 2013-03-15 | 2018-04-06 | Ｃ１エステラーゼ抑制因子欠乏に関連する障害の予防及び治療のためのｃ１−ｉｎｈ組成物ならびに方法 |
| JP2018073689A Active JP6473534B2 (ja) | 2013-03-15 | 2018-04-06 | Ｃ１エステラーゼ抑制因子欠乏に関連する障害の予防及び治療のためのｃ１−ｉｎｈ組成物ならびに方法 |
| JP2018073690A Active JP6473535B2 (ja) | 2013-03-15 | 2018-04-06 | Ｃ１エステラーゼ抑制因子欠乏に関連する障害の予防及び治療のためのｃ１−ｉｎｈ組成物ならびに方法 |
| JP2019011084A Active JP6877472B2 (ja) | 2013-03-15 | 2019-01-25 | Ｃ１エステラーゼ抑制因子欠乏に関連する障害の予防及び治療のためのｃ１−ｉｎｈ組成物ならびに方法 |
| JP2019011079A Active JP6877470B2 (ja) | 2013-03-15 | 2019-01-25 | Ｃ１エステラーゼ抑制因子欠乏に関連する障害の予防及び治療のためのｃ１−ｉｎｈ組成物ならびに方法 |
| JP2019011082A Active JP6877471B2 (ja) | 2013-03-15 | 2019-01-25 | Ｃ１エステラーゼ抑制因子欠乏に関連する障害の予防及び治療のためのｃ１−ｉｎｈ組成物ならびに方法 |
| JP2021032716A Pending JP2021088599A (ja) | 2013-03-15 | 2021-03-02 | Ｃ１エステラーゼ抑制因子欠乏に関連する障害の予防及び治療のためのｃ１−ｉｎｈ組成物ならびに方法 |
Family Applications After (8)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017051361A Active JP6422520B2 (ja) | 2013-03-15 | 2017-03-16 | Ｃ１エステラーゼ抑制因子欠乏に関連する障害の予防及び治療のためのｃ１−ｉｎｈ組成物ならびに方法 |
| JP2018073691A Active JP6473536B2 (ja) | 2013-03-15 | 2018-04-06 | Ｃ１エステラーゼ抑制因子欠乏に関連する障害の予防及び治療のためのｃ１−ｉｎｈ組成物ならびに方法 |
| JP2018073689A Active JP6473534B2 (ja) | 2013-03-15 | 2018-04-06 | Ｃ１エステラーゼ抑制因子欠乏に関連する障害の予防及び治療のためのｃ１−ｉｎｈ組成物ならびに方法 |
| JP2018073690A Active JP6473535B2 (ja) | 2013-03-15 | 2018-04-06 | Ｃ１エステラーゼ抑制因子欠乏に関連する障害の予防及び治療のためのｃ１−ｉｎｈ組成物ならびに方法 |
| JP2019011084A Active JP6877472B2 (ja) | 2013-03-15 | 2019-01-25 | Ｃ１エステラーゼ抑制因子欠乏に関連する障害の予防及び治療のためのｃ１−ｉｎｈ組成物ならびに方法 |
| JP2019011079A Active JP6877470B2 (ja) | 2013-03-15 | 2019-01-25 | Ｃ１エステラーゼ抑制因子欠乏に関連する障害の予防及び治療のためのｃ１−ｉｎｈ組成物ならびに方法 |
| JP2019011082A Active JP6877471B2 (ja) | 2013-03-15 | 2019-01-25 | Ｃ１エステラーゼ抑制因子欠乏に関連する障害の予防及び治療のためのｃ１−ｉｎｈ組成物ならびに方法 |
| JP2021032716A Pending JP2021088599A (ja) | 2013-03-15 | 2021-03-02 | Ｃ１エステラーゼ抑制因子欠乏に関連する障害の予防及び治療のためのｃ１−ｉｎｈ組成物ならびに方法 |
Country Status (30)
| Country | Link |
|---|---|
| US (9) | US9616111B2 (enExample) |
| EP (3) | EP3290046B1 (enExample) |
| JP (9) | JP6184581B2 (enExample) |
| KR (4) | KR102579789B1 (enExample) |
| CN (2) | CN111529708A (enExample) |
| AU (3) | AU2014232912A1 (enExample) |
| BR (1) | BR112015023207A8 (enExample) |
| CA (2) | CA3054718A1 (enExample) |
| CY (2) | CY1119419T1 (enExample) |
| DE (1) | DE202014011208U1 (enExample) |
| DK (2) | DK2968434T3 (enExample) |
| EA (1) | EA201591278A1 (enExample) |
| ES (2) | ES2713004T3 (enExample) |
| GB (1) | GB2530921B (enExample) |
| HK (1) | HK1250912B (enExample) |
| HR (2) | HRP20171269T1 (enExample) |
| HU (2) | HUE041837T2 (enExample) |
| IL (2) | IL241549B (enExample) |
| LT (2) | LT2968434T (enExample) |
| ME (2) | ME02865B (enExample) |
| MX (3) | MX373965B (enExample) |
| PL (2) | PL2968434T3 (enExample) |
| PT (2) | PT3290046T (enExample) |
| RS (2) | RS56285B1 (enExample) |
| SG (2) | SG11201507616VA (enExample) |
| SI (2) | SI2968434T1 (enExample) |
| SM (2) | SMT201900141T1 (enExample) |
| TR (1) | TR201900319T4 (enExample) |
| WO (1) | WO2014145519A2 (enExample) |
| ZA (3) | ZA201507604B (enExample) |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ME02865B (me) | 2013-03-15 | 2018-04-20 | Shire Viropharma Inc | C1-inh kompozicije za upotrebu u prevenciji i liječenju naslednog angioedema (hae) |
| ME03318B (me) | 2013-11-22 | 2019-10-20 | Shire Viropharma Inc | Postupci lečenja odbacivanja posredovanog antitelima pacijenata sa transplatiranim organom sa inhibitorom c1-esteraze |
| WO2016131958A1 (en) * | 2015-02-20 | 2016-08-25 | Csl Behring Gmbh | Pharmaceutical formulations of c1 esterase inhibitor |
| CN113999875A (zh) * | 2015-05-28 | 2022-02-01 | 康奈尔大学 | 腺相关病毒介导的c1ei递送作为用于血管性水肿的疗法 |
| CN108463243B (zh) * | 2015-11-19 | 2022-06-14 | 夏尔人类遗传性治疗公司 | 重组人c1酯酶抑制剂及其用途 |
| CN109562149A (zh) * | 2016-08-05 | 2019-04-02 | 德国杰特贝林生物制品有限公司 | C1酯酶抑制剂的药物制剂 |
| AU2017316513A1 (en) * | 2016-08-23 | 2019-03-28 | Csl Behring Gmbh | Method of preventing acute attacks of hereditary angioedema associated with C1 esterase inhibitor deficiency |
| CA3061279A1 (en) | 2017-05-16 | 2018-11-22 | Octapharma Ag | C1-esterase inhibitor preparation |
| BR112020017626A2 (pt) | 2018-02-28 | 2020-12-22 | Pharming Intellectual Property B.V. | Tratamento e prevenção de pré-eclâmpsia |
| WO2019166572A1 (en) | 2018-02-28 | 2019-09-06 | Pharming Intellectual Property B.V. | Pharmaceutical system for transdermal administration of a c1 -esterase inhibitor |
| AU2019288683A1 (en) | 2018-06-22 | 2021-01-21 | Junten Bio Co., Ltd. | Antibody capable of inducing immune tolerance produced using cell mixture having complexed state, and induced lymphocyte or cell therapeutic agent and cell therapy method each using induced lymphocyte |
| TWI832868B (zh) | 2018-06-22 | 2024-02-21 | 日商順天生化股份有限公司 | 用於誘發感染性免疫耐受之組合物 |
| US12139537B2 (en) | 2018-06-22 | 2024-11-12 | Junten Bio Co., Ltd. | Antibody inducing immune tolerance, induced lymphocyte, and cell therapy agent therapeutic method using induced lymphocyte |
| CN114786724A (zh) * | 2019-12-16 | 2022-07-22 | 尼普洛株式会社 | 防聚集剂以及使用该防聚集剂的药物组合物和医疗用设备 |
| EP3895726A1 (en) | 2020-04-17 | 2021-10-20 | Pharming Intellectual Property BV | Using c1 esterase inhibitor to treat viral infection-related acute respiratory distress |
| CN117120076A (zh) * | 2021-01-27 | 2023-11-24 | 斯帕克治疗公司 | 用于治疗遗传性血管性水肿的组合物和方法 |
| JP2024525084A (ja) | 2021-07-09 | 2024-07-09 | ファーミング・インテレクチュアル・プロパティー・ビー．ブイ． | Ｃ１エステラーゼ阻害剤によるウイルス感染関連症状の治療 |
| KR20230046146A (ko) | 2021-09-29 | 2023-04-05 | 주식회사 엘지에너지솔루션 | 배터리 제어 시스템 및 방법 |
| WO2025090843A1 (en) * | 2023-10-27 | 2025-05-01 | Kansas State University Research Foundation | Small-molecule inhibitors of c1s protease and classical complement pathway |
| CN119823254B (zh) * | 2025-03-14 | 2025-06-03 | 深圳市卫光生物制品股份有限公司 | 一种c1酯酶抑制剂重组变体及其制备方法和应用 |
Family Cites Families (36)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5304482A (en) | 1989-03-06 | 1994-04-19 | The Board Of Regents Of The University Of Texas System | Serine protease mutants of the chymotrypsin superfamily resistant to inhibition by their cognate inhibitors |
| WO1992022320A1 (en) | 1991-06-14 | 1992-12-23 | Genentech, Inc. | C1 inhibitor variants and treating inflammatory response with c1 inhibitor |
| EP0716611B1 (en) * | 1993-09-01 | 2002-02-06 | Stichting Sanquin Bloedvoorziening | C1-esterase inhibitor to reduce myocardial injury during acute myocardial infarction |
| EP0868191A1 (en) | 1995-12-18 | 1998-10-07 | Stichting Sanquin Bloedvoorziening | Potentiation of complement and coagulation inhibitory properties of c1-inhibitor. |
| AT409336B (de) | 1999-12-22 | 2002-07-25 | Baxter Ag | Verfahren zur herstellung einer c1-esterase-inhibitor (c1-inh)-hältigen zusammensetzung |
| US7067713B2 (en) | 2000-01-31 | 2006-06-27 | Pharming Intellectual Property B.V. | C1 Inhibitor produced in the milk of transgenic non-human mammals |
| EP1252184B1 (en) | 2000-01-31 | 2008-01-02 | Pharming Intellectual Property B.V. | Human c1 inhibitor produced in the milk of transgenic mammals |
| DE60139944D1 (de) | 2000-10-12 | 2009-10-29 | Genentech Inc | Niederviskose konzentrierte proteinformulierungen |
| DE10112617A1 (de) | 2001-03-14 | 2002-10-02 | Aventis Behring Gmbh | Verwendung eines C1-Esterase-Inhibitors zur Verhinderung oder Verzögerung der Abstoßung von Xenotransplantaten in Säugetieren |
| WO2004034971A2 (en) | 2002-09-25 | 2004-04-29 | The Center For Blood Research, Inc. | Methods for treating and preventing sepsis using modified c1 inhibitor or fragments thereof |
| WO2004110356A2 (en) | 2003-05-15 | 2004-12-23 | Cbr Institute For Biomedical Research, Inc. | Methods for modulating cell-to-cell adhesion using an agonist of c1inh-type protein activity |
| US7544853B2 (en) | 2003-05-16 | 2009-06-09 | Pharming Intellectual Property B.V. | C1 inhibitor with short half-life transient treatment |
| US20060233776A1 (en) | 2003-08-19 | 2006-10-19 | Norbert Heimburger | C1-inh as a drug for treating viruses pathogenic to humans |
| US8501705B2 (en) | 2003-09-11 | 2013-08-06 | The Board Of Regents Of The University Of Texas System | Methods and materials for treating autoimmune and/or complement mediated diseases and conditions |
| EP1598428A1 (en) | 2004-05-18 | 2005-11-23 | Georg Dewald | Methods and kits to detect Hereditary angioedema type III |
| EP1893227A2 (en) | 2005-06-06 | 2008-03-05 | Girish J. Kotwal | Methods for treatment or prophylaxis of atherosclerosis and reperfusion injury |
| KR101126423B1 (ko) | 2005-10-21 | 2012-07-11 | 카탈리스트 바이오사이언시즈, 인코포레이티드 | 보체 활성화를 억제하는 변형된 프로테아제 |
| US8071532B2 (en) | 2005-12-21 | 2011-12-06 | Pharming Intellectual Property B.V. | Use of C1 inhibitor for the prevention of ischemia-reperfusion injury |
| PT2380587T (pt) * | 2005-12-21 | 2018-01-19 | Pharming Intellectual Property B V | Resumo |
| US7837992B2 (en) | 2006-06-22 | 2010-11-23 | Beth Israel Deaconess Medical Center | C-1 inhibitor prevents non-specific plasminogen activation by a prourokinase mutant without impeding fibrin-specific fibrinolysis |
| DK2109457T3 (en) | 2007-02-12 | 2016-04-11 | Csl Behring Gmbh | THERAPEUTIC USE OF KAZAL TYPE SERINE PROTEASE INHIBITORS |
| US8883146B2 (en) | 2007-11-30 | 2014-11-11 | Abbvie Inc. | Protein formulations and methods of making same |
| US8420081B2 (en) | 2007-11-30 | 2013-04-16 | Abbvie, Inc. | Antibody formulations and methods of making same |
| US20100143325A1 (en) | 2008-12-09 | 2010-06-10 | Vascular Laboratory, Inc. | Composition And Methods Involving Thrombolytic Agents |
| JP5871798B2 (ja) | 2009-07-02 | 2016-03-01 | エムユーエスシー ファウンデーション フォー リサーチ ディベロップメント | 肝再生を刺激する方法 |
| EP3150635A3 (en) | 2009-10-16 | 2017-06-21 | Omeros Corporation | Methods for treating disseminated intravascular coagulation by inhibiting masp-2 dependent complement activation |
| AU2011222883B2 (en) | 2010-03-05 | 2016-05-26 | Omeros Corporation | Chimeric inhibitor molecules of complement activation |
| WO2011116291A1 (en) * | 2010-03-18 | 2011-09-22 | Thrombolytic Science International | Production of human c1 inhibitor in human cells |
| WO2013013017A2 (en) * | 2011-07-21 | 2013-01-24 | Alnylam Pharmaceuticals, Inc. | Compositions and methods for modifying the glycosylation of lysosomal storage disorder therapeutics |
| DK2758076T3 (en) | 2011-09-24 | 2019-04-01 | Csl Behring Gmbh | COMBINATION THERAPY USING IMMUNOGLOBULIN AND C1 INHIBITOR |
| WO2013093027A1 (en) * | 2011-12-22 | 2013-06-27 | Csl Behring Gmbh | Use of c1-inhibitor for the treatment of secondary edema of the central nervous system |
| CA2867611A1 (en) | 2012-03-16 | 2013-09-19 | Belrose Pharma, Inc. | Polymeric conjugates of c1-inhibitors |
| CA2902841A1 (en) | 2013-03-13 | 2014-10-02 | Creatics Llc | Methods and compositions for detecting pancreatic cancer |
| ME02865B (me) * | 2013-03-15 | 2018-04-20 | Shire Viropharma Inc | C1-inh kompozicije za upotrebu u prevenciji i liječenju naslednog angioedema (hae) |
| JP6935245B2 (ja) * | 2017-06-29 | 2021-09-15 | 大和ハウス工業株式会社 | 収容ラック |
| JP6889626B2 (ja) * | 2017-06-29 | 2021-06-18 | トキコシステムソリューションズ株式会社 | 燃料供給システム |
-
2014
- 2014-03-17 ME MEP-2017-182A patent/ME02865B/me unknown
- 2014-03-17 SM SM20190141T patent/SMT201900141T1/it unknown
- 2014-03-17 ME MEP-2019-45A patent/ME03326B/me unknown
- 2014-03-17 KR KR1020227016244A patent/KR102579789B1/ko active Active
- 2014-03-17 PL PL14762343T patent/PL2968434T3/pl unknown
- 2014-03-17 WO PCT/US2014/030309 patent/WO2014145519A2/en not_active Ceased
- 2014-03-17 DK DK14762343.3T patent/DK2968434T3/en active
- 2014-03-17 MX MX2015011281A patent/MX373965B/es active IP Right Grant
- 2014-03-17 EP EP17177676.8A patent/EP3290046B1/en active Active
- 2014-03-17 HU HUE17177676A patent/HUE041837T2/hu unknown
- 2014-03-17 SI SI201430368T patent/SI2968434T1/sl unknown
- 2014-03-17 SM SM20170415T patent/SMT201700415T1/it unknown
- 2014-03-17 ES ES17177676T patent/ES2713004T3/es active Active
- 2014-03-17 JP JP2016503371A patent/JP6184581B2/ja active Active
- 2014-03-17 CA CA3054718A patent/CA3054718A1/en not_active Abandoned
- 2014-03-17 ES ES14762343.3T patent/ES2639833T3/es active Active
- 2014-03-17 CN CN202010362851.6A patent/CN111529708A/zh active Pending
- 2014-03-17 PT PT17177676T patent/PT3290046T/pt unknown
- 2014-03-17 KR KR1020217033628A patent/KR102430453B1/ko active Active
- 2014-03-17 KR KR1020217004777A patent/KR20210021146A/ko not_active Ceased
- 2014-03-17 TR TR2019/00319T patent/TR201900319T4/tr unknown
- 2014-03-17 RS RS20170802A patent/RS56285B1/sr unknown
- 2014-03-17 PL PL17177676T patent/PL3290046T3/pl unknown
- 2014-03-17 BR BR112015023207A patent/BR112015023207A8/pt not_active Application Discontinuation
- 2014-03-17 RS RS20190198A patent/RS58351B1/sr unknown
- 2014-03-17 SG SG11201507616VA patent/SG11201507616VA/en unknown
- 2014-03-17 HU HUE14762343A patent/HUE036224T2/hu unknown
- 2014-03-17 SG SG10201707598QA patent/SG10201707598QA/en unknown
- 2014-03-17 SI SI201431032T patent/SI3290046T1/sl unknown
- 2014-03-17 CN CN201480014712.7A patent/CN105517559A/zh active Pending
- 2014-03-17 DE DE202014011208.8U patent/DE202014011208U1/de not_active Expired - Lifetime
- 2014-03-17 EP EP18206413.9A patent/EP3508213A1/en not_active Withdrawn
- 2014-03-17 PT PT147623433T patent/PT2968434T/pt unknown
- 2014-03-17 HR HRP20171269TT patent/HRP20171269T1/hr unknown
- 2014-03-17 MX MX2020004724A patent/MX389449B/es unknown
- 2014-03-17 EA EA201591278A patent/EA201591278A1/ru unknown
- 2014-03-17 CA CA2904543A patent/CA2904543C/en active Active
- 2014-03-17 LT LTEP14762343.3T patent/LT2968434T/lt unknown
- 2014-03-17 KR KR1020157022897A patent/KR20150135242A/ko not_active Ceased
- 2014-03-17 DK DK17177676.8T patent/DK3290046T3/en active
- 2014-03-17 AU AU2014232912A patent/AU2014232912A1/en not_active Abandoned
- 2014-03-17 EP EP14762343.3A patent/EP2968434B1/en not_active Revoked
- 2014-03-17 LT LTEP17177676.8T patent/LT3290046T/lt unknown
- 2014-03-17 GB GB1519921.9A patent/GB2530921B/en active Active
-
2015
- 2015-08-28 MX MX2021011946A patent/MX2021011946A/es unknown
- 2015-09-10 IL IL241549A patent/IL241549B/en active IP Right Grant
- 2015-09-15 US US14/855,168 patent/US9616111B2/en active Active
- 2015-10-13 ZA ZA2015/07604A patent/ZA201507604B/en unknown
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2017
- 2017-01-20 US US15/411,744 patent/US20170224788A1/en not_active Abandoned
- 2017-03-16 JP JP2017051361A patent/JP6422520B2/ja active Active
- 2017-09-12 CY CY20171100961T patent/CY1119419T1/el unknown
- 2017-10-12 ZA ZA2017/06929A patent/ZA201706929B/en unknown
- 2017-12-11 US US15/837,969 patent/US10201595B2/en active Active
- 2017-12-11 US US15/837,693 patent/US10105423B2/en active Active
- 2017-12-11 US US15/837,938 patent/US10130690B2/en active Active
- 2017-12-11 US US15/837,677 patent/US10080788B2/en active Active
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2018
- 2018-04-06 JP JP2018073691A patent/JP6473536B2/ja active Active
- 2018-04-06 JP JP2018073689A patent/JP6473534B2/ja active Active
- 2018-04-06 JP JP2018073690A patent/JP6473535B2/ja active Active
- 2018-08-02 US US16/053,457 patent/US11534482B2/en active Active
- 2018-08-10 HK HK18110262.0A patent/HK1250912B/en unknown
- 2018-09-05 US US16/122,015 patent/US20190160158A1/en not_active Abandoned
- 2018-09-17 AU AU2018229558A patent/AU2018229558B2/en active Active
- 2018-10-12 ZA ZA2018/06793A patent/ZA201806793B/en unknown
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2019
- 2019-01-25 JP JP2019011084A patent/JP6877472B2/ja active Active
- 2019-01-25 JP JP2019011079A patent/JP6877470B2/ja active Active
- 2019-01-25 JP JP2019011082A patent/JP6877471B2/ja active Active
- 2019-02-11 HR HRP20190270TT patent/HRP20190270T1/hr unknown
- 2019-03-15 CY CY20191100308T patent/CY1121653T1/el unknown
- 2019-10-02 US US16/591,184 patent/US11364288B2/en active Active
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2020
- 2020-05-15 AU AU2020203183A patent/AU2020203183B2/en active Active
- 2020-07-19 IL IL276153A patent/IL276153B/en unknown
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2021
- 2021-03-02 JP JP2021032716A patent/JP2021088599A/ja active Pending
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