JP2015502389A5 - - Google Patents
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- Publication number
- JP2015502389A5 JP2015502389A5 JP2014548078A JP2014548078A JP2015502389A5 JP 2015502389 A5 JP2015502389 A5 JP 2015502389A5 JP 2014548078 A JP2014548078 A JP 2014548078A JP 2014548078 A JP2014548078 A JP 2014548078A JP 2015502389 A5 JP2015502389 A5 JP 2015502389A5
- Authority
- JP
- Japan
- Prior art keywords
- pharmaceutical composition
- inhibitor
- composition according
- stroke
- brain
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000008194 pharmaceutical composition Substances 0.000 claims 27
- 239000003112 inhibitor Substances 0.000 claims 15
- 206010030113 Oedema Diseases 0.000 claims 7
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 6
- 208000035475 disorder Diseases 0.000 claims 6
- 230000010410 reperfusion Effects 0.000 claims 6
- 208000006011 Stroke Diseases 0.000 claims 5
- 210000003169 central nervous system Anatomy 0.000 claims 5
- 208000003174 Brain Neoplasms Diseases 0.000 claims 4
- 108700040183 Complement C1 Inhibitor Proteins 0.000 claims 4
- 102000055157 Complement C1 Inhibitor Human genes 0.000 claims 4
- 208000016988 Hemorrhagic Stroke Diseases 0.000 claims 4
- 208000032382 Ischaemic stroke Diseases 0.000 claims 4
- 206010073945 Perinatal stroke Diseases 0.000 claims 4
- 230000037396 body weight Effects 0.000 claims 4
- 210000004556 brain Anatomy 0.000 claims 4
- 208000020658 intracerebral hemorrhage Diseases 0.000 claims 4
- 230000035699 permeability Effects 0.000 claims 4
- 208000030886 Traumatic Brain injury Diseases 0.000 claims 3
- 230000004888 barrier function Effects 0.000 claims 3
- 210000004369 blood Anatomy 0.000 claims 3
- 239000008280 blood Substances 0.000 claims 3
- 230000008499 blood brain barrier function Effects 0.000 claims 3
- 210000001218 blood-brain barrier Anatomy 0.000 claims 3
- 238000001802 infusion Methods 0.000 claims 3
- 238000000034 method Methods 0.000 claims 3
- 210000000278 spinal cord Anatomy 0.000 claims 3
- 208000020431 spinal cord injury Diseases 0.000 claims 3
- 230000009529 traumatic brain injury Effects 0.000 claims 3
- 208000035143 Bacterial infection Diseases 0.000 claims 2
- 201000006474 Brain Ischemia Diseases 0.000 claims 2
- 206010048962 Brain oedema Diseases 0.000 claims 2
- 206010008120 Cerebral ischaemia Diseases 0.000 claims 2
- 101001081555 Homo sapiens Plasma protease C1 inhibitor Proteins 0.000 claims 2
- 201000009906 Meningitis Diseases 0.000 claims 2
- 206010063837 Reperfusion injury Diseases 0.000 claims 2
- 208000036142 Viral infection Diseases 0.000 claims 2
- 208000022362 bacterial infectious disease Diseases 0.000 claims 2
- 208000006752 brain edema Diseases 0.000 claims 2
- 229940088950 c1 esterase inhibitor (human) Drugs 0.000 claims 2
- 206010008118 cerebral infarction Diseases 0.000 claims 2
- 206010012601 diabetes mellitus Diseases 0.000 claims 2
- 230000000977 initiatory effect Effects 0.000 claims 2
- 238000002347 injection Methods 0.000 claims 2
- 239000007924 injection Substances 0.000 claims 2
- 230000001394 metastastic effect Effects 0.000 claims 2
- 206010061289 metastatic neoplasm Diseases 0.000 claims 2
- 201000006417 multiple sclerosis Diseases 0.000 claims 2
- 230000009385 viral infection Effects 0.000 claims 2
- 108090000144 Human Proteins Proteins 0.000 claims 1
- 102000003839 Human Proteins Human genes 0.000 claims 1
- 206010059282 Metastases to central nervous system Diseases 0.000 claims 1
- 206010053648 Vascular occlusion Diseases 0.000 claims 1
- 230000002491 angiogenic effect Effects 0.000 claims 1
- 230000000740 bleeding effect Effects 0.000 claims 1
- 230000006378 damage Effects 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 230000007774 longterm Effects 0.000 claims 1
- 239000000203 mixture Substances 0.000 claims 1
- 229940110272 plasma derived c1-inhibitor Drugs 0.000 claims 1
- 208000021331 vascular occlusion disease Diseases 0.000 claims 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP11195254 | 2011-12-22 | ||
| EP11195254.5 | 2011-12-22 | ||
| US201261587371P | 2012-01-17 | 2012-01-17 | |
| US61/587,371 | 2012-01-17 | ||
| PCT/EP2012/076691 WO2013093027A1 (en) | 2011-12-22 | 2012-12-21 | Use of c1-inhibitor for the treatment of secondary edema of the central nervous system |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2015502389A JP2015502389A (ja) | 2015-01-22 |
| JP2015502389A5 true JP2015502389A5 (enExample) | 2016-02-12 |
| JP6127063B2 JP6127063B2 (ja) | 2017-05-10 |
Family
ID=48667767
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014548078A Active JP6127063B2 (ja) | 2011-12-22 | 2012-12-21 | 中枢神経系の続発性浮腫の治療のためのｃ１インヒビターの使用 |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US9452203B2 (enExample) |
| EP (1) | EP2793935B1 (enExample) |
| JP (1) | JP6127063B2 (enExample) |
| KR (1) | KR102022231B1 (enExample) |
| CN (1) | CN104080474B (enExample) |
| AU (1) | AU2012318275B2 (enExample) |
| CA (1) | CA2858984C (enExample) |
| DK (1) | DK2793935T3 (enExample) |
| ES (1) | ES2587863T3 (enExample) |
| WO (1) | WO2013093027A1 (enExample) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20210069016A1 (en) * | 2008-11-13 | 2021-03-11 | Gholam A. Peyman | Neurodegenerative Disorder Treatment Method |
| EP2912065A4 (en) | 2012-10-25 | 2016-10-19 | True North Therapeutics Inc | ANTI COMPLEMENT C1S ANTIBODIES AND USES THEREOF |
| RS63212B1 (sr) | 2012-11-02 | 2022-06-30 | Bioverativ Usa Inc | Antikomplementna c1s antitela i njihove primene |
| SI2968434T1 (sl) | 2013-03-15 | 2017-11-30 | Shire Viropharma Incorporated, | C1-INH sestavki za uporabo pri preprečevanju in zdravljenju hereditarnega angioedema (HAE) |
| US20160130324A1 (en) * | 2014-10-31 | 2016-05-12 | Shire Human Genetic Therapies, Inc. | C1 Inhibitor Fusion Proteins and Uses Thereof |
| WO2016081889A1 (en) * | 2014-11-21 | 2016-05-26 | Kurt Baekgaard Osther | Recombinant c1 esterase inhibitor and use thereof |
| BR112017021289A2 (en) | 2015-04-06 | 2018-06-26 | Bioverativ Usa Inc. | humanized anti-c1s antibodies and methods of use |
| WO2017087882A1 (en) * | 2015-11-19 | 2017-05-26 | Shire Human Genetic Therapies, Inc. | Recombinant human c1 esterase inhibitor and uses thereof |
| EP3525583B8 (en) | 2016-10-12 | 2025-09-10 | Bioverativ USA Inc. | Anti-c1s antibodies and methods of use thereof |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3228502A1 (de) | 1982-07-30 | 1984-02-02 | Behringwerke Ag, 3550 Marburg | Verfahren zur herstellung des c1-inaktivators und seine verwendung |
| DE4222534A1 (de) | 1992-07-09 | 1994-01-13 | Behringwerke Ag | Verwendung von Komplement-Inhibitoren zur Herstellung eines Arzneimittels zur Prophylaxe und Therapie von entzündlichen Darm- und Hauterkrankungen sowie Purpura |
| DE4227762A1 (de) | 1992-08-24 | 1994-03-03 | Behringwerke Ag | Verwendung eines Kallikrein-Inhibitors zur Herstellung eines Arzneimittels zur Prophylaxe und Therapie bestimmter Krankheiten |
| JP3941174B2 (ja) | 1996-08-26 | 2007-07-04 | 富士ゼロックス株式会社 | 複合材料及びその製造方法 |
| EP1216052A1 (en) | 1999-09-16 | 2002-06-26 | Byk Gulden Lomberg Chemische Fabrik GmbH | Combination of c1-inh and lung surfactant for the treatment of respiratory disorders |
| CA2405550A1 (en) | 2000-04-12 | 2001-10-25 | Human Genome Sciences, Inc. | Albumin fusion proteins |
| DK1965831T3 (da) * | 2005-12-21 | 2011-10-24 | Pharming Intellectual Pty Bv | Anvendelse af C1-inhibitor til forebyggelse af iskæmi-reperfusionsskade |
| HRP20110622T1 (hr) * | 2005-12-21 | 2011-09-30 | Pharming Intellectual Property B.V. | Upotreba inhibitora c1 u sprječavanju ishemijsko-reperfuzijske ozljede |
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2012
- 2012-12-21 EP EP12808401.9A patent/EP2793935B1/en active Active
- 2012-12-21 ES ES12808401.9T patent/ES2587863T3/es active Active
- 2012-12-21 AU AU2012318275A patent/AU2012318275B2/en active Active
- 2012-12-21 CA CA2858984A patent/CA2858984C/en active Active
- 2012-12-21 KR KR1020147020461A patent/KR102022231B1/ko active Active
- 2012-12-21 CN CN201280063159.7A patent/CN104080474B/zh active Active
- 2012-12-21 WO PCT/EP2012/076691 patent/WO2013093027A1/en not_active Ceased
- 2012-12-21 US US14/364,097 patent/US9452203B2/en active Active
- 2012-12-21 DK DK12808401.9T patent/DK2793935T3/en active
- 2012-12-21 JP JP2014548078A patent/JP6127063B2/ja active Active