JP2015514115A5 - - Google Patents
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- JP2015514115A5 JP2015514115A5 JP2015504730A JP2015504730A JP2015514115A5 JP 2015514115 A5 JP2015514115 A5 JP 2015514115A5 JP 2015504730 A JP2015504730 A JP 2015504730A JP 2015504730 A JP2015504730 A JP 2015504730A JP 2015514115 A5 JP2015514115 A5 JP 2015514115A5
- Authority
- JP
- Japan
- Prior art keywords
- pharmaceutical preparation
- polypeptide
- amino acid
- seq
- acid sequence
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261621154P | 2012-04-06 | 2012-04-06 | |
| US61/621,154 | 2012-04-06 | ||
| PCT/US2013/035305 WO2013152213A1 (en) | 2012-04-06 | 2013-04-04 | Methods and compositions for increasing red blood cells |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017144654A Division JP2017190344A (ja) | 2012-04-06 | 2017-07-26 | 赤血球を増加させるための方法および組成物 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2015514115A JP2015514115A (ja) | 2015-05-18 |
| JP2015514115A5 true JP2015514115A5 (enExample) | 2016-06-02 |
| JP6234993B2 JP6234993B2 (ja) | 2017-11-22 |
Family
ID=49301055
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015504730A Expired - Fee Related JP6234993B2 (ja) | 2012-04-06 | 2013-04-04 | 赤血球を増加させるための方法および組成物 |
| JP2017144654A Withdrawn JP2017190344A (ja) | 2012-04-06 | 2017-07-26 | 赤血球を増加させるための方法および組成物 |
| JP2019123059A Withdrawn JP2019156858A (ja) | 2012-04-06 | 2019-07-01 | 赤血球を増加させるための方法および組成物 |
| JP2021077695A Pending JP2021107453A (ja) | 2012-04-06 | 2021-04-30 | 赤血球を増加させるための方法および組成物 |
Family Applications After (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017144654A Withdrawn JP2017190344A (ja) | 2012-04-06 | 2017-07-26 | 赤血球を増加させるための方法および組成物 |
| JP2019123059A Withdrawn JP2019156858A (ja) | 2012-04-06 | 2019-07-01 | 赤血球を増加させるための方法および組成物 |
| JP2021077695A Pending JP2021107453A (ja) | 2012-04-06 | 2021-04-30 | 赤血球を増加させるための方法および組成物 |
Country Status (6)
| Country | Link |
|---|---|
| US (4) | US9809636B2 (enExample) |
| EP (2) | EP3351260B1 (enExample) |
| JP (4) | JP6234993B2 (enExample) |
| AU (3) | AU2013243388B2 (enExample) |
| CA (1) | CA2869474C (enExample) |
| WO (1) | WO2013152213A1 (enExample) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9809636B2 (en) | 2012-04-06 | 2017-11-07 | Acceleron Pharma Inc. | Methods for increasing red blood cell levels comprising administering BMP9 |
| GB201412290D0 (en) | 2014-07-10 | 2014-08-27 | Cambridge Entpr Ltd | Novel use |
| CA2983440C (en) | 2015-04-22 | 2024-03-12 | Alivegen Usa Inc. | Novel hybrid actriib ligand trap proteins for treating muscle wasting diseases |
| SG11201707815RA (en) | 2015-06-05 | 2017-12-28 | Novartis Ag | Antibodies targeting bone morphogenetic protein 9 (bmp9) and methods therefor |
| EP3370754B1 (en) | 2015-11-04 | 2026-04-29 | Acceleron Pharma, Inc. | Methods for increasing red blood cell levels and treating ineffective erythropoiesis |
| AU2017296040C1 (en) | 2016-07-15 | 2023-06-22 | Acceleron Pharma Inc. | Compositions and methods for treating pulmonary hypertension |
| JOP20190085A1 (ar) | 2016-10-20 | 2019-04-17 | Biogen Ma Inc | طرق علاج الضمور العضلي ومرض العظام باستخدام بروتينات احتجاز مركب ترابطي actriib هجين حديثة |
| KR20220021207A (ko) | 2020-08-13 | 2022-02-22 | 주식회사 나이벡 | 이소골 형성 부작용 경감으로 치료효과가 증진된 골형성 단백질-9, 10의 변이체 및 이를 포함하는 약학적 조성물 |
Family Cites Families (29)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS63502716A (ja) | 1986-03-07 | 1988-10-13 | マサチューセッツ・インステチュート・オブ・テクノロジー | 糖タンパク安定性の強化方法 |
| CA2108770C (en) | 1991-06-25 | 2007-04-03 | John M. Wozney | Bmp-9 compositions |
| US6287816B1 (en) | 1991-06-25 | 2001-09-11 | Genetics Institute, Inc. | BMP-9 compositions |
| CA2157387C (en) * | 1993-03-04 | 1998-12-15 | David C. Rueger | Method and compositions for recombinant osteogenic protein production |
| US5637480A (en) | 1993-05-12 | 1997-06-10 | Genetics Institute, Inc. | DNA molecules encoding bone morphogenetic protein-10 |
| ATE265529T1 (de) | 1993-05-12 | 2004-05-15 | Inst Genetics Llc | Bmp-10 zusammensetzungen |
| US6034062A (en) | 1997-03-13 | 2000-03-07 | Genetics Institute, Inc. | Bone morphogenetic protein (BMP)-9 compositions and their uses |
| US20030224501A1 (en) | 2000-03-17 | 2003-12-04 | Young Paul E. | Bone morphogenic protein polynucleotides, polypeptides, and antibodies |
| WO2005113590A2 (en) | 2004-05-12 | 2005-12-01 | Acceleron Pharma Inc. | Bmp10 propeptides and related methods |
| JP2008507288A (ja) | 2004-07-23 | 2008-03-13 | アクセルロン ファーマ インコーポレーテッド | ＡｃｔＲＩＩ受容体ポリペプチド、方法、および組成物 |
| JP2008534607A (ja) * | 2005-03-30 | 2008-08-28 | ワイス | Ｂｍｐを投与することによって毛髪の成長を刺激するための方法 |
| BRPI0618947B1 (pt) | 2005-11-23 | 2022-07-19 | Acceleron Pharma Inc | Polipeptídeo actriia que se liga à ativina, polinucleotídeo isolado, polinucleotídeo recombinante, métodopara preparar um polipeptídeo actriia que se liga à ativina, preparação farmacêutica e uso de uma proteína de fusão actriia-fc para promover o crescimento ósseo e inibir a ressorção óssea |
| GB0615129D0 (en) | 2006-07-29 | 2006-09-06 | Univ Cardiff | Anti-cancer activity of BMP-9 and BMP-10 and their use in cancer therapies |
| CA2672758C (en) | 2006-12-18 | 2019-07-30 | Acceleron Pharma Inc. | Activin-actrii antagonists and uses for increasing red blood cell levels |
| TWI584815B (zh) | 2007-02-01 | 2017-06-01 | 艾瑟勒朗法瑪公司 | 活化素-ＡｃｔＲＩＩａ拮抗劑及其治療或預防乳癌之用途 |
| TW201627320A (zh) | 2007-02-02 | 2016-08-01 | 艾瑟勒朗法瑪公司 | 衍生自ＡｃｔＲＩＩＢ的變體與其用途 |
| MX2009008510A (es) | 2007-02-09 | 2010-01-15 | Acceleron Pharma Inc | Antagonistas de activina-actriia y usos para promover el crecimiento de huesos en pacientes con cancer. |
| CA2699936A1 (en) | 2007-09-18 | 2009-03-26 | Acceleron Pharma Inc. | Activin-actriia antagonists and uses for decreasing or inhibiting fsh secretion |
| EP2265603B1 (en) | 2008-03-13 | 2014-05-07 | The General Hospital Corporation | Inhibitors of the bmp signaling pathway |
| CN105963695A (zh) | 2008-05-02 | 2016-09-28 | 阿塞勒隆制药公司 | 用于调节血管发生和周细胞包裹的基于alk1拮抗剂的方法和组合物 |
| EP2291401A2 (en) | 2008-05-15 | 2011-03-09 | Acceleron Pharma, Inc. | Antagonists of bmp9, bmp10, alk1 and other alk1 ligands, and uses thereof |
| KR20110031951A (ko) | 2008-06-26 | 2011-03-29 | 악셀레론 파마 인코포레이티드 | 액티빈-ａｃｔｒｉｉａ의 길항물질 및 적혈구 수준을 증가시키기 위한 이들의 용도 |
| DK3750552T5 (da) | 2008-08-14 | 2024-08-26 | Acceleron Pharma Inc | Gdf-fælder |
| CN107267520A (zh) | 2009-06-12 | 2017-10-20 | 阿塞勒隆制药公司 | 截短的actriib‑fc融合蛋白 |
| KR102170682B1 (ko) | 2009-08-13 | 2020-10-28 | 악셀레론 파마 인코포레이티드 | 적혈구 수준을 증가시키기 위한 ｇｄｆ 트랩과 에리트로포이에틴 수용체 활성인자의 병용 |
| JP2012238811A (ja) | 2011-05-13 | 2012-12-06 | Toshiba Corp | 半導体不揮発性記憶装置およびその製造方法 |
| US9809636B2 (en) * | 2012-04-06 | 2017-11-07 | Acceleron Pharma Inc. | Methods for increasing red blood cell levels comprising administering BMP9 |
| CA2874117C (en) * | 2012-07-02 | 2021-10-12 | Kyowa Hakko Kirin Co., Ltd. | Pharmaceutical agent comprising anti-bmp9 antibody as active ingredient for treatment of anemia such as renal anemia and cancer anemia |
| TWI814187B (zh) | 2015-05-13 | 2023-09-01 | 美商西建公司 | 使用ACTRII配位體捕捉以治療β-地中海型貧血 |
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2013
- 2013-03-14 US US13/827,477 patent/US9809636B2/en active Active
- 2013-04-04 AU AU2013243388A patent/AU2013243388B2/en not_active Ceased
- 2013-04-04 CA CA2869474A patent/CA2869474C/en active Active
- 2013-04-04 WO PCT/US2013/035305 patent/WO2013152213A1/en not_active Ceased
- 2013-04-04 EP EP17208236.4A patent/EP3351260B1/en active Active
- 2013-04-04 EP EP13772302.9A patent/EP2844272A4/en not_active Withdrawn
- 2013-04-04 JP JP2015504730A patent/JP6234993B2/ja not_active Expired - Fee Related
-
2017
- 2017-07-26 JP JP2017144654A patent/JP2017190344A/ja not_active Withdrawn
- 2017-10-13 US US15/783,056 patent/US10344066B2/en active Active
-
2018
- 2018-04-03 AU AU2018202326A patent/AU2018202326B2/en not_active Ceased
-
2019
- 2019-05-24 US US16/422,117 patent/US10829534B2/en active Active
- 2019-07-01 JP JP2019123059A patent/JP2019156858A/ja not_active Withdrawn
-
2020
- 2020-10-06 US US17/063,848 patent/US11807673B2/en active Active
-
2021
- 2021-02-24 AU AU2021201196A patent/AU2021201196A1/en not_active Abandoned
- 2021-04-30 JP JP2021077695A patent/JP2021107453A/ja active Pending