DK3290046T3 - C1-INH COMPOSITIONS AND PROCEDURES FOR PREVENTION AND TREATMENT OF DISEASES ASSOCIATED WITH C1-ESTERASE INHIBITOR LACK - Google Patents

C1-INH COMPOSITIONS AND PROCEDURES FOR PREVENTION AND TREATMENT OF DISEASES ASSOCIATED WITH C1-ESTERASE INHIBITOR LACK Download PDF

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Publication number
DK3290046T3
DK3290046T3 DK17177676.8T DK17177676T DK3290046T3 DK 3290046 T3 DK3290046 T3 DK 3290046T3 DK 17177676 T DK17177676 T DK 17177676T DK 3290046 T3 DK3290046 T3 DK 3290046T3
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Prior art keywords
esterase inhibitor
composition
use according
hae
units
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DK17177676.8T
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Danish (da)
English (en)
Inventor
Cynthia Gallagher
Stephen Ruddy
Mark Cornell Manning
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Shire Viropharma Inc
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/55Protease inhibitors
    • A61K38/57Protease inhibitors from animals; from humans
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/14Blood; Artificial blood
    • A61K35/16Blood plasma; Blood serum
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/1703Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • A61K38/1709Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/55Protease inhibitors
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/02Inorganic compounds
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/12Carboxylic acids; Salts or anhydrides thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/16Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
    • A61K47/18Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/16Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
    • A61K47/18Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
    • A61K47/183Amino acids, e.g. glycine, EDTA or aspartame
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/22Heterocyclic compounds, e.g. ascorbic acid, tocopherol or pyrrolidones
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/34Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0019Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0019Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A61K9/0021Intradermal administration, e.g. through microneedle arrays, needleless injectors
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/08Solutions
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/81Protease inhibitors

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Immunology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Dermatology (AREA)
  • Inorganic Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Communicable Diseases (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Marine Sciences & Fisheries (AREA)
  • Oncology (AREA)
  • Cell Biology (AREA)
  • Hematology (AREA)
  • Biophysics (AREA)
  • Virology (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • Developmental Biology & Embryology (AREA)
  • Molecular Biology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
DK17177676.8T 2013-03-15 2014-03-17 C1-INH COMPOSITIONS AND PROCEDURES FOR PREVENTION AND TREATMENT OF DISEASES ASSOCIATED WITH C1-ESTERASE INHIBITOR LACK DK3290046T3 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201361791399P 2013-03-15 2013-03-15
EP14762343.3A EP2968434B1 (en) 2013-03-15 2014-03-17 C1-inh compositions for use in the prevention and treatment of hereditary angioedema (hae).

Publications (1)

Publication Number Publication Date
DK3290046T3 true DK3290046T3 (en) 2019-03-18

Family

ID=51538486

Family Applications (2)

Application Number Title Priority Date Filing Date
DK17177676.8T DK3290046T3 (en) 2013-03-15 2014-03-17 C1-INH COMPOSITIONS AND PROCEDURES FOR PREVENTION AND TREATMENT OF DISEASES ASSOCIATED WITH C1-ESTERASE INHIBITOR LACK
DK14762343.3T DK2968434T3 (en) 2013-03-15 2014-03-17 C1-INH compositions for use in the prevention and treatment of hereditary angioedema (HAE).

Family Applications After (1)

Application Number Title Priority Date Filing Date
DK14762343.3T DK2968434T3 (en) 2013-03-15 2014-03-17 C1-INH compositions for use in the prevention and treatment of hereditary angioedema (HAE).

Country Status (30)

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US (9) US9616111B2 (enExample)
EP (3) EP3290046B1 (enExample)
JP (9) JP6184581B2 (enExample)
KR (4) KR20150135242A (enExample)
CN (2) CN111529708A (enExample)
AU (3) AU2014232912A1 (enExample)
BR (1) BR112015023207A8 (enExample)
CA (2) CA2904543C (enExample)
CY (2) CY1119419T1 (enExample)
DE (1) DE202014011208U1 (enExample)
DK (2) DK3290046T3 (enExample)
EA (1) EA201591278A1 (enExample)
ES (2) ES2713004T3 (enExample)
GB (1) GB2530921B (enExample)
HK (1) HK1250912B (enExample)
HR (2) HRP20171269T1 (enExample)
HU (2) HUE041837T2 (enExample)
IL (2) IL241549B (enExample)
LT (2) LT3290046T (enExample)
ME (2) ME02865B (enExample)
MX (3) MX389449B (enExample)
PL (2) PL2968434T3 (enExample)
PT (2) PT2968434T (enExample)
RS (2) RS58351B1 (enExample)
SG (2) SG10201707598QA (enExample)
SI (2) SI3290046T1 (enExample)
SM (2) SMT201700415T1 (enExample)
TR (1) TR201900319T4 (enExample)
WO (1) WO2014145519A2 (enExample)
ZA (3) ZA201507604B (enExample)

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PT2968434T (pt) 2017-09-18
US20170224788A1 (en) 2017-08-10
US20190160158A1 (en) 2019-05-30
US20190160157A1 (en) 2019-05-30
EP3290046B1 (en) 2019-01-02
JP6473535B2 (ja) 2019-02-20
ZA201507604B (en) 2018-05-30
LT2968434T (lt) 2017-09-25
JP6473534B2 (ja) 2019-02-20
CA2904543C (en) 2019-10-08
LT3290046T (lt) 2019-03-12
EA201591278A1 (ru) 2016-03-31
SG11201507616VA (en) 2015-10-29
JP6877470B2 (ja) 2021-05-26
HRP20190270T1 (hr) 2019-04-05
ME02865B (me) 2018-04-20
IL276153B (en) 2022-06-01
CY1121653T1 (el) 2020-07-31
TR201900319T4 (tr) 2019-02-21
JP2017105847A (ja) 2017-06-15
KR20150135242A (ko) 2015-12-02
AU2020203183B2 (en) 2022-06-02
JP6184581B2 (ja) 2017-08-23
CN111529708A (zh) 2020-08-14
SMT201700415T1 (it) 2017-11-15
GB201519921D0 (en) 2015-12-23
ME03326B (me) 2019-10-20
EP2968434B1 (en) 2017-06-28
KR20220070049A (ko) 2022-05-27
HRP20171269T1 (hr) 2017-11-03
JP2019073544A (ja) 2019-05-16
NZ751555A (en) 2021-07-30
SI3290046T1 (sl) 2019-04-30
JP2018119000A (ja) 2018-08-02
SG10201707598QA (en) 2017-10-30
EP3508213A1 (en) 2019-07-10
ES2713004T3 (es) 2019-05-17
JP2019073546A (ja) 2019-05-16
MX389449B (es) 2025-03-20
BR112015023207A8 (pt) 2018-01-23
EP2968434A4 (en) 2016-03-02
US20180085441A1 (en) 2018-03-29
MX373965B (es) 2020-07-13
US11534482B2 (en) 2022-12-27
IL276153A (en) 2020-09-30
CY1119419T1 (el) 2018-03-07
NZ710730A (en) 2021-07-30
US10130690B2 (en) 2018-11-20
PT3290046T (pt) 2019-02-18
US20180110844A1 (en) 2018-04-26
KR20210129267A (ko) 2021-10-27
AU2018229558A1 (en) 2018-10-04
AU2020203183A1 (en) 2020-06-04
RS58351B1 (sr) 2019-03-29
EP3290046A1 (en) 2018-03-07
MX2021011946A (es) 2021-11-17
EP2968434A2 (en) 2016-01-20
HUE036224T2 (hu) 2018-06-28
CN105517559A (zh) 2016-04-20
AU2014232912A1 (en) 2015-09-03
BR112015023207A2 (pt) 2017-11-21
DE202014011208U1 (de) 2018-08-23
US9616111B2 (en) 2017-04-11
PL2968434T3 (pl) 2018-01-31
JP6877472B2 (ja) 2021-05-26
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US20200261556A1 (en) 2020-08-20
US10080788B2 (en) 2018-09-25
PL3290046T3 (pl) 2019-05-31
SMT201900141T1 (it) 2019-05-10
DK2968434T3 (en) 2017-09-11
JP6422520B2 (ja) 2018-11-14
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US10201595B2 (en) 2019-02-12
US20180110843A1 (en) 2018-04-26
KR20210021146A (ko) 2021-02-24
WO2014145519A3 (en) 2014-12-31
IL241549B (en) 2020-08-31
HUE041837T2 (hu) 2019-05-28
HK1250912B (en) 2020-01-10
CA2904543A1 (en) 2014-09-18
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WO2014145519A2 (en) 2014-09-18
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GB2530921A (en) 2016-04-06
GB2530921B (en) 2017-09-20
MX2020004724A (es) 2022-01-18
HK1220403A1 (en) 2017-05-05
AU2018229558B2 (en) 2020-03-05
ES2639833T3 (es) 2017-10-30
SI2968434T1 (sl) 2017-11-30
KR102579789B1 (ko) 2023-09-15
CA3054718A1 (en) 2014-09-18
US11364288B2 (en) 2022-06-21
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US20160015795A1 (en) 2016-01-21
US20180153972A1 (en) 2018-06-07
US10105423B2 (en) 2018-10-23
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ZA201706929B (en) 2019-05-29
KR102430453B1 (ko) 2022-08-05

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