JP2018502906A5 - - Google Patents
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- JP2018502906A5 JP2018502906A5 JP2017551003A JP2017551003A JP2018502906A5 JP 2018502906 A5 JP2018502906 A5 JP 2018502906A5 JP 2017551003 A JP2017551003 A JP 2017551003A JP 2017551003 A JP2017551003 A JP 2017551003A JP 2018502906 A5 JP2018502906 A5 JP 2018502906A5
- Authority
- JP
- Japan
- Prior art keywords
- methyl
- imidazolidine
- dione
- piperazin
- oxo
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 150000003839 salts Chemical class 0.000 description 18
- 150000001875 compounds Chemical class 0.000 description 17
- 125000000217 alkyl group Chemical group 0.000 description 15
- 239000000126 substance Substances 0.000 description 8
- 125000003545 alkoxy group Chemical group 0.000 description 7
- 125000005842 heteroatom Chemical group 0.000 description 7
- 229910052760 oxygen Inorganic materials 0.000 description 6
- 229910052717 sulfur Inorganic materials 0.000 description 6
- 239000008194 pharmaceutical composition Substances 0.000 description 5
- 125000002950 monocyclic group Chemical group 0.000 description 4
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 description 4
- 239000012453 solvate Substances 0.000 description 4
- 239000003814 drug Substances 0.000 description 3
- 125000001475 halogen functional group Chemical group 0.000 description 3
- 125000005843 halogen group Chemical group 0.000 description 3
- 0 CC(C(C(CCC([C@](*)CC[C@](*)C(N1CC(*)N(*)C(*)C1)=O)=O)=N)=O)=N Chemical compound CC(C(C(CCC([C@](*)CC[C@](*)C(N1CC(*)N(*)C(*)C1)=O)=O)=N)=O)=N 0.000 description 2
- -1 and -One ・ OH Chemical group 0.000 description 2
- 210000000845 cartilage Anatomy 0.000 description 2
- 230000008355 cartilage degradation Effects 0.000 description 2
- 201000010099 disease Diseases 0.000 description 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 2
- 230000013632 homeostatic process Effects 0.000 description 2
- 230000004968 inflammatory condition Effects 0.000 description 2
- 125000006578 monocyclic heterocycloalkyl group Chemical group 0.000 description 2
- 230000002265 prevention Effects 0.000 description 2
- 229940124597 therapeutic agent Drugs 0.000 description 2
- NVCCYYKMLFBFPP-SYTFOFBDSA-N (5R)-5-[(2S)-3-[(3S)-4-(3-chloro-4-fluorophenyl)-3-methylpiperazin-1-yl]-2-methyl-3-oxopropyl]-5-methylimidazolidine-2,4-dione Chemical compound ClC=1C=C(C=CC=1F)N1[C@H](CN(CC1)C([C@H](C[C@@]1(C(NC(N1)=O)=O)C)C)=O)C NVCCYYKMLFBFPP-SYTFOFBDSA-N 0.000 description 1
- ITEARTLSQDZAFU-SJCJKPOMSA-N (5S)-1-cyclopropyl-5-[3-[(3S)-4-(3,5-difluorophenyl)-3-methylpiperazin-1-yl]-3-oxopropyl]imidazolidine-2,4-dione Chemical compound C1(CC1)N1C(NC([C@@H]1CCC(=O)N1C[C@@H](N(CC1)C1=CC(=CC(=C1)F)F)C)=O)=O ITEARTLSQDZAFU-SJCJKPOMSA-N 0.000 description 1
- MKGHITYLXXYNMZ-QAJFTPDKSA-N (5S)-5-[(2S)-3-[(3S)-4-(3-chloro-4-fluorophenyl)-3-methylpiperazin-1-yl]-2-methyl-3-oxopropyl]-5-(methoxymethyl)imidazolidine-2,4-dione Chemical compound ClC=1C=C(C=CC=1F)N1[C@H](CN(CC1)C([C@H](C[C@@]1(C(NC(N1)=O)=O)COC)C)=O)C MKGHITYLXXYNMZ-QAJFTPDKSA-N 0.000 description 1
- RKYYWBHSYPIJKC-BYVOGVQKSA-N (5S)-5-cyclopropyl-5-[(2S)-3-[(3S)-4-(3,4-difluorophenyl)-3-methylpiperazin-1-yl]-2-methyl-3-oxopropyl]imidazolidine-2,4-dione Chemical compound C1(CC1)[C@]1(C(NC(N1)=O)=O)C[C@@H](C(=O)N1C[C@@H](N(CC1)C1=CC(=C(C=C1)F)F)C)C RKYYWBHSYPIJKC-BYVOGVQKSA-N 0.000 description 1
- VAKWUGCSPIRJRO-YUNKPMOVSA-N (5S)-5-cyclopropyl-5-[3-[(3S)-4-(3,4-dichlorophenyl)-3-methylpiperazin-1-yl]-3-oxopropyl]imidazolidine-2,4-dione Chemical compound C1(CC1)[C@]1(C(NC(N1)=O)=O)CCC(=O)N1C[C@@H](N(CC1)C1=CC(=C(C=C1)Cl)Cl)C VAKWUGCSPIRJRO-YUNKPMOVSA-N 0.000 description 1
- BTEUURMBUUDUGB-YUNKPMOVSA-N (5S)-5-cyclopropyl-5-[3-[(3S)-4-(3,5-dichlorophenyl)-3-methylpiperazin-1-yl]-3-oxopropyl]imidazolidine-2,4-dione Chemical compound C1(CC1)[C@]1(C(NC(N1)=O)=O)CCC(=O)N1C[C@@H](N(CC1)C1=CC(=CC(=C1)Cl)Cl)C BTEUURMBUUDUGB-YUNKPMOVSA-N 0.000 description 1
- YILYUDCSMINQHO-UHFFFAOYSA-N 5-[2-[4-(3,5-dichlorophenyl)piperazine-1-carbonyl]butyl]-5-methylimidazolidine-2,4-dione Chemical compound ClC=1C=C(C=C(C=1)Cl)N1CCN(CC1)C(=O)C(CC1(C(NC(N1)=O)=O)C)CC YILYUDCSMINQHO-UHFFFAOYSA-N 0.000 description 1
- ASLMJZFVIFDYPI-XLEXHMCLSA-N 5-[3-[(3S)-4-(3,4-dichlorophenyl)-3-methylpiperazin-1-yl]-3-oxopropyl]-5-pyridin-2-ylimidazolidine-2,4-dione Chemical compound ClC=1C=C(C=CC=1Cl)N1[C@H](CN(CC1)C(CCC1(C(NC(N1)=O)=O)C1=NC=CC=C1)=O)C ASLMJZFVIFDYPI-XLEXHMCLSA-N 0.000 description 1
- LUSRDLQFGWFJPD-VZSHHBOJSA-N 5-[3-[(3S)-4-(3,4-difluorophenyl)-3-methylpiperazin-1-yl]-2-methyl-3-oxopropyl]-5-pyridin-2-ylimidazolidine-2,4-dione Chemical compound FC=1C=C(C=CC=1F)N1[C@H](CN(CC1)C(C(CC1(C(NC(N1)=O)=O)C1=NC=CC=C1)C)=O)C LUSRDLQFGWFJPD-VZSHHBOJSA-N 0.000 description 1
- KXFPWCKTSXRQIS-LAMFTWINSA-N 5-[3-[(3S)-4-(3-chloro-4-fluorophenyl)-3-methylpiperazin-1-yl]-2-methyl-3-oxopropyl]-5-cyclopropylimidazolidine-2,4-dione Chemical compound ClC=1C=C(C=CC=1F)N1[C@H](CN(CC1)C(C(CC1(C(NC(N1)=O)=O)C1CC1)C)=O)C KXFPWCKTSXRQIS-LAMFTWINSA-N 0.000 description 1
- FCEJLOVSBUDTHL-VZSHHBOJSA-N 5-[3-[(3S)-4-(3-chloro-4-fluorophenyl)-3-methylpiperazin-1-yl]-2-methyl-3-oxopropyl]-5-pyridin-2-ylimidazolidine-2,4-dione Chemical compound ClC=1C=C(C=CC=1F)N1[C@H](CN(CC1)C(C(CC1(C(NC(N1)=O)=O)C1=NC=CC=C1)C)=O)C FCEJLOVSBUDTHL-VZSHHBOJSA-N 0.000 description 1
- OOQSIBQKXZCHOC-LAMFTWINSA-N 5-[3-[(3S)-4-(3-chloro-5-fluorophenyl)-3-methylpiperazin-1-yl]-2-methyl-3-oxopropyl]-5-cyclopropylimidazolidine-2,4-dione Chemical compound ClC=1C=C(C=C(C=1)F)N1[C@H](CN(CC1)C(C(CC1(C(NC(N1)=O)=O)C1CC1)C)=O)C OOQSIBQKXZCHOC-LAMFTWINSA-N 0.000 description 1
- ARVDGBFKIFLARF-PMFMOCITSA-N 5-[3-[(3S)-4-(3-chlorophenyl)-3-methylpiperazin-1-yl]-2-methyl-3-oxopropyl]-5-pyridin-2-ylimidazolidine-2,4-dione Chemical compound ClC=1C=C(C=CC=1)N1[C@H](CN(CC1)C(C(CC1(C(NC(N1)=O)=O)C1=NC=CC=C1)C)=O)C ARVDGBFKIFLARF-PMFMOCITSA-N 0.000 description 1
- XHYNCBKYQFMAJL-PMFMOCITSA-N 5-[3-[(3S)-4-(3-fluorophenyl)-3-methylpiperazin-1-yl]-2-methyl-3-oxopropyl]-5-pyridin-2-ylimidazolidine-2,4-dione Chemical compound FC=1C=C(C=CC=1)N1[C@H](CN(CC1)C(C(CC1(C(NC(N1)=O)=O)C1=NC=CC=C1)C)=O)C XHYNCBKYQFMAJL-PMFMOCITSA-N 0.000 description 1
- ZIXRMLDHKPIARA-JVIGMCFJSA-N 5-[3-[(3S)-4-(4-chloro-3,5-difluorophenyl)-3-methylpiperazin-1-yl]-2-methyl-3-oxopropyl]-5-methylimidazolidine-2,4-dione Chemical compound ClC1=C(C=C(C=C1F)N1[C@H](CN(CC1)C(C(CC1(C(NC(N1)=O)=O)C)C)=O)C)F ZIXRMLDHKPIARA-JVIGMCFJSA-N 0.000 description 1
- HYCYFNRXRRBATO-GJGORFQUSA-N 5-[3-[(3S)-4-(4-chlorophenyl)-3-methylpiperazin-1-yl]-2-methyl-3-oxopropyl]-5-cyclopropylimidazolidine-2,4-dione Chemical compound ClC1=CC=C(C=C1)N1[C@H](CN(CC1)C(C(CC1(C(NC(N1)=O)=O)C1CC1)C)=O)C HYCYFNRXRRBATO-GJGORFQUSA-N 0.000 description 1
- KISNQJUMQDMWMF-UHFFFAOYSA-N 5-[3-[4-(3,4-difluorophenyl)piperazin-1-yl]-2-methyl-3-oxopropyl]-5-(methoxymethyl)imidazolidine-2,4-dione Chemical compound FC=1C=C(C=CC=1F)N1CCN(CC1)C(C(CC1(C(NC(N1)=O)=O)COC)C)=O KISNQJUMQDMWMF-UHFFFAOYSA-N 0.000 description 1
- LHKXLEZLEFHFJV-UHFFFAOYSA-N 5-[3-[4-(3,5-dichlorophenyl)piperazin-1-yl]-2-(hydroxymethyl)-3-oxopropyl]-5-methylimidazolidine-2,4-dione Chemical compound ClC=1C=C(C=C(C=1)Cl)N1CCN(CC1)C(C(CC1(C(NC(N1)=O)=O)C)CO)=O LHKXLEZLEFHFJV-UHFFFAOYSA-N 0.000 description 1
- RZRHUPMJEFKEEG-UHFFFAOYSA-N 5-[3-[4-(3,5-dichlorophenyl)piperazin-1-yl]-2-methyl-3-oxopropyl]-5-(2-methylsulfonylethyl)imidazolidine-2,4-dione Chemical compound ClC=1C=C(C=C(C=1)Cl)N1CCN(CC1)C(C(CC1(C(NC(N1)=O)=O)CCS(=O)(=O)C)C)=O RZRHUPMJEFKEEG-UHFFFAOYSA-N 0.000 description 1
- HNYCVJJYDZYSOS-UHFFFAOYSA-N 5-[3-[4-(3,5-dichlorophenyl)piperazin-1-yl]-2-methyl-3-oxopropyl]-5-(methoxymethyl)imidazolidine-2,4-dione Chemical compound ClC=1C=C(C=C(C=1)Cl)N1CCN(CC1)C(C(CC1(C(NC(N1)=O)=O)COC)C)=O HNYCVJJYDZYSOS-UHFFFAOYSA-N 0.000 description 1
- JDBUKSMCZPXYJU-UHFFFAOYSA-N 5-[3-[4-(3,5-dichlorophenyl)piperazin-1-yl]-2-methyl-3-oxopropyl]-5-pyridin-2-ylimidazolidine-2,4-dione Chemical compound ClC=1C=C(C=C(C=1)Cl)N1CCN(CC1)C(C(CC1(C(NC(N1)=O)=O)C1=NC=CC=C1)C)=O JDBUKSMCZPXYJU-UHFFFAOYSA-N 0.000 description 1
- TVZULDOLODKVIB-UHFFFAOYSA-N 5-[3-[4-(3-chloro-2-methylphenyl)piperazin-1-yl]-2-methyl-3-oxopropyl]-5-cyclopropylimidazolidine-2,4-dione Chemical compound ClC=1C(=C(C=CC=1)N1CCN(CC1)C(C(CC1(C(NC(N1)=O)=O)C1CC1)C)=O)C TVZULDOLODKVIB-UHFFFAOYSA-N 0.000 description 1
- DLWHWYIHKZASJX-UHFFFAOYSA-N 5-[3-[4-(3-chlorophenyl)piperazin-1-yl]-2-methyl-3-oxopropyl]-5-cyclopropylimidazolidine-2,4-dione Chemical compound ClC=1C=C(C=CC=1)N1CCN(CC1)C(C(CC1(C(NC(N1)=O)=O)C1CC1)C)=O DLWHWYIHKZASJX-UHFFFAOYSA-N 0.000 description 1
- UHKJKGYIHRIXMQ-UHFFFAOYSA-N 5-[3-[4-(4-chloro-3,5-difluorophenyl)piperazin-1-yl]-2-methyl-3-oxopropyl]-5-(methoxymethyl)imidazolidine-2,4-dione Chemical compound ClC1=C(C=C(C=C1F)N1CCN(CC1)C(C(CC1(C(NC(N1)=O)=O)COC)C)=O)F UHKJKGYIHRIXMQ-UHFFFAOYSA-N 0.000 description 1
- VAKWUGCSPIRJRO-SVZXGPMESA-N 5-cyclopropyl-5-[3-[(3S)-4-(3,4-dichlorophenyl)-3-methylpiperazin-1-yl]-3-oxopropyl]imidazolidine-2,4-dione Chemical compound C1(CC1)C1(C(NC(N1)=O)=O)CCC(=O)N1C[C@@H](N(CC1)C1=CC(=C(C=C1)Cl)Cl)C VAKWUGCSPIRJRO-SVZXGPMESA-N 0.000 description 1
- RKYYWBHSYPIJKC-LAMFTWINSA-N 5-cyclopropyl-5-[3-[(3S)-4-(3,4-difluorophenyl)-3-methylpiperazin-1-yl]-2-methyl-3-oxopropyl]imidazolidine-2,4-dione Chemical compound C1(CC1)C1(C(NC(N1)=O)=O)CC(C(=O)N1C[C@@H](N(CC1)C1=CC(=C(C=C1)F)F)C)C RKYYWBHSYPIJKC-LAMFTWINSA-N 0.000 description 1
- MNUPPLNWLDYAPV-RMJFEQTRSA-N 5-cyclopropyl-5-[3-[(3S)-4-[3-fluoro-5-(1H-pyrazol-4-yl)phenyl]-3-methylpiperazin-1-yl]-2-methyl-3-oxopropyl]imidazolidine-2,4-dione Chemical compound C1(CC1)C1(C(NC(N1)=O)=O)CC(C(=O)N1C[C@@H](N(CC1)C1=CC(=CC(=C1)C=1C=NNC=1)F)C)C MNUPPLNWLDYAPV-RMJFEQTRSA-N 0.000 description 1
- KHOCDFJBVDAQHO-UHFFFAOYSA-N 5-cyclopropyl-5-[3-[4-(3,5-dichlorophenyl)piperazin-1-yl]-2-methyl-3-oxopropyl]imidazolidine-2,4-dione Chemical compound C1(CC1)C1(C(NC(N1)=O)=O)CC(C(=O)N1CCN(CC1)C1=CC(=CC(=C1)Cl)Cl)C KHOCDFJBVDAQHO-UHFFFAOYSA-N 0.000 description 1
- KNNZSFMCVFUPON-UHFFFAOYSA-N 5-cyclopropyl-5-[3-[4-(5-fluoro-2-methylphenyl)piperazin-1-yl]-2-methyl-3-oxopropyl]imidazolidine-2,4-dione Chemical compound C1(CC1)C1(C(NC(N1)=O)=O)CC(C(=O)N1CCN(CC1)C1=C(C=CC(=C1)F)C)C KNNZSFMCVFUPON-UHFFFAOYSA-N 0.000 description 1
- PCBZRNYXXCIELG-WYFCWLEVSA-N COC1=CC=C(C[C@H](NC(=O)OC2CCCC3(C2)OOC2(O3)C3CC4CC(C3)CC2C4)C(=O)N[C@@H]2[C@@H](CO)O[C@H]([C@@H]2O)N2C=NC3=C2N=CN=C3N(C)C)C=C1 Chemical compound COC1=CC=C(C[C@H](NC(=O)OC2CCCC3(C2)OOC2(O3)C3CC4CC(C3)CC2C4)C(=O)N[C@@H]2[C@@H](CO)O[C@H]([C@@H]2O)N2C=NC3=C2N=CN=C3N(C)C)C=C1 PCBZRNYXXCIELG-WYFCWLEVSA-N 0.000 description 1
- 125000005036 alkoxyphenyl group Chemical group 0.000 description 1
- 125000002877 alkyl aryl group Chemical group 0.000 description 1
- 125000005037 alkyl phenyl group Chemical group 0.000 description 1
- 125000003118 aryl group Chemical group 0.000 description 1
- 230000000975 bioactive effect Effects 0.000 description 1
- 229910052799 carbon Inorganic materials 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 239000003937 drug carrier Substances 0.000 description 1
- 125000000592 heterocycloalkyl group Chemical group 0.000 description 1
- 229910052739 hydrogen Inorganic materials 0.000 description 1
- 239000002207 metabolite Substances 0.000 description 1
- 125000002911 monocyclic heterocycle group Chemical group 0.000 description 1
- 229910052757 nitrogen Inorganic materials 0.000 description 1
- 125000004194 piperazin-1-yl group Chemical group [H]N1C([H])([H])C([H])([H])N(*)C([H])([H])C1([H])[H] 0.000 description 1
- 125000000999 tert-butyl group Chemical group [H]C([H])([H])C(*)(C([H])([H])[H])C([H])([H])[H] 0.000 description 1
- 125000005309 thioalkoxy group Chemical group 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EPEP14307129.8 | 2014-12-22 | ||
| EP14307129 | 2014-12-22 | ||
| PCT/EP2015/080430 WO2016102347A1 (en) | 2014-12-22 | 2015-12-18 | 5-[(piperazin-1-yl)-3-oxo-propyl]-imidazolidine-2,4-dione derivatives as adamts inhibitors for the treatment of osteoarthritis |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019227801A Division JP2020063278A (ja) | 2014-12-22 | 2019-12-18 | 変形性関節症の治療のためのａｄａｍｔｓ阻害剤としての５−［（ピペラジン−１−イル）−３−オキソ−プロピル］−イミダゾリジン−２，４−ジオン誘導体 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2018502906A JP2018502906A (ja) | 2018-02-01 |
| JP2018502906A5 true JP2018502906A5 (enExample) | 2018-11-29 |
| JP6636539B2 JP6636539B2 (ja) | 2020-01-29 |
Family
ID=52345014
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017551003A Active JP6636539B2 (ja) | 2014-12-22 | 2015-12-18 | 変形性関節症の治療のためのａｄａｍｔｓ阻害剤としての５−［（ピペラジン−１−イル）−３−オキソ−プロピル］−イミダゾリジン−２，４−ジオン誘導体 |
| JP2019227801A Pending JP2020063278A (ja) | 2014-12-22 | 2019-12-18 | 変形性関節症の治療のためのａｄａｍｔｓ阻害剤としての５−［（ピペラジン−１−イル）−３−オキソ−プロピル］−イミダゾリジン−２，４−ジオン誘導体 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019227801A Pending JP2020063278A (ja) | 2014-12-22 | 2019-12-18 | 変形性関節症の治療のためのａｄａｍｔｓ阻害剤としての５−［（ピペラジン−１−イル）−３−オキソ−プロピル］−イミダゾリジン−２，４−ジオン誘導体 |
Country Status (50)
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JO3501B1 (ar) * | 2014-12-22 | 2020-07-05 | Servier Lab | مشتقات 5-{(بيبرازين - 1-يل)-3-أوكسو - بروبيل}- إيميدازوليدين-2، 4 - دايون كمثبطات ل adamts لمعالجة هشاشة العظام) |
| GB201610056D0 (en) * | 2016-06-09 | 2016-07-27 | Galapagos Nv And Laboratoires Servier Les | Novel compounds and pharmaceutical compositions thereof for the treatment of inflammatory disorders and osteoarthritis |
| GB201610055D0 (en) * | 2016-06-09 | 2016-07-27 | Galapagos Nv And Laboratoires Servier Les | Novel compounds and pharmaceutical compositions thereof for the treatment of inflammatory disorders and osteoarthritis |
| CN107652277A (zh) * | 2017-08-09 | 2018-02-02 | 江苏工程职业技术学院 | 一种依帕列净的制备方法 |
| CN107540648A (zh) * | 2017-08-09 | 2018-01-05 | 江苏工程职业技术学院 | 一种达格列净的制备方法 |
| WO2021011720A2 (en) * | 2019-07-18 | 2021-01-21 | Avidence Therapeutics, Inc. | Anti-osteoarthritis compounds and related compositions and methods |
| WO2021158626A1 (en) * | 2020-02-04 | 2021-08-12 | Eternity Bioscience Inc. | Adamts inhibitors, preparation methods and medicinal uses thereof |
| WO2021204185A1 (zh) * | 2020-04-10 | 2021-10-14 | 深圳信立泰药业股份有限公司 | 一种苯并[d]氮杂卓类衍生物蛋白聚糖酶2抑制剂及其制备方法和医药用途 |
| CN113735825B (zh) * | 2020-05-27 | 2024-08-27 | 成都康弘药业集团股份有限公司 | 1,2,3,6-四氢吡啶类化合物及其制备方法和用途 |
| CN113754635B (zh) * | 2020-06-02 | 2024-06-21 | 成都康弘药业集团股份有限公司 | 稠环类化合物及其制备方法和用途 |
| WO2022007866A1 (zh) * | 2020-07-09 | 2022-01-13 | 深圳信立泰药业股份有限公司 | 并三环类衍生物、其制备方法及其在医药上的应用 |
| CN113943255B (zh) * | 2020-07-17 | 2024-08-06 | 深圳信立泰药业股份有限公司 | 一种手性3-(4-环丙基-2,5-二氧杂咪唑啉-4-基)丙酸的制备方法 |
| CN116723840A (zh) * | 2020-12-15 | 2023-09-08 | 加拉帕戈斯股份有限公司 | (5s)-环丙基-5-[3-[(3s)-4-(3,5-二氟苯基)-3-甲基-哌嗪-1-基]-3-氧代-丙基]咪唑烷-2,4-二酮的固体形式 |
| EP4263530A1 (en) | 2020-12-15 | 2023-10-25 | Galapagos N.V. | Solid forms of (5s)-cyclopropyl-5-[3-[(3s)-4-(3,5-difluorophenyl)-3-methyl-piperazin-1-yl]-3-oxo-propyl]imidazolidine-2,4-dione |
| CN117136051A (zh) * | 2021-04-02 | 2023-11-28 | 江苏恒瑞医药股份有限公司 | Adamts抑制剂的前药、其制备方法和医药用途 |
| CN117794900A (zh) * | 2021-08-03 | 2024-03-29 | 江苏恒瑞医药股份有限公司 | 抑制adamts-5和/或adamts-4功能的化合物的晶型及其制备方法和应用 |
| US20250313558A1 (en) | 2023-03-17 | 2025-10-09 | Cellus Inc. | Imidazolidine derivative or pharmaceutically acceptable salt thereof, and use thereof |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4556670A (en) * | 1982-12-06 | 1985-12-03 | Pfizer Inc. | Spiro-3-hetero-azolones for treatment of diabetic complications |
| HU198212B (en) * | 1984-07-20 | 1989-08-28 | Pfizer | Process for production of spiro-imidasolones |
| US5043447A (en) * | 1987-04-24 | 1991-08-27 | Syntex Pharmaceuticals, Ltd. | Substituted imidazolyl-alkyl-piperazine and -diazepine derivatives |
| SE0100902D0 (sv) | 2001-03-15 | 2001-03-15 | Astrazeneca Ab | Compounds |
| US6890915B2 (en) | 2001-05-25 | 2005-05-10 | Bristol-Myers Squibb Pharma Company | Hydantoins and related heterocycles as inhibitors of matrix metalloproteinases and/or TNF-α converting enzyme (TACE) |
| GB0405101D0 (en) | 2004-03-06 | 2004-04-07 | Astrazeneca Ab | Compounds |
| US7504424B2 (en) * | 2004-07-16 | 2009-03-17 | Schering Corporation | Compounds for the treatment of inflammatory disorders |
| PT2650310T (pt) | 2012-04-13 | 2016-09-01 | Rottapharm Biotech Srl | Anticorpo anti-adamts-5, derivados e utilizações dos mesmos |
| AR092971A1 (es) * | 2012-10-26 | 2015-05-06 | Lilly Co Eli | Inhibidores de agrecanasa |
| ES2627281T3 (es) | 2013-02-06 | 2017-07-27 | Merck Patent Gmbh | Derivados del ácido carboxílico sustituidos como agregados agrecanasa para el tratamiento de la artrosis |
| JO3501B1 (ar) | 2014-12-22 | 2020-07-05 | Servier Lab | مشتقات 5-{(بيبرازين - 1-يل)-3-أوكسو - بروبيل}- إيميدازوليدين-2، 4 - دايون كمثبطات ل adamts لمعالجة هشاشة العظام) |
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