CU20170085A7 - Derivados de imidazolidindiona para el tratamiento de la osteoartritis - Google Patents
Derivados de imidazolidindiona para el tratamiento de la osteoartritisInfo
- Publication number
- CU20170085A7 CU20170085A7 CUP2017000085A CU20170085A CU20170085A7 CU 20170085 A7 CU20170085 A7 CU 20170085A7 CU P2017000085 A CUP2017000085 A CU P2017000085A CU 20170085 A CU20170085 A CU 20170085A CU 20170085 A7 CU20170085 A7 CU 20170085A7
- Authority
- CU
- Cuba
- Prior art keywords
- treatment
- imidazolidindiona
- osteoartritis
- derivatives
- present
- Prior art date
Links
- 238000011282 treatment Methods 0.000 title abstract 3
- 150000001875 compounds Chemical class 0.000 abstract 3
- 210000000845 cartilage Anatomy 0.000 abstract 2
- 238000000034 method Methods 0.000 abstract 2
- 102000029750 ADAMTS Human genes 0.000 abstract 1
- 108091022879 ADAMTS Proteins 0.000 abstract 1
- 230000015556 catabolic process Effects 0.000 abstract 1
- 238000006731 degradation reaction Methods 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 230000013632 homeostatic process Effects 0.000 abstract 1
- 230000004968 inflammatory condition Effects 0.000 abstract 1
- 230000002401 inhibitory effect Effects 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 238000011321 prophylaxis Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D233/72—Two oxygen atoms, e.g. hydantoin
- C07D233/76—Two oxygen atoms, e.g. hydantoin with substituted hydrocarbon radicals attached to the third ring carbon atom
- C07D233/78—Radicals substituted by oxygen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/04—Drugs for skeletal disorders for non-specific disorders of the connective tissue
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Physical Education & Sports Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Rheumatology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Immunology (AREA)
- Biomedical Technology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP14307129 | 2014-12-22 | ||
| PCT/EP2015/080430 WO2016102347A1 (en) | 2014-12-22 | 2015-12-18 | 5-[(piperazin-1-yl)-3-oxo-propyl]-imidazolidine-2,4-dione derivatives as adamts inhibitors for the treatment of osteoarthritis |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CU20170085A7 true CU20170085A7 (es) | 2017-10-05 |
Family
ID=52345014
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CUP2017000085A CU20170085A7 (es) | 2014-12-22 | 2015-12-18 | Derivados de imidazolidindiona para el tratamiento de la osteoartritis |
Country Status (50)
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JO3501B1 (ar) | 2014-12-22 | 2020-07-05 | Servier Lab | مشتقات 5-{(بيبرازين - 1-يل)-3-أوكسو - بروبيل}- إيميدازوليدين-2، 4 - دايون كمثبطات ل adamts لمعالجة هشاشة العظام) |
| GB201610055D0 (en) * | 2016-06-09 | 2016-07-27 | Galapagos Nv And Laboratoires Servier Les | Novel compounds and pharmaceutical compositions thereof for the treatment of inflammatory disorders and osteoarthritis |
| GB201610056D0 (en) * | 2016-06-09 | 2016-07-27 | Galapagos Nv And Laboratoires Servier Les | Novel compounds and pharmaceutical compositions thereof for the treatment of inflammatory disorders and osteoarthritis |
| CN107652277A (zh) * | 2017-08-09 | 2018-02-02 | 江苏工程职业技术学院 | 一种依帕列净的制备方法 |
| CN107540648A (zh) * | 2017-08-09 | 2018-01-05 | 江苏工程职业技术学院 | 一种达格列净的制备方法 |
| WO2021011720A2 (en) * | 2019-07-18 | 2021-01-21 | Avidence Therapeutics, Inc. | Anti-osteoarthritis compounds and related compositions and methods |
| KR20220137657A (ko) * | 2020-02-04 | 2022-10-12 | 지앙수 헨그루이 파마슈티컬스 컴퍼니 리미티드 | Adamts 억제제, 이의 제조 방법 및 의약적 용도 |
| WO2021204185A1 (zh) * | 2020-04-10 | 2021-10-14 | 深圳信立泰药业股份有限公司 | 一种苯并[d]氮杂卓类衍生物蛋白聚糖酶2抑制剂及其制备方法和医药用途 |
| CN113735825A (zh) * | 2020-05-27 | 2021-12-03 | 成都康弘药业集团股份有限公司 | 1,2,3,6-四氢吡啶类化合物及其制备方法和用途 |
| CN113754635A (zh) * | 2020-06-02 | 2021-12-07 | 成都康弘药业集团股份有限公司 | 稠环类化合物及其制备方法和用途 |
| CN115720578A (zh) * | 2020-07-09 | 2023-02-28 | 深圳信立泰药业股份有限公司 | 并三环类衍生物、其制备方法及其在医药上的应用 |
| JP2023552908A (ja) | 2020-12-15 | 2023-12-19 | ガラパゴス・ナムローゼ・フェンノートシャップ | （５ｓ）－シクロプロピル－５－［３－［（３ｓ）－４－（３，５－ジフルオロフェニル）－３－メチル－ピペラジン－１－イル］－３－オキソ－プロピル］イミダゾリジン－２，４－ジオンの固体形態 |
| WO2022212638A1 (en) * | 2021-04-02 | 2022-10-06 | Jiangsu Hengrui Pharmaceuticals Co., Ltd. | Prodrugs of adamts inhibitors, preparation methods and medicinal uses thereof |
| WO2023011547A1 (zh) * | 2021-08-03 | 2023-02-09 | 江苏恒瑞医药股份有限公司 | 抑制adamts-5和/或adamts-4功能的化合物的晶型及其制备方法和应用 |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4556670A (en) * | 1982-12-06 | 1985-12-03 | Pfizer Inc. | Spiro-3-hetero-azolones for treatment of diabetic complications |
| WO1986000807A1 (en) * | 1984-07-20 | 1986-02-13 | Pfizer Inc. | Spiro-imidazolones for treatment of diabetes complications |
| US5043447A (en) * | 1987-04-24 | 1991-08-27 | Syntex Pharmaceuticals, Ltd. | Substituted imidazolyl-alkyl-piperazine and -diazepine derivatives |
| SE0100902D0 (sv) * | 2001-03-15 | 2001-03-15 | Astrazeneca Ab | Compounds |
| EP1397137B1 (en) | 2001-05-25 | 2009-10-14 | Bristol-Myers Squibb Company | Hydantion derivatives as inhibitors of matrix metalloproteinases |
| GB0405101D0 (en) | 2004-03-06 | 2004-04-07 | Astrazeneca Ab | Compounds |
| US7504424B2 (en) * | 2004-07-16 | 2009-03-17 | Schering Corporation | Compounds for the treatment of inflammatory disorders |
| HUE031089T2 (en) | 2012-04-13 | 2017-06-28 | Rottapharm Biotech Srl | Anti-ADAMTS-5 antibody, derivatives and uses |
| AR092971A1 (es) * | 2012-10-26 | 2015-05-06 | Lilly Co Eli | Inhibidores de agrecanasa |
| AU2014214325B2 (en) | 2013-02-06 | 2018-06-07 | Merck Patent Gmbh | Substituted carboxylic acid derivatives as aggrecanase inhibitors for the treatment of osteoarthritis |
| JO3501B1 (ar) | 2014-12-22 | 2020-07-05 | Servier Lab | مشتقات 5-{(بيبرازين - 1-يل)-3-أوكسو - بروبيل}- إيميدازوليدين-2، 4 - دايون كمثبطات ل adamts لمعالجة هشاشة العظام) |
-
2015
- 2015-11-19 JO JOP/2015/0284A patent/JO3501B1/ar active
- 2015-12-14 TW TW104141953A patent/TWI687414B/zh active
- 2015-12-18 EA EA201791451A patent/EA030637B1/ru unknown
- 2015-12-18 CN CN201580070274.0A patent/CN107108579B/zh active Active
- 2015-12-18 SI SI201530668T patent/SI3237406T1/sl unknown
- 2015-12-18 RS RS20190497A patent/RS58617B1/sr unknown
- 2015-12-18 RU RU2017126187A patent/RU2693459C2/ru active
- 2015-12-18 UA UAA201707702A patent/UA122065C2/uk unknown
- 2015-12-18 TR TR2019/04158T patent/TR201904158T4/tr unknown
- 2015-12-18 LT LTEP15813831.3T patent/LT3237406T/lt unknown
- 2015-12-18 ES ES15813831T patent/ES2724989T3/es active Active
- 2015-12-18 DK DK15813831.3T patent/DK3237406T3/da active
- 2015-12-18 WO PCT/EP2015/080430 patent/WO2016102347A1/en active Application Filing
- 2015-12-18 GE GEAP201514546A patent/GEP20197043B/en unknown
- 2015-12-18 NZ NZ732909A patent/NZ732909A/en unknown
- 2015-12-18 TN TN2017000213A patent/TN2017000213A1/en unknown
- 2015-12-18 PT PT15813831T patent/PT3237406T/pt unknown
- 2015-12-18 BR BR112017013258-3A patent/BR112017013258B1/pt active IP Right Grant
- 2015-12-18 CR CR20170248A patent/CR20170248A/es unknown
- 2015-12-18 PE PE2017001122A patent/PE20171099A1/es unknown
- 2015-12-18 US US15/538,393 patent/US9926281B2/en active Active
- 2015-12-18 MD MDE20170225T patent/MD3237406T2/ro unknown
- 2015-12-18 ME MEP-2019-92A patent/ME03374B/me unknown
- 2015-12-18 JP JP2017551003A patent/JP6636539B2/ja active Active
- 2015-12-18 MY MYPI2017702301A patent/MY189764A/en unknown
- 2015-12-18 HU HUE15813831A patent/HUE042840T2/hu unknown
- 2015-12-18 SG SG11201705030SA patent/SG11201705030SA/en unknown
- 2015-12-18 CA CA2971110A patent/CA2971110C/en active Active
- 2015-12-18 AU AU2015371400A patent/AU2015371400B2/en active Active
- 2015-12-18 AR ARP150104189A patent/AR103170A1/es unknown
- 2015-12-18 EP EP15813831.3A patent/EP3237406B1/en active Active
- 2015-12-18 PL PL15813831T patent/PL3237406T3/pl unknown
- 2015-12-18 EP EP19154886.6A patent/EP3575294A1/en not_active Withdrawn
- 2015-12-18 KR KR1020177020379A patent/KR20170122720A/ko not_active Application Discontinuation
- 2015-12-18 CU CUP2017000085A patent/CU20170085A7/xx unknown
- 2015-12-18 MA MA41238A patent/MA41238B1/fr unknown
- 2015-12-18 MX MX2017008048A patent/MX2017008048A/es active IP Right Grant
- 2015-12-22 UY UY0001036470A patent/UY36470A/es not_active Application Discontinuation
-
2017
- 2017-05-24 GT GT201700107A patent/GT201700107A/es unknown
- 2017-06-07 ZA ZA2017/03905A patent/ZA201703905B/en unknown
- 2017-06-14 DO DO2017000139A patent/DOP2017000139A/es unknown
- 2017-06-15 SA SA517381743A patent/SA517381743B1/ar unknown
- 2017-06-18 IL IL252981A patent/IL252981B/en active IP Right Grant
- 2017-06-20 PH PH12017501160A patent/PH12017501160A1/en unknown
- 2017-06-21 CL CL2017001650A patent/CL2017001650A1/es unknown
- 2017-06-21 NI NI201700081A patent/NI201700081A/es unknown
- 2017-06-21 CO CONC2017/0006174A patent/CO2017006174A2/es unknown
- 2017-07-20 EC ECIEPI201746848A patent/ECSP17046848A/es unknown
-
2018
- 2018-02-14 US US15/896,779 patent/US10487060B2/en active Active
- 2018-04-26 HK HK18105455.7A patent/HK1245793B/zh unknown
-
2019
- 2019-03-15 HR HRP20190514TT patent/HRP20190514T1/hr unknown
- 2019-05-02 CY CY20191100464T patent/CY1121692T1/el unknown
- 2019-10-15 US US16/653,668 patent/US10941117B2/en active Active
- 2019-12-18 JP JP2019227801A patent/JP2020063278A/ja active Pending
-
2021
- 2021-01-05 US US17/141,902 patent/US11718588B2/en active Active
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CU20170085A7 (es) | Derivados de imidazolidindiona para el tratamiento de la osteoartritis | |
| UY35975A (es) | Macrociclos con grupos p2? heterocíclicos como inhibidores del factor xia | |
| CL2017002483A1 (es) | Compuestos heterocíclicos como inhibidores de lsd1 | |
| SV2017005487A (es) | Derivados de 4h-pirrol[3,2-c]piridin-4-ona | |
| UY35972A (es) | Inhibidores macrocíclicos de fxia que tienen grupos heterocíclicos | |
| UY36170A (es) | Compuestos de dihidroisoquinolinona sustituida | |
| UY34960A (es) | Dihidropiridona p1 como inhibidores del factor xia | |
| UY36244A (es) | Derivados de la pirimidinona como inhibidores del factor xia y/o de la calicreína plasmática y composiciones farmacéuticas que los contienen | |
| DOP2015000201A (es) | Compuestos de azabencimidazol como inhibidores de pde4 isoenzimas para el tratamiento del snc y otros trastornos | |
| ECSP17064695A (es) | Compuestos y composiciones de alfa-cinamida como inhibidores de hdac8 | |
| ECSP15045801A (es) | Inhibidores de la phd de 6(5hidroxi1hpirazol1il)nicotinamida | |
| UY34959A (es) | Dihidropiridona p1 como inhibidores del factor xia | |
| UY34657A (es) | ?derivados macrocíclicos para el tratamiento de enfermedades?. | |
| DOP2017000278A (es) | Piridinas sustituidas y método de uso | |
| GT201400063A (es) | Benzilindazoles sustituidos para uso como inhibidores de la quinasa bub1 en el tratamiento de enfermedades hiperproliferativas | |
| CU24410B1 (es) | Benzimidazol-2-aminas como inhibidores de midh1 | |
| CU24263B1 (es) | Derivados de imidazopiridazinas inhibidores de quinasa akt, útiles para el tratamiento del cáncer | |
| UY34615A (es) | Nuevos compuestos útiles para el tratamiento de enfermedades degenerativas e inflamatorias. | |
| BR112017001221A2 (pt) | derivados de indolizina que são aplicáveis a doenças neurodegenerativas | |
| UY35785A (es) | Derivados de piperazina sustituidos como moduladores del transportador de la glicina-1 (glyt1) | |
| UY35610A (es) | Derivados de prodroga de triazolpiridinas sustituidas | |
| NI201500172A (es) | Composiciones farmacéuticas | |
| EA201690236A1 (ru) | Производные индол-3-карбинола | |
| ECSP17003149A (es) | Compuestos de dihidroisoquinolinona sustituida | |
| GT201500232A (es) | Compuestos de azabencimidazol como inhibidores de las isozimas pde4 para el tratamiento de cns y otros trastornos |