BR112017013258A2 - Derivados de 5-[(piperazin-1-il)-3-oxo-propil]- imidazolidina-2,4-diona como inibidores de adamts para o tratamento de osteoartrite - Google Patents
Derivados de 5-[(piperazin-1-il)-3-oxo-propil]- imidazolidina-2,4-diona como inibidores de adamts para o tratamento de osteoartriteInfo
- Publication number
- BR112017013258A2 BR112017013258A2 BR112017013258-3A BR112017013258A BR112017013258A2 BR 112017013258 A2 BR112017013258 A2 BR 112017013258A2 BR 112017013258 A BR112017013258 A BR 112017013258A BR 112017013258 A2 BR112017013258 A2 BR 112017013258A2
- Authority
- BR
- Brazil
- Prior art keywords
- treatment
- propil
- diona
- imidazolidin
- piperazin
- Prior art date
Links
- 238000011282 treatment Methods 0.000 title abstract 2
- 239000003112 inhibitor Substances 0.000 title 1
- 201000008482 osteoarthritis Diseases 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 2
- 238000000034 method Methods 0.000 abstract 2
- 210000000845 cartilage Anatomy 0.000 abstract 1
- 230000008355 cartilage degradation Effects 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 229940079593 drug Drugs 0.000 abstract 1
- 230000013632 homeostatic process Effects 0.000 abstract 1
- 230000004968 inflammatory condition Effects 0.000 abstract 1
- 230000002401 inhibitory effect Effects 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 238000011321 prophylaxis Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D233/72—Two oxygen atoms, e.g. hydantoin
- C07D233/76—Two oxygen atoms, e.g. hydantoin with substituted hydrocarbon radicals attached to the third ring carbon atom
- C07D233/78—Radicals substituted by oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/04—Drugs for skeletal disorders for non-specific disorders of the connective tissue
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Physical Education & Sports Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Rheumatology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Immunology (AREA)
- Biomedical Technology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
a presente invenção refere-se compostos de acordo com a fórmula i, em que r, r2, r3a, r3b e cy são como aqui definido. a presente invenção refere-se a compostos de inibição de adamts, métodos para sua produção, composições farmacêuticas compreendendo os mesmos e métodos para a profilaxia e/ou tratamento de condições inflamatórias e/ou doenças envolvendo degradação de cartilagem e/ou rompimento de homeostase de cartilagem.
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EPEP14307129.8 | 2014-12-22 | ||
EP14307129.8 | 2014-12-22 | ||
EP14307129 | 2014-12-22 | ||
PCT/EP2015/080430 WO2016102347A1 (en) | 2014-12-22 | 2015-12-18 | 5-[(piperazin-1-yl)-3-oxo-propyl]-imidazolidine-2,4-dione derivatives as adamts inhibitors for the treatment of osteoarthritis |
Publications (3)
Publication Number | Publication Date |
---|---|
BR112017013258A2 true BR112017013258A2 (pt) | 2018-02-06 |
BR112017013258A8 BR112017013258A8 (pt) | 2022-08-16 |
BR112017013258B1 BR112017013258B1 (pt) | 2023-02-07 |
Family
ID=52345014
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR112017013258-3A BR112017013258B1 (pt) | 2014-12-22 | 2015-12-18 | Derivados de 5-[(piperazin-1-il)-3-oxo-propil]-imidazolidina-2,4-diona como inibidores de adamts para o tratamento de osteoartrite e composição farmacêutica que os compreende |
Country Status (50)
Families Citing this family (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JO3501B1 (ar) * | 2014-12-22 | 2020-07-05 | Servier Lab | مشتقات 5-{(بيبرازين - 1-يل)-3-أوكسو - بروبيل}- إيميدازوليدين-2، 4 - دايون كمثبطات ل adamts لمعالجة هشاشة العظام) |
GB201610055D0 (en) * | 2016-06-09 | 2016-07-27 | Galapagos Nv And Laboratoires Servier Les | Novel compounds and pharmaceutical compositions thereof for the treatment of inflammatory disorders and osteoarthritis |
GB201610056D0 (en) | 2016-06-09 | 2016-07-27 | Galapagos Nv And Laboratoires Servier Les | Novel compounds and pharmaceutical compositions thereof for the treatment of inflammatory disorders and osteoarthritis |
CN107652277A (zh) * | 2017-08-09 | 2018-02-02 | 江苏工程职业技术学院 | 一种依帕列净的制备方法 |
CN107540648A (zh) * | 2017-08-09 | 2018-01-05 | 江苏工程职业技术学院 | 一种达格列净的制备方法 |
WO2021011720A2 (en) * | 2019-07-18 | 2021-01-21 | Avidence Therapeutics, Inc. | Anti-osteoarthritis compounds and related compositions and methods |
CN115052596B (zh) * | 2020-02-04 | 2024-06-14 | 江苏恒瑞医药股份有限公司 | Adamts抑制剂、其制备方法和医药用途 |
WO2021204185A1 (zh) * | 2020-04-10 | 2021-10-14 | 深圳信立泰药业股份有限公司 | 一种苯并[d]氮杂卓类衍生物蛋白聚糖酶2抑制剂及其制备方法和医药用途 |
CN113735825A (zh) * | 2020-05-27 | 2021-12-03 | 成都康弘药业集团股份有限公司 | 1,2,3,6-四氢吡啶类化合物及其制备方法和用途 |
CN113754635B (zh) * | 2020-06-02 | 2024-06-21 | 成都康弘药业集团股份有限公司 | 稠环类化合物及其制备方法和用途 |
WO2022007866A1 (zh) * | 2020-07-09 | 2022-01-13 | 深圳信立泰药业股份有限公司 | 并三环类衍生物、其制备方法及其在医药上的应用 |
IL303642A (en) | 2020-12-15 | 2023-08-01 | Galapagos Nv | Solid forms of (5S)-cyclopropyl-5-[3-[(3S)-4-(5,3-difluorophenyl)-3-methyl-piperazin-1-yl]-3-oxo-propyl]imidazolidin-4, 2-Dion |
WO2022212638A1 (en) * | 2021-04-02 | 2022-10-06 | Jiangsu Hengrui Pharmaceuticals Co., Ltd. | Prodrugs of adamts inhibitors, preparation methods and medicinal uses thereof |
TW202321221A (zh) * | 2021-08-03 | 2023-06-01 | 大陸商江蘇恒瑞醫藥股份有限公司 | 抑制adamts-5和/或adamts-4功能的化合物的晶型及其製備方法和應用 |
Family Cites Families (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4556670A (en) * | 1982-12-06 | 1985-12-03 | Pfizer Inc. | Spiro-3-hetero-azolones for treatment of diabetic complications |
HU198212B (en) * | 1984-07-20 | 1989-08-28 | Pfizer | Process for production of spiro-imidasolones |
US5043447A (en) * | 1987-04-24 | 1991-08-27 | Syntex Pharmaceuticals, Ltd. | Substituted imidazolyl-alkyl-piperazine and -diazepine derivatives |
SE0100902D0 (sv) | 2001-03-15 | 2001-03-15 | Astrazeneca Ab | Compounds |
ES2333412T3 (es) | 2001-05-25 | 2010-02-22 | Bristol-Myers Squibb Company | Derivados de hidantoina como inhibidores de metaloproteinasas de matriz. |
GB0405101D0 (en) | 2004-03-06 | 2004-04-07 | Astrazeneca Ab | Compounds |
US7504424B2 (en) * | 2004-07-16 | 2009-03-17 | Schering Corporation | Compounds for the treatment of inflammatory disorders |
PT2650310T (pt) | 2012-04-13 | 2016-09-01 | Rottapharm Biotech Srl | Anticorpo anti-adamts-5, derivados e utilizações dos mesmos |
AR092971A1 (es) * | 2012-10-26 | 2015-05-06 | Lilly Co Eli | Inhibidores de agrecanasa |
AU2014214325B2 (en) | 2013-02-06 | 2018-06-07 | Merck Patent Gmbh | Substituted carboxylic acid derivatives as aggrecanase inhibitors for the treatment of osteoarthritis |
JO3501B1 (ar) | 2014-12-22 | 2020-07-05 | Servier Lab | مشتقات 5-{(بيبرازين - 1-يل)-3-أوكسو - بروبيل}- إيميدازوليدين-2، 4 - دايون كمثبطات ل adamts لمعالجة هشاشة العظام) |
-
2015
- 2015-11-19 JO JOP/2015/0284A patent/JO3501B1/ar active
- 2015-12-14 TW TW104141953A patent/TWI687414B/zh active
- 2015-12-18 RS RS20190497A patent/RS58617B1/sr unknown
- 2015-12-18 AR ARP150104189A patent/AR103170A1/es unknown
- 2015-12-18 ME MEP-2019-92A patent/ME03374B/me unknown
- 2015-12-18 PE PE2017001122A patent/PE20171099A1/es unknown
- 2015-12-18 DK DK15813831.3T patent/DK3237406T3/da active
- 2015-12-18 EA EA201791451A patent/EA030637B1/ru unknown
- 2015-12-18 AU AU2015371400A patent/AU2015371400B2/en active Active
- 2015-12-18 TR TR2019/04158T patent/TR201904158T4/tr unknown
- 2015-12-18 UA UAA201707702A patent/UA122065C2/uk unknown
- 2015-12-18 CA CA2971110A patent/CA2971110C/en active Active
- 2015-12-18 WO PCT/EP2015/080430 patent/WO2016102347A1/en active Application Filing
- 2015-12-18 SI SI201530668T patent/SI3237406T1/sl unknown
- 2015-12-18 US US15/538,393 patent/US9926281B2/en active Active
- 2015-12-18 MY MYPI2017702301A patent/MY189764A/en unknown
- 2015-12-18 BR BR112017013258-3A patent/BR112017013258B1/pt active IP Right Grant
- 2015-12-18 PL PL15813831T patent/PL3237406T3/pl unknown
- 2015-12-18 SG SG11201705030SA patent/SG11201705030SA/en unknown
- 2015-12-18 GE GEAP201514546A patent/GEP20197043B/en unknown
- 2015-12-18 CN CN201580070274.0A patent/CN107108579B/zh active Active
- 2015-12-18 RU RU2017126187A patent/RU2693459C2/ru active
- 2015-12-18 CU CUP2017000085A patent/CU20170085A7/xx unknown
- 2015-12-18 TN TN2017000213A patent/TN2017000213A1/en unknown
- 2015-12-18 KR KR1020177020379A patent/KR20170122720A/ko not_active Application Discontinuation
- 2015-12-18 EP EP15813831.3A patent/EP3237406B1/en active Active
- 2015-12-18 MD MDE20170225T patent/MD3237406T2/ro unknown
- 2015-12-18 NZ NZ732909A patent/NZ732909A/en unknown
- 2015-12-18 ES ES15813831T patent/ES2724989T3/es active Active
- 2015-12-18 JP JP2017551003A patent/JP6636539B2/ja active Active
- 2015-12-18 HU HUE15813831A patent/HUE042840T2/hu unknown
- 2015-12-18 PT PT15813831T patent/PT3237406T/pt unknown
- 2015-12-18 MA MA41238A patent/MA41238B1/fr unknown
- 2015-12-18 LT LTEP15813831.3T patent/LT3237406T/lt unknown
- 2015-12-18 EP EP19154886.6A patent/EP3575294A1/en not_active Withdrawn
- 2015-12-18 MX MX2017008048A patent/MX2017008048A/es active IP Right Grant
- 2015-12-18 CR CR20170248A patent/CR20170248A/es unknown
- 2015-12-22 UY UY0001036470A patent/UY36470A/es not_active Application Discontinuation
-
2017
- 2017-05-24 GT GT201700107A patent/GT201700107A/es unknown
- 2017-06-07 ZA ZA2017/03905A patent/ZA201703905B/en unknown
- 2017-06-14 DO DO2017000139A patent/DOP2017000139A/es unknown
- 2017-06-15 SA SA517381743A patent/SA517381743B1/ar unknown
- 2017-06-18 IL IL252981A patent/IL252981B/en active IP Right Grant
- 2017-06-20 PH PH12017501160A patent/PH12017501160A1/en unknown
- 2017-06-21 NI NI201700081A patent/NI201700081A/es unknown
- 2017-06-21 CL CL2017001650A patent/CL2017001650A1/es unknown
- 2017-06-21 CO CONC2017/0006174A patent/CO2017006174A2/es unknown
- 2017-07-20 EC ECIEPI201746848A patent/ECSP17046848A/es unknown
-
2018
- 2018-02-14 US US15/896,779 patent/US10487060B2/en active Active
- 2018-04-26 HK HK18105455.7A patent/HK1245793B/zh unknown
-
2019
- 2019-03-15 HR HRP20190514TT patent/HRP20190514T1/hr unknown
- 2019-05-02 CY CY20191100464T patent/CY1121692T1/el unknown
- 2019-10-15 US US16/653,668 patent/US10941117B2/en active Active
- 2019-12-18 JP JP2019227801A patent/JP2020063278A/ja active Pending
-
2021
- 2021-01-05 US US17/141,902 patent/US11718588B2/en active Active
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
BR112017013258A2 (pt) | Derivados de 5-[(piperazin-1-il)-3-oxo-propil]- imidazolidina-2,4-diona como inibidores de adamts para o tratamento de osteoartrite | |
PH12017500941A1 (en) | Bile acid derivatives as fxr/tgr5 agonists and methods of use thereof | |
NI201600165A (es) | Inhibidores de desmetilasa 1 específica a lisina | |
PH12016502382A1 (en) | Substituted indazole compounds as irak4 inhibitors | |
EA201792205A1 (ru) | Гетероциклические соединения как ингибиторы lsd1 | |
MY192717A (en) | Bile acid derivatives as fxr/tgr5 agonists and methods of use thereof | |
MX2015013042A (es) | Compuestos organicos. | |
BR112017000816A2 (pt) | compostos inibitórios terapêuticos | |
CO2017009298A2 (es) | Compuestos y composiciones de alfa-cinamida como inhibidores de hdac8 | |
UY35975A (es) | Macrociclos con grupos p2? heterocíclicos como inhibidores del factor xia | |
UY35972A (es) | Inhibidores macrocíclicos de fxia que tienen grupos heterocíclicos | |
BR112016029612A2 (pt) | compostos de di-hidroisoquinolinona substituídos | |
PH12016501462A1 (en) | Neprilysin inhibitors | |
JO3722B1 (ar) | مثبطات 6-(5- هيدروكسي-1h- بيرازول-1- يل) و مشتقات نيكوتيناميد واستخدامها كمثبطات | |
BR112018069147A2 (pt) | composto da fórmula iii, composição farmacêutica, método de inibição da função de fimh e método de tratamento de uma doença mediada por fimh | |
MX2017004618A (es) | Inhibidores de la biosintesis de sulfato de heparano para el tratamiento de enfermedades. | |
EA201691670A1 (ru) | Тетразолонзамещенные дигидропиридиноновые ингибиторы mgat2 | |
MX2017007377A (es) | Compuestos organicos. | |
BR112018001451A2 (pt) | compostos úteis para a inibição de ror-gama-t | |
NZ727715A (en) | Novel heterocyclic compounds having prs enzyme inhibitory effect | |
MX371158B (es) | Compuestos inhibidores de pde2. | |
BR112017005859A2 (pt) | inibidores de aldosterona sintase |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
B07D | Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette] |
Free format text: DE ACORDO COM O ARTIGO 229-C DA LEI NO 10196/2001, QUE MODIFICOU A LEI NO 9279/96, A CONCESSAO DA PATENTE ESTA CONDICIONADA A ANUENCIA PREVIA DA ANVISA. CONSIDERANDO A APROVACAO DOS TERMOS DO PARECER NO 337/PGF/EA/2010, BEM COMO A PORTARIA INTERMINISTERIAL NO 1065 DE 24/05/2012, ENCAMINHA-SE O PRESENTE PEDIDO PARA AS PROVIDENCIAS CABIVEIS. |
|
B07E | Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette] | ||
B06U | Preliminary requirement: requests with searches performed by other patent offices: procedure suspended [chapter 6.21 patent gazette] | ||
B25A | Requested transfer of rights approved |
Owner name: GALAPAGOS N.V. (BE) |
|
B06A | Patent application procedure suspended [chapter 6.1 patent gazette] | ||
B09A | Decision: intention to grant [chapter 9.1 patent gazette] | ||
B16A | Patent or certificate of addition of invention granted [chapter 16.1 patent gazette] |
Free format text: PRAZO DE VALIDADE: 20 (VINTE) ANOS CONTADOS A PARTIR DE 18/12/2015, OBSERVADAS AS CONDICOES LEGAIS |