JP2018500271A - 細菌株を含む組成物 - Google Patents
細菌株を含む組成物 Download PDFInfo
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- JP2018500271A JP2018500271A JP2017501389A JP2017501389A JP2018500271A JP 2018500271 A JP2018500271 A JP 2018500271A JP 2017501389 A JP2017501389 A JP 2017501389A JP 2017501389 A JP2017501389 A JP 2017501389A JP 2018500271 A JP2018500271 A JP 2018500271A
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Abstract
Description
本発明の組成物は、エンテロコッカス・ガリナラム種の細菌株を含む。実施例は、この種の細菌が、がんを治療又は予防するために有用であることを実証している。
(i)L−アラビノース、D−リボース、D−キシロース、D−ガラクトース、D−グルコース、D−フルクトース、D−マンノース、N−アセチルグルコサミン、アミグダリン、アルブチン、サリシン、D−セロビオース、D−マルトース、スクロース、D−トレハロース、ゲンチオビオース、D−タガトース及びグルコン酸カリウムの少なくとも1つ(例えば、少なくとも2、3、4、5、6、7、8、9、10、11、12、13、14、15、16、17又は全て)の発酵に対して陽性、並びに/又は
(ii)D−マンニトール、メチル−αD−グルコピラノシド(Methyl-αD-glycopyranoside)、D−ラクトース、デンプン及びL−フコースの少なくとも1つ(例えば、少なくとも2、3、4又は全て)の発酵に対して中間
であり、好ましくは、それらの決定は、API50CHL分析(好ましくは、bioMerieux社のAPI50CHLパネルを使用)による。
(i)マンノース発酵、グルタミン酸デカルボキシラーゼ、アルギニンアリールアミダーゼ、フェニルアラニンアリールアミダーゼ、ピログルタミン酸アリールアミダーゼ、チロシンアリールアミダーゼ、ヒスチジンアリールアミダーゼ及びセリンアリールアミダーゼの少なくとも1つ(例えば、少なくとも2、3、4、5、6、7又は全て)に対して陽性、並びに/又は
(ii)β−ガラクトシダーゼ−6−ホスフェート、β−グルコシダーゼ及びN−アセチル−β−グルコサミニダーゼの少なくとも1つ(例えば、少なくとも2又は全て)に対して中間、並びに/又は
(iii)ラフィノース発酵、プロリンアリールアミダーゼ、ロイシルグリシンアリールアミダーゼ、ロイシンアリールアミダーゼ、アラニンアリールアミダーゼ、グリシンアリールアミダーゼ及びグルタミルグルタミン酸アリールアミダーゼの少なくとも1つ(例えば、少なくとも2、3、4、5、6又は全て)に対して陰性
であり、好ましくは、それらの決定は、炭水化物、アミノ酸及び硝酸塩の代謝アッセイにより、並びにアルカリホスファターゼ活性分析によるものでもよく、より好ましくはRapid ID 32A分析(好ましくは、bioMerieux社のRapid ID 32A系を使用)による。
(i)グリシンアリールアミダーゼ、ラフィノース発酵、プロリンアリールアミダーゼ、及びロイシンアリールアミダーゼの少なくとも1つ(例えば、少なくとも2、3又は4つ全て)に対して陰性であり、例えば、それらの決定は、炭水化物、アミノ酸及び硝酸塩の代謝アッセイにより、好ましくはRapid ID 32A分析(好ましくは、bioMerieux社のRapid ID 32A系を使用)により;並びに/又は
(ii)L−フコースの発酵に対して中間陽性であり、好ましくは、それらの決定は、API50CHL分析(好ましくは、bioMerieux社のAPI50CHLパネルを使用)による。
好ましい実施形態において、本発明の組成物は、がんの治療又は予防に使用するための組成物である。実施例は、本発明の組成物の投与が、いくつかの腫瘍モデルで腫瘍増殖の低減を導くことができることを実証している。
IMMU-132(Immunomedics社製);E7449(Eisai社製);Thermodox(Celsion社製);Cometriq(Exellxis社製);Lonsurf(Taiho Pharmaceuticals社製);Camptosar(Pfizer社製);UFT(Taiho Pharmaceuticals社製);及びTS-1(Taiho Pharmaceuticals社製)。
好ましくは、本発明の組成物は、本発明の細菌株を腸管へ送達及び/又は部分的若しくは全体的に定着させるために胃腸管に投与される。一般に、本発明の組成物は経口により投与されるが、直腸的に、鼻内に、又は頬側若しくは舌下経路を介して投与されてもよい。
一般に、本発明の組成物は、細菌を含む。本発明の好ましい実施形態において、組成物は、フリーズドライ形態で製剤化されている。例えば、本発明の組成物は、本発明の細菌株を含む顆粒又はゼラチンカプセル、例えばハードゼラチンカプセルを含みうる。
本発明に使用するための細菌株は、標準的な微生物学技術、例えば、参照文献Handbook of Microbiological Media, Fourth Edition (2010) Ronald Atlas, CRC Press、Maintaining Cultures for Biotechnology and Industry (1996) Jennie C. Hunter-Cevera, Academic Press、Strobel (2009) Methods Mol Biol. 581:247-61に詳細に記載の技術を使用して培養することができる。
本発明者らは、本発明の細菌株が、がんを治療及び予防するために有用であることを明らかにした。これは、本発明の細菌株が宿主免疫系に与える効果の結果と考えられる。したがって、本発明の組成物は、ワクチン組成物として投与されるとき、がんを予防するためにも有用でありうる。特定のそのような実施形態において、本発明の細菌株は生存している。特定のそのような実施形態において、本発明の細菌株は、腸管に部分的又は全体的に定着することができる。特定のそのような実施形態において、本発明の細菌株は生存しており、腸管に部分的又は全体的に定着することができる。他の特定のそのような実施形態において、本発明の細菌株は、殺傷、不活化又は減弱化されていてもよい。特定のそのような実施形態において、組成物は、ワクチンアジュバントを含んでもよい。特定の実施形態において、組成物は、注射、例えば、皮下注射を介した投与のためのものである。
本発明の実施は、別段の記載がない限り、化学、生化学、分子生物学、免疫学及び薬理学の従来の方法を当該分野の技能の範囲内で利用しうる。そのような技術は、文献において十分に説明されている。例えば、参照文献Gennaro (2000) Remington: The Science and Practice of Pharmacy. 20th edition, ISBN: 0683306472及びMolecular Biology Techniques: An Intensive Laboratory Course, (Ream et al., eds., 1998, Academic Press)、Methods In Enzymology (S. Colowick and N. Kaplan, eds., Academic Press, Inc.)、Handbook of Experimental Immunology, Vols. I IV (D.M. Weir and C.C. Blackwell, eds, 1986, Blackwell Scientific Publications)、Sambrook et al. (2001) Molecular Cloning: A Laboratory Manual, 3rd edition (Cold Spring Harbor Laboratory Press)、Handbook of Surface and Colloidal Chemistry (Birdi, K.S. ed., CRC Press, 1997)、Ausubel et al. (eds) (2002) Short protocols in molecular biology, 5th edition (Current Protocols)、PCR (Introduction to Biotechniques Series), 2nd ed. (Newton & Graham eds., 1997, Springer Verlag)などを参照。
概要
この試験では、本発明による細菌株を含む組成物の有効性を、4種の腫瘍モデルで試験した。
被検物質 − 細菌株#MRX518
リファレンス物質 − 抗CTLA−4抗体(クローン:9H10、カタログ:BE0131、アイソタイプ:シリアンハムスターIgG1、Bioxcell社製)。
・10mLのYCFAを(調製した10mLのE&O lab社製ボトルから)Hungateチューブにピペッティングする
・チューブを密封し、シリンジインプットを使用してCO2でフラッシュし、系を使い切る
・Hungateチューブをオートクレーブする
・冷却されるとき、Hungateチューブに、1mLのグリセロール原液を接種する
・チューブを、静止した37℃インキュベータ内に約16時間置く
・翌日、この継代培養物を1mL取り、10mLのYCFA(事前に加温され、再度フラッシュされたHungateチューブ、全て2連)に接種する
・それらを、静止した37℃インキュベータ内に5〜6時間置く。
使用した細胞株の詳細を下記表に示す:
抗腫瘍活性、EMT6モデル
処置スケジュール − 最初の投与開始を0日目とした。0日目に、Vivo manager(登録商標)ソフトウェア(Biosystemes社製、クテルノン、仏国)を使用して、個々の体重に応じて非移植マウスをランダムに9/8匹の群にした。0日目に、マウスは、媒体(培養培地)又は細菌株を受けた。14日目に、全てのマウスに、下記のようにEMT−6腫瘍細胞を移植した。24日目に、陽性対照群のマウスは、抗CTLA−4抗体処置を受けた。
処置スケジュール−最初の投与開始を0日目とした。0日目に、Vivo manager(登録商標)ソフトウェア(Biosystemes社製、クテルノン、仏国)を使用して、個々の体重に応じて非移植マウスをランダムに9/8匹の7つの群にした。0日目に、マウスは、媒体(培養培地)又は細菌株を受ける。14日目に、全てのマウスに、下記のようにLL/2腫瘍細胞を移植した。27日目に、陽性対照群のマウスは、抗CTLA−4抗体処置を受けた。
処置スケジュール−最初の投与開始を0日目とした。0日目に、Vivo manager(登録商標)ソフトウェア(Biosystemes社製、クテルノン、仏国)を使用して、個々の体重に応じて非移植マウスをランダムに9匹の7つの群にした。0日目に、マウスは、媒体(培養培地)又は細菌株を受けた。14日目に、全てのマウスに、下記のようにHepa1−6腫瘍細胞を移植した。16日目に、陽性対照群のマウスは、抗CTLA−4抗体処置を受けた。
臨床的モニタリング − 腫瘍の長さ及び幅を、週に2回カリパスで測定し、腫瘍の容量を次式により見積もった(Simpson-Herren and Lloyd (1970) Cancer Chemother Rep. 54:143-74):
抗腫瘍活性、EMT6モデル
結果を図1に示す。本発明の細菌株を用いた処置は、両方の陰性対照と比較して、腫瘍容量の明らかな低減を導いた。陽性対照では、予想されたように、腫瘍容量の低減も導かれた。
結果を図2に示す。本発明の細菌株を用いた処置は、両方の陰性対照と比較して、腫瘍容量の明らかな低減を導いた。
結果を図3に示す。未処置陰性対照群は、この群が他の群よりも肝重量が少なかったために、予想されたような態様ではない。しかしながら、媒体陰性対照群及び陽性対照群は、媒体のみで処置したマウスが抗CTLA4抗体で処置したマウスよりも肝臓が大きく、媒体陰性対照群で腫瘍負荷がより大きいことを反映していたために、いずれも予想された態様を示した。本発明の細菌株を用いた治療は、媒体陰性対照群のマウスと比較して肝重量(したがって腫瘍負荷)の明らかな低減を導いた。
細菌MRX518の純粋な培養物をPCR遺伝子分析で試験した。実験には2つのアームがあった:1)MRX518を、ヒト結腸細胞(CaCo2)と共培養して、宿主に対する細菌の効果を調査した、及び2)MRX518を、IL1で刺激したCaCo2細胞と共培養し、炎症環境における細菌の効果を模倣した。両方のシナリオにおける効果は、遺伝子発現分析を通じて評価した。結果を以下に示す。
本明細書に記載の少なくとも1つの細菌株を含む本明細書に記載の組成物を、密封容器中に25℃又は4℃で保存し、容器を30%、40%、50%、60%、70%、75%、80%、90%又は95%の相対湿度を有する雰囲気中に置く。1カ月、2カ月、3カ月、6カ月、1年、1.5年、2年、2.5年又は3年後、標準的プロトコルで決定されるコロニー形成単位で測定される細菌株が、少なくとも50%、60%、70%、80%又は90%残存する。
概要
この試験では、MRX518細菌株単独及びリポ多糖(LPS)との組合せでの、未熟樹状細胞におけるサイトカイン産生に対する効果を試験した。
これらの試験の結果は、図4a〜dで見ることができる。MRX518単独の添加は、陰性対照と比較して、サイトカインIL−6及びTNF−αのレベルの実質的な増加を導く(図4a及びc)。LPS(陽性対照)の添加は、陰性対照と比較して、IL−6及びTNF−αのレベルの増加を導くが、IL−1βについては増加を導かない(図4b)。MRX518とLPSとの組合せは、産生されるIL−1βのレベルの相乗的増加を導いた(図4d)。
MRX518は、未熟樹状細胞におけるIL−6及びTNF−αサイトカイン産生をより高く誘導する能力を有する。LPSとMRX518との組合せは、未熟樹状細胞においてサイトカインIL−1βのレベルを増加させることができる。これらのデータは、MRX518が単独又はLPSとの組合せで、炎症促進によりがんを抑制可能な炎症性サイトカインIL−1β、IL−6及びTNF−αを増加させることができることを示している。MRX518の単独又は組合せでの処置は、腫瘍増殖を制限することのできるサイトカインを誘導することができる。
概要
この試験では、MRX518細菌株単独及びLPSとの組合せでの、単球及びマクロファージについてのモデル細胞株であるTHP−1細胞のサイトカイン産生に対する効果を試験した。
これらの試験の結果は、図5a〜cで見ることができる。LPSなしでのMRX518の添加は、細菌なし及び細菌沈降対照と比較して、IL−1β、IL−6及びTNF−αのサイトカインレベルの増加を導く。LPS及びMRX518の添加は、サイトカイン産生の相乗的増加を導く。
MRX518は、THP−1細胞におけるサイトカイン産生を誘導させる能力を有し、この産生は、LPSの添加により、相乗的に増加させることができる。これらのデータは、MRX518が単独又はLPSとの組合せで、炎症促進によりがんを抑制可能な炎症性サイトカインIL−1β、IL−6及びTNF−αを増加させることができることを示している。MRX518の単独又は組合せでの処置は、腫瘍増殖を制限することのできるサイトカインを誘導することができる。
配列番号1(エンテロコッカス・ガリナラム16S rRNA遺伝子−AF039900)
1 taatacatgc aagtcgaacg ctttttcttt caccggagct tgctccaccg aaagaaaaag
61 agtggcgaac gggtgagtaa cacgtgggta acctgcccat cagaagggga taacacttgg
121 aaacaggtgc taataccgta taacactatt ttccgcatgg aagaaagttg aaaggcgctt
181 ttgcgtcact gatggatgga cccgcggtgc attagctagt tggtgaggta acggctcacc
241 aaggccacga tgcatagccg acctgagagg gtgatcggcc acactgggac tgagacacgg
301 cccagactcc tacgggaggc agcagtaggg aatcttcggc aatggacgaa agtctgaccg
361 agcaacgccg cgtgagtgaa gaaggttttc ggatcgtaaa actctgttgt tagagaagaa
421 caaggatgag agtagaacgt tcatcccttg acggtatcta accagaaagc cacggctaac
481 tacgtgccag cagccgcggt aatacgtagg tggcaagcgt tgtccggatt tattgggcgt
541 aaagcgagcg caggcggttt cttaagtctg atgtgaaagc ccccggctca accggggagg
601 gtcattggaa actgggagac ttgagtgcag aagaggagag tggaattcca tgtgtagcgg
661 tgaaatgcgt agatatatgg aggaacacca gtggcgaagg cggctctctg gtctgtaact
721 gacgctgagg ctcgaaagcg tggggagcga acaggattag ataccctggt agtccacgcc
781 gtaaacgatg agtgctaagt gttggagggt ttccgccctt cagtgctgca gcaaacgcat
841 taagcactcc gcctggggag tacgaccgca aggttgaaac tcaaaggaat tgacgggggc
901 ccgcacaagc ggtggagcat gtggtttaat tcgaagcaac gcgaagaacc ttaccaggtc
961 ttgacatcct ttgaccactc tagagataga gcttcccctt cgggggcaaa gtgacaggtg
1021 gtgcatggtt gtcgtcagct cgtgtcgtga gatgttgggt taagtcccgc aacgagcgca
1081 acccttattg ttagttgcca tcatttagtt gggcactcta gcgagactgc cggtgacaaa
1141 ccggaggaag gtggggatga cgtcaaatca tcatgcccct tatgacctgg gctacacacg
1201 tgctacaatg ggaagtacaa cgagttgcga agtcgcgagg ctaagctaat ctcttaaagc
1261 ttctctcagt tcggattgta ggctgcaact cgcctacatg aagccggaat cgctagtaat
1321 cgcggatcag cacgccgcgg tgaatacgtt cccgggcctt gtacacaccg cccgtcacac
1381 cacgagagtt tgtaacaccc gaagtcggtg aggtaacctt tttggagcca gccgcctaag
1441 gtgggataga tgattggggt gaagtcgtaa caaggtagcc gtatcggaag gtgcggctgg
1501 atcacc
配列番号2(エンテロコッカス・ガリナラムMRX518株の16S rRNAのコンセンサス配列)
TGCTATACATGCAGTCGAACGCTTTTTCTTTCACCGGAGCTTGCTCCACCGAAAGAAAAAGAGTGGCGAACGGGTGAGTAACACGTGGGTAACCTGCCCATCAGAAGGGGATAACACTTGGAAACAGGTGCTAATACCGTATAACACTATTTTCCGCATGGAAGAAAGTTGAAAGGCGCTTTTGCGTCACTGATGGATGGACCCGCGGTGCATTAGCTAGTTGGTGAGGTAACGGCTCACCAAGGCCACGATGCATAGCCGACCTGAGAGGGTGATCGGCCACACTGGGACTGAGACACGGCCCAGACTCCTACGGGAGGCAGCAGTAGGGAATCTTCGGCAATGGACGAAAGTCTGACCGAGCAACGCCGCGTGAGTGAAGAAGGTTTTCGGATCGTAAAACTCTGTTGTTAGAGAAGAACAAGGATGAGAGTAGAACGTTCATCCCTTGACGGTATCTAACCAGAAAGCCACGGCTAACTACGTGCCAGCAGCCGCGGTAATACGTAGGTGGCAAGCGTTGTCCGGATTTATTGGGCGTAAAGCGAGCGCAGGCGGTTTCTTAAGTCTGATGTGAAAGCCCCCGGCTCAACCGGGGAGGGTCATTGGAAACTGGGAGACTTGAGTGCAGAAGAGGAGAGTGGAATTCCATGTGTAGCGGTGAAATGCGTAGATATATGGAGGAACACCAGTGGCGAAGGCGGCTCTCTGGTCTGTAACTGACGCTGAGGCTCGAAAGCGTGGGGAGCGAACAGGATTAGATACCCTGGTAGTCCACGCCGTAAACGATGAGTGCTAAGTGTTGGAGGGTTTCCGCCCTTCAGTGCTGCAGCAAACGCATTAAGCACTCCGCCTGGGGAGTACGACCGCAAGGTTGAAACTCAAAGGAATTGACGGGGGCCCGCACAAGCGGTGGAGCATGTGGTTTAATTCGAAGCAACGCGAAGAACCTTACCAGGTCTTGACATCCTTTGACCACTCTAGAGATAGAGCTTCCCCTTCGGGGGCAAAGTGACAGGTGGTGCATGGTTGTCGTCAGCTCGTGTCGTGAGATGTTGGGTTAAGTCCCGCAACGAGCGCAACCCTTATTGTTAGTTGCCATCATTTAGTTGGGCACTCTAGCGAGACTGCCGGTGACAAACCGGAGGAAGGTGGGGATGACGTCAAATCATCATGCCCCTTATGACCTGGGCTACACACGTGCTACAATGGGAAGTACAACGAGTTGCGAAGTCGCGAGGCTAAGCTAATCTCTTAAAGCTTCTCTCAGTTCGGATTGTAGGCTGCAACTCGCCTACATGAAGCCGGAATCGCTAGTAATCGCGGATCAGCACGCCGCGGTGAATACGTTCCCGGGCCTTGTACACACCGCCCGTCACACCACGAGAGTTTGTAACACCCGAAGTCGGTGAGGTAACCTTTTTGGAGCCAGCCGCCTAAGGTG
配列番号3(MRX518株の染色体の配列)−電子形式配列表参照。
配列番号4(MRX518株のプラスミドの配列)−電子形式配列表参照。
[1] Spor et al. (2011) Nat Rev Microbiol. 9(4):279-90
[2] Eckburg et al. (2005) Science. 10;308(5728):1635-8
[3] Macpherson et al. (2001) Microbes Infect. 3(12):1021-35
[4] Macpherson et al. (2002) Cell Mol Life Sci. 59(12):2088-96
[5] Mazmanian et al. (2005) Cell 15;122(1):107-18
[6] Frank et al. (2007) PNAS 104(34):13780-5
[7] Scanlan et al. (2006) J Clin Microbiol. 44(11):3980-8
[8] Kang et al. (2010) Inflamm Bowel Dis. 16(12):2034-42
[9] Machiels et al. (2013) Gut. 63(8):1275-83
[10] WO 2013/050792
[11] WO 03/046580
[12] WO 2013/008039
[13] WO 2014/167338
[14] Goldin and Gorbach (2008) Clin Infect Dis. 46 Suppl 2:S96-100
[15] Azad et al. (2013) BMJ. 347:f6471
[16] Strickertsson et al. (2014) Genes. 5(3): 726-738
[17] Collins et al. (1984) Int J Syst Evol Microbiol. 34: 220-223
[18] Masco et al. (2003) Systematic and Applied Microbiology, 26:557-563
[19] Srutkova et al. (2011) J. Microbiol. Methods, 87(1):10-6
[20] Haabeth et al. (2012) OncoImmunology 1(1):1146-1152
[21] Lejeune et al. (2006) Cancer Immun. 6:6
[22] Pace et al. (1983) PNAS. 80:8782-6
[23] Sgadari et al. (1996) PNAS. 93:13791-6
[24] Arenberg et al. (1996) J. Exp. Med. 184:981-92
[25] Sgadari et al. (1997) Blood. 89:2635-43
[26] Miyamoto-Shinohara et al. (2008) J. Gen. Appl. Microbiol., 54, 9-24
[27] Cryopreservation and Freeze-Drying Protocols, ed. by Day and McLellan, Humana Press
[28] Leslie et al. (1995) Appl. Environ. Microbiol. 61, 3592-3597
[29] Mitropoulou et al. (2013) J Nutr Metab. (2013) 716861
[30] Kailasapathy et al. (2002) Curr Issues Intest Microbiol. 3(2):39-48
[31] Handbook of Pharmaceutical Excipients, 2nd Edition, (1994), Edited by A Wade and PJ Weller
[32] Remington's Pharmaceutical Sciences, Mack Publishing Co. (A. R. Gennaro edit. 1985)
[33] US 2016/0067188
[34] Handbook of Microbiological Media, Fourth Edition (2010) Ronald Atlas, CRC Press
[35] Maintaining Cultures for Biotechnology and Industry (1996) Jennie C. Hunter-Cevera, Academic Press
[36] Strobel (2009) Methods Mol Biol. 581:247-61
[37] Gennaro (2000) Remington: The Science and Practice of Pharmacy. 20th edition, ISBN: 0683306472
[38] Molecular Biology Techniques: An Intensive Laboratory Course, (Ream et al., eds., 1998, Academic Press)
[39] Methods In Enzymology (S. Colowick and N. Kaplan, eds., Academic Press, Inc.)
[40] Handbook of Experimental Immunology, Vols. I IV (D.M. Weir and C.C. Blackwell, eds, 1986, Blackwell Scientific Publications)
[41] Sambrook et al. (2001) Molecular Cloning: A Laboratory Manual, 3rd edition (Cold Spring Harbor Laboratory Press)
[42] Handbook of Surface and Colloidal Chemistry (Birdi, K.S. ed., CRC Press, 1997)
[43] Ausubel et al. (eds) (2002) Short protocols in molecular biology, 5th edition (Current Protocols)
[44] PCR (Introduction to Biotechniques Series), 2nd ed. (Newton & Graham eds., 1997, Springer Verlag)
[45] Current Protocols in Molecular Biology (F.M. Ausubel et al., eds., 1987) Supplement 30
[46] Smith & Waterman (1981) Adv. Appl. Math. 2: 482-489
[47] Rockwell et al., (1972) J Natl Cancer Inst. 49:735-49
[48] Bertram and Janik (1980) Cancer Lett. 11:63-73
[49] Darlington (1987) Meth Enzymol. 151:19-38
[50] Principe d’ethique de l’experimentation animale, Directive n°2010/63 CEE 22nd September 2010, Decret n°2013-118 1st February 2013
[51] Guide for the Care and Use of Laboratory Animals: Eighth Edition. The National Academies Press; 2011
[52] Simpson-Herren and Lloyd (1970) Cancer Chemother Rep. 54:143-74
[53] Workman et al. (2010) Br. J. Cancer. 102:1555-77
Claims (25)
- がんを治療又は予防する方法に使用するための、配列番号2と少なくとも95%同一である16s rRNA配列を有する細菌株を含む組成物。
- エンテロコッカス・ガリナラム種の細菌株を含む、請求項1に記載の使用のための組成物。
- 細菌株が、配列番号3の少なくとも90%にわたり配列番号3と少なくとも95%の配列同一性を有する染色体を有する、請求項1又は2に記載の使用のための組成物。
- 肺がん、乳がん、肝臓がん又は結腸がんを治療又は予防する方法に使用するための、請求項1〜3のいずれかに記載の組成物。
- 腫瘍サイズを低減させる、腫瘍増殖を低減させる、転移を予防する、又は血管新生を予防する方法に使用するための、請求項1〜4のいずれかに記載の組成物。
- 細菌株が、エンテロコッカス・ガリナラムの細菌株の16s rRNA配列と少なくとも95%、96%、97%、98%、99%、99.5%又は99.9%同一である16s rRNA配列を有する、請求項1〜5のいずれかに記載の組成物。
- 細菌株が、配列番号1又は2と少なくとも95%、96%、97%、98%、99%、99.5%又は99.9%同一である16s rRNA配列を有する、請求項1〜6のいずれかに記載の組成物。
- 細菌株が、配列番号2と少なくとも95%、96%、97%、98%、99%、99.5%若しくは99.9%同一である16s rRNA配列を有するか、或いは
細菌株が、配列番号2によって表される16s rRNA配列を有する、
請求項7に記載の組成物。 - 経口投与用である、請求項1〜8のいずれかに記載の組成物。
- 1又は2以上の薬学的に許容される賦形剤又は担体を含む、請求項1〜9のいずれかに記載の組成物。
- 細菌株が凍結乾燥されている、請求項1〜10のいずれかに記載の組成物。
- 細菌株が生存しており、腸管に部分的又は全体的に定着することができる、請求項1〜11のいずれかに記載の組成物。
- エンテロコッカス・ガリナラムの単一株を含む、請求項1〜12のいずれかに記載の組成物。
- 微生物コンソーシアの一部としてエンテロコッカス・ガリナラム細菌株を含む、請求項1〜13のいずれかに記載の組成物。
- 請求項1〜5のいずれかに記載の使用のための、請求項1〜14のいずれかに記載の組成物を含む食品。
- 請求項1〜5のいずれかに記載の使用のための、請求項1〜14のいずれかに記載の組成物を含むワクチン組成物。
- がんを治療又は予防する方法であって、配列番号2と少なくとも95%同一である16s rRNA配列を有する細菌株を含む組成物を、それを必要とする患者に投与することを含む、前記方法。
- がんを治療又は予防する方法であって、それを必要とする患者にエンテロコッカス・ガリナラム種の細菌株を含む組成物を投与することを含む、前記方法。
- 受託番号NCIMB42488で寄託されたエンテロコッカス・ガリナラム株又はその派生物の細胞。
- 請求項19に記載の細胞を含む組成物。
- 薬学的に許容される担体又は賦形剤を含む、請求項20に記載の組成物。
- 受託番号NCIMB42488で寄託されたエンテロコッカス・ガリナラム株又はその派生物の生物学的に純粋な培養物。
- 治療に使用するための、受託番号NCIMB42488で寄託されたエンテロコッカス・ガリナラム株又はその派生物の細胞。
- 請求項1〜5のいずれかに規定の方法に使用するための、請求項23に記載の細胞。
- エンテロコッカス・ガリナラム種の1又は2以上の細菌株を含み、他の種の細菌を含有していない又はごく微量の若しくは生物学的に無関係な量の別の種の細菌のみを含む、治療に使用するための組成物。
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Cited By (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2021510688A (ja) * | 2018-01-19 | 2021-04-30 | フォーディー ファーマ リサーチ リミテッド4D Pharma Research Limited | がんを処置または予防するための併用療法 |
JP2021516216A (ja) * | 2018-01-19 | 2021-07-01 | フォーディー ファーマ リサーチ リミテッド4D Pharma Research Limited | がんを処置または予防するための併用療法 |
JP2021516662A (ja) * | 2018-01-19 | 2021-07-08 | フォーディー ファーマ リサーチ リミテッド4D Pharma Research Limited | がんを処置または予防するための併用療法 |
JP2021516661A (ja) * | 2018-01-19 | 2021-07-08 | フォーディー ファーマ リサーチ リミテッド4D Pharma Research Limited | がんを処置または予防するための併用療法 |
JP2021518414A (ja) * | 2018-03-19 | 2021-08-02 | フォーディー ファーマ リサーチ リミテッド4D Pharma Research Limited | 細菌株を含む組成物 |
Families Citing this family (47)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB201112091D0 (en) | 2011-07-14 | 2011-08-31 | Gt Biolog Ltd | Bacterial strains isolated from pigs |
GB201117313D0 (en) | 2011-10-07 | 2011-11-16 | Gt Biolog Ltd | Bacterium for use in medicine |
GB201306536D0 (en) | 2013-04-10 | 2013-05-22 | Gt Biolog Ltd | Polypeptide and immune modulation |
HUE037476T2 (hu) | 2014-12-23 | 2018-08-28 | 4D Pharma Res Ltd | Pirin polipeptid és immunmodulálás |
EP3065748B1 (en) | 2014-12-23 | 2017-11-22 | 4D Pharma Research Limited | A bacteroides thetaiotaomicron strain and its use in reducing inflammation |
KR102138209B1 (ko) | 2015-05-06 | 2020-07-28 | 스니프르 테크놀로지스 리미티드 | 미생물 개체군 변경 및 미생물군 변형 |
EP3307288B1 (en) | 2015-06-15 | 2019-07-24 | 4D Pharma Research Limited | Compositions comprising bacterial strains |
PL3240554T3 (pl) | 2015-06-15 | 2020-02-28 | 4D Pharma Research Limited | Blautia stercosis i wexlerae do stosowania w leczeniu chorób zapalnych i autoimmunologicznych |
MA41060B1 (fr) | 2015-06-15 | 2019-11-29 | 4D Pharma Res Ltd | Compositions comprenant des souches bactériennes |
RS63089B1 (sr) | 2015-06-15 | 2022-04-29 | 4D Pharma Res Ltd | Kompozicije koje sadrže bakterijske sojeve |
MA41010B1 (fr) | 2015-06-15 | 2020-01-31 | 4D Pharma Res Ltd | Compositions comprenant des souches bactériennes |
GB201520497D0 (en) | 2015-11-20 | 2016-01-06 | 4D Pharma Res Ltd | Compositions comprising bacterial strains |
MA41013B1 (fr) | 2015-11-20 | 2018-07-31 | 4D Pharma Res Ltd | Compositions comprenant des souches bactériennes |
GB201520638D0 (en) | 2015-11-23 | 2016-01-06 | 4D Pharma Res Ltd | Compositions comprising bacterial strains |
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PT3313423T (pt) | 2016-03-04 | 2019-07-10 | 4D Pharma Plc | Composições que compreendem a estirpe blautia bacteriana para tratar a hipersensibilidade visceral |
GB201612191D0 (en) | 2016-07-13 | 2016-08-24 | 4D Pharma Plc | Compositions comprising bacterial strains |
US11786562B2 (en) * | 2016-04-19 | 2023-10-17 | Genome Research Limited | Bacteriotherapy |
GB201609811D0 (en) | 2016-06-05 | 2016-07-20 | Snipr Technologies Ltd | Methods, cells, systems, arrays, RNA and kits |
US9999641B2 (en) | 2016-06-14 | 2018-06-19 | Vedanta Biosciences, Inc. | Treatment of clostridium difficile infection |
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GB201621123D0 (en) | 2016-12-12 | 2017-01-25 | 4D Pharma Plc | Compositions comprising bacterial strains |
EP3606325A4 (en) | 2017-04-03 | 2021-01-20 | Gusto Global, LLC | RATIONAL DESIGN OF BIOTHERAPEUTICS BASED ON MICROBES |
PT3630136T (pt) | 2017-05-22 | 2021-06-11 | 4D Pharma Res Ltd | Composições que compreendem estirpes bacterianas |
MA41708A (fr) * | 2017-05-24 | 2020-04-08 | 4D Pharma Res Ltd | Compositions comprenant des souches bactériennes |
HRP20220747T1 (hr) | 2017-06-14 | 2022-10-14 | 4D Pharma Research Limited | Pripravci koji sadrže bakterijske sojeve |
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WO2019149859A1 (en) * | 2018-01-31 | 2019-08-08 | Universität Basel | Gut commensal bacteria for treatment of human colorectal cancer |
US10760075B2 (en) | 2018-04-30 | 2020-09-01 | Snipr Biome Aps | Treating and preventing microbial infections |
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US20190388344A1 (en) * | 2018-06-22 | 2019-12-26 | Probiotech Llc | Method to Improve The Health Of The Microbiome In A Human Gastrointestinal System and Multi-Chamber Probiotic Delivery Products Therefor |
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EP3839039A1 (en) | 2019-12-16 | 2021-06-23 | 4D Pharma Research Limited | Providing bacterial biomass with improved storage stability |
TW202220639A (zh) | 2020-08-06 | 2022-06-01 | 英商4D製藥有限公司 | 凍乾方法 |
KR20220028425A (ko) | 2020-08-28 | 2022-03-08 | 주식회사 리비옴 | 항종양 세균 균주, 및 이를 이용한 조성물 및 방법 |
CA3193310A1 (en) | 2020-08-28 | 2022-03-03 | Liveome Inc. | Antitumor bacterial strain, and composition and method using same |
CA3200126A1 (en) | 2020-11-26 | 2022-06-02 | Christophe Rene Leonard CARITE | Process |
CN112779350A (zh) * | 2021-02-07 | 2021-05-11 | 四川农业大学 | 与小麦小穗粒数QTLQGns.sicau-2D紧密连锁的分子标记及其应用 |
CN113604563B (zh) * | 2021-06-02 | 2022-07-26 | 武汉艾米森生命科技有限公司 | 一种肝癌诊断或辅助诊断的核酸组合、检测试剂盒及其应用 |
CN113481185B (zh) * | 2021-08-05 | 2022-12-02 | 云南师范大学 | 一种耐盐β-半乳糖苷酶GalNC2-13及其制备方法和应用 |
WO2023072968A1 (en) * | 2021-10-25 | 2023-05-04 | 4D Pharma Research Ltd | Compositions comprising bacterial strains |
CN116574160B (zh) * | 2023-05-10 | 2024-06-28 | 华中农业大学 | 一种猪链球菌抗原蛋白及其应用 |
Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH08259450A (ja) * | 1995-03-17 | 1996-10-08 | Nichinichi Seiyaku Kk | インターフェロン産生増強剤 |
JP2007116991A (ja) * | 2005-10-28 | 2007-05-17 | Eternal Light General Institute Inc | 機能性食品 |
Family Cites Families (359)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
NL154598B (nl) | 1970-11-10 | 1977-09-15 | Organon Nv | Werkwijze voor het aantonen en bepalen van laagmoleculire verbindingen en van eiwitten die deze verbindingen specifiek kunnen binden, alsmede testverpakking. |
US3817837A (en) | 1971-05-14 | 1974-06-18 | Syva Corp | Enzyme amplification assay |
US3939350A (en) | 1974-04-29 | 1976-02-17 | Board Of Trustees Of The Leland Stanford Junior University | Fluorescent immunoassay employing total reflection for activation |
US3996345A (en) | 1974-08-12 | 1976-12-07 | Syva Company | Fluorescence quenching with immunological pairs in immunoassays |
US4275149A (en) | 1978-11-24 | 1981-06-23 | Syva Company | Macromolecular environment control in specific receptor assays |
US4277437A (en) | 1978-04-05 | 1981-07-07 | Syva Company | Kit for carrying out chemically induced fluorescence immunoassay |
US4366241A (en) | 1980-08-07 | 1982-12-28 | Syva Company | Concentrating zone method in heterogeneous immunoassays |
NL8300698A (nl) | 1983-02-24 | 1984-09-17 | Univ Leiden | Werkwijze voor het inbouwen van vreemd dna in het genoom van tweezaadlobbige planten; agrobacterium tumefaciens bacterien en werkwijze voor het produceren daarvan; planten en plantecellen met gewijzigde genetische eigenschappen; werkwijze voor het bereiden van chemische en/of farmaceutische produkten. |
US4816567A (en) | 1983-04-08 | 1989-03-28 | Genentech, Inc. | Recombinant immunoglobin preparations |
US4683202A (en) | 1985-03-28 | 1987-07-28 | Cetus Corporation | Process for amplifying nucleic acid sequences |
DK122686D0 (da) | 1986-03-17 | 1986-03-17 | Novo Industri As | Fremstilling af proteiner |
FR2613624B1 (fr) | 1987-04-10 | 1990-11-23 | Roussy Inst Gustave | Composition pharmaceutique, administrable par voie orale, destinee a reduire les effets des b-lactamines |
DE68928665T2 (de) | 1988-08-02 | 1998-11-12 | Gastro Services Pty Ltd | Behandlung von gastro-intestinalen krankheiten |
US5443826A (en) | 1988-08-02 | 1995-08-22 | Borody; Thomas J. | Treatment of gastro-intestinal disorders with a fecal composition or a composition of bacteroides and E. Coli |
JP2802097B2 (ja) * | 1989-05-31 | 1998-09-21 | 財団法人微生物化学研究会 | 新規な制癌抗生物質mi43―37f11及びその製造法 |
KR100225087B1 (ko) | 1990-03-23 | 1999-10-15 | 한스 발터라벤 | 피타아제의 식물내 발현 |
ES2068586T5 (es) | 1990-05-09 | 2004-12-01 | Novozymes A/S | Una preparacion de celulasa que comprende una enzima endoglucanasa. |
JP2859450B2 (ja) | 1991-01-31 | 1999-02-17 | 富士写真フイルム株式会社 | 画像記録装置及び画像記録方法 |
GB9107305D0 (en) | 1991-04-08 | 1991-05-22 | Unilever Plc | Probiotic |
EP0581171B1 (en) | 1992-07-20 | 1998-02-04 | Kabushiki Kaisha Yakult Honsha | Species-specific oligonucleotides for bifidobacteria and a method of detection using the same |
DK0673429T3 (da) | 1992-12-10 | 2002-10-07 | Dsm Nv | Fremstilling af heterologe proteiner i filamentøse svampe |
US5741665A (en) | 1994-05-10 | 1998-04-21 | University Of Hawaii | Light-regulated promoters for production of heterologous proteins in filamentous fungi |
US5599795A (en) | 1994-08-19 | 1997-02-04 | Mccann; Michael | Method for treatment of idiopathic inflammatory bowel disease (IIBD) |
AUPM823094A0 (en) | 1994-09-16 | 1994-10-13 | Goodman Fielder Limited | Probiotic compositions |
AUPM864894A0 (en) | 1994-10-07 | 1994-11-03 | Borody, Thomas Julius | Treatment of bowel-dependent neurological disorders |
RU2078815C1 (ru) | 1995-01-17 | 1997-05-10 | Московский научно-исследовательский институт эпидемиологии и микробиологии им.Г.Н.Габричевского | Штамм бактерий bifidobacterium breve, используемый для получения бактерийных лечебно-профилактических бифидосодержащих препаратов |
US6861053B1 (en) | 1999-08-11 | 2005-03-01 | Cedars-Sinai Medical Center | Methods of diagnosing or treating irritable bowel syndrome and other disorders caused by small intestinal bacterial overgrowth |
AUPN698495A0 (en) | 1995-12-06 | 1996-01-04 | Pharma Pacific Pty Ltd | Improved therapeutic formulation and method |
SE508045C2 (sv) | 1996-02-26 | 1998-08-17 | Arla Ekonomisk Foerening | Adhesionsinhibitorer, preparat innehållande desamma och förfarande för framställning därav |
AUPN881396A0 (en) | 1996-03-20 | 1996-04-18 | Arnott's Biscuits Limited | Enhancement of microbial colonization of the gastrointestinal tract |
ATE407700T1 (de) | 1996-03-20 | 2008-09-15 | Univ New South Wales | Veränderung der mikrobenflora im verdauungstrakt |
WO1997035956A1 (en) | 1996-03-27 | 1997-10-02 | Novo Nordisk A/S | Alkaline protease deficient filamentous fungi |
US6033864A (en) | 1996-04-12 | 2000-03-07 | The Regents Of The University Of California | Diagnosis, prevention and treatment of ulcerative colitis, and clinical subtypes thereof, using microbial UC pANCA antigens |
WO1998043081A1 (en) | 1997-03-26 | 1998-10-01 | Ligand Pharmaceuticals Incorporated | Treatment of gastrointestinal disease with ppar modulators |
SE511524C2 (sv) | 1997-06-02 | 1999-10-11 | Essum Ab | Lactobacillus casei rhamnosus-stam samt farmaceutisk beredning för bekämpning av patogena tarmbakterier |
US5925657A (en) | 1997-06-18 | 1999-07-20 | The General Hospital Corporation | Use of PPARγ agonists for inhibition of inflammatory cytokine production |
AUPO758297A0 (en) | 1997-06-27 | 1997-07-24 | Rowe, James Baber | Control of acidic gut syndrome |
EP0904784A1 (en) | 1997-09-22 | 1999-03-31 | N.V. Nutricia | Probiotic nutritional preparation |
US5951977A (en) | 1997-10-14 | 1999-09-14 | The United States Of America, As Represented By The Secretary Of Agriculture | Competitive exclusion culture for swine |
IT1298918B1 (it) | 1998-02-20 | 2000-02-07 | Mendes Srl | Uso di batteri dotati di arginina deiminasi per indurre apoptosi e/o ridurre una reazione infiammatoria e composizioni farmaceutiche |
DE19826928A1 (de) | 1998-06-17 | 1999-12-23 | Novartis Consumer Health Gmbh | Arzneimittel, lebensfähige anaerobe Bakterien enthaltend, die die Sulfatreduktion sulfatreduzierender Bakterien hemmen |
ID29150A (id) | 1999-01-15 | 2001-08-02 | Entpr Ireland Cs | Penggunaan lactobacillus salivarius |
US7090973B1 (en) | 1999-04-09 | 2006-08-15 | Oscient Pharmaceuticals Corporation | Nucleic acid sequences relating to Bacteroides fragilis for diagnostics and therapeutics |
US6417212B1 (en) | 1999-08-27 | 2002-07-09 | Eli Lilly & Company | Modulators of peroxisome proliferator activated receptors |
EP1257176B1 (en) | 2000-02-08 | 2008-04-30 | DSM IP Assets B.V. | Use of acid-stable proteases in animal feed |
FR2808689B1 (fr) | 2000-05-11 | 2004-09-03 | Agronomique Inst Nat Rech | Utilisation de souches acetogenes hydrogenotrophes pour la prevention ou le traitement de troubles digestifs |
US20020013270A1 (en) | 2000-06-05 | 2002-01-31 | Bolte Ellen R. | Method for treating a mental disorder |
AUPQ899700A0 (en) | 2000-07-25 | 2000-08-17 | Borody, Thomas Julius | Probiotic recolonisation therapy |
AU2002226984A1 (en) | 2000-11-27 | 2002-06-03 | Astrazeneca Ab | Method for studying the effects of commensal microflora on mammalian intestine and treatments of gastrointestinal-associated disease based thereon |
DE10101793A1 (de) | 2001-01-17 | 2002-08-01 | Manfred Nilius | Verwendung von SLPI zur Behandlung chronisch-entzündlicher Darmerkrankungen |
EP1227152A1 (en) | 2001-01-30 | 2002-07-31 | Société des Produits Nestlé S.A. | Bacterial strain and genome of bifidobacterium |
KR100437497B1 (ko) | 2001-03-07 | 2004-06-25 | 주식회사 프로바이오닉 | 로타바이러스 및 유해 미생물 억제 활성을 가지는 신규내산성 락토바실러스 루테리 프로바이오-16 및 이를함유하는 생균활성제 |
EP1243273A1 (en) | 2001-03-22 | 2002-09-25 | Societe Des Produits Nestle S.A. | Composition comprising a prebiotic for decreasing infammatory process and abnormal activation of non-specific immune parameters |
ATE463505T1 (de) | 2001-04-20 | 2010-04-15 | Inst Systems Biology | Toll-ähnlichen-rezeptor-5-liganden und verwendungsverfahren |
EP1260227A1 (en) | 2001-05-23 | 2002-11-27 | Societe Des Produits Nestle S.A. | Lipoteichoic acid from lactic acid bacteria and its use to modulate immune responses mediated by gram-negative bacteria, potential pathogenic gram-positive bacteria |
US20030092163A1 (en) | 2001-07-26 | 2003-05-15 | Collins John Kevin | Probiotic bifidobacterium strains |
US20040241149A1 (en) | 2001-09-05 | 2004-12-02 | Claudio De Simone | Use of unmethylatd cpg |
GB0127916D0 (en) | 2001-11-21 | 2002-01-16 | Rowett Res Inst | Method |
US20050037955A1 (en) | 2001-11-27 | 2005-02-17 | Hooper Laura Virginia | Therapeutic protein and treatments |
CA2860702C (en) | 2001-12-17 | 2019-02-26 | Corixa Corporation | Compositions and methods for the therapy and diagnosis of inflammatory bowel disease |
US7101565B2 (en) | 2002-02-05 | 2006-09-05 | Corpak Medsystems, Inc. | Probiotic/prebiotic composition and delivery method |
DE10206995B4 (de) | 2002-02-19 | 2014-01-02 | Orthomol Pharmazeutische Vertriebs Gmbh | Mikronährstoffkombinationsprodukt mit Pro- und Prebiotika |
JP2003261453A (ja) | 2002-03-11 | 2003-09-16 | Nippon Berumu Kk | E.フェカリスからなる抗腫瘍剤及び放射線防護剤 |
EP1565547B2 (en) | 2002-06-28 | 2012-09-19 | Biosearch S.A. | Probiotic strains, a process for the selection of them, compositions thereof, and their use |
US20040005304A1 (en) | 2002-07-08 | 2004-01-08 | Mak Wood, Inc. | Novel compositions and methods for treating neurological disorders and associated gastrointestinal conditions |
GB0307026D0 (en) | 2003-03-27 | 2003-04-30 | Rowett Res Inst | Bacterial supplement |
EP1481681A1 (en) | 2003-05-30 | 2004-12-01 | Claudio De Simone | Lactic acid bacteria combination and compositions thereof |
GB0316915D0 (en) | 2003-07-18 | 2003-08-20 | Glaxo Group Ltd | Compounds |
AU2003247193A1 (en) | 2003-07-23 | 2005-02-04 | M.D.Lab Corp. | Acid tolerant probiotic lactobacillus plantarum probio-38 that can suppress the growth of pathogenic microorganism and tge coronavirus |
US7485325B2 (en) | 2003-08-06 | 2009-02-03 | Gayle Dorothy Swain | Animal food supplement compositions and methods of use |
JP4683881B2 (ja) | 2003-08-27 | 2011-05-18 | 有限会社アーク技研 | 抗腫瘍活性剤 |
US8192733B2 (en) | 2003-08-29 | 2012-06-05 | Cobb & Associates | Probiotic composition useful for dietary augmentation and/or combating disease states and adverse physiological conditions |
US20050163764A1 (en) | 2003-09-22 | 2005-07-28 | Yale University | Treatment with agonists of toll-like receptors |
GB0323039D0 (en) | 2003-10-01 | 2003-11-05 | Danisco | Method |
PT1675481E (pt) | 2003-10-24 | 2009-01-02 | Nutricia Nv | Composição sinbiótica para bebés |
US20050239706A1 (en) | 2003-10-31 | 2005-10-27 | Washington University In St. Louis | Modulation of fiaf and the gastrointestinal microbiota as a means to control energy storage in a subject |
EP1696941A1 (en) | 2003-12-17 | 2006-09-06 | N.V. Nutricia | Lactic acid producing bacteria and lung function |
ES2235642B2 (es) * | 2003-12-18 | 2006-03-01 | Gat Formulation Gmbh | Proceso de multi-microencapsulacion continuo para la mejora de la estabilidad y almacenamiento de ingredientes biologicamente activos. |
CN1954066A (zh) * | 2004-03-22 | 2007-04-25 | 美国政府健康及人类服务部 | 细胞和病毒灭活 |
WO2005107381A2 (en) | 2004-05-07 | 2005-11-17 | Hans-Gustaf Ljunggren | Use of flagellin as an adjuvant for vaccine |
PE20060426A1 (es) | 2004-06-02 | 2006-06-28 | Schering Corp | DERIVADOS DE ACIDO TARTARICO COMO INHIBIDORES DE MMPs, ADAMs, TACE Y TNF-alfa |
US7638513B2 (en) | 2004-06-02 | 2009-12-29 | Schering Corporation | Compounds for the treatment of inflammatory disorders |
EP1765391B1 (en) | 2004-06-07 | 2013-03-06 | Qu Biologics Inc | Bacterial compositions for the treatment of cancer |
ATE361101T1 (de) | 2004-08-24 | 2007-05-15 | Nutricia Nv | Nahrungszusammensetzung die unverdauliche oligosaccharide enthält |
US20060062773A1 (en) | 2004-09-21 | 2006-03-23 | The Procter & Gamble Company | Compositions for maintaining and restoring normal gastrointestinal flora |
KR100468522B1 (ko) | 2004-10-12 | 2005-01-31 | 주식회사 프로바이오닉 | 코로나바이러스와 돼지 써코바이러스 2형의 생육을 억제하는 신규한 내산성 프로바이오틱 엔테로코커스훼시움 프로바이오-63 |
US20060115465A1 (en) | 2004-10-29 | 2006-06-01 | Macfarlane George | Treatment of gastrointestinal disorders |
ITMI20042189A1 (it) | 2004-11-16 | 2005-02-16 | Anidral Srl | Composizione a base di batteri probiotici e suo uso nella prevenzione e-o nel trattamento di patologie e-o infezioni respiratorie e nel miglioramento della funzionalita' intestinale |
US20060194241A1 (en) | 2005-02-28 | 2006-08-31 | Jan Knol | Lactobacillus specific probes |
WO2006102536A2 (en) | 2005-03-23 | 2006-09-28 | University Of Southern California | Treatment of disease conditions through modulation of hydrogen sulfide produced by small intestinal bacterial overgrowth |
WO2006102350A1 (en) | 2005-03-23 | 2006-09-28 | Washington University In St. Louis | The use of archaea to modulate the nutrient harvesting functions of the gastrointestinal microbiota |
JP2006265212A (ja) | 2005-03-25 | 2006-10-05 | Institute Of Physical & Chemical Research | Il−21産生誘導剤 |
US20100233312A9 (en) | 2005-04-11 | 2010-09-16 | The Procter & Gamble Company | Compositions comprising probiotic and sweetener components |
EP1714660A1 (en) | 2005-04-21 | 2006-10-25 | N.V. Nutricia | Uronic acid and probiotics |
DK1874917T3 (da) | 2005-04-26 | 2012-05-14 | Teagasc Agric Food Dev Authori | Probiotisk sammensætning, der er egnet til dyr |
CN101213297B (zh) | 2005-05-09 | 2013-02-13 | 小野药品工业株式会社 | 程序性死亡-1(pd-1)的人单克隆抗体及单独使用或与其它免疫治疗剂联合使用抗pd-1抗体来治疗癌症的方法 |
US7572474B2 (en) | 2005-06-01 | 2009-08-11 | Mead Johnson Nutrition Company | Method for simulating the functional attributes of human milk oligosaccharides in formula-fed infants |
US8075934B2 (en) | 2008-10-24 | 2011-12-13 | Mead Johnson Nutrition Company | Nutritional composition with improved digestibility |
JP2007084533A (ja) | 2005-08-24 | 2007-04-05 | Prima Meat Packers Ltd | 免疫応答調節組成物及び該組成物を有効成分とする食品 |
US7625704B2 (en) | 2005-08-31 | 2009-12-01 | Fred Hutchinson Cancer Research Center | Methods and compositions for identifying bacteria associated with bacteria vaginosis |
EP1933869B1 (en) | 2005-09-01 | 2009-10-14 | Schering Corporation | Use of il-23 and il-17 antagonists to treat autoimmune ocular inflammatory disease |
US20090028840A1 (en) | 2005-09-23 | 2009-01-29 | Gwangju Institute Of Sciecne And Technology | Compositions For Preventing Or Treating Arthritis Comprising Lactic Acid Bacteria and Collangen As Active Ingredients |
EP1776877A1 (en) | 2005-10-21 | 2007-04-25 | N.V. Nutricia | Method for stimulating the intestinal flora |
WO2007050656A2 (en) | 2005-10-24 | 2007-05-03 | Nestec S.A. | Dietary fiber formulation and method of administration |
US7767420B2 (en) | 2005-11-03 | 2010-08-03 | Momenta Pharmaceuticals, Inc. | Heparan sulfate glycosaminoglycan lyase and uses thereof |
US7553864B2 (en) | 2005-12-01 | 2009-06-30 | Schering Corporation | Compounds for the treatment of inflammatory disorders and microbial diseases |
US8889149B2 (en) | 2006-02-16 | 2014-11-18 | Wayne State University | Use of flagellin to prevent and treat gram negative bacterial infection |
US20080260906A1 (en) | 2006-03-17 | 2008-10-23 | Marko Stojanovic | Compositions comprising probiotic and sweetener components |
JP5031249B2 (ja) | 2006-03-22 | 2012-09-19 | 学校法人北里研究所 | 炎症抑制作用のある菌体含有組成物 |
US20090252708A1 (en) | 2006-05-18 | 2009-10-08 | Biobalance Llc | Biotherapeutic compositions comprising probiotic escherichia coli and uses thereof |
MY147954A (en) | 2006-05-26 | 2013-02-15 | Nestec Sa | Methods of use and nutritional compositions of touchi extract |
CA2654457A1 (en) | 2006-06-06 | 2007-12-13 | Mcgill University | Fermented milk product and use thereof |
TW200819540A (en) | 2006-07-11 | 2008-05-01 | Genelux Corp | Methods and compositions for detection of microorganisms and cells and treatment of diseases and disorders |
AU2007280272A1 (en) | 2006-08-04 | 2008-02-07 | Shs International Ltd | Protein free formula |
WO2008031438A2 (en) | 2006-09-13 | 2008-03-20 | Region Hovedstaden V/Gentofte Hospital | Treatment of asthma, eczema and/or allergy using non-pathogenic organisms |
US20080069861A1 (en) | 2006-09-19 | 2008-03-20 | National Starch And Chemical Investment Holding Corporation | Probiotic/Non-Probiotic Combinations |
ES2895666T3 (es) | 2006-10-27 | 2022-02-22 | Capsugel Belgium Nv | Cápsulas duras de hidroxipropilmetilcelulosa y proceso de fabricación |
WO2008053444A2 (en) | 2006-11-01 | 2008-05-08 | The Procter & Gamble Company | Treating a respiratory condition with bifidobacterium |
PL1920781T3 (pl) | 2006-11-10 | 2015-06-30 | Glycotope Gmbh | Kompozycje zawierające core-1-dodatnie mikroorganizmy i ich zastosowanie w leczeniu lub profilaktyce nowotworów |
WO2008064489A1 (en) | 2006-12-01 | 2008-06-05 | Mcmaster University | Probiotics to inhibit inflammation |
US20100172874A1 (en) | 2006-12-18 | 2010-07-08 | The Washington University | Gut microbiome as a biomarker and therapeutic target for treating obesity or an obesity related disorder |
DE102006062250A1 (de) | 2006-12-22 | 2008-06-26 | Roland Saur-Brosch | Verwendung einer Zusammensetzung aus Mineralstoffen und/oder Vitaminen und gegebenenfalls acetogenen und/oder butyrogenen Bakterien zur oralen oder rektalen Verabreichung für die Behandlung und Vorbeugung von abdominalen Beschwerden |
WO2008083157A2 (en) | 2006-12-29 | 2008-07-10 | Washington University In St. Louis | Altering pgc-1alapha, ampk, fiaf, or the gastrointestinal microbiota as a means to modulate body fat and/or weight loss in a subject |
JP2008195635A (ja) | 2007-02-09 | 2008-08-28 | Crossfield Bio Inc | 馬用乳酸菌製剤 |
EP1958647A1 (en) | 2007-02-15 | 2008-08-20 | Helmholtz-Zentrum für Infektionsforschung GmbH | Pharmaceutical composition with bacteria for tumor treatment |
ATE544457T1 (de) | 2007-02-28 | 2012-02-15 | Mead Johnson Nutrition Co | Verfahren zur behandlung bzw. prävention systemischer entzündungen |
CN101679938B (zh) | 2007-03-28 | 2014-03-19 | 营养健康有限公司 | 益生双歧杆菌菌株 |
US8557233B2 (en) | 2007-03-28 | 2013-10-15 | Alimentary Heath Limited | Probiotic bifidobacterium strains |
EP2147091A4 (en) | 2007-04-24 | 2010-12-08 | Kemin Ind Inc | ANTIBACTERIAL AND ANTIFUNGAL ACTIVITY WITH LACTOBACILLUS JOHNSONII D115 LARGE SPECTRUM |
EP1997499A1 (en) | 2007-05-31 | 2008-12-03 | Puleva Biotech, S.A. | Mammalian milk microorganisms, compositions containing them and their use for the treatment of mastitis |
EP1997907A1 (en) | 2007-06-01 | 2008-12-03 | Friesland Brands B.V. | Bifidobacteria |
EP1997905A1 (en) | 2007-06-01 | 2008-12-03 | Friesland Brands B.V. | Nucleic acid amplification |
EP1997906A1 (en) | 2007-06-01 | 2008-12-03 | Friesland Brands B.V. | Lactobacillus |
WO2008153377A1 (en) | 2007-06-15 | 2008-12-18 | N.V. Nutricia | Nutrition with non-viable bifidobacterium and non-digestible oligosaccharide |
WO2009000899A1 (en) | 2007-06-27 | 2008-12-31 | Laboratorios Ordesa, S.L. | A novel strain of bifidobacterium and active peptides against rotavirus infections |
HUP0700552A2 (en) | 2007-08-27 | 2009-03-30 | Janos Dr Feher | Method and composition inhibiting inflammation |
WO2009030254A1 (en) | 2007-09-04 | 2009-03-12 | Curevac Gmbh | Complexes of rna and cationic peptides for transfection and for immunostimulation |
EP2192909A2 (en) | 2007-10-01 | 2010-06-09 | University College Cork-National University of Ireland, Cork | Modulation of tissue fatty acid composition of a host by human gut bacteria |
EP2203551B1 (en) | 2007-10-20 | 2013-08-21 | Université de Liège | Bifidobacterial species |
WO2009055362A1 (en) | 2007-10-26 | 2009-04-30 | Moore Brenda E | Probiotic compositions and methods for inducing and supporting weight loss |
EP2205642B1 (en) | 2007-11-02 | 2016-01-27 | Momenta Pharmaceuticals, Inc. | Non-anticoagulant polysaccharide compositions |
EP2065048A1 (en) | 2007-11-30 | 2009-06-03 | Institut Pasteur | Use of a L. casei strain, for the preparation of a composition for inhibiting mast cell activation |
EP2898889B1 (en) | 2007-12-07 | 2017-03-22 | N.V. Nutricia | Bifidobacterium for dust mite allergy |
US20100330190A1 (en) | 2007-12-17 | 2010-12-30 | Compans Richard W | Immunogenic compositions and methods of use thereof |
ES2343499B1 (es) | 2007-12-24 | 2011-06-10 | Consejo Superior De Investigaciones Cientificas | Microorganismos para mejorar el estado de salud de individuos con desordenes relacionados con la ingesta de gluten. |
CN101939411A (zh) | 2008-02-06 | 2011-01-05 | 宝洁公司 | 用于提高呼吸病症免疫应答的组合物、方法和试剂盒 |
EP2103226A1 (en) | 2008-03-18 | 2009-09-23 | Friesland Brands B.V. | Long-life probiotic food product |
JP2011519828A (ja) | 2008-04-18 | 2011-07-14 | バクシネート コーポレーション | フラジェリンの欠失変異体と使用方法 |
US8741365B2 (en) | 2008-05-13 | 2014-06-03 | Glycotope Gmbh | Fermentation process |
MX2008006546A (es) | 2008-05-21 | 2009-11-23 | Sigma Alimentos Sa De Cv | Bifidobacteria productora de ácido fólico, composición alimenticia y uso de la bifidobacteria. |
CN101590081A (zh) | 2008-05-28 | 2009-12-02 | 青岛东海药业有限公司 | 凸腹真杆菌和两形真杆菌制剂及其应用 |
CN102940652B (zh) | 2008-05-28 | 2015-03-25 | 青岛东海药业有限公司 | 两形真杆菌制剂及其应用 |
US8586029B2 (en) | 2008-06-04 | 2013-11-19 | Trustees Of Dartmouth College | Prevention or treatment of immune-relevant disease by modification of microfloral populations |
EP2133088A3 (en) | 2008-06-09 | 2010-01-27 | Nestec S.A. | Rooibos and inflammation |
WO2009151315A1 (en) | 2008-06-13 | 2009-12-17 | N.V. Nutricia | Nutritional composition for infants delivered via caesarean section |
WO2009154463A2 (en) | 2008-06-20 | 2009-12-23 | Stichting Top Institute Food And Nutrition | Butyrate as a medicament to improve visceral perception in humans |
EP2138186A1 (en) | 2008-06-24 | 2009-12-30 | Nestec S.A. | Probiotics, secretory IgA and inflammation |
WO2010002241A1 (en) | 2008-06-30 | 2010-01-07 | N.V. Nutricia | Nutritional composition for infants delivered via caesarean section |
KR101017448B1 (ko) | 2008-09-18 | 2011-02-23 | 주식회사한국야쿠르트 | 대장의 건강 증진 효능을 갖는 비피도박테리움 롱검 에이취와이8004 및 이를 유효성분으로 함유하는 제품 |
US8137718B2 (en) | 2008-09-19 | 2012-03-20 | Mead Johnson Nutrition Company | Probiotic infant products |
US20100074870A1 (en) | 2008-09-19 | 2010-03-25 | Bristol-Myers Squibb Company | Probiotic infant products |
KR101057357B1 (ko) | 2008-09-22 | 2011-08-17 | 광주과학기술원 | 유산균 및 콜라겐을 유효성분으로 포함하는 관절염 예방 또는 치료용 약제학적 조성물 및 식품 조성물 |
WO2010036876A2 (en) | 2008-09-25 | 2010-04-01 | New York University | Compositions and methods for characterizing and restoring gastrointestinal, skin, and nasal microbiota |
WO2010037408A1 (en) | 2008-09-30 | 2010-04-08 | Curevac Gmbh | Composition comprising a complexed (m)rna and a naked mrna for providing or enhancing an immunostimulatory response in a mammal and uses thereof |
WO2010037402A1 (en) | 2008-10-02 | 2010-04-08 | Dako Denmark A/S | Molecular vaccines for infectious disease |
WO2010063601A1 (en) | 2008-12-05 | 2010-06-10 | Nestec S.A. | Compositions for use in low-birth weight infants |
BRPI0923171A2 (pt) | 2008-12-19 | 2015-08-11 | Nestec Sa | Prevenção e tratamento da diarréia causada por rotavírus. |
IT1392672B1 (it) | 2009-01-12 | 2012-03-16 | Wyeth Consumer Healthcare S P A | Composizioni comprendenti componenti probiotici e prebiotici e sali minerali, con lactoferrina |
RU2015132478A (ru) | 2009-03-05 | 2015-12-10 | Эббви Инк. | Связывающие il-17 белки |
JP5710876B2 (ja) | 2009-03-26 | 2015-04-30 | クロスフィールドバイオ株式会社 | 新規ビフィドバクテリウム属微生物およびその利用 |
JP6077303B2 (ja) | 2009-05-07 | 2017-02-08 | タト エ リル アングルディアント フランス ソシエテ パ アクシオンス シンプリフィエ | アルファ−(1,2)−分岐アルファ−(1,6)オリゴデキストランを含有する組成物及びアルファ−(1,2)−分岐アルファ−(1,6)オリゴデキストランの製造方法 |
EP2251022A1 (en) | 2009-05-11 | 2010-11-17 | Nestec S.A. | Non-replicating micro-organisms and their immune boosting effect |
EP2251020A1 (en) | 2009-05-11 | 2010-11-17 | Nestec S.A. | Short-time high temperature treatment generates microbial preparations with anti-inflammatory profiles |
JP2012526752A (ja) | 2009-05-11 | 2012-11-01 | ネステク ソシエテ アノニム | ビフィドバクテリウム・ロンガムncc2705(cncmi−2618)及び免疫障害 |
KR20100128168A (ko) | 2009-05-27 | 2010-12-07 | 중앙대학교 산학협력단 | 공액 리놀레산 생산능이 우수한 신규한 균주 |
US20100311686A1 (en) | 2009-06-03 | 2010-12-09 | Kasper Lloyd H | Nutraceutical composition and methods for preventing or treating multiple sclerosis |
WO2010143940A1 (en) | 2009-06-12 | 2010-12-16 | N.V. Nutricia | Synergistic mixture of beta-galacto-oligosaccharides with beta-1,3 and beta-1,4/1,6 linkages |
WO2010147714A1 (en) | 2009-06-16 | 2010-12-23 | The Trustees Of Columbia University In The City Of New York | Autism-associated biomarkers and uses thereof |
WO2011005756A1 (en) | 2009-07-06 | 2011-01-13 | Puretech Ventures, Llc | Delivery of agents targeted to microbiota niches |
EP2456891A4 (en) | 2009-07-24 | 2013-04-03 | Southwest Regional Pcr Llc | DIAGNOSIS, DETECTION, QUANTIFICATION UNIVERSAL MICROBIENS, AND TARGETED THERAPY ON A SAMPLE |
SG178167A1 (en) | 2009-08-18 | 2012-03-29 | Nestec Sa | A nutritional composition comprising bifidobacterium longum strains and reducing food allergy symptoms, especially in infants and children |
US20110053829A1 (en) | 2009-09-03 | 2011-03-03 | Curevac Gmbh | Disulfide-linked polyethyleneglycol/peptide conjugates for the transfection of nucleic acids |
PL2480255T3 (pl) | 2009-09-23 | 2018-07-31 | Thomas Julius Borody | Terapia przewlekłych zakażeń jelitowych |
EP2308498A1 (en) | 2009-09-30 | 2011-04-13 | Nestec S.A. | Administration of Bifidobacterium breve during infancy to prevent inflammation later in life |
US20120238468A1 (en) | 2009-10-05 | 2012-09-20 | Aak Patent B.V. | Methods for diagnosing irritable bowel syndrome |
WO2011044208A1 (en) | 2009-10-06 | 2011-04-14 | Scott Dorfner | Antibiotic formulations providing reduced gastrointentestinal side effects |
CA2779418C (en) | 2009-11-11 | 2018-03-20 | Alimentary Health Limited | Probiotic bifidobacterium strain |
RU2533024C2 (ru) | 2009-12-18 | 2014-11-20 | Хилл`С Пет Ньютришн, Инк. | Композиции кормовых продуктов для домашних животных, включающие пробиотики, способы их получения и применение |
US20150104418A1 (en) | 2014-12-18 | 2015-04-16 | Microbios, Inc. | Bacterial composition |
FR2955774A1 (fr) | 2010-02-02 | 2011-08-05 | Aragan | Preparation destinee a traiter l'exces ponderal et les desordres associes et applications de ladite preparation |
NL2004200C2 (en) | 2010-02-05 | 2011-08-08 | Friesland Brands Bv | Use of sialyl oligosaccharides in weight management. |
NL2004201C2 (en) | 2010-02-05 | 2011-08-08 | Friesland Brands Bv | Use of sialyl oligosaccharides to modulate the immune system. |
IT1398553B1 (it) | 2010-03-08 | 2013-03-01 | Probiotical Spa | Composizione comprendente batteri probiotici per il trattamento di patologie associate con le alterazioni del sistema immunitario. |
JP5737646B2 (ja) | 2010-03-24 | 2015-06-17 | 森下仁丹株式会社 | 抗アレルギー剤 |
WO2011121379A1 (en) | 2010-03-30 | 2011-10-06 | Assistance Publique - Hopitaux De Paris | Use of bifidobacteria for preventing allergy in breastfed infants |
US8951512B2 (en) | 2010-05-04 | 2015-02-10 | New York University | Methods for treating bone disorders by characterizing and restoring mammalian bacterial microbiota |
WO2011149335A1 (en) | 2010-05-25 | 2011-12-01 | N.V. Nutricia | Immune imprinting nutritional composition |
KR20130086155A (ko) | 2010-06-01 | 2013-07-31 | 무어 리서치 엔터프라이지스 엘엘씨 | 박테로이데스로부터의 세포 성분, 그의 조성물, 및 박테로이데스 또는 그의 세포 성분을 이용하는 치료 방법 |
WO2011151941A1 (ja) | 2010-06-04 | 2011-12-08 | 国立大学法人東京大学 | 制御性t細胞の増殖または集積を誘導する作用を有する組成物 |
TWI417054B (zh) | 2010-06-15 | 2013-12-01 | Jen Shine Biotechnology Co Ltd | 新穎糞腸球菌ljs-01及其益生用途 |
EP2397145A1 (en) | 2010-06-18 | 2011-12-21 | Nestec S.A. | L. johnsonii La1, B. longum NCC2705 and immune disorders |
FR2962045B1 (fr) | 2010-07-05 | 2012-08-17 | Bifinove | Complexe macromoleculaire d'origine bacterienne et utilisation dudit complexe moleculaire pour prevenir et traiter les rhumatismes inflammatoires |
TWI401086B (zh) | 2010-07-20 | 2013-07-11 | Univ China Medical | 胚芽乳酸桿菌及其用途 |
KR102157718B1 (ko) | 2010-07-26 | 2020-09-18 | 큐 바이올로직스 인코포레이티드 | 면역원성 소염 조성물 |
AU2011286165B2 (en) | 2010-08-04 | 2016-10-20 | Thomas Julius Borody | Compositions for fecal floral transplantation and methods for making and using them and devices for delivering them |
WO2012024638A2 (en) | 2010-08-20 | 2012-02-23 | New York University | Compositions and methods for treating obesity and related disorders by characterizing and restoring mammalian bacterial microbiota |
KR101250463B1 (ko) | 2010-10-12 | 2013-04-15 | 대한민국 | 신생아 분변에서 분리한 내산소성 비피도박테리움 롱검 비피더스 유산균 및 이를 이용한 프로바이오틱 조성물 |
WO2012055408A1 (en) | 2010-10-27 | 2012-05-03 | Quantibact A/S | Capture of target dna and rna by probes comprising intercalator molecules |
CN102031235B (zh) | 2010-11-09 | 2012-07-25 | 中国农业大学 | 一种粪肠球菌anse228及其应用 |
EP2455092A1 (en) | 2010-11-11 | 2012-05-23 | Nestec S.A. | Non-replicating probiotic micro-organisms protect against upper respiratory tract infections |
US20120128644A1 (en) | 2010-11-24 | 2012-05-24 | Oragenics, Inc. | Use of Bacteria to Treat and Prevent Respiratory Infections |
CN102093967B (zh) | 2010-12-02 | 2013-01-30 | 中国农业科学院特产研究所 | 一株水貂源屎肠球菌及其应用 |
ES2389547B1 (es) | 2010-12-07 | 2013-08-08 | Consejo Superior De Investigaciones Científicas (Csic) | Bifidobacterium cect 7765 y su uso en la prevención y/o tratamiento del sobrepeso, la obesidad y patologías asociadas. |
AU2012205681B2 (en) | 2011-01-10 | 2016-07-28 | Cleveland Biolabs, Inc. | Use of toll-like receptor agonist for treating cancer |
PT2481299T (pt) | 2011-01-31 | 2017-03-08 | Synformulas Gmbh | Estirpes de bifidobacterium bifidum para aplicação em doenças gastrointestinais |
JP5840368B2 (ja) | 2011-02-02 | 2016-01-06 | カルピス株式会社 | 関節炎予防改善用物質 |
PL2672980T3 (pl) | 2011-02-09 | 2018-05-30 | Lavivo Ab | Synbiotyczne kompozycje dla odnowienia i odtworzenia flory bakteryjnej jelita |
EP3610881A1 (en) | 2011-03-09 | 2020-02-19 | Regents Of The University Of Minnesota | Compositions and methods for transplantation of colon microbiota |
BRPI1100857A2 (pt) | 2011-03-18 | 2013-05-21 | Alexandre Eduardo Nowill | agente imunomodulador e suas combinaÇÕes, seu uso e mÉtodo imunoterÁpico para a recontextualizaÇço, reprogramaÇço e reconduÇço do sistema imune em tempo real |
WO2012140636A1 (en) | 2011-04-11 | 2012-10-18 | Alimentary Health Limited | A probiotic formulation |
WO2012142605A1 (en) | 2011-04-15 | 2012-10-18 | Samaritan Health Services | Rapid recolonization deployment agent |
EA201391553A1 (ru) * | 2011-04-20 | 2014-03-31 | Майко Байо, Инк. | Композиция и способ усиления иммунного ответа |
US9567361B2 (en) | 2011-05-13 | 2017-02-14 | Glycosyn LLC | Use of purified 2′-fucosyllactose, 3-fucosyllactose and lactodifucotetraose as prebiotics |
KR20120133133A (ko) | 2011-05-30 | 2012-12-10 | 한국 한의학 연구원 | 생약 추출물 또는 이의 유산균 발효물을 포함하는 호흡기 질환의 예방 또는 치료용 조성물 |
US20140171339A1 (en) | 2011-06-06 | 2014-06-19 | The University Of North Carolina At Chapel Hill | Methods and kits for detecting adenomas, colorectal cancer, and uses thereof |
GB201110095D0 (en) | 2011-06-15 | 2011-07-27 | Danisco | Method of treatment |
JP2013005759A (ja) | 2011-06-24 | 2013-01-10 | Kyodo Milk Industry Co Ltd | マウス腸内菌叢の推測方法 |
US20140128585A1 (en) | 2011-07-07 | 2014-05-08 | Nagaoka Perfumery Co., Ltd. | Fructose absorption inhibitor |
WO2013008102A2 (en) | 2011-07-14 | 2013-01-17 | R.E.D. Laboratories N.V../ S.A. | Methods and compositions for evaluating and/or treating chronic immune diseases |
GB201112091D0 (en) | 2011-07-14 | 2011-08-31 | Gt Biolog Ltd | Bacterial strains isolated from pigs |
US20130022575A1 (en) | 2011-07-19 | 2013-01-24 | Microbial Rx | Systems and methods of replacing intestinal flora |
CN102304483A (zh) | 2011-08-12 | 2012-01-04 | 北京金泰得生物科技股份有限公司 | 一株饲用屎肠球菌及其应用 |
KR101261872B1 (ko) | 2011-08-23 | 2013-05-14 | 대한민국 (식품의약품안전처장) | 장내 미생물 효소복합체 및 이의 제조방법 |
CA2848762C (en) | 2011-09-14 | 2021-07-27 | Queen's University At Kingston | Method for treatment of disorders of the gastrointestinal system |
GB201117313D0 (en) | 2011-10-07 | 2011-11-16 | Gt Biolog Ltd | Bacterium for use in medicine |
EA201490512A1 (ru) | 2011-10-11 | 2014-09-30 | Ачим Байотерапьютикс Аб | Композиции, содержащие культивируемую в анаэробных условиях микробиоту кишечника человека |
CN103082292B (zh) | 2011-11-02 | 2015-03-04 | 深圳华大基因研究院 | 罗斯氏菌(Roseburia)在治疗和预防肥胖相关疾病中的应用 |
CN102373172B (zh) | 2011-11-03 | 2013-03-20 | 北京龙科方舟生物工程技术有限公司 | 一株屎肠球菌及其应用 |
CA2892588A1 (en) | 2011-12-01 | 2013-06-06 | School Corporation, Azabu Veterinary Medicine Educational Institution | Human-derived bacteria that induce proliferation or accumulation of regulatory t cells |
ES2408279B1 (es) * | 2011-12-15 | 2014-09-09 | Universidad De Las Palmas De Gran Canaria | Bacteria acido láctica probiótica |
ITBG20120010A1 (it) | 2012-02-24 | 2013-08-25 | Milano Politecnico | Dispositivo per l'addestramento chirurgico |
ITMI20120471A1 (it) | 2012-03-26 | 2013-09-27 | Giovanni Mogna | Composizione a base di ceppi di batteri bifidobacterium longum in grado di aiutare il prolungamento della vita |
JP5792105B2 (ja) | 2012-03-27 | 2015-10-07 | 森永乳業株式会社 | ラクト−n−ビオースiの製造方法 |
EP2832859B1 (en) | 2012-03-30 | 2018-07-25 | Ajinomoto Co., Inc. | Diabetes-inducible bacterium |
FR2989002B1 (fr) | 2012-04-10 | 2015-05-15 | Beepratte Lab | Compositions a base de probiotiques et d'un complexe beepollen/argile, leur preparation et leurs utilisations en nutrition et therapeutique |
WO2013154826A2 (en) | 2012-04-11 | 2013-10-17 | Nestec Sa | Methods for diagnosing impending diarrhea |
EP2836218A4 (en) | 2012-04-13 | 2015-10-21 | Trustees Boston College | PROBIOTIC COMPOSITIONS AND METHODS OF USE |
GB201206599D0 (en) | 2012-04-13 | 2012-05-30 | Univ Manchester | Probiotic bacteria |
WO2013171515A1 (en) | 2012-05-18 | 2013-11-21 | Genome Research Limited | Methods and groups |
ES2436251B1 (es) | 2012-05-25 | 2014-10-08 | Consejo Superior De Investigaciones Científicas (Csic) | Bacteroides cect 7771 y su uso en la prevención y tratamiento de sobrepeso, obesidad y alteraciones metabólicas e inmunológicas. |
NZ703394A (en) | 2012-06-04 | 2017-01-27 | Centre For Digestive Diseases | Compositions and methods for treating crohn’s disease and related conditions and infections |
CN106620189B (zh) | 2012-06-06 | 2021-11-19 | 上海交通大学 | 改善肠道菌群结构的方法及应用 |
EP2864355B1 (en) | 2012-06-25 | 2016-10-12 | Orega Biotech | Il-17 antagonist antibodies |
CA2877811C (en) | 2012-07-31 | 2019-07-23 | Nestec S.A. | Nutritional composition for promoting musculoskeletal health in patients with inflammatory bowel disease (ibd) |
WO2014019271A1 (en) | 2012-08-01 | 2014-02-06 | Bgi Shenzhen | Biomarkers for diabetes and usages thereof |
KR20150046310A (ko) | 2012-08-29 | 2015-04-29 | 샐릭스 파마슈티컬스 인코포레이티드 | 완화제 조성물 및 변비 및 관련 위장관 질병 및 증상 치료를 위한 방법 |
EP2890808A4 (en) | 2012-08-29 | 2016-09-28 | California Inst Of Techn | DIAGNOSIS AND TREATMENT OF AUTISTICAL DISEASES |
WO2014043593A2 (en) | 2012-09-13 | 2014-03-20 | Massachusetts Institute Of Technology | Programmable drug delivery profiles of tumor-targeted bacteria |
KR101473058B1 (ko) | 2012-09-19 | 2014-12-16 | 주식회사 쎌바이오텍 | 과민성 대장 증후군 예방 또는 치료용 조성물 |
CN103652322B (zh) | 2012-09-21 | 2016-02-10 | 临沂思科生物科技有限公司 | 一种含乳酸菌的复合益生菌饲料添加剂的制备方法 |
EP2904096A1 (en) | 2012-10-03 | 2015-08-12 | Metabogen AB | Identification of a person having risk for atherosclerosis and associated diseases by the person's gut microbiome and the prevention of such diseases |
FR2997091B1 (fr) | 2012-10-22 | 2016-05-06 | Fond Mediterranee Infection | Utilisation d'un compose antioxydant pour la culture de bacteries sensibles a la tension en oxygene |
WO2014067976A1 (en) | 2012-10-30 | 2014-05-08 | Nestec S.A. | Compositions comprising microparticles and probiotics to deliver a synergistic immune effect |
US9839657B2 (en) | 2012-10-30 | 2017-12-12 | Deerland Enzymes, Inc. | Prebiotic compositions comprising one or more types of bacteriophage |
EP3345606A1 (en) | 2012-11-01 | 2018-07-11 | Rijksuniversiteit Groningen | Methods and compositions for stimulating beneficial bacteria in the gastrointestinal tract |
WO2014075745A1 (en) | 2012-11-19 | 2014-05-22 | Université Catholique de Louvain | Use of akkermansia for treating metabolic disorders |
US8906668B2 (en) | 2012-11-23 | 2014-12-09 | Seres Health, Inc. | Synergistic bacterial compositions and methods of production and use thereof |
SG10201704035TA (en) | 2012-11-23 | 2017-06-29 | Seres Therapeutics Inc | Synergistic bacterial compositions and methods of production and use thereof |
US20150297642A1 (en) | 2012-11-26 | 2015-10-22 | Thomas Julius Borody | Compositions for the restoration of a fecal microbiota and methods for making and using them |
MX2015007550A (es) | 2012-12-12 | 2017-02-02 | Broad Inst Inc | Suministro, modificación y optimización de sistemas, métodos y composiciones para la manipulación de secuencias y aplicaciones terapéuticas. |
PT2898075E (pt) | 2012-12-12 | 2016-06-16 | Harvard College | Manipulação e otimização de sistemas, métodos e composições de enzima melhorados para manipulação de sequências |
US8993233B2 (en) | 2012-12-12 | 2015-03-31 | The Broad Institute Inc. | Engineering and optimization of systems, methods and compositions for sequence manipulation with functional domains |
US20140193464A1 (en) | 2013-01-08 | 2014-07-10 | Imagilin Technology, Llc | Effects of probiotics on humans and animals under environmental or biological changes |
EP2951283A4 (en) | 2013-02-04 | 2017-01-25 | Seres Therapeutics, Inc. | Compositions and methods |
KR102222273B1 (ko) | 2013-02-04 | 2021-03-08 | 세레스 테라퓨틱스, 인코포레이티드 | 조성물 및 방법 |
EP2958575B1 (en) | 2013-02-22 | 2019-04-03 | The Regents of The University of California | Composition comprising lactobaccilus johnsonii 456 and its use in treating or preventing diseases |
BR112015020819A2 (pt) | 2013-03-05 | 2017-07-18 | Academisch Ziekenhuis Groningen | uso de faecalibacterium prausnitzii htf-f (dsm 26943) para supressão de inflamação |
US20160040215A1 (en) | 2013-03-14 | 2016-02-11 | Seres Therapeutics, Inc. | Methods for Pathogen Detection and Enrichment from Materials and Compositions |
RU2015140610A (ru) | 2013-03-14 | 2017-04-17 | ТЕРАБАЙОМ, ЭлЭлСи | Направленная доставка в желудочно-кишечный тракт пробиотических микроорганизмов и/или терапевтических средств |
WO2014150094A1 (en) | 2013-03-15 | 2014-09-25 | University Of Florida Research Foundation, Inc. | Butyrogenic bacteria as probiotics to treat clostridium difficile |
AU2014232370B2 (en) | 2013-03-15 | 2018-11-01 | Seres Therapeutics, Inc. | Network-based microbial compositions and methods |
CN103142656A (zh) | 2013-03-18 | 2013-06-12 | 广州知光生物科技有限公司 | 脆弱拟杆菌在制备防治结肠癌组合物中的应用 |
CN103156888A (zh) | 2013-03-18 | 2013-06-19 | 广州知光生物科技有限公司 | 脆弱拟杆菌在制备治疗炎症性肠病组合物中的应用 |
CN103146620A (zh) | 2013-03-25 | 2013-06-12 | 广州知光生物科技有限公司 | 具有益生菌特性的脆弱拟杆菌 |
JP2014196260A (ja) | 2013-03-29 | 2014-10-16 | 公立大学法人奈良県立医科大学 | 慢性閉塞性肺疾患の予防又は治療用組成物 |
GB201306536D0 (en) | 2013-04-10 | 2013-05-22 | Gt Biolog Ltd | Polypeptide and immune modulation |
EP2994161B1 (en) | 2013-05-10 | 2020-10-28 | California Institute of Technology | Probiotic prevention and treatment of colon cancer |
KR102093537B1 (ko) | 2013-06-05 | 2020-04-23 | 리바이오틱스, 인코퍼레이티드 | 미생물상 복원 요법(mrt), 조성물 및 제조방법 |
US9511099B2 (en) | 2013-06-05 | 2016-12-06 | Rebiotix, Inc. | Microbiota restoration therapy (MRT), compositions and methods of manufacture |
US20160120915A1 (en) | 2013-06-10 | 2016-05-05 | New York University | Methods for manipulating immune responses by altering microbiota |
WO2014200334A1 (en) | 2013-06-14 | 2014-12-18 | N.V. Nutricia | Synbiotic composition for treatment of infections in allergic patients |
WO2015003001A1 (en) | 2013-07-01 | 2015-01-08 | The Washington University | Methods for identifying supplements that increase gut colonization by an isolated bacterial species, and compositions derived therefrom |
WO2015003305A1 (zh) | 2013-07-08 | 2015-01-15 | 吉瑞高新科技股份有限公司 | 电子烟盒 |
JP2016530239A (ja) | 2013-07-09 | 2016-09-29 | ピュアテック ベンチャーズ、エルエルシー | 微生物叢由来生物活性分子の組み合わせを含む疾患治療用組成物 |
US10633714B2 (en) | 2013-07-21 | 2020-04-28 | Pendulum Therapeutics, Inc. | Methods and systems for microbiome characterization, monitoring and treatment |
US20160192689A1 (en) | 2013-07-31 | 2016-07-07 | Wikifoods, Inc. | Encapsulated functional food compositions |
CN105658226B (zh) | 2013-08-16 | 2019-05-14 | 港大科桥有限公司 | 使用益生菌治疗癌症的方法和组合物 |
CN103509741B (zh) | 2013-08-22 | 2015-02-18 | 河北农业大学 | 布劳特菌auh-jld56及其在牛蒡苷元转化中的应用 |
US10203329B2 (en) | 2013-09-12 | 2019-02-12 | The Johns Hopkins University | Biofilm formation to define risk for colon cancer |
US10292413B2 (en) | 2013-10-18 | 2019-05-21 | Innovachildfood Ab | Nutritionally balanced composite meal for infants and small children and a method of producing said meal |
PL229020B1 (pl) | 2013-11-13 | 2018-05-30 | Inst Biotechnologii Surowic I Szczepionek Biomed Spolka Akcyjna | Nowy szczep Bifidobacterium breve |
EP2876167A1 (en) * | 2013-11-21 | 2015-05-27 | Institut Gustave Roussy | Microbiota composition, as a marker of responsiveness to chemotherapy, and use of microbial modulators (pre-,pro- or synbiotics) for improving the efficacy of a cancer treatment |
KR102379658B1 (ko) | 2013-11-25 | 2022-03-28 | 세레스 테라퓨틱스, 인코포레이티드 | 상승적 박테리아 조성물 및 그것의 생산 방법 및 용도 |
US9956282B2 (en) | 2013-12-16 | 2018-05-01 | Seres Therapeutics, Inc. | Bacterial compositions and methods of use thereof for treatment of immune system disorders |
CN103981117B (zh) | 2013-12-24 | 2018-10-26 | 北京大伟嘉生物技术股份有限公司 | 一株高抗逆性屎肠球菌及其培养方法和应用 |
CN103981115B (zh) | 2013-12-24 | 2018-10-26 | 北京大伟嘉生物技术股份有限公司 | 一株高抗逆性屎肠球菌及其应用 |
CN103820363B (zh) | 2014-01-27 | 2016-02-24 | 福建省农业科学院生物技术研究所 | 一种屎肠球菌菌粉的制备与应用 |
CN103865846B (zh) | 2014-02-27 | 2016-03-30 | 扬州绿保生物科技有限公司 | 一种屎肠球菌及其制备方法 |
CN103849590B (zh) | 2014-03-25 | 2016-07-06 | 上海交通大学 | 一株耐酸短双歧杆菌BB8dpH及其应用 |
KR101683474B1 (ko) | 2014-03-26 | 2016-12-08 | 주식회사 쎌바이오텍 | 과민성 대장 증후군 예방 또는 치료용 조성물 |
US9783858B2 (en) | 2014-04-02 | 2017-10-10 | Northwestern University | Altered microbiome of chronic pelvic pain |
KR101583546B1 (ko) | 2014-04-09 | 2016-01-11 | 국립암센터 | 유전자 다형성을 이용한 소라페닙 치료에 대한 반응성 예측방법 |
WO2015156419A1 (en) | 2014-04-10 | 2015-10-15 | Riken | Compositions and methods for induction of th17 cells |
CN104195075B (zh) | 2014-08-14 | 2017-04-19 | 生合生物科技股份有限公司 | 一种屎肠球菌ef08及包含它的饲料添加物和饲料 |
WO2015168534A1 (en) | 2014-05-02 | 2015-11-05 | Novogy, Inc. | Therapeutic treatment of gastrointestinal microbial imbalances through competitive microbe displacement |
AU2015257651B2 (en) | 2014-05-08 | 2020-01-23 | Panoptes Pharma Ges.M.B.H. | Compounds for treating ophthalmic diseases and disorders |
CN106687130B (zh) | 2014-08-05 | 2020-01-21 | 深圳华大基因科技有限公司 | 真杆菌属在预防和治疗结直肠癌相关疾病中的用途 |
WO2016033439A2 (en) | 2014-08-28 | 2016-03-03 | Yale University | Compositions and methods for the treating an inflammatory disease or disorder |
WO2016036615A1 (en) | 2014-09-03 | 2016-03-10 | California Institute Of Technology | Microbe-based modulation of serotonin biosynthesis |
CN104546932A (zh) | 2014-09-30 | 2015-04-29 | 深圳华大基因科技有限公司 | 卵形拟杆菌在治疗或预防类风湿性关节炎或其相关疾病中的应用 |
CN104546940A (zh) | 2014-09-30 | 2015-04-29 | 深圳华大基因科技有限公司 | 平常拟杆菌在治疗或预防类风湿性关节炎或其相关疾病中的应用 |
CN104546942A (zh) | 2014-09-30 | 2015-04-29 | 深圳华大基因科技有限公司 | 多氏拟杆菌在治疗或预防类风湿性关节炎或其相关疾病中的应用 |
CN104546935A (zh) | 2014-09-30 | 2015-04-29 | 深圳华大基因科技有限公司 | 多形拟杆菌在治疗或预防类风湿性关节炎或其相关疾病中的应用 |
CN104546933A (zh) | 2014-09-30 | 2015-04-29 | 深圳华大基因科技有限公司 | 粪拟杆菌在治疗或预防类风湿性关节炎或其相关疾病中的应用 |
CN104546934B (zh) | 2014-09-30 | 2019-04-09 | 深圳华大基因科技有限公司 | 粪副拟杆菌在治疗或预防类风湿性关节炎或其相关疾病中的应用 |
US10046030B2 (en) | 2014-10-07 | 2018-08-14 | University Of Virginia Patent Foundation | Compositions and methods for preventing and treating infection |
DK3209308T3 (da) | 2014-10-24 | 2022-10-03 | Evolve Biosystems Inc | Aktiverede bifidobakterier og fremgangsmåder til anvendelse deraf |
EP3212207A4 (en) | 2014-10-30 | 2018-06-13 | California Institute of Technology | Compositions and methods comprising bacteria for improving behavior in neurodevelopmental disorders |
AU2015339290B8 (en) | 2014-10-30 | 2021-08-26 | California Institute Of Technology | Compositions and methods comprising bacteria for improving behavior in neurodevelopmental disorders |
CA2964480A1 (en) | 2014-10-31 | 2016-05-06 | Whole Biome Inc. | Methods and compositions relating to microbial treatment and diagnosis of disorders |
CN104435000A (zh) | 2014-11-12 | 2015-03-25 | 江南大学 | 乳酸菌对支气管哮喘治疗中的应用 |
CN107249609A (zh) | 2014-11-25 | 2017-10-13 | 纪念斯隆-凯特琳癌症中心 | 肠道微生物群和gvhd |
MA41020A (fr) | 2014-11-25 | 2017-10-03 | Evelo Biosciences Inc | Compositions probiotiques et prébiotiques, et leurs procédés d'utilisation pour la modulation du microbiome |
HUE037476T2 (hu) | 2014-12-23 | 2018-08-28 | 4D Pharma Res Ltd | Pirin polipeptid és immunmodulálás |
EP3065748B1 (en) | 2014-12-23 | 2017-11-22 | 4D Pharma Research Limited | A bacteroides thetaiotaomicron strain and its use in reducing inflammation |
CN104560820B (zh) | 2014-12-30 | 2017-10-20 | 杭州师范大学 | 屎肠球菌kq2.6及应用 |
KR20170128247A (ko) | 2015-01-23 | 2017-11-22 | 템플 유니버시티-오브 더 커먼웰쓰 시스템 오브 하이어 에듀케이션 | 암 예방에서 단쇄 지방산의 용도 |
CN105982919A (zh) | 2015-02-26 | 2016-10-05 | 王汉成 | 生物减速剂抗癌技术 |
WO2016139217A1 (en) | 2015-03-04 | 2016-09-09 | Ab-Biotics, S.A. | Composition comprising anaerobically cultivated human intestinal microbiota |
CA2976956A1 (en) | 2015-03-18 | 2016-09-22 | Whole Biome Inc. | Methods and compositions relating to microbial treatment and diagnosis of skin disorders |
US20180078587A1 (en) | 2015-03-18 | 2018-03-22 | Trustees Of Tufts College | Compositions and methods for preventing colorectal cancer |
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EP3307288B1 (en) | 2015-06-15 | 2019-07-24 | 4D Pharma Research Limited | Compositions comprising bacterial strains |
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MA41060B1 (fr) | 2015-06-15 | 2019-11-29 | 4D Pharma Res Ltd | Compositions comprenant des souches bactériennes |
MA41010B1 (fr) | 2015-06-15 | 2020-01-31 | 4D Pharma Res Ltd | Compositions comprenant des souches bactériennes |
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GB201520497D0 (en) | 2015-11-20 | 2016-01-06 | 4D Pharma Res Ltd | Compositions comprising bacterial strains |
MA41013B1 (fr) | 2015-11-20 | 2018-07-31 | 4D Pharma Res Ltd | Compositions comprenant des souches bactériennes |
GB201520638D0 (en) | 2015-11-23 | 2016-01-06 | 4D Pharma Res Ltd | Compositions comprising bacterial strains |
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GB201621123D0 (en) | 2016-12-12 | 2017-01-25 | 4D Pharma Plc | Compositions comprising bacterial strains |
WO2018112363A1 (en) | 2016-12-16 | 2018-06-21 | Evelo Biosciences, Inc. | Methods of treating cancer using parabacteroides |
WO2018112365A2 (en) | 2016-12-16 | 2018-06-21 | Evelo Biosciences, Inc. | Methods of treating colorectal cancer and melanoma using parabacteroides goldsteinii |
MA41708A (fr) | 2017-05-24 | 2020-04-08 | 4D Pharma Res Ltd | Compositions comprenant des souches bactériennes |
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Patent Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH08259450A (ja) * | 1995-03-17 | 1996-10-08 | Nichinichi Seiyaku Kk | インターフェロン産生増強剤 |
JP2007116991A (ja) * | 2005-10-28 | 2007-05-17 | Eternal Light General Institute Inc | 機能性食品 |
Non-Patent Citations (4)
Title |
---|
EUR. FOOD RES. TECHNOL., vol. 228, no. 2, JPN6017045922, 2008, pages 231 - 237, ISSN: 0003692813 * |
JOURNAL OF CLINICAL MICROBIOLOGY, vol. 36, no. 11, JPN6017045919, 1998, pages 3399 - 3407, ISSN: 0003692812 * |
POLISH JOURNAL OF MICROBIOLOGY, vol. 63, no. 4, JPN6017045920, 2014, pages 415 - 422, ISSN: 0003692814 * |
食品工業, vol. 44, no. 6, JPN4004008098, 30 March 2001 (2001-03-30), pages 35 - 39, ISSN: 0003692811 * |
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JP2021516216A (ja) * | 2018-01-19 | 2021-07-01 | フォーディー ファーマ リサーチ リミテッド4D Pharma Research Limited | がんを処置または予防するための併用療法 |
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