JP2018188440A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2018188440A5 JP2018188440A5 JP2018091739A JP2018091739A JP2018188440A5 JP 2018188440 A5 JP2018188440 A5 JP 2018188440A5 JP 2018091739 A JP2018091739 A JP 2018091739A JP 2018091739 A JP2018091739 A JP 2018091739A JP 2018188440 A5 JP2018188440 A5 JP 2018188440A5
- Authority
- JP
- Japan
- Prior art keywords
- composition
- atropine
- ophthalmic
- pharmaceutically acceptable
- acceptable salt
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000000203 mixture Substances 0.000 claims description 35
- 229930003347 Atropine Natural products 0.000 claims description 27
- RKUNBYITZUJHSG-UHFFFAOYSA-N Hyosciamin-hydrochlorid Natural products CN1C(C2)CCC1CC2OC(=O)C(CO)C1=CC=CC=C1 RKUNBYITZUJHSG-UHFFFAOYSA-N 0.000 claims description 27
- RKUNBYITZUJHSG-SPUOUPEWSA-N atropine Chemical compound O([C@H]1C[C@H]2CC[C@@H](C1)N2C)C(=O)C(CO)C1=CC=CC=C1 RKUNBYITZUJHSG-SPUOUPEWSA-N 0.000 claims description 27
- 229960000396 atropine Drugs 0.000 claims description 27
- 238000000034 method Methods 0.000 claims description 14
- 238000009472 formulation Methods 0.000 claims description 12
- 239000000872 buffer Substances 0.000 claims description 8
- VBSTXRUAXCTZBQ-UHFFFAOYSA-N 1-hexyl-4-phenylpiperazine Chemical compound C1CN(CCCCCC)CCN1C1=CC=CC=C1 VBSTXRUAXCTZBQ-UHFFFAOYSA-N 0.000 claims description 3
- JACRWUWPXAESPB-QMMMGPOBSA-N Tropic acid Natural products OC[C@H](C(O)=O)C1=CC=CC=C1 JACRWUWPXAESPB-QMMMGPOBSA-N 0.000 claims description 3
- 239000003755 preservative agent Substances 0.000 claims description 2
- 150000003839 salts Chemical class 0.000 claims 13
- 239000002738 chelating agent Substances 0.000 claims 7
- 239000004034 viscosity adjusting agent Substances 0.000 claims 7
- 239000007864 aqueous solution Substances 0.000 claims 6
- 239000002253 acid Substances 0.000 claims 4
- 239000007853 buffer solution Substances 0.000 claims 4
- 229920000663 Hydroxyethyl cellulose Polymers 0.000 claims 2
- 239000004354 Hydroxyethyl cellulose Substances 0.000 claims 2
- 229920002153 Hydroxypropyl cellulose Polymers 0.000 claims 2
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical group [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 claims 2
- 239000004480 active ingredient Substances 0.000 claims 2
- 230000015556 catabolic process Effects 0.000 claims 2
- 239000001913 cellulose Substances 0.000 claims 2
- 229920002678 cellulose Polymers 0.000 claims 2
- 238000006731 degradation reaction Methods 0.000 claims 2
- 229940061607 dibasic sodium phosphate Drugs 0.000 claims 2
- BNIILDVGGAEEIG-UHFFFAOYSA-L disodium hydrogen phosphate Chemical compound [Na+].[Na+].OP([O-])([O-])=O BNIILDVGGAEEIG-UHFFFAOYSA-L 0.000 claims 2
- 235000019447 hydroxyethyl cellulose Nutrition 0.000 claims 2
- 239000001863 hydroxypropyl cellulose Substances 0.000 claims 2
- 235000010977 hydroxypropyl cellulose Nutrition 0.000 claims 2
- 239000001866 hydroxypropyl methyl cellulose Substances 0.000 claims 2
- 229920003088 hydroxypropyl methyl cellulose Polymers 0.000 claims 2
- 235000010979 hydroxypropyl methyl cellulose Nutrition 0.000 claims 2
- UFVKGYZPFZQRLF-UHFFFAOYSA-N hydroxypropyl methyl cellulose Chemical compound OC1C(O)C(OC)OC(CO)C1OC1C(O)C(O)C(OC2C(C(O)C(OC3C(C(O)C(O)C(CO)O3)O)C(CO)O2)O)C(CO)O1 UFVKGYZPFZQRLF-UHFFFAOYSA-N 0.000 claims 2
- 239000007788 liquid Substances 0.000 claims 2
- 229940045641 monobasic sodium phosphate Drugs 0.000 claims 2
- AJPJDKMHJJGVTQ-UHFFFAOYSA-M sodium dihydrogen phosphate Chemical compound [Na+].OP(O)([O-])=O AJPJDKMHJJGVTQ-UHFFFAOYSA-M 0.000 claims 2
- 239000000243 solution Substances 0.000 claims 2
- 239000007951 isotonicity adjuster Substances 0.000 claims 1
- 239000011780 sodium chloride Substances 0.000 claims 1
- 238000011146 sterile filtration Methods 0.000 claims 1
- 239000012929 tonicity agent Substances 0.000 claims 1
- 150000003627 tricarboxylic acid derivatives Chemical class 0.000 claims 1
- 150000003628 tricarboxylic acids Chemical class 0.000 claims 1
- XLYOFNOQVPJJNP-ZSJDYOACSA-N Heavy water Chemical compound [2H]O[2H] XLYOFNOQVPJJNP-ZSJDYOACSA-N 0.000 description 3
- YZCKVEUIGOORGS-OUBTZVSYSA-N Deuterium Chemical compound [2H] YZCKVEUIGOORGS-OUBTZVSYSA-N 0.000 description 2
- 229910052805 deuterium Inorganic materials 0.000 description 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 2
- 210000004087 cornea Anatomy 0.000 description 1
- 229920006237 degradable polymer Polymers 0.000 description 1
- 230000007062 hydrolysis Effects 0.000 description 1
- 238000006460 hydrolysis reaction Methods 0.000 description 1
- 239000007943 implant Substances 0.000 description 1
- 230000005445 isotope effect Effects 0.000 description 1
- 239000011159 matrix material Substances 0.000 description 1
- 230000002911 mydriatic effect Effects 0.000 description 1
- 229920000642 polymer Polymers 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 230000004515 progressive myopia Effects 0.000 description 1
- 210000003786 sclera Anatomy 0.000 description 1
- 229920003169 water-soluble polymer Polymers 0.000 description 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201762505027P | 2017-05-11 | 2017-05-11 | |
| US62/505,027 | 2017-05-11 |
Related Child Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019129396A Division JP6865476B2 (ja) | 2017-05-11 | 2019-07-11 | 眼科用アトロピン組成物 |
| JP2019129403A Division JP6681502B2 (ja) | 2017-05-11 | 2019-07-11 | 貯蔵安定性液体低用量アトロピン眼科用製剤を調製する方法 |
| JP2019129405A Division JP6681503B2 (ja) | 2017-05-11 | 2019-07-11 | 近視の治療用の治療キット、および、近視の治療のための薬剤の製造におけるアトロピンの使用 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2018188440A JP2018188440A (ja) | 2018-11-29 |
| JP2018188440A5 true JP2018188440A5 (enExample) | 2019-02-07 |
| JP6557379B2 JP6557379B2 (ja) | 2019-08-07 |
Family
ID=64096170
Family Applications (5)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018091739A Active JP6557379B2 (ja) | 2017-05-11 | 2018-05-10 | アトロピン医薬組成物 |
| JP2019129403A Active JP6681502B2 (ja) | 2017-05-11 | 2019-07-11 | 貯蔵安定性液体低用量アトロピン眼科用製剤を調製する方法 |
| JP2019129396A Active JP6865476B2 (ja) | 2017-05-11 | 2019-07-11 | 眼科用アトロピン組成物 |
| JP2019129405A Active JP6681503B2 (ja) | 2017-05-11 | 2019-07-11 | 近視の治療用の治療キット、および、近視の治療のための薬剤の製造におけるアトロピンの使用 |
| JP2021056894A Active JP7332179B2 (ja) | 2017-05-11 | 2021-03-30 | 眼科用アトロピン組成物 |
Family Applications After (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019129403A Active JP6681502B2 (ja) | 2017-05-11 | 2019-07-11 | 貯蔵安定性液体低用量アトロピン眼科用製剤を調製する方法 |
| JP2019129396A Active JP6865476B2 (ja) | 2017-05-11 | 2019-07-11 | 眼科用アトロピン組成物 |
| JP2019129405A Active JP6681503B2 (ja) | 2017-05-11 | 2019-07-11 | 近視の治療用の治療キット、および、近視の治療のための薬剤の製造におけるアトロピンの使用 |
| JP2021056894A Active JP7332179B2 (ja) | 2017-05-11 | 2021-03-30 | 眼科用アトロピン組成物 |
Country Status (23)
| Country | Link |
|---|---|
| US (14) | US10251875B2 (enExample) |
| EP (2) | EP3548000B1 (enExample) |
| JP (5) | JP6557379B2 (enExample) |
| KR (1) | KR102281667B1 (enExample) |
| CN (1) | CN110621298B (enExample) |
| AU (1) | AU2018265257B2 (enExample) |
| CA (1) | CA3063228C (enExample) |
| CL (1) | CL2019003228A1 (enExample) |
| CO (1) | CO2019012893A2 (enExample) |
| CY (1) | CY1124880T1 (enExample) |
| ES (1) | ES2901140T3 (enExample) |
| HR (1) | HRP20212019T1 (enExample) |
| HU (1) | HUE056595T2 (enExample) |
| LT (1) | LT3548000T (enExample) |
| MX (1) | MX392558B (enExample) |
| PH (1) | PH12019502701A1 (enExample) |
| PL (1) | PL3548000T3 (enExample) |
| PT (1) | PT3548000T (enExample) |
| RS (1) | RS62817B1 (enExample) |
| RU (1) | RU2745603C1 (enExample) |
| SG (1) | SG11201910085UA (enExample) |
| SI (1) | SI3548000T1 (enExample) |
| WO (1) | WO2018209051A1 (enExample) |
Families Citing this family (34)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US10154923B2 (en) | 2010-07-15 | 2018-12-18 | Eyenovia, Inc. | Drop generating device |
| WO2016172712A2 (en) | 2015-04-23 | 2016-10-27 | Sydnexis, Inc. | Ophthalmic composition |
| US9421199B2 (en) | 2014-06-24 | 2016-08-23 | Sydnexis, Inc. | Ophthalmic composition |
| US11052094B2 (en) | 2015-05-29 | 2021-07-06 | Sydnexis, Inc. | D2O stabilized pharmaceutical formulations |
| SG11201809822SA (en) * | 2016-05-25 | 2018-12-28 | Singapore Health Serv Pte Ltd | Atropine-containing aqueous composition |
| MX392558B (es) | 2017-05-11 | 2025-03-24 | Vyluma Inc | Composición oftálmica líquida estable, que comprende una solución acuosa con un tampón, un agente de tonicidad, un quelante, un modificador de la viscosidad y atropina; y el uso de la misma para el tratamiento de la miopía. |
| CN115300226A (zh) | 2017-06-10 | 2022-11-08 | 艾诺维亚股份有限公司 | 用于将一体积的流体输送到眼睛的设备 |
| US11554115B2 (en) * | 2018-03-14 | 2023-01-17 | Chia Tai Tianqing Pharmaceutical Group Co., Ltd. | Quinoline derivative for treatment of triple-negative breast cancer |
| WO2019216395A1 (ja) * | 2018-05-11 | 2019-11-14 | 千寿製薬株式会社 | 眼科用組成物 |
| CN110934816B (zh) * | 2018-09-25 | 2022-04-08 | 沈阳兴齐眼科医院有限公司 | 一种提高低浓度阿托品眼用制剂稳定性的方法 |
| WO2020219707A1 (en) * | 2019-04-24 | 2020-10-29 | Allergan, Inc. | Compositions and methods for treatment of ocular conditions |
| WO2021001806A1 (en) * | 2019-07-04 | 2021-01-07 | Ocular Discovery Ltd. | Stable dipyridamole formulations with reduced impurities |
| CN115038414A (zh) | 2019-12-11 | 2022-09-09 | 艾诺维亚股份有限公司 | 用于向眼睛输送流体的系统和装置及使用方法 |
| JP2023505841A (ja) * | 2019-12-16 | 2023-02-13 | シドネキシス，インク． | Ｄ２ｏを含む眼科用組成物 |
| CN110917133A (zh) * | 2019-12-23 | 2020-03-27 | 河北科技大学 | 一种治疗近视的滴眼剂及其制备方法 |
| WO2021226153A1 (en) * | 2020-05-05 | 2021-11-11 | The Procter & Gamble Company | Oral care compositions comprising dicarboxylic acid |
| CN111821259A (zh) * | 2020-07-14 | 2020-10-27 | 艾尔健康眼药(辽宁)有限公司 | 一种眼用药物组合物 |
| CN111840221A (zh) * | 2020-08-25 | 2020-10-30 | 安徽博诺美科生物医药有限公司 | 一种硫酸阿托品滴眼液 |
| WO2022130033A1 (en) * | 2020-12-17 | 2022-06-23 | Sun Pharmaceutical Industries Limited | An aqueous sterile solution of atropine for ophthalmic use |
| EP4308080A4 (en) * | 2021-03-16 | 2025-02-26 | Vyluma Inc. | MULTI-DOSE CONTAINERS FOR OPHTHALMIC COMPOSITIONS |
| EP4088714A1 (en) | 2021-05-10 | 2022-11-16 | Warszawskie Zaklady Farmaceutyczne Polfa S.A. | Ophthalmic pharmaceutical composition comprising atropine |
| EP4088713A1 (en) | 2021-05-10 | 2022-11-16 | Warszawskie Zaklady Farmaceutyczne Polfa S.A. | Ophthalmic pharmaceutical composition comprising atropine |
| CN113440486B (zh) * | 2021-06-02 | 2022-12-20 | 苏州欧康维视生物科技有限公司 | 一种用于预防或治疗眼科疾病的滴眼剂组合物及其制备方法 |
| CN117295491A (zh) * | 2021-09-13 | 2023-12-26 | 安徽欧普视方医药科技有限公司 | 阿托品滴眼液及其制备方法 |
| CN118541148A (zh) | 2021-11-10 | 2024-08-23 | 视觉治疗股份有限公司 | 增强抗老花眼作用的碳酰胆碱制剂 |
| CN114129511A (zh) * | 2021-12-07 | 2022-03-04 | 河南润弘制药股份有限公司 | 一种具有改进稳定性的硫酸阿托品注射液 |
| WO2023152642A1 (en) * | 2022-02-08 | 2023-08-17 | Avaca Pharma Private Limited | Ophthalmic compositions and methods thereof |
| US20230277521A1 (en) * | 2022-03-07 | 2023-09-07 | Harrow Ip, Llc | Extended-release pharmaceutical compositions for treating eye conditions |
| CN114569551A (zh) * | 2022-03-21 | 2022-06-03 | 杭州赫尔斯科技有限公司 | 阿托品滴眼液及其制备方法 |
| WO2023201315A2 (en) * | 2022-04-14 | 2023-10-19 | TearClear Corp. | Ophthalmic agent in preservative removal device |
| CN115177584A (zh) * | 2022-07-14 | 2022-10-14 | 成都市海通药业有限公司 | 一种硫酸阿托品注射液的制备方法 |
| WO2024091789A1 (en) * | 2022-10-26 | 2024-05-02 | Vyluma Inc. | Childhood atropine for myopia progression |
| CN115998692A (zh) * | 2023-02-15 | 2023-04-25 | 苏州欧康维视生物科技有限公司 | 一种阿托品药物产品及其用途 |
| WO2025146828A1 (ja) * | 2024-01-05 | 2025-07-10 | ロート製薬株式会社 | 眼科組成物 |
Family Cites Families (31)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| LU86521A1 (fr) | 1986-07-18 | 1988-02-02 | Oreal | Procede de teinture des cheveux avec des colorants hydroxyquinoniques et des sels metalliques |
| IL85312A (en) | 1988-02-03 | 1991-08-16 | Israel State | Injectable pharmaceutical compositions having improved stability |
| JP2617508B2 (ja) | 1988-02-05 | 1997-06-04 | エーザイ株式会社 | 安定なジフェンヒドラミン含有水溶液 |
| US5460834A (en) * | 1991-12-13 | 1995-10-24 | Alcon Laboratories, Inc. | Combinations of polymers for use in physiological tear compositions |
| US5716952A (en) * | 1992-03-18 | 1998-02-10 | Allergan | Method for reducing intraocular pressure in the mammalian eye by administration of muscarinic antagonists |
| SE9401108D0 (sv) * | 1994-03-31 | 1994-03-31 | Leiras Oy | Ophthalmic composition I |
| US20030129083A1 (en) | 1997-11-26 | 2003-07-10 | Advanced Medical Optics, Inc. | Multi purpose contact lens care compositions including propylene glycol or glycerin |
| US6164282A (en) | 1999-01-27 | 2000-12-26 | Allergan Sales, Inc. | Methods for restoring and/or enhancing accommodation in pseudo phakia |
| EP1301210A2 (en) * | 2000-07-14 | 2003-04-16 | Allergan, Inc. | Compositions containing therapeutically active components having enhanced solubility |
| US20020198209A1 (en) | 2001-05-03 | 2002-12-26 | Allergan Sales Inc. | Compositions having enhanced pharmacokinetic characteristics |
| US8758816B2 (en) | 2004-11-24 | 2014-06-24 | Meda Pharmaceuticals Inc. | Compositions comprising azelastine and methods of use thereof |
| US7851504B2 (en) | 2005-03-16 | 2010-12-14 | Allergan, Inc. | Enhanced bimatoprost ophthalmic solution |
| CN101049287A (zh) | 2006-04-07 | 2007-10-10 | 财团法人长庚纪念医院 | 抑制近视度数增加的低浓度阿托平眼药剂及其制造方法 |
| US20070254914A1 (en) | 2006-05-01 | 2007-11-01 | Non-Profit Organization Chang Gung Memorial Hospital | Low-concentration atropine solution for preventing myopia progression and preparing method thereof |
| JP2007308398A (ja) * | 2006-05-17 | 2007-11-29 | Chang Gung Memorial Hospital | 目薬、及びその製造方法 |
| BRPI0819081A8 (pt) * | 2007-10-08 | 2016-08-30 | Fovea Pharmaceuticals Sa | Formulação oftálmica aquosa, processo para preparar a mesma, e, método para inibir, tratar ou prevenir doenças oculares e doença ou condição relacionada, em um paciente em necessidade de tal tratamento |
| WO2010083129A2 (en) | 2009-01-13 | 2010-07-22 | The Regents Of The University Of California | Implantable delivery vehicle for ocular delivery of muscarinic antagonists |
| EP2464387A4 (en) | 2009-08-12 | 2013-05-15 | Seros Medical Llc | DEUTERATED WATER SOLUTION AND RIBOFLAVIN FOR EXTENDED OXYGEN SINGULET LIFETIME IN THE TREATMENT OF OCULAR TISSUE AND METHOD OF USE |
| WO2012161655A1 (en) | 2011-05-23 | 2012-11-29 | Singapore Health Services Pte Ltd | Composition and/or method for reducing and/or preventing myopia progression comprising atropine |
| WO2014119642A1 (ja) * | 2013-01-31 | 2014-08-07 | 千寿製薬株式会社 | 安定な水性液剤 |
| KR102027663B1 (ko) | 2013-05-06 | 2019-10-01 | 가오슝 창 궁 메모리얼 하스피털 | 약학적 조성물 및 이의 용도 |
| EP3973954A1 (en) * | 2013-10-15 | 2022-03-30 | Pharmathen S.A. | Preservative free pharmaceutical compositions for ophthalmic administration |
| US9421199B2 (en) * | 2014-06-24 | 2016-08-23 | Sydnexis, Inc. | Ophthalmic composition |
| US20160009705A1 (en) | 2014-06-24 | 2016-01-14 | Sydnexis, Inc. | Ophthalmic composition |
| WO2016172712A2 (en) | 2015-04-23 | 2016-10-27 | Sydnexis, Inc. | Ophthalmic composition |
| WO2016013993A1 (en) | 2014-07-25 | 2016-01-28 | Imuneks Farma Llac Sanayi Ve Ticaret A.Ş. | Stable preservative free ophthalmic formulations of opioid antagonists |
| WO2016187426A1 (en) | 2015-05-19 | 2016-11-24 | Amorphex Therapeutics Llc | A device that delivers a sustained low-dose of a myopia-suppressing drug |
| CN107920984A (zh) * | 2015-06-18 | 2018-04-17 | 远视眼治疗有限责任公司 | 储存稳定的组合物以及治疗眼睛屈光不正的方法 |
| SG11201809822SA (en) | 2016-05-25 | 2018-12-28 | Singapore Health Serv Pte Ltd | Atropine-containing aqueous composition |
| MX392558B (es) | 2017-05-11 | 2025-03-24 | Vyluma Inc | Composición oftálmica líquida estable, que comprende una solución acuosa con un tampón, un agente de tonicidad, un quelante, un modificador de la viscosidad y atropina; y el uso de la misma para el tratamiento de la miopía. |
| US11191751B1 (en) | 2020-10-08 | 2021-12-07 | Ads Therapeutics Llc | Topical ophthalmological atropine free base compositions |
-
2018
- 2018-05-10 MX MX2019013218A patent/MX392558B/es unknown
- 2018-05-10 PL PL18798073T patent/PL3548000T3/pl unknown
- 2018-05-10 SI SI201830521T patent/SI3548000T1/sl unknown
- 2018-05-10 WO PCT/US2018/032017 patent/WO2018209051A1/en not_active Ceased
- 2018-05-10 EP EP18798073.5A patent/EP3548000B1/en active Active
- 2018-05-10 ES ES18798073T patent/ES2901140T3/es active Active
- 2018-05-10 PT PT187980735T patent/PT3548000T/pt unknown
- 2018-05-10 US US15/976,279 patent/US10251875B2/en active Active
- 2018-05-10 JP JP2018091739A patent/JP6557379B2/ja active Active
- 2018-05-10 EP EP21205568.5A patent/EP3970694A1/en active Pending
- 2018-05-10 CN CN201880031247.6A patent/CN110621298B/zh active Active
- 2018-05-10 LT LTEPPCT/US2018/032017T patent/LT3548000T/lt unknown
- 2018-05-10 HR HRP20212019TT patent/HRP20212019T1/hr unknown
- 2018-05-10 CA CA3063228A patent/CA3063228C/en active Active
- 2018-05-10 KR KR1020197036249A patent/KR102281667B1/ko active Active
- 2018-05-10 RS RS20211580A patent/RS62817B1/sr unknown
- 2018-05-10 RU RU2019139290A patent/RU2745603C1/ru active
- 2018-05-10 AU AU2018265257A patent/AU2018265257B2/en active Active
- 2018-05-10 SG SG11201910085U patent/SG11201910085UA/en unknown
- 2018-05-10 HU HUE18798073A patent/HUE056595T2/hu unknown
-
2019
- 2019-02-20 US US16/280,585 patent/US10610525B2/en active Active
- 2019-02-20 US US16/280,552 patent/US11071732B2/en active Active
- 2019-02-20 US US16/280,405 patent/US10583132B2/en active Active
- 2019-02-20 US US16/280,384 patent/US10568875B2/en active Active
- 2019-02-20 US US16/280,669 patent/US10576074B2/en not_active Ceased
- 2019-07-11 JP JP2019129403A patent/JP6681502B2/ja active Active
- 2019-07-11 JP JP2019129396A patent/JP6865476B2/ja active Active
- 2019-07-11 JP JP2019129405A patent/JP6681503B2/ja active Active
- 2019-11-11 CL CL2019003228A patent/CL2019003228A1/es unknown
- 2019-11-18 CO CONC2019/0012893A patent/CO2019012893A2/es unknown
- 2019-11-28 PH PH12019502701A patent/PH12019502701A1/en unknown
-
2020
- 2020-07-20 US US16/933,642 patent/US11464769B2/en active Active
- 2020-08-31 US US17/007,816 patent/US11730727B2/en active Active
- 2020-08-31 US US17/007,900 patent/US11730728B2/en active Active
- 2020-09-09 US US17/016,186 patent/US11707458B2/en active Active
-
2021
- 2021-01-11 US US17/145,589 patent/US11642338B2/en active Active
- 2021-03-30 JP JP2021056894A patent/JP7332179B2/ja active Active
- 2021-12-23 CY CY20211101132T patent/CY1124880T1/el unknown
-
2022
- 2022-03-02 US US17/685,286 patent/USRE50040E1/en active Active
-
2023
- 2023-06-28 US US18/343,636 patent/US12036217B2/en active Active
-
2024
- 2024-06-26 US US18/755,212 patent/US20240342154A1/en active Pending
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2018188440A5 (enExample) | ||
| CA2932967C (fr) | Compositions d'acide hyaluronique comprenant de la mepivacaine | |
| EP2446878B1 (en) | Ketorolac tromethamine compositions for treating or preventing ocular pain | |
| RU2018128980A (ru) | Офтальмологические составы для доставки лекарственных средств к заднему сегменту глаза | |
| WO2008074853A1 (en) | Ophthalmic rebamipide solution | |
| CN102170863B (zh) | 类粘液状组合物及其应用 | |
| JP6603785B2 (ja) | 水溶性高分子を含む水性液剤 | |
| WO2006112029A1 (ja) | 眼科用組成物 | |
| KR20010012521A (ko) | 방부 조성물 | |
| DE60109742T2 (de) | Antiallergische ophthalmische zubereitungen, geeignet zur anwendung mit kontaktlinsen | |
| JP5843975B2 (ja) | 後発性白内障抑制用組成物およびその製造方法 | |
| US6281224B1 (en) | Pranoprofen eyedrops containing organic amine | |
| JP5925823B2 (ja) | ヒアルロン酸又はその薬学的に許容される塩を含む保存組成物及び関連する方法 | |
| JP2017190348A (ja) | 水性眼科組成物 | |
| KR20180115295A (ko) | 폴리쿼터늄을 함유하는 항미생물 조성물 | |
| ES2899759T3 (es) | Composición hiperosmolar de ácido hialurónico | |
| KR102365008B1 (ko) | 디쿠아포솔을 포함하는 점안 조성물 | |
| KR101840256B1 (ko) | 레바미피드를 함유하는 새로운 안구건조증 치료용 점안 조성물 및 이의 가용화 및 안정화 방법 | |
| JP2012031184A (ja) | 眼科用組成物 | |
| KR101723703B1 (ko) | 안구 통증을 치료 또는 예방하기 위한 케토롤락 트로메타민 조성물 | |
| CN113520995A (zh) | 一种离子敏感型眼用原位凝胶、其制备方法及应用 | |
| JP2004238346A (ja) | トラニラストの安定な水溶液製剤 | |
| JP5382973B2 (ja) | 粘度低下が防止された組成物 | |
| JP5318850B2 (ja) | 粘度低下が防止された組成物 | |
| EP2419081B1 (en) | Aqueous ophthalmic compositions containing anionic therapeutic agents |