CN110621298B - 阿托品药物组合物 - Google Patents

阿托品药物组合物 Download PDF

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Publication number
CN110621298B
CN110621298B CN201880031247.6A CN201880031247A CN110621298B CN 110621298 B CN110621298 B CN 110621298B CN 201880031247 A CN201880031247 A CN 201880031247A CN 110621298 B CN110621298 B CN 110621298B
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Prior art keywords
atropine
composition
ophthalmic
weight
pharmaceutically acceptable
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Chinese (zh)
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CN110621298A (zh
Inventor
纳瓦尼特·普里
普雷姆·萨格尔·阿卡萨普
伊尔凡·A·穆罕默德
库马雷什·索皮马思
尤里·V·艾利特切夫
张涛
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Veluma Co ltd
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Nevada Ltd
Veluma Co ltd
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0048—Eye, e.g. artificial tears
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/46—8-Azabicyclo [3.2.1] octane; Derivatives thereof, e.g. atropine, cocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/02—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
    • A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
    • A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
    • A61K47/183—Amino acids, e.g. glycine, EDTA or aspartame
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A61K47/38—Cellulose; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/08—Solutions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/08—Mydriatics or cycloplegics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/10—Ophthalmic agents for accommodation disorders, e.g. myopia

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Ophthalmology & Optometry (AREA)
  • Inorganic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Emergency Medicine (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Peptides Or Proteins (AREA)
CN201880031247.6A 2017-05-11 2018-05-10 阿托品药物组合物 Active CN110621298B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201762505027P 2017-05-11 2017-05-11
US62/505,027 2017-05-11
PCT/US2018/032017 WO2018209051A1 (en) 2017-05-11 2018-05-10 Atropine pharmaceutical compositions

Publications (2)

Publication Number Publication Date
CN110621298A CN110621298A (zh) 2019-12-27
CN110621298B true CN110621298B (zh) 2022-12-20

Family

ID=64096170

Family Applications (1)

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CN201880031247.6A Active CN110621298B (zh) 2017-05-11 2018-05-10 阿托品药物组合物

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US (14) US10251875B2 (enExample)
EP (2) EP3548000B1 (enExample)
JP (5) JP6557379B2 (enExample)
KR (1) KR102281667B1 (enExample)
CN (1) CN110621298B (enExample)
AU (1) AU2018265257B2 (enExample)
CA (1) CA3063228C (enExample)
CL (1) CL2019003228A1 (enExample)
CO (1) CO2019012893A2 (enExample)
CY (1) CY1124880T1 (enExample)
ES (1) ES2901140T3 (enExample)
HR (1) HRP20212019T1 (enExample)
HU (1) HUE056595T2 (enExample)
LT (1) LT3548000T (enExample)
MX (1) MX392558B (enExample)
PH (1) PH12019502701A1 (enExample)
PL (1) PL3548000T3 (enExample)
PT (1) PT3548000T (enExample)
RS (1) RS62817B1 (enExample)
RU (1) RU2745603C1 (enExample)
SG (1) SG11201910085UA (enExample)
SI (1) SI3548000T1 (enExample)
WO (1) WO2018209051A1 (enExample)

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WO2019216395A1 (ja) * 2018-05-11 2019-11-14 千寿製薬株式会社 眼科用組成物
CN114557955B (zh) * 2018-09-25 2024-06-18 沈阳兴齐眼药股份有限公司 药物组合物、其制备方法和用途
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CN115038414A (zh) 2019-12-11 2022-09-09 艾诺维亚股份有限公司 用于向眼睛输送流体的系统和装置及使用方法
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CN110917133A (zh) * 2019-12-23 2020-03-27 河北科技大学 一种治疗近视的滴眼剂及其制备方法
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CN111821259A (zh) * 2020-07-14 2020-10-27 艾尔健康眼药(辽宁)有限公司 一种眼用药物组合物
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KR20240052048A (ko) * 2021-09-13 2024-04-22 오우푸시팡 파마수티칼 테크놀로지 씨오., 엘티디 아트로핀 점안액 및 이의 제조 방법
EP4429652A4 (en) * 2021-11-10 2025-09-10 Visus Therapeutics Inc CARBACHOL FORMULATIONS TO ENHANCE ANTI-PRESBYOPIA EFFECTS
CN114129511A (zh) * 2021-12-07 2022-03-04 河南润弘制药股份有限公司 一种具有改进稳定性的硫酸阿托品注射液
WO2023152642A1 (en) * 2022-02-08 2023-08-17 Avaca Pharma Private Limited Ophthalmic compositions and methods thereof
US20230277521A1 (en) * 2022-03-07 2023-09-07 Harrow Ip, Llc Extended-release pharmaceutical compositions for treating eye conditions
CN114569551A (zh) * 2022-03-21 2022-06-03 杭州赫尔斯科技有限公司 阿托品滴眼液及其制备方法
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PH12019502701A1 (en) 2020-12-07
ES2901140T3 (es) 2022-03-21
RS62817B1 (sr) 2022-02-28
CL2019003228A1 (es) 2020-01-31
US20200397776A1 (en) 2020-12-24
US20180325888A1 (en) 2018-11-15
SI3548000T1 (sl) 2022-02-28
US10251875B2 (en) 2019-04-09
PL3548000T3 (pl) 2022-01-17
JP6557379B2 (ja) 2019-08-07
US11730728B2 (en) 2023-08-22
US20200397775A1 (en) 2020-12-24
US10610525B2 (en) 2020-04-07
US20230355604A1 (en) 2023-11-09
WO2018209051A1 (en) 2018-11-15
HRP20212019T1 (hr) 2022-04-01
SG11201910085UA (en) 2019-11-28
MX392558B (es) 2025-03-24
BR112019023515A2 (pt) 2020-05-19
EP3548000A1 (en) 2019-10-09
USRE50040E1 (en) 2024-07-16
US11642338B2 (en) 2023-05-09
NZ758555A (en) 2021-10-29
US20190175579A1 (en) 2019-06-13
CA3063228C (en) 2022-06-28
CY1124880T1 (el) 2022-11-25
US10583132B2 (en) 2020-03-10
JP6865476B2 (ja) 2021-04-28
KR102281667B9 (ko) 2024-01-08
US20190175580A1 (en) 2019-06-13
JP2019194248A (ja) 2019-11-07
KR20190138714A (ko) 2019-12-13
HUE056595T2 (hu) 2022-02-28
US11707458B2 (en) 2023-07-25
AU2018265257B2 (en) 2020-08-06
JP2019172704A (ja) 2019-10-10
EP3548000B1 (en) 2021-11-10
US11464769B2 (en) 2022-10-11
PT3548000T (pt) 2021-12-10
US11730727B2 (en) 2023-08-22
LT3548000T (lt) 2022-03-10
KR102281667B1 (ko) 2021-07-23
US10576074B2 (en) 2020-03-03
US20200405705A1 (en) 2020-12-31
US20190209545A1 (en) 2019-07-11
JP2018188440A (ja) 2018-11-29
US10568875B2 (en) 2020-02-25
JP2021102647A (ja) 2021-07-15
JP6681502B2 (ja) 2020-04-15
EP3970694A1 (en) 2022-03-23
US20190192499A1 (en) 2019-06-27
US20240342154A1 (en) 2024-10-17
US20190183876A1 (en) 2019-06-20
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US12036217B2 (en) 2024-07-16
US20200352928A1 (en) 2020-11-12
CA3063228A1 (en) 2018-11-15
US20210128546A1 (en) 2021-05-06
CN110621298A (zh) 2019-12-27
EP3548000A4 (en) 2019-12-04
JP7332179B2 (ja) 2023-08-23
CO2019012893A2 (es) 2020-02-28
JP6681503B2 (ja) 2020-04-15
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