JP2018064560A5 - - Google Patents
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- JP2018064560A5 JP2018064560A5 JP2017213749A JP2017213749A JP2018064560A5 JP 2018064560 A5 JP2018064560 A5 JP 2018064560A5 JP 2017213749 A JP2017213749 A JP 2017213749A JP 2017213749 A JP2017213749 A JP 2017213749A JP 2018064560 A5 JP2018064560 A5 JP 2018064560A5
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- antibody antagonist
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- 239000005557 antagonist Substances 0.000 claims 23
- 239000012634 fragment Substances 0.000 claims 19
- 101000852968 Homo sapiens Interleukin-1 receptor-like 1 Proteins 0.000 claims 14
- 239000008194 pharmaceutical composition Substances 0.000 claims 11
- 101000680096 Homo sapiens Transmembrane emp24 domain-containing protein 1 Proteins 0.000 claims 10
- 102100022243 Transmembrane emp24 domain-containing protein 1 Human genes 0.000 claims 10
- 210000003630 histaminocyte Anatomy 0.000 claims 6
- 230000036755 cellular response Effects 0.000 claims 5
- 230000001404 mediated effect Effects 0.000 claims 5
- 208000009329 Graft vs Host Disease Diseases 0.000 claims 4
- 201000009794 Idiopathic Pulmonary Fibrosis Diseases 0.000 claims 4
- 208000022559 Inflammatory bowel disease Diseases 0.000 claims 4
- 108010067003 Interleukin-33 Proteins 0.000 claims 4
- 102000017761 Interleukin-33 Human genes 0.000 claims 4
- 238000010494 dissociation reaction Methods 0.000 claims 4
- 230000005593 dissociations Effects 0.000 claims 4
- 208000024908 graft versus host disease Diseases 0.000 claims 4
- 102000055002 human IL1RL1 Human genes 0.000 claims 4
- 208000036971 interstitial lung disease 2 Diseases 0.000 claims 4
- 210000004027 cell Anatomy 0.000 claims 3
- 230000003993 interaction Effects 0.000 claims 3
- 208000006545 Chronic Obstructive Pulmonary Disease Diseases 0.000 claims 2
- 201000003883 Cystic fibrosis Diseases 0.000 claims 2
- 206010012438 Dermatitis atopic Diseases 0.000 claims 2
- 208000007342 Diabetic Nephropathies Diseases 0.000 claims 2
- 206010064212 Eosinophilic oesophagitis Diseases 0.000 claims 2
- 101001037140 Homo sapiens Immunoglobulin heavy variable 3-23 Proteins 0.000 claims 2
- 101001047617 Homo sapiens Immunoglobulin kappa variable 3-11 Proteins 0.000 claims 2
- 206010020751 Hypersensitivity Diseases 0.000 claims 2
- 102100040220 Immunoglobulin heavy variable 3-23 Human genes 0.000 claims 2
- 102100022955 Immunoglobulin kappa variable 3-11 Human genes 0.000 claims 2
- 208000005615 Interstitial Cystitis Diseases 0.000 claims 2
- 206010034277 Pemphigoid Diseases 0.000 claims 2
- 206010039085 Rhinitis allergic Diseases 0.000 claims 2
- 206010039710 Scleroderma Diseases 0.000 claims 2
- 206010052568 Urticaria chronic Diseases 0.000 claims 2
- 208000026935 allergic disease Diseases 0.000 claims 2
- 201000010105 allergic rhinitis Diseases 0.000 claims 2
- 208000006673 asthma Diseases 0.000 claims 2
- 201000008937 atopic dermatitis Diseases 0.000 claims 2
- 208000000594 bullous pemphigoid Diseases 0.000 claims 2
- 208000024376 chronic urticaria Diseases 0.000 claims 2
- 230000000295 complement effect Effects 0.000 claims 2
- 208000033679 diabetic kidney disease Diseases 0.000 claims 2
- 201000000708 eosinophilic esophagitis Diseases 0.000 claims 2
- 210000002175 goblet cell Anatomy 0.000 claims 2
- 230000009610 hypersensitivity Effects 0.000 claims 2
- 210000004969 inflammatory cell Anatomy 0.000 claims 2
- 230000002401 inhibitory effect Effects 0.000 claims 2
- 210000004072 lung Anatomy 0.000 claims 2
- 210000003097 mucus Anatomy 0.000 claims 2
- 102000040430 polynucleotide Human genes 0.000 claims 2
- 108091033319 polynucleotide Proteins 0.000 claims 2
- 239000002157 polynucleotide Substances 0.000 claims 2
- 206010039073 rheumatoid arthritis Diseases 0.000 claims 2
- 201000000306 sarcoidosis Diseases 0.000 claims 2
- 230000028327 secretion Effects 0.000 claims 2
- 238000006467 substitution reaction Methods 0.000 claims 2
- 230000008719 thickening Effects 0.000 claims 2
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 1
- 108010017213 Granulocyte-Macrophage Colony-Stimulating Factor Proteins 0.000 claims 1
- 102100039620 Granulocyte-macrophage colony-stimulating factor Human genes 0.000 claims 1
- 101000998949 Homo sapiens Immunoglobulin heavy variable 1-24 Proteins 0.000 claims 1
- 101000989058 Homo sapiens Immunoglobulin heavy variable 1-69-2 Proteins 0.000 claims 1
- 101001138128 Homo sapiens Immunoglobulin kappa variable 1-12 Proteins 0.000 claims 1
- 101001138123 Homo sapiens Immunoglobulin kappa variable 1-27 Proteins 0.000 claims 1
- 101001138121 Homo sapiens Immunoglobulin kappa variable 1-33 Proteins 0.000 claims 1
- 101001138089 Homo sapiens Immunoglobulin kappa variable 1-39 Proteins 0.000 claims 1
- 101001138133 Homo sapiens Immunoglobulin kappa variable 1-5 Proteins 0.000 claims 1
- 101001138130 Homo sapiens Immunoglobulin kappa variable 1-9 Proteins 0.000 claims 1
- 101001047618 Homo sapiens Immunoglobulin kappa variable 3-15 Proteins 0.000 claims 1
- 102100036890 Immunoglobulin heavy variable 1-24 Human genes 0.000 claims 1
- 102100029422 Immunoglobulin heavy variable 1-69-2 Human genes 0.000 claims 1
- 102100020773 Immunoglobulin kappa variable 1-12 Human genes 0.000 claims 1
- 102100020902 Immunoglobulin kappa variable 1-27 Human genes 0.000 claims 1
- 102100020901 Immunoglobulin kappa variable 1-33 Human genes 0.000 claims 1
- 102100020910 Immunoglobulin kappa variable 1-39 Human genes 0.000 claims 1
- 102100020769 Immunoglobulin kappa variable 1-5 Human genes 0.000 claims 1
- 102100020770 Immunoglobulin kappa variable 1-9 Human genes 0.000 claims 1
- 102100022965 Immunoglobulin kappa variable 3-15 Human genes 0.000 claims 1
- 108090000174 Interleukin-10 Proteins 0.000 claims 1
- 108090000176 Interleukin-13 Proteins 0.000 claims 1
- 108010002616 Interleukin-5 Proteins 0.000 claims 1
- 108090001007 Interleukin-8 Proteins 0.000 claims 1
- 230000006041 cell recruitment Effects 0.000 claims 1
- 238000012258 culturing Methods 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 210000004700 fetal blood Anatomy 0.000 claims 1
- 230000005764 inhibitory process Effects 0.000 claims 1
- 238000002955 isolation Methods 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 238000000034 method Methods 0.000 claims 1
Applications Claiming Priority (8)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261640407P | 2012-04-30 | 2012-04-30 | |
| US201261640238P | 2012-04-30 | 2012-04-30 | |
| US61/640,238 | 2012-04-30 | ||
| US61/640,407 | 2012-04-30 | ||
| US13/798,226 US9212227B2 (en) | 2012-04-30 | 2013-03-13 | ST2L antibody antagonists for the treatment of ST2L-mediated inflammatory pulmonary conditions |
| US13/798,226 | 2013-03-13 | ||
| US13/798,204 | 2013-03-13 | ||
| US13/798,204 US9090694B2 (en) | 2012-04-30 | 2013-03-13 | ST2L antibody antagonists |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015510362A Division JP6283354B2 (ja) | 2012-04-30 | 2013-04-29 | Ｓｔ２ｌ拮抗物質及び使用方法 |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019097226A Division JP2019162136A (ja) | 2012-04-30 | 2019-05-24 | Ｓｔ２ｌ拮抗物質及び使用方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2018064560A JP2018064560A (ja) | 2018-04-26 |
| JP2018064560A5 true JP2018064560A5 (enExample) | 2018-09-27 |
| JP6622274B2 JP6622274B2 (ja) | 2019-12-18 |
Family
ID=49477497
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015510362A Expired - Fee Related JP6283354B2 (ja) | 2012-04-30 | 2013-04-29 | Ｓｔ２ｌ拮抗物質及び使用方法 |
| JP2017213749A Expired - Fee Related JP6622274B2 (ja) | 2012-04-30 | 2017-11-06 | Ｓｔ２ｌ拮抗物質及び使用方法 |
| JP2019097226A Withdrawn JP2019162136A (ja) | 2012-04-30 | 2019-05-24 | Ｓｔ２ｌ拮抗物質及び使用方法 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015510362A Expired - Fee Related JP6283354B2 (ja) | 2012-04-30 | 2013-04-29 | Ｓｔ２ｌ拮抗物質及び使用方法 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019097226A Withdrawn JP2019162136A (ja) | 2012-04-30 | 2019-05-24 | Ｓｔ２ｌ拮抗物質及び使用方法 |
Country Status (37)
Families Citing this family (43)
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| US10040859B2 (en) | 2014-04-21 | 2018-08-07 | The Children's Hospital Of Philadelphia | Methods of treating hemophagocytic lymphohistiocytosis with an IL-33 receptor antibody |
| WO2015200073A1 (en) * | 2014-06-23 | 2015-12-30 | Bionomics, Inc. | Antibodies that bind lgr4 |
| CN107109494B (zh) | 2014-11-10 | 2023-10-27 | 豪夫迈·罗氏有限公司 | Il-33介导型疾病的治疗方法和诊断方法 |
| CA2960297A1 (en) | 2014-11-10 | 2016-05-19 | Genentech, Inc. | Anti-interleukin-33 antibodies and uses thereof |
| CA2978449A1 (en) * | 2015-03-02 | 2016-09-09 | 180 Therapeutics Lp | Method of treating a localized fibrotic disorder using an il-33 antagonist |
| JP7114460B2 (ja) | 2015-06-26 | 2022-08-08 | サノフィ・バイオテクノロジー | モノクローナル抗ＩＬ－１ＲＡｃＰ抗体 |
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| US20190225682A1 (en) * | 2016-09-02 | 2019-07-25 | 180 Therapeutics Lp | Method of treating localized fibrotic disorders using an il-33/tnf bispecific antibody |
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| CN111527107B (zh) | 2017-12-21 | 2024-10-01 | 豪夫迈·罗氏有限公司 | 结合hla-a2/wt1的抗体 |
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| CN113286814A (zh) * | 2018-10-31 | 2021-08-20 | 德里尼亚公司 | 多价调节性t细胞调节子 |
| KR102353568B1 (ko) * | 2018-11-14 | 2022-01-20 | 주식회사 헬릭스미스 | 안정성이 향상된 항 c-Met 항체 또는 그의 항원 결합 단편 |
| CN110045131B (zh) * | 2019-06-14 | 2019-09-03 | 迈威(上海)生物科技有限公司 | 用于测定人il-33/st2通路抑制剂的生物学活性的方法 |
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| KR20220164555A (ko) | 2020-04-06 | 2022-12-13 | 메디뮨 리미티드 | Il-33 축 결합 길항제를 사용한 급성 호흡 곤란 증후군의 치료 |
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| CN113501878B (zh) * | 2021-02-03 | 2022-12-02 | 北京智仁美博生物科技有限公司 | 针对人tslp的多种抗体及其用途 |
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| EP2569337A1 (en) | 2010-05-14 | 2013-03-20 | Rinat Neuroscience Corp. | Heterodimeric proteins and methods for producing and purifying them |
| EP2420253A1 (en) | 2010-08-20 | 2012-02-22 | Leadartis, S.L. | Engineering multifunctional and multivalent molecules with collagen XV trimerization domain |
| EP2621950A4 (en) | 2010-09-27 | 2015-09-02 | Janssen Biotech Inc | ANTIBODIES FOR BINDING HUMAN COLLAGEN II |
| RU2604490C2 (ru) | 2010-11-05 | 2016-12-10 | Займворкс Инк. | ДИЗАЙН УСТОЙЧИВОГО ГЕТЕРОДИМЕРНОГО АНТИТЕЛА С МУТАЦИЯМИ В Fc ДОМЕНЕ |
| BR112013021473A2 (pt) | 2011-02-23 | 2020-08-04 | F. Hoffmann-La Roche Ag | anticorpos contra il33r humano e seus usos |
| US9090694B2 (en) * | 2012-04-30 | 2015-07-28 | Janssen Biotech, Inc. | ST2L antibody antagonists |
| JO3623B1 (ar) | 2012-05-18 | 2020-08-27 | Amgen Inc | البروتينات المرتبطة بمولد المستضاد st2 |
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