JP2018516537A5 - - Google Patents

Info

Publication number

JP2018516537A5

JP2018516537A5 JP2017552827A JP2017552827A JP2018516537A5 JP 2018516537 A5 JP2018516537 A5 JP 2018516537A5 JP 2017552827 A JP2017552827 A JP 2017552827A JP 2017552827 A JP2017552827 A JP 2017552827A JP 2018516537 A5 JP2018516537 A5 JP 2018516537A5

Authority

JP

Japan

Prior art keywords

amino acid

region

hvr

seq

acid sequence

Prior art date

2016-04-06

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Granted

Links

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• 239000000427 antigen Substances 0.000 claims description 62
• 102000036639 antigens Human genes 0.000 claims description 62
• 108091007433 antigens Proteins 0.000 claims description 62
• 229920001184 polypeptide Polymers 0.000 claims description 50
• 102000004196 processed proteins & peptides Human genes 0.000 claims description 50
• 108090000765 processed proteins & peptides Proteins 0.000 claims description 50
• 125000003275 alpha amino acid group Chemical group 0.000 claims 69
• 238000000034 method Methods 0.000 claims 21
• 230000004048 modification Effects 0.000 claims 19
• 238000012986 modification Methods 0.000 claims 19
• 102000000844 Cell Surface Receptors Human genes 0.000 claims 17
• 108010001857 Cell Surface Receptors Proteins 0.000 claims 17
• 239000001601 sodium adipate Substances 0.000 claims 12
• 238000006467 substitution reaction Methods 0.000 claims 11
• 102100022153 Tumor necrosis factor receptor superfamily member 4 Human genes 0.000 claims 10
• 101710165473 Tumor necrosis factor receptor superfamily member 4 Proteins 0.000 claims 10
• 150000001413 amino acids Chemical class 0.000 claims 9
• 210000004027 cell Anatomy 0.000 claims 9
• 230000004540 complement-dependent cytotoxicity Effects 0.000 claims 6
• 239000012636 effector Substances 0.000 claims 6
• FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 5
• 102000003688 G-Protein-Coupled Receptors Human genes 0.000 claims 4
• 108090000045 G-Protein-Coupled Receptors Proteins 0.000 claims 4
• 108060008683 Tumor Necrosis Factor Receptor Proteins 0.000 claims 4
• 238000012217 deletion Methods 0.000 claims 4
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• 102000003298 tumor necrosis factor receptor Human genes 0.000 claims 4
• 239000000556 agonist Substances 0.000 claims 3
• 230000000694 effects Effects 0.000 claims 3
• 102000039446 nucleic acids Human genes 0.000 claims 3
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• 150000007523 nucleic acids Chemical class 0.000 claims 3
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• 101100481408 Danio rerio tie2 gene Proteins 0.000 claims 2
• 101000851370 Homo sapiens Tumor necrosis factor receptor superfamily member 9 Proteins 0.000 claims 2
• 101100481410 Mus musculus Tek gene Proteins 0.000 claims 2
• 230000001270 agonistic effect Effects 0.000 claims 2
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