JP2020511946A5 - - Google Patents
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- Publication number
- JP2020511946A5 JP2020511946A5 JP2019533076A JP2019533076A JP2020511946A5 JP 2020511946 A5 JP2020511946 A5 JP 2020511946A5 JP 2019533076 A JP2019533076 A JP 2019533076A JP 2019533076 A JP2019533076 A JP 2019533076A JP 2020511946 A5 JP2020511946 A5 JP 2020511946A5
- Authority
- JP
- Japan
- Prior art keywords
- antibody
- seq
- sequence
- gremlin
- light chain
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 102100038367 Gremlin-1 Human genes 0.000 claims 7
- 101710169781 Gremlin-1 Proteins 0.000 claims 7
- 239000008194 pharmaceutical composition Substances 0.000 claims 3
- 108010047041 Complementarity Determining Regions Proteins 0.000 claims 2
- 239000000178 monomer Substances 0.000 claims 2
- 102000040430 polynucleotide Human genes 0.000 claims 2
- 108091033319 polynucleotide Proteins 0.000 claims 2
- 239000002157 polynucleotide Substances 0.000 claims 2
- 108010032595 Antibody Binding Sites Proteins 0.000 claims 1
- 208000007342 Diabetic Nephropathies Diseases 0.000 claims 1
- 201000009794 Idiopathic Pulmonary Fibrosis Diseases 0.000 claims 1
- 241001465754 Metazoa Species 0.000 claims 1
- 206010028980 Neoplasm Diseases 0.000 claims 1
- 206010064911 Pulmonary arterial hypertension Diseases 0.000 claims 1
- 108010003723 Single-Domain Antibodies Proteins 0.000 claims 1
- 239000002671 adjuvant Substances 0.000 claims 1
- 230000033115 angiogenesis Effects 0.000 claims 1
- 201000011510 cancer Diseases 0.000 claims 1
- 238000012258 culturing Methods 0.000 claims 1
- 208000033679 diabetic kidney disease Diseases 0.000 claims 1
- 239000013604 expression vector Substances 0.000 claims 1
- 208000036971 interstitial lung disease 2 Diseases 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 238000000034 method Methods 0.000 claims 1
- 230000002265 prevention Effects 0.000 claims 1
- 201000002793 renal fibrosis Diseases 0.000 claims 1
- 238000003571 reporter gene assay Methods 0.000 claims 1
- 239000013598 vector Substances 0.000 claims 1
- 238000002424 x-ray crystallography Methods 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB1621635.0A GB201621635D0 (en) | 2016-12-19 | 2016-12-19 | Crystal structure |
| GB1621635.0 | 2016-12-19 | ||
| PCT/EP2017/083650 WO2018115017A2 (en) | 2016-12-19 | 2017-12-19 | Gremlin-1 crystal structure and inhibitory antibody |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2020511946A JP2020511946A (ja) | 2020-04-23 |
| JP2020511946A5 true JP2020511946A5 (enExample) | 2021-01-14 |
| JP7097364B2 JP7097364B2 (ja) | 2022-07-07 |
Family
ID=58284547
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019533076A Active JP7097364B2 (ja) | 2016-12-19 | 2017-12-19 | グレムリン－１の結晶構造及び阻害抗体 |
Country Status (31)
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB201621635D0 (en) | 2016-12-19 | 2017-02-01 | Ucb Biopharma Sprl | Crystal structure |
| GB201802486D0 (en) | 2018-02-15 | 2018-04-04 | Ucb Biopharma Sprl | Methods |
| AU2019289176B2 (en) * | 2018-06-18 | 2026-02-19 | Adelaide university | Gremlin-1 antagonist for the prevention and treatment of cancer |
| EP4232475A1 (en) * | 2020-10-20 | 2023-08-30 | Kantonsspital St. Gallen | Antibodies or antigen-binding fragments specifically binding to gremlin-1 and uses thereof |
| AU2022207030A1 (en) * | 2021-01-18 | 2023-08-24 | Suzhou Transcenta Therapeutics Co., Ltd. | Novel anti-gremlin1 antibodies |
| KR20230156936A (ko) * | 2021-03-11 | 2023-11-15 | 상하이 지아오통 대학 | 그렘린1 길항제를 사용하여 질환을 치료하는 방법 |
| GB202205203D0 (en) | 2022-04-08 | 2022-05-25 | UCB Biopharma SRL | Combination with inhibitor |
| GB202205200D0 (en) | 2022-04-08 | 2022-05-25 | Ucb Biopharma Sprl | Combination with chemotherapy |
| AU2023258146A1 (en) * | 2022-04-20 | 2024-09-05 | Kantonsspital St. Gallen | Antibodies or antigen-binding fragments pan-specifically binding to gremlin-1 and gremlin-2 and uses thereof |
| CN121399157A (zh) | 2023-06-12 | 2026-01-23 | 美国安进公司 | 淋巴毒素β受体激动剂结合蛋白 |
| WO2026027660A1 (en) | 2024-08-02 | 2026-02-05 | UCB Biopharma SRL | Formulations of anti-gremlin-1 antibodies |
Family Cites Families (57)
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| US545806A (en) | 1895-09-03 | Trolley-wire support | ||
| GB8422238D0 (en) | 1984-09-03 | 1984-10-10 | Neuberger M S | Chimeric proteins |
| DK336987D0 (da) | 1987-07-01 | 1987-07-01 | Novo Industri As | Immobiliseringsmetode |
| GB8719042D0 (en) | 1987-08-12 | 1987-09-16 | Parker D | Conjugate compounds |
| GB8720833D0 (en) | 1987-09-04 | 1987-10-14 | Celltech Ltd | Recombinant dna product |
| DE68927933T2 (de) | 1988-09-02 | 1997-08-14 | Dyax Corp | Herstellung und auswahl von rekombinantproteinen mit verschiedenen bindestellen |
| US5223409A (en) | 1988-09-02 | 1993-06-29 | Protein Engineering Corp. | Directed evolution of novel binding proteins |
| GB8823869D0 (en) | 1988-10-12 | 1988-11-16 | Medical Res Council | Production of antibodies |
| GB8907617D0 (en) | 1989-04-05 | 1989-05-17 | Celltech Ltd | Drug delivery system |
| US5859205A (en) * | 1989-12-21 | 1999-01-12 | Celltech Limited | Humanised antibodies |
| GB8928874D0 (en) | 1989-12-21 | 1990-02-28 | Celltech Ltd | Humanised antibodies |
| AU7247191A (en) | 1990-01-11 | 1991-08-05 | Molecular Affinities Corporation | Production of antibodies using gene libraries |
| US5780225A (en) | 1990-01-12 | 1998-07-14 | Stratagene | Method for generating libaries of antibody genes comprising amplification of diverse antibody DNAs and methods for using these libraries for the production of diverse antigen combining molecules |
| EP1690935A3 (en) | 1990-01-12 | 2008-07-30 | Abgenix, Inc. | Generation of xenogeneic antibodies |
| US5427908A (en) | 1990-05-01 | 1995-06-27 | Affymax Technologies N.V. | Recombinant library screening methods |
| GB9015198D0 (en) | 1990-07-10 | 1990-08-29 | Brien Caroline J O | Binding substance |
| CA2090126C (en) | 1990-08-02 | 2002-10-22 | John W. Schrader | Methods for the production of proteins with a desired function |
| US5633425A (en) | 1990-08-29 | 1997-05-27 | Genpharm International, Inc. | Transgenic non-human animals capable of producing heterologous antibodies |
| ES2246502T3 (es) | 1990-08-29 | 2006-02-16 | Genpharm International, Inc. | Animales no humanos transgenicos capaces de producir anticuerpos heterologos. |
| US5661016A (en) | 1990-08-29 | 1997-08-26 | Genpharm International Inc. | Transgenic non-human animals capable of producing heterologous antibodies of various isotypes |
| US5625126A (en) | 1990-08-29 | 1997-04-29 | Genpharm International, Inc. | Transgenic non-human animals for producing heterologous antibodies |
| US5545806A (en) | 1990-08-29 | 1996-08-13 | Genpharm International, Inc. | Ransgenic non-human animals for producing heterologous antibodies |
| US5770429A (en) | 1990-08-29 | 1998-06-23 | Genpharm International, Inc. | Transgenic non-human animals capable of producing heterologous antibodies |
| US5698426A (en) | 1990-09-28 | 1997-12-16 | Ixsys, Incorporated | Surface expression libraries of heteromeric receptors |
| DE69129154T2 (de) | 1990-12-03 | 1998-08-20 | Genentech, Inc., South San Francisco, Calif. | Verfahren zur anreicherung von proteinvarianten mit geänderten bindungseigenschaften |
| PT100379B (pt) | 1991-04-10 | 1999-01-29 | Scripps Research Inst | Bibliotecas de receptores heterodimericos usando fagomideos |
| GB9112536D0 (en) | 1991-06-11 | 1991-07-31 | Celltech Ltd | Chemical compounds |
| GB9113120D0 (en) | 1991-06-18 | 1991-08-07 | Kodak Ltd | Photographic processing apparatus |
| GB9120467D0 (en) | 1991-09-26 | 1991-11-06 | Celltech Ltd | Anti-hmfg antibodies and process for their production |
| PT1024191E (pt) | 1991-12-02 | 2008-12-22 | Medical Res Council | Produção de auto-anticorpos a partir de reportórios de segmentos de anticorpo e exibidos em fagos |
| US5733743A (en) | 1992-03-24 | 1998-03-31 | Cambridge Antibody Technology Limited | Methods for producing members of specific binding pairs |
| JPH09506262A (ja) | 1993-12-08 | 1997-06-24 | ジェンザイム・コーポレイション | 特異的抗体の製造方法 |
| ES2201097T3 (es) | 1994-01-31 | 2004-03-16 | Trustees Of Boston University | Bibliotecas de anticuerpos policlonales. |
| FR2716640B1 (fr) | 1994-02-28 | 1996-05-03 | Procedes Machines Speciales | Dispositif de centrage et de blocage d'une pièce en vue de son rodage à l'aide d'un rodoir à expansion. |
| US5516637A (en) | 1994-06-10 | 1996-05-14 | Dade International Inc. | Method involving display of protein binding pairs on the surface of bacterial pili and bacteriophage |
| JP2978435B2 (ja) | 1996-01-24 | 1999-11-15 | チッソ株式会社 | アクリロキシプロピルシランの製造方法 |
| GB9625640D0 (en) | 1996-12-10 | 1997-01-29 | Celltech Therapeutics Ltd | Biological products |
| EP1357828A2 (en) | 2001-01-12 | 2003-11-05 | University of Medicine and Dentistry of New Jersey | Bone morphogenetic protein-2 in the treatment and diagnosis of cancer |
| US6908963B2 (en) | 2001-10-09 | 2005-06-21 | Nektar Therapeutics Al, Corporation | Thioester polymer derivatives and method of modifying the N-terminus of a polypeptide therewith |
| WO2004051268A1 (en) | 2002-12-03 | 2004-06-17 | Celltech R & D Limited | Assay for identifying antibody producing cells |
| GB0312481D0 (en) | 2003-05-30 | 2003-07-09 | Celltech R&D Ltd | Antibodies |
| PT1644412E (pt) | 2003-07-01 | 2015-12-23 | Ucb Biopharma Sprl | Fragmentos de anticorpos fab modificados |
| GB0315457D0 (en) | 2003-07-01 | 2003-08-06 | Celltech R&D Ltd | Biological products |
| GB0315450D0 (en) | 2003-07-01 | 2003-08-06 | Celltech R&D Ltd | Biological products |
| WO2005023993A2 (en) | 2003-09-09 | 2005-03-17 | Integrigen, Inc. | Methods and compositions for generation of germline human antibody genes |
| EP1571159A1 (en) | 2004-03-04 | 2005-09-07 | Bayerische Julius-Maximilians-Universität Würzburg | Mutein of a bone morphogenetic protein and use thereof |
| GB0411186D0 (en) | 2004-05-19 | 2004-06-23 | Celltech R&D Ltd | Biological products |
| GB0412181D0 (en) | 2004-06-01 | 2004-06-30 | Celltech R&D Ltd | Biological products |
| US20090203041A1 (en) | 2006-04-21 | 2009-08-13 | Wei Shi | Bmp4 inhibitors |
| GB0619291D0 (en) | 2006-09-29 | 2006-11-08 | Ucb Sa | Altered antibodies |
| US8383349B2 (en) | 2007-03-16 | 2013-02-26 | The Board Of Trustees Of The Leland Stanford Junior University | Bone morphogenetic protein antagonist and uses thereof |
| EP2535350B1 (en) | 2007-09-26 | 2018-01-24 | UCB Biopharma SPRL | Dual specificity antibody fusions |
| WO2013137686A1 (ko) | 2012-03-15 | 2013-09-19 | 서울대학교 산학협력단 | 그렘린-1에 대한 항체 |
| BR112015021979A2 (pt) * | 2013-03-14 | 2017-08-29 | Regeneron Pharma | Anticorpos humanos para grem1 |
| GB201621635D0 (en) | 2016-12-19 | 2017-02-01 | Ucb Biopharma Sprl | Crystal structure |
| GB201802486D0 (en) | 2018-02-15 | 2018-04-04 | Ucb Biopharma Sprl | Methods |
| AU2019289176B2 (en) | 2018-06-18 | 2026-02-19 | Adelaide university | Gremlin-1 antagonist for the prevention and treatment of cancer |
-
2016
- 2016-12-19 GB GBGB1621635.0A patent/GB201621635D0/en not_active Ceased
-
2017
- 2017-12-19 MA MA47669A patent/MA47669B1/fr unknown
- 2017-12-19 PE PE2019001251A patent/PE20191542A1/es unknown
- 2017-12-19 CN CN201780079116.0A patent/CN110099924B/zh active Active
- 2017-12-19 RS RS20260692A patent/RS68186B1/sr unknown
- 2017-12-19 EP EP17825499.1A patent/EP3555129B1/en active Active
- 2017-12-19 AU AU2017384471A patent/AU2017384471B2/en active Active
- 2017-12-19 HR HRP20260798TT patent/HRP20260798T1/hr unknown
- 2017-12-19 JP JP2019533076A patent/JP7097364B2/ja active Active
- 2017-12-19 BR BR112019010903-0A patent/BR112019010903A2/pt unknown
- 2017-12-19 UY UY0001037528A patent/UY37528A/es unknown
- 2017-12-19 US US16/470,996 patent/US10947304B2/en active Active
- 2017-12-19 RU RU2019122648A patent/RU2769285C2/ru active
- 2017-12-19 EP EP26169654.6A patent/EP4768043A2/en active Pending
- 2017-12-19 IL IL267287A patent/IL267287B2/en unknown
- 2017-12-19 UA UAA201906847A patent/UA126025C2/uk unknown
- 2017-12-19 ES ES17825499T patent/ES3069589T3/es active Active
- 2017-12-19 MX MX2019006630A patent/MX2019006630A/es unknown
- 2017-12-19 PL PL17825499.1T patent/PL3555129T3/pl unknown
- 2017-12-19 KR KR1020197020545A patent/KR102557216B1/ko active Active
- 2017-12-19 TW TW106144629A patent/TWI787223B/zh active
- 2017-12-19 AR ARP170103569A patent/AR110394A1/es unknown
- 2017-12-19 TN TNP/2019/000188A patent/TN2019000188A1/en unknown
- 2017-12-19 CA CA3045742A patent/CA3045742A1/en active Pending
- 2017-12-19 WO PCT/EP2017/083650 patent/WO2018115017A2/en not_active Ceased
- 2017-12-19 EA EA201991511A patent/EA201991511A1/ru unknown
- 2017-12-19 MY MYPI2019003411A patent/MY202395A/en unknown
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2019
- 2019-06-11 PH PH12019501319A patent/PH12019501319A1/en unknown
- 2019-06-11 CO CONC2019/0006073A patent/CO2019006073A2/es unknown
- 2019-06-12 ZA ZA2019/03810A patent/ZA201903810B/en unknown
- 2019-06-19 CL CL2019001715A patent/CL2019001715A1/es unknown
- 2019-07-19 EC ECSENADI201951912A patent/ECSP19051912A/es unknown
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2021
- 2021-02-10 US US17/172,109 patent/US11807680B2/en active Active
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2023
- 2023-11-06 US US18/502,188 patent/US12473355B2/en active Active
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