CO2019006073A2 - Estructura cristalina de gremlina 1 y anticuerpo inhibidor - Google Patents
Estructura cristalina de gremlina 1 y anticuerpo inhibidorInfo
- Publication number
- CO2019006073A2 CO2019006073A2 CONC2019/0006073A CO2019006073A CO2019006073A2 CO 2019006073 A2 CO2019006073 A2 CO 2019006073A2 CO 2019006073 A CO2019006073 A CO 2019006073A CO 2019006073 A2 CO2019006073 A2 CO 2019006073A2
- Authority
- CO
- Colombia
- Prior art keywords
- gremlina
- human
- guild
- crystal structure
- inhibitor antibody
- Prior art date
Links
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
- A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/475—Growth factors; Growth regulators
- C07K14/51—Bone morphogenetic factor; Osteogenins; Osteogenic factor; Bone-inducing factor
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/22—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against growth factors ; against growth regulators
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2863—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for growth factors, growth regulators
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6854—Immunoglobulins
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/13—Crystalline forms, e.g. polymorphs
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2299/00—Coordinates from 3D structures of peptides, e.g. proteins or enzymes
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/55—Fab or Fab'
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biochemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biophysics (AREA)
- Biomedical Technology (AREA)
- Urology & Nephrology (AREA)
- Hematology (AREA)
- Microbiology (AREA)
- Zoology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Biotechnology (AREA)
- Physics & Mathematics (AREA)
- Gastroenterology & Hepatology (AREA)
- Toxicology (AREA)
- Cell Biology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Food Science & Technology (AREA)
- Analytical Chemistry (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Pulmonology (AREA)
- General Engineering & Computer Science (AREA)
Abstract
RESUMEN Esta invención se refiere a cristales de la proteína gremlina 1 humana y a la proteína de gremlina 1 humana en la forma de un complejo con un anticuerpo inhibidor. La invención también se refiere a la estructura de gremlina 1 humana (por sí misma, o en un complejo con el anticuerpo) y a los usos de estas estructuras en la selección de agentes que modulan la actividad de gremlina 1. La invención proporciona además anticuerpos que se unen a un sitio inhibidor alostérico en la gremlina 1, junto con las composiciones farmacéuticas y a los usos médicos de tales anticuerpos y agentes identificados por los métodos de selección.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GBGB1621635.0A GB201621635D0 (en) | 2016-12-19 | 2016-12-19 | Crystal structure |
PCT/EP2017/083650 WO2018115017A2 (en) | 2016-12-19 | 2017-12-19 | Gremlin-1 crystal structure and inhibitory antibody |
Publications (1)
Publication Number | Publication Date |
---|---|
CO2019006073A2 true CO2019006073A2 (es) | 2019-06-19 |
Family
ID=58284547
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CONC2019/0006073A CO2019006073A2 (es) | 2016-12-19 | 2019-06-11 | Estructura cristalina de gremlina 1 y anticuerpo inhibidor |
Country Status (27)
Country | Link |
---|---|
US (3) | US10947304B2 (es) |
EP (1) | EP3555129A2 (es) |
JP (1) | JP7097364B2 (es) |
KR (1) | KR102557216B1 (es) |
CN (1) | CN110099924B (es) |
AR (1) | AR110394A1 (es) |
AU (1) | AU2017384471A1 (es) |
BR (1) | BR112019010903A2 (es) |
CA (1) | CA3045742A1 (es) |
CL (1) | CL2019001715A1 (es) |
CO (1) | CO2019006073A2 (es) |
EA (1) | EA201991511A1 (es) |
EC (1) | ECSP19051912A (es) |
GB (1) | GB201621635D0 (es) |
IL (1) | IL267287A (es) |
MA (1) | MA47669A (es) |
MX (1) | MX2019006630A (es) |
MY (1) | MY202395A (es) |
PE (1) | PE20191542A1 (es) |
PH (1) | PH12019501319A1 (es) |
RU (1) | RU2769285C2 (es) |
TN (1) | TN2019000188A1 (es) |
TW (1) | TWI787223B (es) |
UA (1) | UA126025C2 (es) |
UY (1) | UY37528A (es) |
WO (1) | WO2018115017A2 (es) |
ZA (1) | ZA201903810B (es) |
Families Citing this family (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB201621635D0 (en) | 2016-12-19 | 2017-02-01 | Ucb Biopharma Sprl | Crystal structure |
GB201802486D0 (en) * | 2018-02-15 | 2018-04-04 | Ucb Biopharma Sprl | Methods |
US20210253688A1 (en) * | 2018-06-18 | 2021-08-19 | UCB Biopharma SRL | Gremlin-1 antagonist for the prevention and treatment of cancer |
JP2024504124A (ja) * | 2021-01-18 | 2024-01-30 | スーチョウ・トランスセンタ・セラピューティクス・カンパニー・リミテッド | 新規の抗グレムリン1抗体 |
JP2024513692A (ja) * | 2021-03-11 | 2024-03-27 | スーチョウ・トランスセンタ・セラピューティクス・カンパニー・リミテッド | グレムリン1アンタゴニストを使用して疾患を処置する方法 |
GB202205203D0 (en) | 2022-04-08 | 2022-05-25 | UCB Biopharma SRL | Combination with inhibitor |
GB202205200D0 (en) | 2022-04-08 | 2022-05-25 | Ucb Biopharma Sprl | Combination with chemotherapy |
WO2023203177A1 (en) * | 2022-04-20 | 2023-10-26 | Kantonsspital St. Gallen | Antibodies or antigen-binding fragments pan-specifically binding to gremlin-1 and gremlin-2 and uses thereof |
Family Cites Families (55)
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GB8422238D0 (en) | 1984-09-03 | 1984-10-10 | Neuberger M S | Chimeric proteins |
DK336987D0 (da) | 1987-07-01 | 1987-07-01 | Novo Industri As | Immobiliseringsmetode |
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GB0411186D0 (en) | 2004-05-19 | 2004-06-23 | Celltech R&D Ltd | Biological products |
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GB0619291D0 (en) | 2006-09-29 | 2006-11-08 | Ucb Sa | Altered antibodies |
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GB201621635D0 (en) | 2016-12-19 | 2017-02-01 | Ucb Biopharma Sprl | Crystal structure |
GB201802486D0 (en) | 2018-02-15 | 2018-04-04 | Ucb Biopharma Sprl | Methods |
US20210253688A1 (en) | 2018-06-18 | 2021-08-19 | UCB Biopharma SRL | Gremlin-1 antagonist for the prevention and treatment of cancer |
-
2016
- 2016-12-19 GB GBGB1621635.0A patent/GB201621635D0/en not_active Ceased
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2017
- 2017-12-19 BR BR112019010903A patent/BR112019010903A2/pt unknown
- 2017-12-19 UA UAA201906847A patent/UA126025C2/uk unknown
- 2017-12-19 AR ARP170103569A patent/AR110394A1/es unknown
- 2017-12-19 CN CN201780079116.0A patent/CN110099924B/zh active Active
- 2017-12-19 EA EA201991511A patent/EA201991511A1/ru unknown
- 2017-12-19 US US16/470,996 patent/US10947304B2/en active Active
- 2017-12-19 MX MX2019006630A patent/MX2019006630A/es unknown
- 2017-12-19 AU AU2017384471A patent/AU2017384471A1/en active Pending
- 2017-12-19 JP JP2019533076A patent/JP7097364B2/ja active Active
- 2017-12-19 MA MA047669A patent/MA47669A/fr unknown
- 2017-12-19 MY MYPI2019003411A patent/MY202395A/en unknown
- 2017-12-19 RU RU2019122648A patent/RU2769285C2/ru active
- 2017-12-19 TN TNP/2019/000188A patent/TN2019000188A1/en unknown
- 2017-12-19 TW TW106144629A patent/TWI787223B/zh active
- 2017-12-19 KR KR1020197020545A patent/KR102557216B1/ko active IP Right Grant
- 2017-12-19 WO PCT/EP2017/083650 patent/WO2018115017A2/en active Application Filing
- 2017-12-19 EP EP17825499.1A patent/EP3555129A2/en active Pending
- 2017-12-19 PE PE2019001251A patent/PE20191542A1/es unknown
- 2017-12-19 UY UY0001037528A patent/UY37528A/es unknown
- 2017-12-19 CA CA3045742A patent/CA3045742A1/en active Pending
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2019
- 2019-06-11 PH PH12019501319A patent/PH12019501319A1/en unknown
- 2019-06-11 CO CONC2019/0006073A patent/CO2019006073A2/es unknown
- 2019-06-12 IL IL267287A patent/IL267287A/en unknown
- 2019-06-12 ZA ZA2019/03810A patent/ZA201903810B/en unknown
- 2019-06-19 CL CL2019001715A patent/CL2019001715A1/es unknown
- 2019-07-19 EC ECSENADI201951912A patent/ECSP19051912A/es unknown
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2021
- 2021-02-10 US US17/172,109 patent/US11807680B2/en active Active
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2023
- 2023-11-06 US US18/502,188 patent/US20240076365A1/en active Pending
Also Published As
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